Contact lens care solution capable of moisturizing, lubricating and resisting bacteria for long time and preparation method of contact lens care solution

Abstract

The invention discloses a contact lens care solution capable of moisturizing, lubricating and resisting bacteria for a long time and a preparation method thereof, and the care solution comprises the following components in percentage by mass: 1.0-2.5% of polyglycerol ether-26; 2.0%-3.5% of a composite natural bacteriostatic agent; 1.0 to 2.0 percent of a thickening agent; 1.5%-2.5% of a surface active agent; 0.15%-1.8% of a pH regulator; 8.5-9.0% of an osmotic pressure regulator; and the balance of purified water. The composite natural bacteriostatic agent is a mixture of catechin and ginkgetin. The preparation method comprises the following steps: adding part of purified water into a container, then adding polyglycerol polyether-26, the composite natural bacteriostatic agent, the thickening agent and the surfactant, then supplementing part of purified water, and stirring for dissolving; adjusting the pH value of the solution to 6.5-7.8 and the osmotic pressure to 260-340 mOsm / kg.H2O, finally adding the balance of purified water, and uniformly stirring; and filtering and sub-packaging to obtain the product. According to the invention, polyglycerol ether-26 has high moisturizing and lubricating properties, catechin and ginkgetin have a synergistic effect, so that the antibacterial property can be improved, and as a natural plant extraction component, the eye cream is non-irritant when entering eyes, is higher in safety and can play a role in protecting the eyes.

Description

Technical Field

[0001] The invention relates to the technical field of contact lens care, in particular to a contact lens care solution capable of long-term moisturizing and antibacterial properties, and also relates to a preparation method of the contact lens care solution. Background Art

[0002] During long-term wearing of contact lenses, deposits, including proteins, lipids, and pathogenic microorganisms, are easily formed on the surface of the lenses, which not only reduce the light transmittance and comfort of the lenses, but also cause varying degrees of pathological changes in the wearer's eyes. Therefore, contact lens care solutions are needed for cleaning and disinfection. However, after long-term use, the moisturizing and lubricating effects of existing contact lens care solutions are reduced, affecting the comfort of the wearer. Therefore, it is urgent to prepare a contact lens care solution with long-term moisturizing and lubrication. At the same time, in order to ensure the safety of contact lenses, the contact lens care solution is also required to have a good bactericidal effect. Summary of the invention

[0003] Based on the above, the purpose of the present invention is to provide a contact lens care solution that can provide long-term moisturizing, lubricating and antibacterial properties, so as to solve the technical problem that the existing contact lens care solution does not have a long-term moisturizing, lubricating effect, and affects the wearing comfort.

[0004] Another object of the present invention is to provide a method for preparing the contact lens care solution.

[0005] To achieve its purpose, the present invention adopts the following technical solution: A contact lens care solution capable of long-term moisturizing, lubricating and antibacterial properties, comprising the following components by mass percentage: Polyglycerol ether-26: 1.0-2.5%; Composite natural antibacterial agent: 2.0-3.5%; Thickener: 1.0-2.0%; Surfactant: 1.5-2.5%; pH adjuster: 0.15-1.8%; Osmotic pressure regulator: 8.5-9.0%; The balance is purified water; The composite natural antibacterial agent is a mixture of catechins and ginkgo flavonoids.

[0006] As a further preferred embodiment of the technical solution of the present invention, the mass ratio of catechins to ginkgo flavonoids is 0.5-1.5:0.5-1.5.

[0007] Furthermore, the mass ratio of the catechins to the ginkgo flavonoids is 1:1.

[0008] Furthermore, the thickener is a mixture of one or more of sodium hyaluronate, hydroxypropyl methylcellulose or methyl glucose derivatives.

[0009] Furthermore, the surfactant is any one of poloxamer 407, glyceride or polysorbate.

[0010] Furthermore, the osmotic pressure regulator is sodium chloride or potassium chloride, or a mixture of the two.

[0011] Furthermore, the pH regulator is a mixture of one or more of boric acid, borax, dipotassium hydrogen phosphate or disodium hydrogen phosphate.

