16 results about "Chalcone derivative" patented technology

The application discloses a kind of tetraphenyl ethylene-chalcone derivative preparation and its application preparation and its application.The structure is as follows: the method includes: 4-(1,2,2-triphenyl ethenyl) acetophenone, aldehyde derivative, sodium hydroxide (provides alkaline condition, pH=8.3~8.5), is placed in anhydrous ethanol, under the condition that heating temperature is 80 DEG C, reflux reaction 12h, after reaction is ended, the functional organic material is separated and purified.The functional organic material synthesized according to the above method has larger conjugated system, and has significant pressure-induced color change characteristics.The functional organic material disclosed in the application has low preparation cost, simple operation, simple method, and the material shows significant pressure-induced color change characteristics, can be applied to pressure-induced color change, luminescent material, printing and dyeing, color printing and anti-counterfeiting technical field.

The invention relates to the technical field of villiaumite, in particular to high-purity villiaumite and a preparation method and application thereof. The purity of the high-purity villiaumite is not lower than 99.999%, a photoelectric device modification layer prepared by combining the high-purity villiaumite with a chalcone derivative can effectively regulate and control the wettability of a perovskite precursor solution, growth is induced through a template effect, and finally a perovskite thin film with high crystallinity and a flat surface is obtained. The high-purity villiaumite can effectively avoid impurity defects and promote ordered anchoring of organic molecules to form an ordered structure, so that efficient interface passivation and charge transfer are achieved, and the carrier mobility is improved. The composite modification layer formed by the chalcone derivative and the high-purity villiaumite constructs a stable interface, ion migration and decomposition are effectively inhibited, and the service life of the device is remarkably prolonged.

The application belongs to the technical field of pharmaceutical chemistry, and specifically discloses a chalcone derivative and a preparation method thereof. 2,4-dihydroxy formaldehyde is used as an initial raw material, isopentenyl is introduced into 2,4-dihydroxybenzaldehyde through a Friedel-Crafts reaction, and then a heterocycle is introduced through a hydroxy aldehyde condensation reaction of the heterocycle-substituted formaldehyde, so that a chalcone structure is formed. The prepared chalcone derivative has a structural formula as shown in Formula I, and the physicochemical properties thereof are studied. It is proved that the chalcone derivatives I-4, I-5, I-7, I-8, I-9, I-10, I-11, I-12 and I-14 all show a strong inhibitory effect on the proliferation of four tumor cells (PC9, MDA-MB-231, SMMC-7721 and SGC-7901). Among them, the chalcone derivative I-4 can effectively inhibit the proliferation of human lung cancer PC9 and H1975 cells in a concentration-dependent manner, and shows good in-vivo anti-tumor activity and can induce iron death of human lung cancer PC9 and H1975 cells, and has a good application prospect as an anticancer drug.

The invention discloses a chalcone compound containing a glycine substituent group or a pharmaceutically acceptable salt thereof as well as a preparation method and application of the chalcone compound, and belongs to the technical field of chalcone derivative preparation, the structural general formula of the chalcone compound containing the glycine substituent group is Ar-C (= O)-CH = C (Ar)-NH-CH2-COOH, wherein Ar and Ar are independently selected from benzene rings with 1-3 substituent groups X, and X is selected from hydrogen, halogen, hydroxyl, methoxyl, nitryl, methyl, carboxyl or amino. According to the chalcone compound containing the glycine substituent, oxidative stress, lipid metabolism disorder and an inflammation pathway are synergistically regulated and controlled, the comprehensive protection effect on alcoholic liver diseases is achieved, the curative effect is better than that of existing clinical drugs, and the chalcone compound containing the glycine substituent has good patent medicine prospects.

The application provides an application of a sulfamoyl-based chalcone derivative, the compound contains a methylsulfonyl structure and is substituted by a benzene ring or other heterocyclic groups at an alpha position, has higher inhibiting capability on Hela cells than glycyrrhiza chalcone A, is a compound with significant antitumor activity, and provides a research basis for screening of new antitumor drugs.

The invention belongs to the technical field of synthesis of unsaturated amide derivatives. The invention provides a method for synthesizing an alpha, beta-unsaturated amide derivative, which comprises the following steps: adding a chalcone derivative and methylsulfonyl hydroxylamine trifluoromethanesulfonate into a solvent, and reacting to obtain a product. According to the method provided by the invention, the'one-pot efficient construction of alpha, beta-unsaturated amide from ketene 'is completed directly by chalcone and methylsulfonyl hydroxylamine trifluoromethanesulfonate only under the room temperature condition in which tetrahydrofuran participates', the steps are short, the conditions are mild, expensive or high-toxicity metal and high-temperature dependence are not needed, and the method is suitable for industrial production. And meanwhile, the atom economy is better, the process heat release is controllable, and gram-level and even larger-scale amplification is facilitated.

The application discloses a chalcone derivative with a structure shown in formula (I) or a pharmaceutically acceptable salt or a stereoisomer thereof and application thereof as an active ingredient in preparation of an NLRP3 inflammasome inhibitor and / or a STATs pathway inhibitor. The compound can selectively inhibit the activation of the NLRP3 inflammasome and can inhibit the STATs pathway, thereby treating or improving diseases related to the NLRP3 inflammasome and / or the STATs pathway, such as acute peritonitis and colitis, and can be used in preparation of a therapeutic drug for diseases related to the NLRP3 inflammasome and / or the STATs pathway.

