This invention relates to the field of
supramolecular chemistry, specifically to a fluorinated functionalized macrocyclic supramolecular host molecular cup, its preparation method, and its applications. It is a 2-difluoromethylbenzimidazole molecular cup host and its
metal derivatives. By introducing a difluoromethyl group to moderately increase
lipophilicity, the excellent properties of the
trifluoromethyl macrocyclic supramolecular host are inherited while increasing water
solubility. Furthermore, it can recognize cycloalkanes,
alkyl carboxylic acids, especially n-
heptanoic acid and n-octanoic acid, thus facilitating a series of
molecular recognition studies in aqueous phase. Compared with existing technologies, this invention features a simple process, readily available raw materials, mild
reaction conditions, high yield, and good reproducibility. The difluoromethyl-modified macrocyclic molecular cup H1 and the
metal molecular cup H formed with
palladium in this invention are also described. 1‑Pd It exhibits novel structure and high degree of functionalization, enhancing its
molecular recognition ability and selectivity, and can be used in
environmental remediation and water
pollutant treatment.