Preparation method of oriented single alkylation of 4-fluorine-N-isopropyl aniline

Abstract

The invention discloses a preparation method of 4-fluorine-N-isopropyl aniline by oriented single substituted N-alkylation reaction, which takes 4-fluoroaniline as a substrate, halogenated iso-propane as an alkylation reagent under the effects of a phase-transfer catalyst, a cocatalyst and an acid binding agent. The method has the advantages of mild reaction condition, simple operation, high raw material conversion rate and products selectivity, convenient products separation and the like. The prepared 4-fluorine-N-isopropyl aniline is an important pesticide intermediate, and can synthesize an oxyacetamide herbicide flufenacet and the like.

Description

technical field

[0001] The invention relates to an alkylation preparation method of 4-fluoro-N-isopropylaniline. Background technique

[0002] 4-Fluoro-N-isopropylaniline, the English name is 4-Fluoro-N-Isopropylanline, the molecular formula is C 9 h 12 FN, molecular weight 153, CAS number 70441-63-3. 4-Fluoro-N-isopropylaniline is an important pesticide intermediate from which the oxyacetamide herbicide flufenacet can be synthesized. The molecular structure of 4-fluoro-N-isopropylaniline can be regarded as a derivative in which the hydrogen in the ammonia molecule is replaced by isopropyl and fluorobenzene. Similar to inorganic ammonia, where the N atom is sp 3 Hybridization, there is a lone pair of electrons on the N atom, which reflects a series of chemical properties, such as the hydrogen on the amino group is prone to neutralization, acylation, sulfonation and other reactions, and a series of useful compounds can be synthesized. Its structural formula is as follows:...

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