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Honey-fried licorice root dispensing granule as well as preparation method and quality control method

A technology of formula granules and roasted licorice, which is applied in the field of roasted licorice formula granules and its preparation, can solve problems such as difficulties in spectrum analysis

Inactive Publication Date: 2009-07-08
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that Chinese herbal medicines, herbal pieces and Chinese patent medicines are much more complex mixture systems than western medicines, it is difficult to analyze the spectra, so that conventional infrared spectroscopy has not been able to play its due role in the quality control and management of traditional Chinese medicines for a long period of time. the role of

Method used

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  • Honey-fried licorice root dispensing granule as well as preparation method and quality control method
  • Honey-fried licorice root dispensing granule as well as preparation method and quality control method
  • Honey-fried licorice root dispensing granule as well as preparation method and quality control method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: Radix Glycyrrhiza Formula Granules

[0044] Take 100kg of Zhigancao decoction pieces, add 800kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 800kg of water to the dregs, extract for 1.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.05- 1.10; the concentrated solution is preheated at 45°C, the air inlet temperature is 180°C, the material pump speed is 550 rpm, the outlet air temperature is 80°C, and the air supply temperature is 45°C, and the spray-dried licorice powder is obtained; Add 0-5% auxiliary material dextrin of its own weight in the spray-dried licorice powder; the spray-dried licorice powder has a pressure of 5 MPa on the main pressure wheel, a pressure of 0.5 MPa on the side pressure wheel, a spindle speed of 400 rpm, and a feeding voltage of 5 MPa. Dry granulation under the condition of 120V to obtain 20-60 mesh Zhiga...

Embodiment 2

[0045] Embodiment 2: Radix Glycyrrhiza Formula Granules

[0046] Take 100kg of Zhigancao decoction pieces, add 1000kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 600kg of water to the dregs, extract for 1 hour, that is, the second decoction; combine the two decoction liquids, and concentrate under reduced pressure to a relative density of 1.00— 1.05; the concentrated solution is preheated at 50°C, the air inlet temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air supply temperature is 50°C, and the spray drying is obtained to obtain the spray-dried licorice powder; Add 5-15% of its own weight of auxiliary material dextrin to the spray-dried licorice powder; under the conditions that the main pressure wheel pressure is 6MPa, the side pressure wheel pressure is 0.4MPa, the spindle speed is 450 rpm, and the feeding voltage is 110V Dry granulation to obtain 20-60 mesh licorice form...

Embodiment 3

[0048] Embodiment 3: Radix Glycyrrhiza Formula Granules

[0049] Take 100kg of Zhigancao decoction pieces, add 1400kg of water, extract for 2.5 hours, that is, the first decoction; after the first decoction, add 1100kg of water to the dregs, extract for 2.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.10- 1.15; the concentrated solution was preheated at 45°C, the inlet air temperature was 170°C, the material pump speed was 600 rpm, the outlet air temperature was 75°C, and the air delivery temperature was 50°C, and spray-dried to obtain the spray-dried licorice powder; Add 15-25% of its own weight of lactose to the spray-dried licorice powder; dry method under the conditions that the pressure of the main pressure roller is 4MPa, the pressure of the side pressure roller is 0.4MPa, the rotation speed of the main shaft is 500 rpm, and the feeding voltage is 130V. Glycyrrhiza granules, 20-60 mesh lic...

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Abstract

The invention discloses a honey-fried licorice root formula particle and preparation and quality control methods thereof. The formula particle uses honey-fried licorice root decoction pieces as raw materials, and the decoction pieces are processed by the technological processes of twice water extraction, vaccum concentration, sponging drying and the like to gain the honey-fried licorice root formula particle; and one gram of honey-fried licorice root formula particle is equivalent to 3 to 5 grams of crude medicines, the content of glycyrrhizic acid in the formula particle is not lower than 2.0 percent, and the quality of the honey-fried licorice root decoction pieces and the honey-fried licorice root formula particle is respectively discriminated by the infrared fingerprint spectra. The honey-fried licorice root formula particle of the invention has the advantages of integrated and advanced production process, specific and controllable quality control standard and advanced and realizable process, and a test method related to the quality standard is scientific, advanced, fast and highly operable. Proved by a lot of experiments, the ingredient of a herbal decoction prepared by the honey-fried licorice root formula particle of the invention is equivalent to the ingredient of the mixed simmer liquid of the honey-fried licorice root contained classical formula, the full ingredient formula particle process is achieved, and the process of the invention is proved to be reasonable; and the invention applies the infrared spectroscopy technology to the quality control of the traditional Chinese medicines, thereby fast solving the principal problem of traditional Chinese medicine truth discrimination in the macroscopic quality control of the traditional Chinese medicines.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule, a preparation method and a quality control method thereof, in particular to a roasted licorice formula granule, a preparation method and a quality control method thereof. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are made of Chinese herbal decoction pieces through various processes, and are used in clinical prescriptions of traditional Chinese medicine. Compared with traditional Chinese medicine decoction, it is convenient to take and the dosage is small , the quality is controllable, easy to store, and easy to carry; Chinese medicine formula granules are currently in the pilot production state in China, and the product technology and quality standards are not uniform. At present, traditional Chinese medicine formula granules are mostly extracted with water, or extracted with water...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K9/16A61J3/00G01N21/35G01N21/3563
Inventor 吴玢付静张翠
Owner BEIJING KANGRENTANG PHARMA
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