6 results about "Amine alkylation" patented technology

The invention discloses a synthesis method of Olrabatinib, which comprises the following steps: by taking 2-methyl-5-nitro trifluorotoluene as a raw material, carrying out a Waller-Ziegler reaction, an alkylation / silanization reaction of amine, nitro reduction, a condensation reaction and a Caslow-Stevens coupling reaction, so as to obtain the Olrabatinib. By optimizing process conditions and a reaction system, the synthesis method disclosed by the invention has the remarkable advantages in the following aspects: the raw material cost is greatly reduced by adopting low solvent consumption; the product yield is improved by accurately controlling reaction parameters; a standardized post-treatment process is developed, and large-scale stable production is realized. According to the technical system, the technical bottlenecks of high energy consumption and high pollution in the traditional synthesis route are effectively solved, and an innovative solution is provided for green manufacturing of fine chemicals.

The invention discloses a catalyst for aniline alkylation and a preparation method, and belongs to the technical field of catalysts. The preparation method of the catalyst comprises the following steps: roasting a catalyst carrier precursor, and adding desalted water into a roasted product to prepare slurry; preparing a mixed solution of copper salt, zinc salt and chromium salt; additionally preparing an alkali solution; adding a metal salt mixed solution and an alkaline solution into the slurry, carrying out a co-precipitation reaction, and then aging; repeatedly filtering and pulping the aged slurry to obtain a catalyst precipitation filter cake; and drying, forming and calcining to obtain the catalyst. The invention also discloses the catalyst for aniline alkylation, which is prepared by the method. The catalyst provided by the invention can realize concerted catalysis of aniline alkylation and methanol steam cracking in a single reactor, methanol and aniline are taken as raw materials, N-methylaniline is synthesized with high selectivity, high-purity hydrogen is co-produced, and no wastewater is discharged in the reaction process.

The invention belongs to the technical field of medicine synthesis, and particularly discloses an aminoalkylated paeonol chalcone derivative as well as a preparation method and medical application thereof. The amine alkylation paeonol chalcone derivative is shown as a general formula (I), and is obtained by taking paeonol as a raw material, connecting phenolic hydroxyl groups on the paeonol with organic amine fragments by utilizing different connecting arms, and then carrying out Claisen-Schmidt condensation with various benzaldehydes. In-vitro anti-tumor experiments prove that the derivative has good anti-tumor activity on human colon cancer cells (HCT116), human hepatoma cells (HepG2), human lung cancer cells (A549) and human osteosarcoma cells (U2OS), has obviously better water solubility than paeonol chalcone, is expected to be developed into a medicine for treating various cancers such as colon cancer, osteosarcoma, lung cancer or liver cancer, and has broad application prospects. The clinical application prospect is wide.

The present invention discloses a bimetallic catalyst, a preparation method thereof, and its application in the alkylation reaction of alcoholamines, relating to the technical field of metal catalysts. The bimetallic catalyst comprises a carrier and an active component supported on the carrier; the active component comprises Ni and Cu; and the loading amounts of Ni and Cu are 8-15% and 3-7% of the weight of the carrier, respectively, in weight percentage. The present invention utilizes a method combining femtosecond laser technology with gradient pressure cryogenic freezing technology to modify and activate alumina, effectively increasing its specific surface area and optimizing its pore structure. Furthermore, by loading appropriate amounts of Ni and Cu active components onto the carrier to form a bimetallic catalyst, the selectivity and yield of the target product, tert-butylaminoethoxyethanol, in the alkylation reaction of alcoholamines using diethylene glycol and tert-butylamine as raw materials are significantly improved, showing broad application prospects.

This invention belongs to the field of pharmaceutical synthesis technology, specifically disclosing an aminoalkylated paeonol chalcone derivative, its preparation method, and its pharmaceutical uses. The aminoalkylated paeonol chalcone derivative of this invention is shown in general formula (I). It is obtained by using paeonol as a raw material, linking the phenolic hydroxyl groups on paeonol to organic amine fragments using different linking arms, and then performing Claisen-Schmidt condensation with various benzaldehydes. In vitro antitumor experiments have demonstrated that the derivative of this invention exhibits good antitumor activity against human colon cancer cells (HCT116), human liver cancer cells (HepG2), human lung cancer cells (A549), and human osteosarcoma cells (U2OS), and has significantly better water solubility than paeonol chalcone. It holds promise for development as a therapeutic drug for various cancers such as colon cancer, osteosarcoma, lung cancer, and liver cancer, with broad clinical application prospects.

The application discloses application of a supported Ni-Cu catalyst in alcohol amine alkylation reaction, wherein the alcohol is a fatty alcohol, and the amine is an organic amine, and the alcohol amine alkylation reaction is carried out under the action of the supported Ni-Cu catalyst. The application can reduce the production cost of the catalyst, reduce the energy consumption of the alcohol amine alkylation reaction, and inhibit the side reaction caused by the breakage of C-N bonds in the raw material amine.