Method for extracting glycyrrhizicacid, licorice flavone and licorice polysaccharide

Abstract

The synchronous extraction and separation method for glycyrrhizic acid, glycyrrhizic flavone and glycyrrhizic polysaccharide comprises: extracting the licorice powder with solvent for 1-3 times by cold seepage, warm leaching or reflux; mixing and condensing on reduced pressure the liquid; extracting with organic solvent, condensing to recover the solvent and obtain the coarse glycyrrhizic flavone; adding 95% ethanol into the extracted residue to adjust ethanol concentration as 50-80%, holding at low or normal temperature to obtain coarse glycyrrhizic polysaccharide by drying the precipitate ; condensing the supernatant, adjusting pH value to 1.5-2.0 with H2SO4 or HCl, holding at low or normal temperature, removing the supernatant, and obtaining coarse glycyrrhizic acid by cleaning with cold water or acid and drying the precipitate. This invention has simple process, improves comprehensive utilization level, and reduces cost for deep process.

Description

technical field

[0001] The invention belongs to the fields of medical medicine and chemical industry, and particularly relates to a method for synchronously extracting and separating glycyrrhizic acid, licorice flavonoids and licorice polysaccharides from natural medicines. Background technique

[0002] Licorice flavonoids, glycyrrhizic acid and glycyrrhizic polysaccharides are the main active ingredients of licorice. The existing extraction techniques are single or intermittent. Often, glycyrrhizic acid is simply extracted through a system, and the licorice residue is discarded or extracted from the residue after extraction. Licorice flavonoids, and then extracted licorice polysaccharides. Chinese patent "A kind of licorice paste and its production process" (CN1144105) discloses a method of extracting licorice flavonoids from the residue after extracting glycyrrhizic acid from licorice, but the yield of flavonoids is very low, indicating that in the extraction of glycyrrhiz...