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Licorice acid double salt, preparing method and use thereof

A technology of glycyrrhizic acid and complexes, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, steroids, etc., can solve the problems of low bioavailability, limited application, poor water solubility and fat solubility, etc. Large oral absorption, improved therapeutic effect, and improved water solubility

Inactive Publication Date: 2005-02-23
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its large molecular weight (>800), more polar groups, and poor water-solubility and fat-solubility, it leads to poor oral absorption and low bioavailability in the gastrointestinal tract, which limits its clinical application.
At present, there is no public report on the formation of double salts between glycyrrhizic acid (including its extracts and acid salts) and matrine (including oxymatrine and matrine extracts)

Method used

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  • Licorice acid double salt, preparing method and use thereof
  • Licorice acid double salt, preparing method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 24kg of glycyrrhizic acid and 74kg of matrine, dissolve in 2000kg of ethanol, heat to reflux at 50°C, react for 3 hours, recover ethanol, and dry the obtained solid to obtain the product.

Embodiment 2

[0026] Weigh the licorice extract containing 46kg of glycyrrhizic acid and the extract of Sophora flavescens containing 48kg of matrine, dissolve in 3000kg of acetone, heat and reflux at 25°C, react for 5 hours, recover the acetone, and dry the obtained solid to obtain the product.

Embodiment 3

[0028] Weigh 30kg of glycyrrhizic acid and 300kg of oxymatrine, dissolve in 31000kg of methanol, heat to reflux at 70°C, react for 2 hours, recover methanol, and dry the obtained solid.

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PUM

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Abstract

Glycyrrhizic acid double salt and its pharmaceutics are prepared from start materials of glycyrrhizic acid to (sophocarpidine ) matrine with weight ratio of 1 to 1-10 by: putting raw materials into organic solvent with weight ratio of 1 to 10- 100 , reflux heating at 25-80deg.C for 1-5 hours , recovering organic solvent , then drying the solid resultant to get the products. Solvent is alcohol or methanol or acetone. This pharmaceutics can be used in therapy of acute or chronic hepatitis, virus hepatitis and hepatic injury.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a glycyrrhizic acid double salt and a preparation method and application thereof. Background technique [0002] Glycyrrhizic acid is the most important active ingredient in licorice. Glycyrrhizic acid has biological activities such as anti-inflammation, anti-virus, and immune function enhancement. It is clinically used to treat hepatitis, bronchitis, gastric ulcer, AIDS and certain cancers. However, due to its large molecular weight (>800), more polar groups, and poor water-solubility and fat-solubility, it leads to poor gastrointestinal absorption and low bioavailability after oral administration, which limits its clinical application. Matrine is an alkaloid extracted from the traditional Chinese medicine Sophora flavescens. Matrine has antiviral (for its main pharmacological effects, it can resist hepatitis B virus and hepatitis C virus), immune regulation, and ...

Claims

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Application Information

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IPC IPC(8): A61K31/706A61P1/16A61P31/12C07J63/00
Inventor 娄红祥李洁翟光喜崔新德
Owner SHANDONG UNIV
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