The invention belongs to the technical field of
medicine and
chemical industry, and discloses an imidazoline spiroquinazolinone compound and a preparation method and application thereof.The compound is novel in structure, has an imidazoline and
quinazolinone double-ring structure, has multiple active sites and large modifiable space, shows good
biological activity application potential, and can be used for preparing a novel compound. The compound has the activity of selectively inhibiting
phosphodiesterase 7 (PDE7). Meanwhile, 2-aminoacetophenone,
isocyanate and
amidine which are low in price and easy to obtain serve as starting raw materials of the compound, a spiro-bicyclic
system is directly constructed through one-pot series cyclization, and the preparation method has the advantages that the raw materials are easy to obtain, steps are simple,
atom economy is high, the
reaction system is green and simple, aftertreatment is simple and convenient, amplification is easy and the like.