Process for extracting siatic toddalia root alkaloid

A technique for extracting the blood of the dragon palm, applied in the field of medicinal chemistry, can solve the problems of low extraction efficiency and the like, and achieve the effects of high extraction efficiency, good economic benefits, and a simple and easy process method.

Inactive Publication Date: 2015-09-16
石磊 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] One of the purposes of the present invention is to provide an economical and simple process for extracting alkaloids from the blood of the dragon’s palm in order to solve the problem of low extraction efficiency in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Take the blood of Feilongzhang and dry the medicinal materials, pulverize them to obtain the coarse powder of the medicinal materials (the requirements of the coarse powder meet the requirements of the "Chinese Pharmacopoeia"), soak the coarse powder of the medicinal materials with 10 times of water as a solvent for 30 minutes, and decoct 3 times, each time for 1.5 hours Combine three extracts, concentrate at 65°C, -1.0mpa under reduced pressure; filter the concentrate; take the filtrate and centrifuge at low speed for 10 minutes, then centrifuge at high speed for 10 minutes. Take the supernatant obtained after centrifugation, and concentrate under reduced pressure at -0.6mpa until its relative density is not less than 1.04. Oral solution can be obtained by filling and sealing after damp heat and high pressure sterilization; if it is made into powder for external use, it needs to be concentrated to a relative density of 1.15-1.3, dried under normal pressure or...

Embodiment 2

[0013] Example 2: take the blood of the dragon's palm and dry the medicinal materials, pulverize them to obtain the coarse powder of the medicinal materials (the requirements of the coarse powder meet the requirements of the "Chinese Pharmacopoeia"), soak the coarse powder of the medicinal materials with 10 times of water as a solvent for 30 minutes, and decoct 3 times for 1.5 hours each time Combine three extracts, concentrate at 70°C, -0.8mpa under reduced pressure; filter the concentrate; take the filtrate and centrifuge at low speed for 15 minutes, and then centrifuge at high speed for 15 minutes. Take the supernatant obtained after centrifugation, and concentrate under reduced pressure at -0.8mpa until its relative density is not less than 1.04. Oral solution can be obtained by filling and sealing after damp heat and high pressure sterilization; if it is made into powder for external use, it needs to be concentrated to a relative density of 1.15-1.3, dried under normal pre...

Embodiment 3

[0014] Example 3: Take the blood of Feilongzhang to dry the medicinal material, pulverize it to obtain the coarse powder of the medicinal material (the requirements of the coarse powder meet the requirements of the "Chinese Pharmacopoeia"), soak the coarse powder of the medicinal material with 10 times of water as a solvent for 30 minutes, decoct 3 times, each time for 1.5h Combine three extracts, concentrate at 75°C, -0.6mpa under reduced pressure; filter the concentrate; take the filtrate and centrifuge at low speed for 20 minutes, then at high speed for 20 minutes, the speed of low speed centrifugation is 5000r / min, and the speed of high speed centrifugation is 10000r / min. Take the supernatant obtained after centrifugation, and concentrate under reduced pressure at -1.0mpa until its relative density is not less than 1.04. Oral solution can be obtained by filling and sealing after damp heat and high pressure sterilization; if it is made into powder for external use, it needs ...

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PUM

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Abstract

The invention discloses a process for extracting an asiatic toddalia root alkaloid. The process comprises the following steps: taking a dry medicinal material of the asiatic toddalia root, and crushing the dry medicinal material of the asiatic toddalia root into coarse powder; adding water to the coarse powder of the medicinal material and soaking for half an hour; decocting the soaked coarse powder for three times and 1.5 hours each time, merging extract liquids of three times, concentrating and filtering to obtain filtrate; centrifuging the filtrate to obtain supernate; and further concentrating the supernate until the relative density is greater than or equal to 1.04. The process for extracting the asiatic toddalia root alkaloid disclosed by the invention is simple and feasible in method and high in extraction efficiency, and has good economic benefits; and the alkaloid in the medicinal material can be fully and effectively extracted.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a process for extracting alkaloids from blood of dragon palm. Background technique [0002] Feilongzhangxue, also known as Jianxuefei, Dajiujia, Langchang, etc., is the dry heel or root bark of Toddalia asiatica Lam., a plant of the Rutaceae family. It is often used to treat rheumatic arthralgia, stomach pain, dysmenorrhea, bruises, etc. The alkaloids accounted for 54.5% of the compounds isolated from Feilongzhangxue medicinal materials, and pharmacological experiments proved that the total alkaloids, as an effective part group, have obvious labor pain, anti-inflammatory and hemostatic activities, so on this basis, the mixed The uniform test design extracts the total alkaloids, and optimizes the process of making powders from the extracts, laying the foundation for further research on its preparations. [0003] Feilongzhang blood is mostly decocted in clinical use...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61P7/04
Inventor 石磊姬志强张振巍
Owner 石磊
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