Pharmaceutical composition for treating cardiovascular diseases and preparation method thereof

A composition and cardiovascular technology, applied in the field of medicine, can solve the problems of large daily dosage, increased dosage, lack of ginger, etc., and achieve the effect of convenient taking, time saving and no side effects

Active Publication Date: 2016-05-04
吉林修正药业新药开发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] "Drug Standards of the Ministry of Health of the People's Republic of China, Traditional Chinese Medicine Prescriptions, Volume 2" discloses the preparation method of Baoxinning Tablets. 0.25g, daily dosage 3~6 tablets / time 3 times / day); patent application number is 201210253441.3 patent discloses a kind of Chinese medicine preparation and preparation method for treating angina pectoris, arrhythmia and coronary heart disease. Angelica and Fructus Aurantii are composed of four medicinal materials, and compared with the composition of Baoxinning Tablets, it lacks ginger, and it is verified by the pharmacodynamics comparison experiment of the present invention that it has low effect in treating cardiac ischemia / reperfusion injury, acute myocardial ischemia, etc. Baoxinning pharmaceutical composition of the present invention

Method used

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  • Pharmaceutical composition for treating cardiovascular diseases and preparation method thereof
  • Pharmaceutical composition for treating cardiovascular diseases and preparation method thereof
  • Pharmaceutical composition for treating cardiovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] (1) Preparation of Salvia Miltiorrhiza Extract:

[0109] Take the Danshen medicinal material, crush it into a coarse powder, reflux extract with 8 times the amount of 75% ethanol for 3 times, each time for 2 hours, filter, combine the filtrate, concentrate to an appropriate amount, and dry to obtain a dry cream powder; add 8 times the dregs Measure water and decoct twice, each time for 1 hour, filter, combine the filtrates, concentrate to an appropriate amount, and dry to obtain a dry cream powder; combine the above dry cream powder, crush, and sieve to obtain the salvia miltiorrhiza extract.

[0110] (2) Preparation of Panax notoginseng saponins:

[0111] Take notoginseng medicinal material, crush it into coarse powder, reflux extract with 8 times the amount of 80% ethanol for 2 times, each time for 1 hour, filter, recover ethanol, concentrate under reduced pressure, load the sample on macroporous resin, and pass through water, 30 %, 50% ethanol for elution, collect t...

Embodiment 2

[0121] (1) Preparation of Salvia Miltiorrhiza Extract:

[0122] Take Danshen medicinal material, crush it into coarse powder, reflux extract with 10 times the amount of 80% ethanol for 3 times, each time for 2 hours, filter, combine the filtrate, concentrate to an appropriate amount, and dry to obtain dry cream powder; add 10 times the dregs Measure water and decoct twice, each time for 1.5 hours, filter, combine the filtrates, concentrate to an appropriate amount, and dry to obtain a dry paste powder; combine the above dry paste powder, crush, and sieve to obtain the salvia miltiorrhiza extract.

[0123] (2) Preparation of Panax notoginseng saponins:

[0124] Take notoginseng medicinal material, crush it into coarse powder, reflux extract with 10 times the amount of 85% ethanol twice, each time for 2 hours, filter, concentrate the filtrate under reduced pressure, load the sample on the macroporous resin, pass through water, 30%, Elute with 70% ethanol, collect the 70% ethano...

Embodiment 3

[0134] (1) Preparation of Salvia Miltiorrhiza Extract:

[0135] Take Salvia miltiorrhiza, crush it into a coarse powder, reflux extract with 6 times the amount of 60% ethanol for 3 times, each time for 1 hour, filter, combine the filtrate, concentrate to an appropriate amount, and dry to obtain a dry cream powder; add 6 times the dregs Measure water and decoct twice for 0.5 hours each time, filter, combine the filtrates, concentrate to an appropriate amount, and dry to obtain a dry cream powder; combine the above dry cream powder, crush, and sieve to obtain the salvia miltiorrhiza extract.

[0136] (2) Preparation of Panax notoginseng saponins:

[0137] Take notoginseng medicinal material, crush it into coarse powder, reflux extract with 6 times the amount of 75% ethanol twice, each time for 1 hour, filter, concentrate the filtrate under reduced pressure, load the sample on the macroporous resin, and pass through water, 30%, Elute with 40% ethanol, collect the 40% ethanol elu...

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Abstract

The invention discloses a pharmaceutical composition for treating cardiovascular diseases and a preparation method thereof. The pharmaceutical composition comprises the following raw materials in parts by weight: 50-200 parts of a danshen root extract, 30-120 parts of panax notoginseng total saponins, 30-120 parts of a bitter orange extract, 30-200 parts of a Chinese angelica extract, 30-200 parts of a ginger extract, 5-40 parts of a Chinese angelica volatile oil inclusion compound and 5-40 parts of a ginger volatile oil inclusion compound. The preparation method comprises the following steps: preparing the danshen root extract, preparing the panax notoginseng total saponins, preparing the bitter orange extract, preparing the Chinese angelica and ginger extracts, preparing the Chinese angelica and ginger volatile oil inclusion compounds, and mixing the raw materials. The pharmaceutical composition disclosed by the invention has the positive effects that the active ingredients of each medicinal material are fully extracted and purified, the usage amount of a solvent is relatively small, the time is saved, and the production cost is reduced. The pharmaceutical composition can be used for effectively treating ischemic heart diseases of coronary heart disease, angina pectoris, miocardial infarction and the like, and also has the effect of reducing the blood pressure and blood fat.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, the prevalence of various diseases that seriously endanger human life is increasing year by year, among which, such as cardiovascular diseases, such as coronary heart disease. The most common cause of myocardial ischemia is atherosclerosis of the coronary arteries and their branches. In addition to age-related causes of arteriosclerosis, high blood pressure, hyperlipidemia, high cholesterol, and diabetes can accelerate the occurrence and development of arteriosclerosis. Ischemic heart disease has become one of the diseases that affect human health and threaten life. Prevention and treatment of ischemic heart disease has also received attention. At present, in the treatment of Chinese an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K47/48A61P9/00
CPCA61K36/232A61K36/258A61K36/537A61K36/752A61K36/9068A61K2236/15A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 徐云任晶白冰徐建于艳辉许艳茹赵源慧
Owner 吉林修正药业新药开发有限公司
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