Thyroid disease auxiliary diagnosis instrument and its application

A technology for thyroid diseases and diagnostic instruments, applied in the field of auxiliary diagnostic instruments for thyroid diseases, can solve the problems of high cost, time-consuming and labor-intensive, unsuitable for large-scale analysis, etc., and achieves the effects of simple method, simplified extraction process, and avoidance of sample preprocessing steps.

Inactive Publication Date: 2005-06-08
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
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Problems solved by technology

Literature [10, 12] utilizes two different polarity SPE columns (silica gel column and C18 column) to successively remove the weak polarity and strong polarity impurities in the plasma, so that the blood sample is purified to a great extent, and the method yields the peak Clean, effective protection and extended column life; however, two-step solid-phase extraction is time-consuming and laborious, and the cost is high, which is not suitable for clinical mass analysis

Method used

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  • Thyroid disease auxiliary diagnosis instrument and its application
  • Thyroid disease auxiliary diagnosis instrument and its application
  • Thyroid disease auxiliary diagnosis instrument and its application

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Embodiment 1

[0025] 1. The instrument of the present invention can realize automatic pretreatment of blood samples, automatic sampling and automatic separation and quantification of coenzyme Q10 components; it is mainly completed through the following steps;

[0026] 1) Take a fresh plasma sample with a volume of 0.3ml, add 1ml of n-propanol (the volume ratio of the two can be 0.2:1 to 0.4:1) and centrifuge to degrease the protein, then directly load the supernatant for analysis;

[0027] 2) When the six-way valve is in the "LOAD" position ( figure 2 ), the analysis sample is directly injected through an autosampler, and pure methanol is used to rinse the octadecyl-bonded silica gel column A, so that the coenzyme Q10 in the plasma is retained on the column A;

[0028] 3) Continue to rinse column A with pure methanol, and some impurities remaining in the plasma will flow through column A into the waste liquid discharge line waste liquid bottle;

[0029] 4) When the six-way valve is in the...

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Abstract

An auxiliary diagnosing apparatus for the thyropathy is composed of three high-pressure pumps, automatic speciment feeder, six-way valve,two octadecyl bonded silica gel columns, mixer and UV-visual light detector, all of which are connected according to the invented logic. Its advantages are high precision and low cost.

Description

technical field [0001] The invention relates to a disease diagnosis instrument, in particular to an auxiliary diagnosis instrument for thyroid disease and its application. Background technique [0002] Hyperthyroidism and hypothyroidism are the two most common thyroid diseases, which are endocrine diseases caused by excessive or insufficient secretion of thyroid hormone in the body. Hyperthyroidism is relatively common, and more common in women; it is reported that the prevalence of hyperthyroidism accounts for 2% of the female population, and the annual new incidence rate is 2 / 1000-3 / 1000 female population, and there is a gradual increase trend. Hyperthyroidism increases the oxygen consumption of the body. On the one hand, it is to meet the needs of excessive metabolism, and on the other hand, it causes the increase of oxygen free radicals in the body [Document 1. Videla LA, SirT, WolffC; Free Radic Res Commun, 1988, 5: 1-10]. Whether coenzyme Q10 is an essential proton t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/145C12Q1/00G01N21/00
Inventor 许国旺江平郑育芳
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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