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General flavone extractive of immature bitter orange or bitter orange extracted through water decoction and use of general flavone extractive

A technology of water decoction and total flavonoids, which is applied in the direction of medical preparations containing active ingredients, drug combinations, plant raw materials, etc., can solve the problems that the similarity of action has not been fully tapped, and resources have not been widely used, so as to promote gastric cancer. dynamic effect

Active Publication Date: 2012-11-21
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Citrus aurantium and Fructus aurantium are only used in a small amount in clinical formulas and Chinese patent medicine preparations, and a large amount of resources have not been widely used. Their natural effects of breaking Qi and eliminating stagnation may not be fully exploited in the similarity with modern gastric motility-promoting drugs.

Method used

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  • General flavone extractive of immature bitter orange or bitter orange extracted through water decoction and use of general flavone extractive
  • General flavone extractive of immature bitter orange or bitter orange extracted through water decoction and use of general flavone extractive
  • General flavone extractive of immature bitter orange or bitter orange extracted through water decoction and use of general flavone extractive

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Preparation method: Take citrus aurantium or citrus aurantium, cut into slices, add 7 times the amount of water, decoct 3 times, extract 1 hour each time, combine the decoction, filter, and pass the filtrate through the processed D101 macropore The resin is eluted with water and 18% ethanol in sequence to remove impurities, then eluted with 35% ethanol and 0.5% sodium hydroxide. Collect the 35% ethanol eluate and concentrate it under reduced pressure to a relative density of about 1.25 (55℃). The paste is dried under reduced pressure (60°C) and crushed to obtain.

Embodiment 2

[0037] Preparation method: take citrus aurantium or citrus aurantium, crush, pass through an 8 mesh sieve, add water and cook 3 times, add 8 times the amount of water for the first time and cook for 2.5 hours, and add 6 and 5 times the amount of water for the second and third times respectively for 1 hour , Filter, combine the filtrate, pass the filtrate through the treated AB-8 macroporous resin column, eluting with water, 15% ethanol, 45% ethanol, 1% sodium hydroxide, collect 45% ethanol eluate, and reduce pressure Concentrate to a liquid extract with a relative density of about 1.31 (65°C), dry under reduced pressure (70°C), and crush to obtain.

Embodiment 3

[0039] Preparation method: Take citrus aurantium or citrus aurantium, cut into pieces, add 8 times the amount of water, decoct 3 times, decoct and extract for 1.5 hours each time, combine the decoction, filter, and pass the filtrate through the processed D101 macropore The resin is eluted with water and 16% ethanol successively to remove impurities, and then eluted with 40% ethanol and 0.6% sodium hydroxide. The 40% ethanol eluate is collected and concentrated under reduced pressure to a flow immersion with a relative density of about 1.20 (50°C) The paste is dried under reduced pressure (65°C) and crushed to obtain.

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Abstract

The invention relates to a general flavone extractive of an immature bitter orange or a bitter orange. The general flavone extractive is extracted through the following steps: cutting the immature bitter orange or the bitter orange into decoction pieces or smashing the immature bitter orange or the bitter orange, adding 4 to 15 times of water, decocting 1 to 3 times (1 to 3 hours each time), merging the decoction liquids, filtering through processed non-polar big hole resin, eluting by water and alcohol of which the concentration is lower than 20 percent sequentially to remove impurities, eluting by alcohol of which the concentration ranges from 25 to 90 percent and sodium hydrate of which the concentration ranges from 0.5 to 2 percent, collecting alcohol eluant, depressuring and concentrating to obtain a liquid extract of which the relative density is 1.20 to 1.40 (under the temperature ranging from 50 DEG C to 70 DEG C), depressuring and drying under the temperature ranging from 60 DEG C to 80 DEG C, and smashing to obtain the general flavone extractive of the immature bitter orange or the bitter orange. The extractive can be used for preparing medicines used for curing gastrointestinal dyskinesia-type functional indigestion, epigastralgia, abdominal distention, asitia, eructation, nausea, and vomit caused by chemotherapeutics and other reasons, and is prepared into dosage forms acceptable for pharmacology.

Description

Technical field [0001] The invention relates to a decoction extract of Fructus Aurantii or Fructus Aurantii total flavonoids extract and its use. Background technique [0002] Functional dyspepsia (FD) is a common and frequently-occurring disease. It is also called gastric hypomotility, or gastric motility disorder. It is a common clinical syndrome. Foreign statistics show that one third of the population has suffered from FD, accounting for 20% to 30% of outpatients. Domestically, it accounts for about 50% of outpatients in the digestive system, and occurs in 20% to 40% of the normal population. In addition, more than 80% of cancer patients will cause vomiting after chemotherapy. The main anti-vomiting drugs are mettalin, Shufuning and other drugs, but the anti-vomiting drugs are accompanied by fatigue, dizziness, headache, and even neck and back muscles may appear. Symptoms of cramps. [0003] At present, Western medicine treatment mainly focuses on domperidone, cisapride, mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P1/08A61P1/14
Inventor 吕武清唐春山谢宁杨小玲孙继寅宋友昕李志勇
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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