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Application of Chinese medicinal herb immature bitter orange extract to preparation of weight-reducing and lipid-lowering medicament or preparation of medicament having lipase activity suppressing effect

A technology of Chinese herbal medicine and water extract, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of unclear pharmacological mechanism, unclear active ingredients of Chinese herbal medicine, and failure of Chinese herbal medicine to go global

Inactive Publication Date: 2012-03-14
BEIJING WBL PEKING UNIV BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to limitations such as unclear active ingredients and pharmacological mechanisms of Chinese herbal medicines, traditional Chinese herbal medicines cannot go to the world. So far, there is no weight-loss drug with independent intellectual property rights in my country.

Method used

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  • Application of Chinese medicinal herb immature bitter orange extract to preparation of weight-reducing and lipid-lowering medicament or preparation of medicament having lipase activity suppressing effect
  • Application of Chinese medicinal herb immature bitter orange extract to preparation of weight-reducing and lipid-lowering medicament or preparation of medicament having lipase activity suppressing effect
  • Application of Chinese medicinal herb immature bitter orange extract to preparation of weight-reducing and lipid-lowering medicament or preparation of medicament having lipase activity suppressing effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: the preparation of Scutellaria baicalensis water extract

[0061] Take Scutellaria baicalensis slices, prefabricate, pulverize; add 5 times the volume of deionized water, boil for 30 minutes, filter, and take the filtrate; use conventional methods to make conventional dosage forms for the preparation of lipase inhibitors.

Embodiment 2

[0062] Example 2: Preparation of Scutellariae Alcohol Extract

[0063] Scutellaria baicalensis slices are taken, prefabricated, and pulverized; 5 times the volume of 75% ethanol is added, ultrasonically extracted for 60 minutes, filtered, and the filtrate is obtained; conventional dosage forms are prepared by conventional methods for the preparation of lipase inhibitors.

Embodiment 3

[0064] Embodiment 3: the preparation of Pu'er tea water extract

[0065] Take Pu'er tea decoction pieces, prefabricate, pulverize; add 10 times the volume of deionized water, boil for 60 minutes, centrifuge at 4000r / min for 20 minutes, and take the supernatant; use conventional methods to make conventional dosage forms for the preparation of lipase inhibitors.

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Abstract

The invention discloses application of a water extract or alcohol extract of Chinese medicinal herb immature bitter orange to the preparation of a weight-reducing and lipid-lowering medicament or the preparation of a medicament having a lipase activity suppressing effect. According to the invention, the defects of low efficiency and large side effect of the conventional clinical weight-reducing medicament, in particular traditional Chinese medicines are overcome, and a weight-reducing and lipid-lowering medicament with a definite mechanism, a scientific target point, a small side effect and high clinical effective rate is provided.

Description

technical field [0001] The invention relates to the application of the Chinese herbal medicine citrus aurantium extract in the preparation of weight-loss and lipid-lowering medicine or the medicine with lipase activity inhibitory effect. Background technique [0002] Metabolic syndrome (MS) mainly includes risk factors such as obesity, impaired glucose tolerance, dyslipidemia, and hypertension. The incidence of diabetes (Diabetes mellitus, DM) and cardiovascular disease in MS patients is often several times that of the normal population. MS has seriously endangered human's physical and mental health and has become a worldwide public health problem, but so far our understanding of MS is very limited. Preliminary studies have confirmed that among many causes, obesity has a particularly close relationship with MS, and is a key factor and core link in the onset and development of MS. With the development of economy, the improvement of people's living standard and the change of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61K36/804A61K36/855A61K45/00A61P3/04A61P3/06
Inventor 段震文郭树仁闫雪秋
Owner BEIJING WBL PEKING UNIV BIOTECH
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