Licorice acid double salt, preparing method and use thereof

A technology of glycyrrhizic acid and complexes, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, steroids, etc., can solve the problems of low bioavailability, limited application, poor water solubility and fat solubility, etc. Large oral absorption, improved therapeutic effect, and improved water solubility
CN1583783AInactive Publication Date: 2005-02-23SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2005-02-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

Glycyrrhizic acid double salt and its pharmaceutics are prepared from start materials of glycyrrhizic acid to (sophocarpidine ) matrine with weight ratio of 1 to 1-10 by: putting raw materials into organic solvent with weight ratio of 1 to 10- 100 , reflux heating at 25-80deg.C for 1-5 hours , recovering organic solvent , then drying the solid resultant to get the products. Solvent is alcohol or methanol or acetone. This pharmaceutics can be used in therapy of acute or chronic hepatitis, virus hepatitis and hepatic injury.
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Description

technical field

[0001] The invention relates to a medicine and a preparation method thereof, in particular to a glycyrrhizic acid double salt and a preparation method and application thereof. Background technique

[0002] Glycyrrhizic acid is the most important active ingredient in licorice. Glycyrrhizic acid has biological activities such as anti-inflammation, anti-virus, and immune function enhancement. It is clinically used to treat hepatitis, bronchitis, gastric ulcer, AIDS and certain cancers. However, due to its large molecular weight (>800), more polar groups, and poor water-solubility and fat-solubility, it leads to poor gastrointestinal absorption and low bioavailability after oral administration, which limits its clinical application. Matrine is an alkaloid extracted from the traditional Chinese medicine Sophora flavescens. Matrine has antiviral (for its main pharmacological effects, it can resist hepatitis B virus and hepatitis C virus), immune regulation, and ...

Claims

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