33 results about "Amine alkylation" patented technology

The invention mainly relates to a method for producing ethylbenzene and styrene through side chain alkylation of toluene and methanol, which is mainly used for solving the problems that methanol is easily decomposed and consequently the utilization rate of methanol is low in the prior art. The method comprises the steps that a) toluene and the first part of methanol enter a first reaction area and contact with a catalyst to generate a material flow I; b) the material flow I and the second part of methanol enter at least one second reaction area and contact with a catalyst to generate a material flow II; c) the material flow II enters at least one third reaction area and contacts with a catalyst to generate a material flow III containing ethylbenzene and styrene. By adopting the technical scheme, the problems are better solved, and the method can be applied to the industrial production of preparing ethylbenzene and styrene through side chain alkylation of toluene and methanol.

The invention relates to a method for preparing ethylbenzene and styrene through toluene and methanol side chain alkylation, and is used for mainly solving the problems that the toluene conversion rate is low, the ethylbenzene and styrene selectivity is low and a catalyst is unstable in the prior art. The problems are solved by adopting the technical scheme that under conditions of toluene and methanol side chain alkylation, raw materials and a catalyst make contact to generate ethylbenzene and styrene; and the catalyst comprises the following components by the weight percentage: a) 0.1-99% of an alkali metal ion exchanged X molecular sieve, b) 0.1-99% of an alkali metal ion exchanged ZSM-5 molecular sieve, and c) 0-5% of a rare earth metal, wherein alkali metals are at least two selected from potassium, rubidium or cesium. The method can be used for industrial production of preparation of ethylbenzene and styrene through toluene and methanol side chain alkylation reaction.

The present invention provides a simple, efficient, and industrially advantageous method for the alkylation of amines. The present invention relates to a production method for N-alkylamines whereby an amine is reacted with an alcohol in the presence of a ruthenium complex represented by general formula (1): RuXY(CO)(L) (wherein X and Y can be the same or different and represent a monovalent anionic ligand, and L represents a tridentate aminodiphosphine ligand).

The invention discloses a method for synthesizing 1,2-dissubstituted olefin compounds by high-selectivity alkyne alkylation. The method comprises the following specific steps: a photosensitizer, an alkyne compound represented as the formula I and hantzsch ester are added to a Schlenk reaction tube, aldehyde represented as the formula II and secondary amine are dissolved in an organic solvent or amixed solvent of 1,4-dioxane and water under protective gas atmosphere, a mixed solution is obtained, the mixed solution is added to the Schlenk reaction tube under the condition of protective gas andis stirred for a reaction at 25 DEG C for 6-14 h, preferably 12 h under the irradiation of a light source, and the 1,2-dissubstituted olefin compounds represented as the formula III are obtained after the obtained reaction solution is subjected to aftertreatment. Polysubstituted alkenes which are difficult to prepare with the conventional method can be synthesized with the method, and the methodhas the advantages of being high in reaction stereoselectivity, relatively mild in reaction condition, high in yield, high in substrate universality and simple and convenient to operate, a catalyst ischeap and available and has lower toxicity, and energy consumption is reduced.

The invention relates to a method for alkylating amine and amino acid, and provides a method for alkylating amine and amino acid, which has high efficiency and chemical selectivity, and is mild and environment-friendly. The method comprises the following steps of: adding amine or amino acid, a catalyst and an alkylating reagent in a reaction flask, pumping air in the system, and introducing hydrogen to enable the whole system to be in a hydrogen atmosphere; after reaction, filtering to remove the catalyst, washing the filter cake, and decompressing and condensing the filtrate to obtain the product, wherein the catalyst is Pd/C or Pd(OH)2/C, and the alkylating reagent is alcohol. The alcohol is directly used as a substrate, and can be conveniently and easily obtained compared with halogenated hydrocarbon. In the reaction, dehydration and condensation are directly carried out to alkylate the amine, thereby halogeno salt generated by using the halogenated hydrocarbon is avoided, in addition, water is the unique side product, thereby the method is environment friendly. Documents report that in the traditional methods, the reaction condition is rigorous, and most methods are carried out under high temperature, but the method provided by the invention has mild reaction condition, and the reaction can be directly carried out under room temperature. The catalyst can be recycled, thereby the invention has very good industrial application prospect.