[0012] The preparation method of the above-mentioned contact lens care solution capable of long-term moisturizing, lubricating and antibacterial comprises the following steps: (1) Weigh each component according to the formula and set aside; (2) Add some purified water into the container, then add polyglycerol polyether-26, composite natural antibacterial agent, thickener and surfactant, then add some purified water, stir and dissolve; (3) Add pH regulator and osmotic pressure regulator to adjust the solution pH to 6.5-7.8 and osmotic pressure to 260-340mOsm / kg·H 2 O, finally add the remaining amount of purified water and stir for 2-3h; (4) The solution prepared in step (3) is filtered and sterilized, and the filtrate is packaged to obtain the contact lens care solution.

[0013] Furthermore, in step (2), the stirring and dissolving time is 1-2 hours.

[0014] Furthermore, the solution prepared in step (3) is filtered and sterilized using a 0.22 μm filter.

[0015] By adopting the above technical solution, the present invention achieves the following beneficial effects: Polyglyceryl ether-26 is a multifunctional nonionic surfactant containing multiple glycerol units, soluble in water, with excellent moisturizing and lubricating properties, emulsification, mildness and stability; Catechins are a class of phenolic active substances extracted from natural plants such as tea leaves. They are also natural antioxidants that can remove free radicals produced by the human body to protect cell membranes. At the same time, catechins have a good antibacterial effect and a broad antibacterial spectrum. They have a significant inhibitory effect on both Gram-positive and Gram-negative bacteria with and without cell walls. Low-concentration medication can achieve a good antibacterial effect, and can also protect and promote the growth of beneficial bacteria and regulate the balance of the bacterial flora. Ginkgo flavonoids, also known as ginkgo leaf extract, are a class of biflavonoid compounds extracted from ginkgo leaves. This substance can cause oxidative damage to pathogenic bacteria, destroy the cell wall and cell membrane structure of pathogenic bacteria, and increase the permeability of cell membranes, causing the leakage of pathogenic bacteria to achieve an antibacterial effect. In addition, the flavonoids in it can alleviate some retinal diseases such as macular degeneration; In summary, in the present invention, polyglycerol ether-26 has high moisturizing and lubricating properties, and the synergistic effect of catechins and ginkgo flavonoids can enhance the antibacterial properties. Moreover, as a natural plant extract, it is non-irritating to the eyes, has higher safety, and can protect the eyes. DETAILED DESCRIPTION

[0016] The composition and performance of the care solution of the present invention are described in detail below through specific examples.

[0017] In the following examples of the present invention, the ginkgo flavonoids were purchased from Shanghai Huayuan Century Trading Co., Ltd. with a purity of 98.0%.

[0018] Example 1 A contact lens care solution capable of long-term moisturizing, lubricating and antibacterial properties comprises, by mass percentage, 1.0% of polyglycerol ether-26, 3.5% of a composite natural antibacterial agent, 1.0% of sodium hyaluronate, 2.0% of poloxamer 407, 1.5% of boric acid, 0.15% of borax, 8.5% of sodium chloride, and the remainder being purified water.

[0019] The composite natural antibacterial agent is a mixture of catechins and ginkgo flavonoids in a mass ratio of 1:1.

[0020] Example 2 A contact lens care solution capable of long-term moisturizing, lubricating and antibacterial properties comprises, by mass percentage, 1.0% of polyglycerol ether-26, 3.5% of a composite natural antibacterial agent, 1.0% of sodium hyaluronate, 2.0% of poloxamer 407, 1.5% of boric acid, 0.15% of borax, 8.5% of sodium chloride, and the remainder being purified water.

[0021] The composite natural antibacterial agent is a mixture of catechins and ginkgo flavonoids in a mass ratio of 1.5:1.

[0022] Example 3 A contact lens care solution capable of long-term moisturizing, lubricating and antibacterial properties comprises, by mass percentage, 1.0% of polyglycerol ether-26, 3.5% of a composite natural antibacterial agent, 1.0% of sodium hyaluronate, 2.0% of poloxamer 407, 1.5% of boric acid, 0.15% of borax, 8.5% of sodium chloride, and the remainder being purified water.

[0023] The composite natural antibacterial agent is a mixture of catechins and ginkgo flavonoids in a mass ratio of 1:1.5.

[0024] Example 4 A contact lens care solution capable of long-term moisturizing, lubricating and antibacterial properties comprises, by mass percentage, 1.5% of polyglycerol ether-26, 2.5% of a composite natural antibacterial agent, 1.5% of sodium hyaluronate, 2.5% of poloxamer 407, 1.8% of boric acid, 0.2% of borax, 8.6% of sodium chloride, and the remainder being purified water.

