Extraction and preparation method for licorice effective ingredients

An effective ingredient, licorice technology, applied in the field of Chinese herbal medicine extraction and processing, to achieve high yield, reduce waste water discharge, ensure purity and quality effects

Inactive Publication Date: 2014-08-06
武汉普赛特膜技术循环利用有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to overcome the problems and defects of the existing technology, the present invention provides a method for simultaneously extracting active ingredients such as glycyrrhizic acid, licorice flavonoids and licorice flavoring from licorice

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 5kg of licorice and crush it, add 25kg of water to the crushed licorice, add ammonia to adjust the pH value to 8.0, stir and extract for 3 hours, filter and separate the extract, add 25kg of water to the solid system, and add ammonia again Adjust the pH value to 8.0, stir and extract for 1 hour, and obtain licorice residue and licorice extract after separation. Then add 13 times of ethanol according to the mass of licorice residue, the ethanol concentration is 85%, leaching for 3 hours, stirring evenly for 1 hour, filtering, recovering ethanol to obtain about 200 g of crude licorice flavonoids. The two licorice extracts are combined, and at a temperature of 35°C, the inlet pressure is 0.3 Mpa, and the ultrafiltration membrane device with a filter aperture of 50nm is used to remove impurities to obtain the ultrafiltration membrane filtrate. Under the conditions of 45°C and an inlet pressure of 1.5 Mpa, use a nanofiltration membrane device with a filter aperture of ...

Embodiment 2

[0034] Weigh 5kg of licorice and crush it, add 35kg of water to the crushed licorice, add ammonia water to adjust the pH value to 8.5, stir and extract for 3.5h, filter and separate the extract, add 35kg of water to the solid system again, and add Adjust the pH value to 8.5 with ammonia water, stir and extract for 1.5 hours, and then obtain licorice residue and licorice extract after separation. Then add 14 times of ethanol according to the mass of licorice dregs, the ethanol concentration is 90%, extract for 3.5 hours, stir evenly and let it stand for 1.5 hours, filter, recover ethanol and obtain about 230 g of crude licorice flavonoids. The two licorice extracts were combined, and at a temperature of 40°C and an inlet pressure of 0.4 Mpa, an ultrafiltration membrane device with a filter aperture of 30 nm was used to remove impurities to obtain an ultrafiltration membrane filtrate. Under the conditions of 45°C and an inlet pressure of 1.7 Mpa, concentrate with a nanofiltratio...

Embodiment 3

[0036] Weigh 5kg of licorice and crush it, add 45kg of water to the crushed licorice, adjust the pH value to 9.0 by adding ammonia, stir and extract for 4 hours, filter and separate the extract, add 45kg of water to the solid system, and add ammonia again Adjust the pH value to 9.0, stir and extract for 2 hours, and obtain licorice residue and licorice extract after separation. Then add 15 times of ethanol according to the mass of licorice residue, the ethanol concentration is 95%, leaching for 4 hours, stirring evenly for 2 hours, filtering, recovering ethanol to obtain about 250 g of crude licorice flavonoids. The two licorice extracts are combined, and at a temperature of 50° C. and an inlet pressure of 0.5 Mpa, an ultrafiltration membrane device with a filter aperture of 20 nm is used to remove impurities to obtain an ultrafiltration membrane filtrate. Under the conditions of 50°C and an inlet pressure of 2.0Mpa, concentrate with a nanofiltration membrane device with a fil...

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Abstract

The invention relates to an extraction and preparation method for licorice effective ingredients, mainly to a method for simultaneously extracting effective ingredients like glycyrrhizic acid, glycyrrhiza flavonoid and a licorice flavoring agent from licorice. The method comprises the following steps: with glycyrrhizic acid as a raw material, carrying out extraction so as to obtain licorice residue and extract liquid and subjecting the licorice residue to ethanol extraction so as to obtain a crude glycyrrhiza flavonoid product; removing impurities in the licorice extract liquid by using an ultrafiltration membrane device, carrying out concentration by using a nanofiltration membrane device, subjecting a nanofiltration membrane concentrate to acid precipitation and drying a precipitate so as to obtain glycyrrhizic acid; and subjecting a supernatant produced after acid precipitation to concentration with the nanofiltration membrane device and carrying out drying so as to obtain the licorice flavoring agent. The method adopts membrane separation technology for impurity removal and concentration of the extract liquid, so working conditions are mild, product purity and quality are guaranteed, and yield of licorice effective ingredients is high; the method has the advantages of simple production flow, low cost, small pollution, reusability of a nanofiltration membrane filtrate generated in production process, reduction in consumption of raw water and great decrease of waste water discharge.

Description

technical field [0001] The invention belongs to the extraction and processing technology of Chinese herbal medicine, and mainly relates to a method for simultaneously extracting active ingredients such as glycyrrhizic acid, licorice flavonoids and licorice flavoring agent from licorice. Background technique [0002] Licorice is a perennial herb, which is a traditional Chinese medicinal material in my country. It is called "Guo Lao" in "Medicinal Materia Medica" in the Tang Dynasty, and it has the effect of reconciling all kinds of medicines. Licorice is widely distributed in my country, with as many as 17 varieties. Licorice is light-loving, cold-resistant, drought-tolerant, and saline-alkali-resistant. It is mainly distributed in the arid and semi-arid areas of the north and northwest of China. Among them, Ural licorice is mainly distributed in Jilin, Liaoning, Inner Mongolia, Ningxia, Qinghai, and Xinjiang; Licorice is mainly distributed in the east and north of Xinjiang;...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40C07J63/00C07H15/256C07H1/08
CPCC07D311/30C07D311/40C07H1/08C07H15/256
Inventor 万端极徐国念吴正奇
Owner 武汉普赛特膜技术循环利用有限公司
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