The invention relates to a method for preparing a strong anion exchange resin with long spacer arms, belonging to the field of the synthesis of ion exchange resins. The method enables macropore or hydrogel polystyrene resin swollen by inert solvent such as nitrobenzene to have amine-alkylation reaction by taking cyclic carbamate as alkylation reagent and Lewis acid or ionic liquid as catalyzer, thus producing polystyrene resin with long spacer arms primary amines; the polystyrene resin with long spacer-arm primary amines reacts with formic acid and formaldehyde to get tert-aminated polystyrene resin which then reacts with ethyl bromide to get strong anion exchange resin with long spacer arms. Directly introducing primary amine groups into white beads through amine-alkylation, the method disclosed by the invention simplifies process, saves cost and is simple in process; therefore, the method is of wide application prospect.

The present invention relates to an improved process of alkylating secondary amines, more particularly of alkylating compounds having amino piperidinic group, which are useful as donepezil intermediates, wherein an alcohol serves as reaction facilitator thus enabling to obtain donepezil and salts thereof in high quality and yield. The present invention also relates to the prevention of unwanted alkylation of donepezil precursors, having amino piperidinic group, by using suitable reaction conditions.

The invention discloses a preparation method of 4-fluorine-N-isopropyl aniline by oriented single substituted N-alkylation reaction, which takes 4-fluoroaniline as a substrate, halogenated iso-propane as an alkylation reagent under the effects of a phase-transfer catalyst, a cocatalyst and an acid binding agent. The method has the advantages of mild reaction condition, simple operation, high raw material conversion rate and products selectivity, convenient products separation and the like. The prepared 4-fluorine-N-isopropyl aniline is an important pesticide intermediate, and can synthesize an oxyacetamide herbicide flufenacet and the like.

Disclosed herein is a process for lubricating an internal combustion engine with a lubricant composition that may be substantially ash free. The ashless lubricant composition described herein may comprise primary antioxidants, such as aminic diphenyl amines, alkylated phenyl-naphthyl amines, and phenolic antioxidants. The ashless lubricant composition described herein may also comprise sulfur containing products that may work as secondary antioxidants. Other components such as ashless antiwear components, dispersants, pour point depressants, friction modifiers, and metal deactivators may also be used to formulate an ashless lubricant composition according to an embodiment.

The invention discloses application of a substituted benzothiazole C2 amide alkylation derivative as a fungicide. The structure of the derivative is shown as a formula (I). In the formula (I), a substitute R1 is hydrogen or C1-C5 alkyl; H on a benzothiazole ring is monosubstituted, polysubstituted or unsubstituted by a substituent R, with the C2 site of the benzothiazole ring is not substituted bythe R; n is an integer of 0 to 4, and represents the number of the substituents R on the benzothiazole ring; when the n is 0, indicating that H on the benzothiazole ring is not substituted; when then is 1, indicating that the H on the benzothiazole ring is monosubstituted by the substituent R; when the n is 2 to 4, indicating that H on the benzothiazole ring is polysubstituted by the substituents R, with the substituents R at different substation positions being same or different; the substituent R is hydrogen, C1-C5 alkyl, C1-C2 alkoxyaryl, or halogen. The derivative has good inhibitory effects on fungi causing wheat scab, corn southern leaf blight, cucumber anthracnose and rice sheath blight disease.