[0025] Example 5 A contact lens care solution capable of long-term moisturizing, lubricating and antibacterial properties comprises, by mass percentage, 2.0% of polyglycerol ether-26, 2.0% of a composite natural antibacterial agent, 2.0% of sodium hyaluronate, 1.5% of poloxamer 407, 1.6% of boric acid, 0.4% of borax, 8.8% of sodium chloride, and the remainder being purified water.

[0026] Example 6 A contact lens care solution capable of long-term moisturizing, lubricating and antibacterial properties comprises, by mass percentage, 2.5% of polyglycerol ether-26, 3.0% of a composite natural antibacterial agent, 1.0% of sodium hyaluronate, 1.5% of poloxamer 407, 1.5% of boric acid, 0.2% of borax, 9.0% of sodium chloride, and the remainder being purified water.

[0027] Comparative Example 1 The other ingredients and contents of the comparative example are the same as those of Example 1, except that no polyglycerol ether-26 is added in the comparative example 1.

[0028] Comparative Example 2 The other ingredients and contents of the comparative example are the same as those of Example 1, except that no composite natural antibacterial agent is added in the comparative example 2.

[0029] Comparative Example 3 The other ingredients and contents of the comparative example are the same as those of Example 1, except that the antibacterial agent in the comparative example 3 is replaced by the conventionally used polyhexamethylene biguanide.

[0030] Comparative Example 4 The other ingredients and contents of the comparative example are the same as those of Example 1, except that the moisturizing lubricant in the comparative example 4 is replaced by the conventionally used propylene glycol.

[0031] Performance characterization test: 1. Physical compatibility of care solution and contact lenses Take 50 lenses and measure their diopters and record them respectively. Soak 5 lenses in the care solutions of Examples 1-6 and Comparative Examples 1-4 respectively for 2 hours. Then measure their diopters and record them again.

[0032] Experimental results: The tolerance of the refractive power of the above 50 lenses after immersion and the refractive power measured before immersion is ±0.25D, which meets the requirements.

[0033] 2. Evaluation of wearing effect 100 volunteers were randomly selected, regardless of gender, and were evenly divided into 6 groups. They tried to wear the contact lenses soaked in Examples 1-6 and Comparative Examples 1-4, soaked for 4 hours, and worn for 12 hours a day for 3 consecutive days. The wearing comfort was scored. The scoring criteria were: 1-2 points for poor, 3-4 for relatively poor, 5-6 for average, 7-8 for relatively good, and 9-10 for very good. The scoring results are shown in Table 1.

[0034] The results show that the wearing comfort of Examples 1-6 is significantly higher than that of Comparative Examples 1-4, indicating that the care solutions prepared in Examples 1-6 have long-lasting moisturizing and lubricating effects, can alleviate dry eyes caused by long-term wearing of contact lenses, and improve wearing comfort.

[0035] (III) Antibacterial effect According to GB19192-2003, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Fusarium solani were selected as experimental bacteria, and 5 lenses were immersed in the care solutions obtained in Examples 1-6 and Comparative Examples 1-3, and the bacterial suspensions of the above 5 experimental bacteria were added at a concentration of 1.0×10 5 -1.0×10 6 cfu / mL, soaked for 30 minutes. After soaking, the number of viable bacteria was detected by agar plate counting method. The antibacterial effect is shown in Table 2 below.

[0036] Evaluation standard of antibacterial effect: the killing rate of the care solution against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa is ≥99.9%, and the killing rate against Candida albicans and Fusarium solani is ≥90.0%.

[0037] The results in Table 2 show that the killing effects of the care solutions obtained in Examples 1-6 and Comparative Example 1 on the five experimental bacteria are all qualified. In Comparative Example 2, no composite natural antibacterial agent is added, and the antibacterial effect is significantly weakened, and the killing rates of the five bacteria do not meet the requirements. The antibacterial agent in Comparative Example 3 is the conventionally used polyhexamethylene biguanide, and its antibacterial effect is worse than that of the composite natural antibacterial agent.

