Method for producing glabridin from glycyrrhiza residue

Abstract

The invention relates to a method for producing glabridin from glycyrrhiza residue, mainly comprising the following processes of: concentrating the glycyrrhiza residue into syrup after aqueous extraction; carrying out activated carbon adsorption after dissolving in methanol; washing by using hot methanol; adsorbing methanol washing solution by macroporous adsorption resin AB-8; washing by using water and alcohol respectively; collecting and concentrating alcohol washing solution; recrystallizing by using organic solvent with 3-5 times amount; and obtaining the glabridin after drying. The method uses the methanol for dissolving syrupy extracting solution, the activated carbon adsorption method elution can be avoided, and the phenomenon of mixed solvent does not occur, thus avoiding the situations in the existing process for extracting and preparing the glabridin of long synthetic step, high cost, a large number of used organic solvents and not being beneficial to environmental protection, and also effectively simplifying procedures and reducing the production cost; especially by using the residue of the glycyrrhizic acid for extraction, the wastes are changed into valuables, the time is saved and the product content is high. The method can also be applied to extract glabridin directly from glycyrrhiza.

Description

technical field

[0001] The invention relates to a method for producing glabridin from licorice residue. technical background

[0002] Glycyrrhiza licorice is mainly distributed in the western part of my country, and it is a traditional Chinese medicinal material with a very long history of application in my country. glabraL.) dry roots and rhizomes. Traditional Chinese medicine believes that licorice has the effects of invigorating the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasms and relieving pain, and harmonizing various medicines. Licorice is mainly used as a flavoring agent, tobacco additive and expectorant in Western countries.

[0003] Studies have shown that flavonoids in licorice have strong biological activity. In recent years, it has been found that flavonoids in licorice also have pharmacological effects such as anti-HIV and anti-tumor.

[0004] But present licorice processing mainly extracts...