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Extraction technology of Engelhardia roxburghiana Wall leaf astilbin

A technology of astilbin and extraction process, which is applied in the field of extraction process of astilbin from yellow qi leaves, can solve the problems of low product purity and low yield of astilbin from huang qi leaves, and achieve simple operation process, low cost of raw materials, and high utilization rate. rate effect

Inactive Publication Date: 2017-04-19
广西来宾绿翔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a process for extracting astilbin from leaves of Huangqi to solve the problems of low yield of astilbin from leaves of Huangqi and low product purity. Provide a strong technical basis for the industrial production of Astilbin from Huangqi leaves

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] S1: Grind the yellow bark leaves, pass through a 40-mesh sieve, add 80% ethanol that is 5 times its weight, and reflux extraction under water bath conditions for 3 times. The extraction time is 1.5h. After the extraction is complete, combine the extracts and adjust the pH of the extracts. To 3, the temperature is controlled at 75°C, decolorized and removed by activated carbon for 0.5h, and filtered to obtain a decolorized solution;

[0026] S2: Concentrate the primary decolorizing liquid in step S1 under reduced pressure in a vacuum and then cool and crystallize. The obtained crystals are washed with distilled water until they are colorless to obtain coarse crystals. The coarse crystals are dried in an oven at 100°C for 3 hours to obtain Astilbin. Through the detection of high performance liquid chromatography, the content of astilbin in the product reached 63.4%;

[0027] S3: dissolving the coarse crystals in step S2 with 60% ethanol at 65° C., decolorizing and removi...

Embodiment 2

[0030] S1: Pulverize the leaves of Huangqi, pass through a 40-mesh sieve, add 80% ethanol that is 6 times its weight, and extract twice under the condition of reflux in a water bath for 3 hours. After the extraction is complete, combine the extracts and adjust the pH value of the extracts to 4. Control the temperature at 80°C, decolorize and remove impurities by activated carbon for 1 hour, and filter to obtain a decolorizing solution;

[0031] S2: Concentrate the primary decolorizing solution in step S1 under reduced pressure in a vacuum and then cool and crystallize. The obtained crystals are washed with distilled water until they are colorless to obtain coarse crystals. The crystals are dried in an oven at 105°C for 3 hours to obtain off-white Neotidine. Through the detection of high performance liquid chromatography, the content of astilbin in the product reached 65.3%;

[0032] S3: dissolving the coarse crystals in step S2 with 60% ethanol at 65° C., decolorizing and rem...

Embodiment 3

[0035] S1: Pulverize the leaves of Huangqi, pass through a 40-mesh sieve, add 80% ethanol that is 8 times its weight, and reflux extraction under water bath conditions for 3 times. The extraction time is 2 hours. After the extraction is complete, combine the extracts and adjust the pH value of the extracts to 5. Control the temperature at 85°C, decolorize and remove impurities by activated carbon for 1.5 hours, and filter to obtain a decolorized solution;

[0036] S2: Concentrate the primary decolorizing liquid in step S1 under reduced pressure in a vacuum, then cool and crystallize, wash the obtained crystals with distilled water until they are colorless to obtain coarse crystals, put the crude crystals in an oven at 110°C and dry them for 2 hours to obtain Astilbin. After detection by high performance liquid chromatography, the content of astilbin in the product reached 60.6%;

[0037] S3: dissolving the coarse crystals in step S2 with 60% ethanol at 65° C., decolorizing an...

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Abstract

The invention discloses an extraction technology of Engelhardia roxburghiana Wall leaf astilbin, and belongs to the technical field of extraction of natural product effective components. The technology comprises the following steps: crushing Engelhardia roxburghiana Wall leaves to form crude powder, carrying out reflux extraction by using 80% ethanol, carrying out decolorizing and impurity removal on obtained extract through active carbon, and filtering the obtained extract to obtain a primarily decolorized liquid; carrying out vacuum reduced pressure concentration on the primarily decolorized liquid, crystallizing the obtained concentrate, and washing obtained crystals with distilled water until the crystals are colorless in order to obtain crude crystals; dissolving the crude crystals in hot alcohol, and carrying out decolorizing and impurity removal on the obtained alcohol solution by using active carbon to obtain a secondarily decolorized liquid; and filtering and concentrating the secondarily decolorized liquid, crystallizing the obtained concentrate at a low temperature, and drying the obtained crystals to prepare 90-96% astilbin. The extraction technology of Engelhardia roxburghiana Wall leaf astilbin has the advantages of low cost of above raw material, simple operating process, full extraction of effective components in the Engelhardia roxburghiana Wall leaves, realization of high purity of the prepared astilbin, and increase of the utilization rate of the raw material.

Description

[0001] The invention belongs to the technical field of extraction of effective components of natural products, and in particular relates to an extraction process of astilbin from leaves of Huang Qi. [0002] 【Background technique】 [0003] Huang Qiye has the function of clearing heat and relieving pain, and can be used to treat cold, fever and abdominal pain due to hernia. Astilbin, the dihydroflavonol glycoside component in Huangqi leaves, has a variety of biological activities, such as strong antioxidant activity, lowering blood sugar, regulating fat metabolism, and selective immunosuppression. At present, in the extraction technology of the effective components of Huangqi leaves, there are generally prominent problems such as low utilization rate, low purity of the prepared product, complicated technical process, and difficulty in realizing industrialized production. In order to develop and utilize Huangqi resources, the yield of astilbin in Huangqi leaves was used as the ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
CPCC07H17/07C07H1/08
Inventor 韦小兰陈桂明陆兴国陆曦
Owner 广西来宾绿翔生物科技有限公司
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