The invention discloses a kilogram-level amplification-scale production chiral biguanide catalyst synthesis method, which comprises: S1, carrying out an amine alkylation reaction by using chiral ethylenediamine and benzyl bromide as raw materials to obtain chiral bis-secondary amine; s2, adding a solvent and thiophosgene into the same kettle, carrying out a thiocarbonylation reaction to obtain chiral thiourea, and carrying out pulping purification treatment on the chiral thiourea; s3, adding oxalyl chloride into the same kettle, and performing reflux reaction in a solvent to obtain chiral 2-chloroimidazoline onium salt; and s4, evaporating out the solvent in the step S3 from the original kettle, then adding piperazine into the same kettle, and carrying out amination coupling reaction to obtain a chiral biguanide salt ion pair catalyst BG-I; and according to the synthesis method, one-kettle multi-step same-kettle feeding is adopted, the production stability and safety are improved, the synthesis route is shortened, meanwhile, the traditional tedious pulping purification process is simplified, the synthesis efficiency is improved, the synthesis cost is reduced, and the method is stable in process and suitable for industrial large-scale production.

The present invention relates to a process for the N-alkylation of amines by reacting an amine with an orthocarboxylic acid ester and with hydrogen in the presence of a hydrogenation catalyst.

The invention discloses a preparation method of an ambroxol hydrochloride impurity reference substance. With ambroxol hydrochloride as a raw material, the ambroxol impurity AXS-13 is obtained through hydroxyl protection, amine alkylation, cyclization, carbonyl reduction, deprotection and other reactions. A basis is provided for research of ambroxol hydrochloride related substances. The method is simple, raw materials are easy to obtain, the product is easy to purify, the yield and the purity are high, and the product can be used as a reference substance in impurity detection.

The invention belongs to the technical field of drug synthesis, and particularly relates to a synthesis method of indacaterol and salt derivatives thereof and intermediate for the synthesis. The synthesis method of indacaterol comprises the following steps: carrying out amine alkylation and deprotection reaction, in a one-pot manner, on a compound shown as a general formula IV and a compound shownas a formula V serving as raw materials to obtain a compound shown as a formula I, wherein the reaction equation is shown as the specification; wherein R is a silane protecting group. According to the technical scheme provided by the invention, by carrying out Boc protection on the amino group, polyalkylation on the amino group is ingeniously avoided, so that under the condition that both the hydroxyl group and the amino group have proper protection, the alkylation reaction effectively avoids the generation of by-products; after the alkylation reaction, hydroxyl and amino deprotection can bedirectly carried out, so that the multi-step reaction is completed in one reactor; according to the method, the intermediate purification and separation process is omitted, the reaction yield is increased to the maximum extent, and the production cost is reduced.

The present invention discloses a single package additive for improving lubricity and conductivity properties of ultra-low sulfur diesel fuels. The single package additive is a reaction product of a fatty acid composition, a glycerol tricarboxylates, a polysulfone, a polyamine, an alkylated benzene sulfonic acid and a phenol derivative. More specifically, the present invention discloses a reaction product of: a fatty acid composition in the range of 60-95% wt/wt; a glycerol tricarboxylate in the range of 0.1-10.0% wt/wt; a polysulfone in the range of 0.1-5.0% wt/wt; a polyamine in the range of 0.1-5.0% wt/wt; an alkylated benzene sulfonic acid in the range of 0.1-5.0% wt/wt; and a phenol derivative in the range of 0.1-10.0% wt/wt. The present invention also discloses a single-pot process for the preparation of said reaction product.

The invention relates to a catalyst applied to preparation of isopropyl benzene by performing liquid-phase alkylation on propylene, which is mainly used for solving the problem of low mono-isopropyl benzene selectivity in a liquid-phase alkylation reaction of benzene and the propylene in the prior art. The catalyst comprises the following components in parts by weight: 50-80 parts of at least onemolecular sieve selected from a Y molecular sieve, a beta molecular sieve or an MCM-22 molecular sieve and 20-50 parts of inorganic oxide, wherein the catalyst is modified with mixed liquor of benzene and isopropyl benzene at the treatment temperature 110-160 DEG C under the treatment pressure 2.0-2.8 MPa for 2-200 hours; the total liquid phase weight space velocity is 2-20 h<-1>; and the weight ratio of the benzene to the isopropyl benzene in the mixed liquor of the benzene and the isopropyl benzene is 15-80. By adopting the technical scheme, the problem is well solved; and the catalyst can be applied to industrial production of isopropyl benzene by performing liquid-phase alkylation on propylene.