The present invention is directed towards catalysts comprising metal nanoparticles and a N-heterocyclic carbene comprising palladium or nickel, their use in carbonylative coupling reactions and hydrogenation reactions, and their use in one-pot carbonylative coupling and hydrogenation reaction. A method employing such catalysts to access ynone and chalcone derivatives is also claimed. The catalysts and methods of the present invention improve upon the disadvantages associated with literature reactions.

The invention relates to a chalcone derivative, a preparation method thereof and application of the chalcone derivative in preparation of an anti-angiogenesis medicine. The molecular structure of the chalcone derivative is shown as a formula I. The chalcone derivative disclosed by the invention can obviously inhibit angiogenesis in a vascular endothelial cell HMEC-1 and a zebra fish body at a relatively low concentration, and can be used as a new chemical entity for preparing a novel anti-angiogenesis medicine.

The present disclosure provides compounds of formula 1 to inhibit or prevent mitochondrial dysfunction by augmenting mitochondrial function. Mitochondrial dysfunction is the hallmark of a wide range of diseases and disorders. Mitochondria are a promising therapeutic target for the detection, prevention and treatment of various human diseases such as cancer, neurodegenerative diseases, ischemia-reperfusion injury, diabetes and obesity.

The invention discloses a pyrazole-containing chalcone derivative as well as a preparation method and application thereof, and belongs to the technical field of pesticide synthesis. A series of pyrazol-containing chalcone derivatives are synthesized by taking chalcone as a leading structure and introducing a pyrazol skeleton with excellent agricultural activity into the structure of chalcone, and plant pathogenic fungus activity inhibition tests are carried out on the synthesized pyrazol-containing chalcone derivatives, so that the activity of the pyrazol-containing chalcone derivatives is shown in the description. The synthesized pyrazole-containing chalcone derivative can effectively inhibit plant pathogenic fungi, and especially has relatively good inhibitory activity on phomopsis, phytophthora capsici and capsicum oxysporum.

This invention belongs to the field of pharmaceutical synthesis technology, specifically disclosing an aminoalkylated paeonol chalcone derivative, its preparation method, and its pharmaceutical uses. The aminoalkylated paeonol chalcone derivative of this invention is shown in general formula (I). It is obtained by using paeonol as a raw material, linking the phenolic hydroxyl groups on paeonol to organic amine fragments using different linking arms, and then performing Claisen-Schmidt condensation with various benzaldehydes. In vitro antitumor experiments have demonstrated that the derivative of this invention exhibits good antitumor activity against human colon cancer cells (HCT116), human liver cancer cells (HepG2), human lung cancer cells (A549), and human osteosarcoma cells (U2OS), and has significantly better water solubility than paeonol chalcone. It holds promise for development as a therapeutic drug for various cancers such as colon cancer, osteosarcoma, lung cancer, and liver cancer, with broad clinical application prospects.

The application discloses a 3'-geranyl-4,2',4',6'-tetrahydroxy dihydrochalcone against gram-positive bacteria, and a chemical structural formula of the dihydrochalcone is shown as formula (I). The application further provides a preparation method and application of the dihydrochalcone derivative. The 3'-geranyl-4,2',4',6'-tetrahydroxy dihydrochalcone has significant antibacterial activity against gram-positive bacteria, MRSA retention bacteria activity, and can significantly inhibit the formation of gram-positive bacterial biofilm.

The present invention relates to a novel chalcone derivative compound and a composition for the prevention or treatment of neurodegenerative diseases, comprising same as an active ingredient. The present invention can fundamentally eliminate the cause of neurotransmission dysfunction by simultaneously inhibiting the activities of two hyperactivated cholinesterases, unlike conventional symptomatic therapies that focus on the control of peripheral symptoms for various neurodegenerative diseases caused by a decrease in acetylcholine concentration, including Alzheimer's disease.

The invention belongs to the technical field of aziridine derivative synthesis. The invention provides a method for synthesizing a 2-aroyl-3-aryl aziridine derivative. The method comprises the following steps: adding a chalcone derivative and methylsulfonyl hydroxylamine trifluoromethanesulfonate into a solvent, and reacting to obtain a product. The reaction is carried out under the condition of stirring at room temperature, the reaction can be efficiently completed without depending on any metal catalyst, the reaction condition is mild, the reaction is rapid, the principle of green chemistry is met, and the problems of heavy metal residues and environmental pollution are avoided. Meanwhile, the method has good substrate practicability and relatively high yield, and various substituted 2-aroyl-3-aryl aziridine compounds can be obtained with good yield.

This invention relates to the field of fluoride salt technology, and more particularly to a high-purity fluoride salt, its preparation method, and its applications. The high-purity fluoride salt has a purity of not less than 99.999%. When combined with chalcone derivatives, it forms a photoelectric device modification layer that effectively controls the wettability of perovskite precursor solutions and induces growth through a template effect, ultimately yielding a perovskite film with high crystallinity and a smooth surface. The high-purity fluoride salt effectively avoids impurities and defects, promoting the orderly anchoring of organic molecules to form an ordered structure, thereby achieving efficient interface passivation and charge transport, and improving carrier mobility. The composite modification layer formed by the chalcone derivatives and the high-purity fluoride salt constructs a stable interface, effectively inhibiting ion migration and decomposition, and significantly extending the device's operating life.