Immature bitter orange or bitter orange general flavone extract extracted in decoction way through water and application thereof

Abstract

The invention relates to an immature bitter orange or bitter orange general flavone extract extracted in a decoction way through water, which is characterized in that: immature bitter orange or bitter orange is cut into slices or is pulverized to be decocted for 1-3 times in the water with the volume being 4 to 15 times of that of the raw material, the raw material is decocted and extracted for 1to 3 hours every time, the decocted liquid is combined and filtered, the filtered liquid passes through a well-processed nonpolar macroporous resin and is sequentially washed by water and 20% ethanolso as to remove the foreign matters, then the filtered liquid is eluted by 25 to 90 percent ethanol and 0. 5 to 2 percent sodium hydroxide, the ethanol eluted liquid is collected, decompressed and concentrated into liquid extract with relative density being about 1.2 to 1.4 (50 DEG C to 70 DEG C), the liquid extract is decompressed and dried at the temperature of 60 to 80 DEG C and pulverized to obtain the immature bitter orange or bitter orange general flavone extract. The extract can be used for preparing medicine for treating motility disturbance type intestine and stomach functional indigestion, epigastric pain, abdominal distension, anorexia, eructation, nausea, vomiting and vomiting caused by chemotherapeutics or other reasons and can be made into a preparation form which is acceptable on the medicine.

Description

technical field [0001] The invention relates to a decocted and extracted total flavonoid extract of Fructus Aurantii or Fructus Fructus Fructus and its application. Background technique [0002] Functional dyspepsia (FD) is a common and frequently-occurring disease. Also known as gastric insufficiency, or gastric motility disorder. Is a common clinical syndrome, foreign statistics show that 1 / 3 of the population suffered from FD, accounting for 20% to 30% of outpatients. Domestically, it accounts for about 50% of digestive system outpatients, and occurs in 20% to 40% of normal people. In addition, more than 80% of cancer patients will cause vomiting after chemotherapy. The main anti-vomiting drugs are Metoclon and Zofran, but chemical drugs are accompanied by fatigue, dizziness, headache, and even neck and back muscle pain. Cramp symptoms. [0003] At present, Western medicine mainly treats modinline, cisapride, mosapride, etc.; however, with the extensive use of them,...

AI Technical Summary

Problems solved by technology

However, Citrus aurantium and Fructus aurantium are only used in a small amount in clinical formulas and Chinese patent medicine preparations, and a large amount of resources have not been widely used. Their natural effects of breaking Qi and eliminating stagnation may not be fully exploited in the similarity with modern gastric motility-promoting drugs.

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