Method for producing glabridin from glycyrrhiza residue

A technology for Glabridin and Glycyrrhiza dregs, applied in the field of Glabridin production, can solve problems such as waste of licorice material resources, and achieve the effects of avoiding long synthesis steps, reducing production costs and saving time.

Active Publication Date: 2009-09-02
SHAANXI FUJIE PHARMA
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

And discarding it with the residue is undoubtedly a great waste of licorice medicinal resources

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Extract the licorice residue with 8-10 times the weight of hot water at 95°C for 3-5 times, each extraction for 3-5 hours, filter the residue with a 1000 μm aperture sieve, and concentrate the extracted solution to a relative density of 1.50-1.80 The syrup-like extract obtained is dissolved in 2 to 5 times of 95% methanol by weight to obtain a methanol solution and filtered with a filter cloth with a pore size of 300 μm; the obtained methanol solution is adsorbed by activated carbon; then the activated carbon after adsorption is used 75% ~90%, 60℃ hot methanol to collect the methanol washing solution, wash the used activated carbon with 100℃~120℃ water for later use; adjust the methanol washing solution to a concentration of 1~3g / ml and pass it through the macroporous adsorption resin AB-8 , washed once with water and then washed with ethanol with a concentration of 85% to 95%, and the ethanol washing liquid was collected; the ethanol washing liquid was concentrated to a...

Embodiment 2

[0021] Extract the licorice residue with 8-10 times the weight of hot water at 98°C for 3-5 times, each extraction for 3-5 hours, filter the residue with a sieve with an aperture of 800 μm, and concentrate the extracted solution to a relative density of 1.50-1.80 syrupy; the obtained syrupy extract was dissolved in 2 to 5 times of 96% methanol by weight to obtain a methanol solution and filtered with a filter cloth with a pore size of 400 μm; the obtained methanol solution was adsorbed by activated carbon; the methanol washing solution was adjusted to a concentration of 1 to After 3g / ml, pass through the macroporous adsorption resin AB-8, wash the resin with ethanol with a concentration of 85% to 95%, and collect the ethanol washing liquid; concentrate the ethanol washing liquid to a relative density of 1.50 to 1.80, and take 3-5 times the weight of the organic Solvent propanol recrystallization: first heat the organic solvent to above 80°C, then add the concentrated product to...

Embodiment 3

[0023] Extract the licorice residue with 8-10 times the weight of hot water at 99°C for 3-5 times, each extraction for 3-5 hours, filter the residue with a 1000 μm aperture sieve, and concentrate the extracted solution to a relative density of 1.50-1.80 The resulting syrupy extract is dissolved in 2 to 5 times of 98% methanol by weight to obtain a methanol solution and filtered with a filter cloth with a pore size of 300 μm; the resulting methanol solution is adsorbed by activated carbon; then the activated carbon after adsorption is treated with 75% ~90%, 70℃ hot methanol to collect the methanol washing solution, wash the used activated carbon with 100℃~120℃ water for later use; adjust the methanol washing solution to a concentration of 1~3g / ml and pass it through the macroporous adsorption resin AB-8 , washed once with water and then washed with ethanol with a concentration of 85% to 95%, and the ethanol washing liquid was collected; the ethanol washing liquid was concentrate...

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Abstract

The invention relates to a method for producing glabridin from glycyrrhiza residue, mainly comprising the following processes of: concentrating the glycyrrhiza residue into syrup after aqueous extraction; carrying out activated carbon adsorption after dissolving in methanol; washing by using hot methanol; adsorbing methanol washing solution by macroporous adsorption resin AB-8; washing by using water and alcohol respectively; collecting and concentrating alcohol washing solution; recrystallizing by using organic solvent with 3-5 times amount; and obtaining the glabridin after drying. The method uses the methanol for dissolving syrupy extracting solution, the activated carbon adsorption method elution can be avoided, and the phenomenon of mixed solvent does not occur, thus avoiding the situations in the existing process for extracting and preparing the glabridin of long synthetic step, high cost, a large number of used organic solvents and not being beneficial to environmental protection, and also effectively simplifying procedures and reducing the production cost; especially by using the residue of the glycyrrhizic acid for extraction, the wastes are changed into valuables, the time is saved and the product content is high. The method can also be applied to extract glabridin directly from glycyrrhiza.

Description

technical field [0001] The invention relates to a method for producing glabridin from licorice residue. technical background [0002] Glycyrrhiza licorice is mainly distributed in the western part of my country, and it is a traditional Chinese medicinal material with a very long history of application in my country. glabraL.) dry roots and rhizomes. Traditional Chinese medicine believes that licorice has the effects of invigorating the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasms and relieving pain, and harmonizing various medicines. Licorice is mainly used as a flavoring agent, tobacco additive and expectorant in Western countries. [0003] Studies have shown that flavonoids in licorice have strong biological activity. In recent years, it has been found that flavonoids in licorice also have pharmacological effects such as anti-HIV and anti-tumor. [0004] But present licorice processing mainly extracts...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04A61K36/484
Inventor 陈振鸿
Owner SHAANXI FUJIE PHARMA
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