Reductive alkylation of amines with orthocarboxylic acid esters
A carboxylate, alkylation technology, applied in reductive alkylation preparation, organic chemistry, cyanide reaction preparation, etc., can solve problems such as difficult separation of amino acids
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[0099] General procedure for the reductive alkylation of amines with orthocarboxylates
[0100] Fill the autoclave with catalyst (1 mol%, based on the molar amount of amine), flush with argon and add amine (0.1 mol) and orthocarboxylate (0.11-0.3 mol) in 10 ml of methanol (or ethanol) solution and 0.5ml of 0.2M anhydrous p-toluenesulfonic acid in methanol (or ethanol). The mixture was heated to 120° C. and injected with hydrogen to 40 bar, then the mixture was stirred at constant pressure until no more hydrogen uptake could be detected (0.2-6 hours). After filtering off the catalyst, the filtrate was distilled.
[0101] Yields can be found in Table 1.
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