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Extraction method for increasing content of glycyrrhizic acid in leftover materials of liquorice

An extraction method and technology of glycyrrhizic acid, which are applied in chemical instruments and methods, preparation of sugar derivatives, steroids, etc., can solve the problems of cumbersome process, inability to effectively utilize glycyrrhizic acid leftovers from licorice, and high cost, and achieve simple process and high cost. Low-cost, high-efficiency extraction

Inactive Publication Date: 2016-05-04
脱德明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problems in the above-mentioned prior art that it is impossible to effectively use the licorice leftovers to extract glycyrrhizic acid, as well as the problems in the prior art that the process is cumbersome and the cost is high, and provides an extraction method related to increasing the content of glycyrrhizic acid in the licorice leftovers, which can Efficient extraction of glycyrrhizic acid in licorice with simple operation and low cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Glycyrrhiza offcuts, ammonia alcohol heat reflux extraction, take a certain amount of Glycyrrhizae, add mass fraction of 10% ethanol aqueous solution according to solid-liquid ratio 1:8, 0.5% (volume mL of concentrated ammonia water: mass g of 10% ethanol aqueous solution ) ammonia water, extract twice under reflux at 80°C, each time for 2h;

[0018] 2) Combine the two extracts and concentrate on a rotary evaporator to a density of 1.01g / cm 3 About, add sulfuric acid in concentrated solution, in described step 2, sulfuric acid is: concentrated sulfuric acid: water=1:1, pH=2.0;

[0019] 3) Suction-filter the acid deposit, wash with 5°C cold water until the pH of the washing solution is 4.5, and obtain coarse glycyrrhizic acid powder after suction-filtration and drying;

[0020] 4) Wash the glycyrrhizic acid coarse powder, wash with pure water, the number of washings is 2 times, the amount of washing water is 4 times the amount of acid sediment, the washing temperatur...

Embodiment 2

[0024] 1) Glycyrrhiza offcuts, ammonia alcohol hot reflux extraction, take a certain amount of Glycyrrhizae, add mass fraction of 10% ethanol aqueous solution according to the solid-to-liquid ratio of 1:9, 0.5% (volume mL of concentrated ammonia water: mass g of 10% ethanol aqueous solution ) ammonia water, extract twice under reflux at 80°C, each time for 2h;

[0025] 2) Combine the two extracts and concentrate on a rotary evaporator to a density of 1.06g / cm 3 About, add sulfuric acid in concentrated solution, in described step 2, sulfuric acid is: concentrated sulfuric acid: water=1:1, pH=2.0;

[0026] 3) Suction-filter the acid deposit, wash with 5°C cold water until the pH of the washing solution is 4.5, and obtain coarse glycyrrhizic acid powder after suction-filtration and drying;

[0027] 4) Glycyrrhizic acid coarse powder was washed with purified water, the number of washings was 2 times, the amount of washing water was 4 times the amount of acid sediment, the washing...

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Abstract

The invention discloses an extraction method for increasing content of glycyrrhizic acid in leftover materials of liquorice. The method is characterized by comprising process steps as follows: 1) the leftover materials of the liquorice are prepared; 2) two times of extraction solutions are mixed; 3) acid precipitate is subjected to suction filtration; 4) coarse glycyrrhizic acid powder is washed; 5) the coarse glycyrrhizic acid powder is purified; 6) a glycyrrhizic acid eluent is prepared. According to the method, glycyrrhizic acid is not refined with a macro-porous adsorption resin method, glycyrrhizic acid in the liquorice can be extracted and refined efficiently, the process is simple, the cost is low, and the leftover materials of the liquorice can be utilized reasonably.

Description

technical field [0001] The invention belongs to the technical field of extraction of active ingredients in traditional Chinese medicines, and in particular relates to an extraction method for increasing the content of glycyrrhizic acid in licorice leftovers. Background technique [0002] Glycyrrhizic acid is a natural substance extracted from licorice. The main component contained in licorice roots and rhizomes is glycyrrhizic acid. As a medicinal material, its early application has a history of more than 2,000 years in my country. Recent studies have shown that, Glycyrrhizic acid can not only regulate the body and prevent diseases, but also can be used as a flavoring agent, emulsifier, foaming agent and additive. It is widely used in industries such as food, beverage, cosmetics and cigarettes. After the glycyrrhizic acid is extracted from licorice with a solvent, the remaining residue can be used to produce feed additives and other products. Licorice is one of the special pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00C07H15/256C07H1/08
CPCC07J63/008C07H1/08C07H15/256
Inventor 脱德明
Owner 脱德明
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