[0038] (IV) Moisturizing effect test Wearing contact lenses for a long time will cause the eyes to lose moisture continuously. The longer the contact lenses contain moisture, the slower the moisture loss, and the better the moisturizing effect. In order to test the moisturizing performance of the care solution, 54 contact lenses of the same model were prepared, and 6 lenses of each were soaked in the standard salt solution, the care solution obtained in Examples 1-6 and Comparative Examples 1 and 4 for 24 hours. After soaking, the lenses were taken out and the surface care solution was wiped clean. The wet weight of the 54 lenses was measured with a precision electronic balance and recorded accordingly. They were placed in an environment with a temperature of 35±1°C and a humidity of 40%±2%. Their weight was measured every 1 hour, and their water loss was calculated. The results are shown in Table 3.

[0039] The results in Table 3 show that compared with the standard saline solution, the care solutions of Examples 1-6 and Comparative Examples 1 and 4 retain moisture for a longer time, and since no polyglyceryl ether-26 is added in Comparative Example 1, the water loss rate of the lens is faster than that in Example 1. The moisturizing lubricants in Example 1 and Comparative Example 4 are polyglyceryl ether-26 and propylene glycol, respectively. By comparison, it can be found that the moisturizing effect of polyglyceryl ether-26 is better than that of propylene glycol. Examples 1-6 can significantly improve and prolong the moisturizing effect of the lens.

Claims

1. A contact lens care solution that can provide long-lasting moisturizing, lubrication and antibacterial properties, characterized in that: In terms of mass percentage, the care solution includes the following components: Polyglycerol ether-26: 1.0-2.5%; Composite natural antibacterial agent: 2.0-3.5%; Thickener: 1.0-2.0%; Surfactant: 1.5-2.5%; pH adjuster: 0.15-1.8%; Osmotic pressure regulator: 8.5-9.0%; The balance is purified water; The composite natural antibacterial agent is a mixture of catechins and ginkgo flavonoids.

2. A long-lasting moisturizing, lubricating and antibacterial contact lens care solution as claimed in claim 1, characterized in that: The mass ratio of the catechins to the ginkgo flavonoids is 0.5-1.5:0.5-1.

5.

3. A long-lasting moisturizing, lubricating and antibacterial contact lens care solution as claimed in claim 2, characterized in that: The mass ratio of the catechins to the ginkgo flavonoids is 1:

1.

4. A long-lasting moisturizing, lubricating and antibacterial contact lens care solution as claimed in claim 1 or 2, characterized in that: The thickener is a mixture of one or more of sodium hyaluronate, hydroxypropyl methylcellulose or methyl glucose derivatives.

5. A long-lasting moisturizing, lubricating and antibacterial contact lens care solution as claimed in claim 1 or 2, characterized in that: The surfactant is any one of poloxamer 407, glyceride or polysorbate.

6. A long-lasting moisturizing, lubricating and antibacterial contact lens care solution as claimed in claim 1 or 2, characterized in that: The osmotic pressure regulator is sodium chloride or potassium chloride or a mixture of the two.

7. A long-lasting moisturizing, lubricating and antibacterial contact lens care solution as claimed in claim 1 or 2, characterized in that: The pH regulator is a mixture of one or more of boric acid, borax, dipotassium hydrogen phosphate or disodium hydrogen phosphate.

8. A method for preparing a long-lasting moisturizing, lubricating and antibacterial contact lens care solution as claimed in any one of claims 1 to 3, characterized in that: The following steps are involved: (1) Weigh each component according to the formula and set aside; (2) Add some purified water into the container, then add polyglycerol polyether-26, composite natural antibacterial agent, thickener and surfactant, then add some purified water, stir and dissolve; (3) Add pH regulator and osmotic pressure regulator to adjust the solution pH to 6.5-7.8 and osmotic pressure to 260-340 mOsm / kg·H2O, and finally add the remaining purified water and stir for 2-3 hours; (4) The solution prepared in step (3) is filtered and sterilized, and the filtrate is packaged to obtain the contact lens care solution.

9. A method for preparing a long-lasting moisturizing, lubricating and antibacterial contact lens care solution as claimed in claim 8, characterized in that: In step (2), the stirring and dissolving time is 1-2 hours.

10. A method for preparing a long-lasting moisturizing, lubricating and antibacterial contact lens care solution as claimed in claim 8, characterized in that: The solution prepared in step (3) was sterilized by filtration using a 0.22 μm filter.

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