17 results about "O-hydroxyacetophenone" patented technology

This invention discloses a method for preparing 2,4-dihydroxyacetophenone using acetaldehyde as the acetyl source. Under the presence of an oxidant and a catalyst, acetaldehyde, as the acetyl source, undergoes a direct free radical acylation reaction with resorcinol to obtain 2,4-dihydroxyacetophenone. No transition metal salts are required during the reaction. This method, using acetaldehyde as the acetyl source, facilitates a highly efficient free radical acylation reaction with resorcinol under the combined action of N-hydroxyphthalimide (NHPI) and benzoyl peroxide (BPO), producing 2,4-dihydroxyacetophenone in one step without the need for any transition metal salts. This method completely solves the environmental pollution and metal residue problems associated with traditional methods. The reaction conditions are mild, no special equipment is required, and the method exhibits high selectivity, non-corrosiveness, high product purity, and low production cost, showing broad prospects for industrial application.

A synergistic antimicrobial mixture comprising a hydroxyacetophenone and an additional antimicrobial agent is suggested. The mixture is particularly useful against Aspergillus brasiliensis.

This invention discloses a 2-phenylimidazo[1,2-] α This paper describes pyridine compounds, their preparation methods, and applications, belonging to the field of pharmaceutical technology. These compounds use imidazo[1,2-α]pyridine as the core skeleton and are prepared via a three-step method: first, cyclization of 2-aminopyridine with hydroxyacetophenone yields intermediate LT1-6; then, etherification with a brominated carboxylic acid ester yields LT7-48; finally, hydroxylamine hydrolysis converts them into the target product HDDI1-42, which contains an isohydroxamic acid group. Activity tests show that these compounds possess significant HDAC1 inhibitory activity and anti-tumor cell proliferation activity.

This invention pertains to organic synthesis and medicinal chemistry, specifically relating to a 4-chromone-cyclohexane spirocyclic trimer compound, its preparation method, and its applications. The 4-chromone-cyclohexane spirocyclic trimer compound has the structure shown in Formula I, II, III, or IV, or stereoisomers of the structures shown in Formulas I to IV. This invention also provides a method for preparing this compound, using 2-hydroxyacetophenone or its derivatives as a starting material, reacting it with dihalomethane in the presence of a base and additives to construct a spirocyclic trimer skeleton in one step. The compound of this invention can inhibit PPM1E and PPM1F protein phosphatases with high activity and high selectivity, achieving nanomolar inhibitory activity against PPM1E and sub-enzyme selectivity exceeding 100-fold. The compound of this invention can be used to prepare drugs for cancers associated with PPM1E / PPM1F overexpression.

The application discloses an anti-hair-loss original solution containing transdermal recombinant collagen and a preparation method thereof. The anti-hair-loss original solution comprises the following components in percentage by mass: 0.5-2% of recombinant collagen glycerol, 2-10% of glycerol, 0.5-5% of 1,2-hexanediol, 0.5-6% of p-hydroxyacetophenone, 0.1-0.7% of sodium hyaluronate, 0.5-5% of 1,2-pentanediol, 0.05-2% of aminomethylpropanol, 0.05-2% of plant soothing agent SGS, 0.1-2% of carbomer U21, and the rest is water. The application uses the glycerol encapsulation technology to encapsulate the high-activity recombinant collagen in the glycerol vesicle, improves the transdermal property of the recombinant collagen, and forms the anti-hair-loss original solution by compounding the transdermal recombinant collagen as the active component with other raw materials, which has the effects of moisturizing and water-locking the skin and preventing hair loss.

This invention provides a method for synthesizing p-hydroxyacetophenone, comprising the following steps: simultaneously introducing phenyl acetate and a solution containing anhydrous hydrogen fluoride into a microchannel reactor to carry out a rearrangement reaction, wherein the rearrangement reaction is carried out at a temperature of 40-140°C and a pressure of 1-2 MPa, to obtain crude p-hydroxyacetophenone. This invention helps to improve the conversion rate of phenyl acetate and the selectivity of p-hydroxyacetophenone.

This invention provides a method for synthesizing p-hydroxyacetophenone, comprising the following steps: introducing a solution containing anhydrous hydrogen fluoride into a reaction vessel containing phenyl acetate to carry out a rearrangement reaction, wherein the rearrangement reaction is carried out at a temperature of 80-140°C and a pressure of 1-2 MPa, to obtain crude p-hydroxyacetophenone. This invention helps to improve the conversion rate of phenyl acetate and the purity of p-hydroxyacetophenone.

The present invention relates to detergents and cleaning compositions that comprise a degreasing agent and an effective amount of a specific type of degreasing boosting agent, such as alkanediols having a carbon chain from 5 to 14 carbon atoms, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin, tropolone, or a mixture of said degreasing boosting agents, and a surfactant, and the use of said detergents and cleaning compositions for the preparation of a detergent and cleaning product for household, institutional and industrial application. Furthermore, the present invention relates to a method of treating a stained and / or soiled substrate using the detergents and cleaning compositions according to the present invention. Additionally, the present invention relates to the use of specific boosting substances as defined herein for boosting the degreasing power of a degreasing detergent and cleaning composition and improving cleaning performance of a degreasing detergent and cleaning composition. Moreover, the present invention relates to a method of boosting the degreasing power of a degreasing detergent and cleaning composition and of improving the cleaning performance of a degreasing detergent and cleaning composition by adding an effective amount of a specific degreasing boosting agent, such as alkanediols having a carbon chain form 5 to 14 carbon atoms, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin, tropolone, or a mixture of said degreasing boosting agents, to said detergent and cleaning composition. Finally, the present invention relates to the use of at least one degreasing boosting agent, such as alkanediols, as defined herein, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin, tropolone, or a mixture of said degreasing boosting agents, as defined herein as degreaser and / or as replacement for a solubilizer.

The present invention relates to an aqueous composition comprising: (a) at least one water-soluble acidic dye; (b) at least one buffer system; and (c) at least one preserving system comprising phenoxyethanol and hydroxyacetophenone. The composition according to the present invention is stable, has a good preservability and can suppress the issue of nozzle-clogging for printing.

The application discloses nano-antibacterial polyester masterbatch and an extrusion preparation method thereof, and belongs to the technical field of polyester masterbatch preparation. The nano-antibacterial polyester masterbatch is composed of the following components in parts by weight: 50-70 parts of polybutylene terephthalate, 10-22 parts of a nano-antibacterial agent, 5-10 parts of a composite anti-yellowing agent, 0.5-1.2 parts of a dispersing agent, 1-3 parts of a lubricant, 6-9 parts of a filler and 0.3-0.6 parts of a plasticizer, wherein the nano-antibacterial agent is prepared from o-phenylenediamine, 2-thiophene formaldehyde, bromine propargyl, 4-fluorochlorobenzyl and sodium azide, and the composite anti-yellowing agent is prepared from 4-hydroxyacetophenone, benzaldehyde, 1,3-dibromopropane, 4-[(methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester and p-methoxybenzenesulfonyl chloride. The polyester masterbatch prepared by the method has excellent antibacterial performance and anti-aging performance.

The present invention relates to the use of a mixture of a) 2'-fucosyllactose (2'-FL) or 3'-sialyllactose (3'-SL); and b) a compound selected from 3-[(2-ethylhexyl)oxy]-1,2-propanediol (= ethylhexylglycerol), propan-1,2-diol, propan-1,3-diol, glyceryl octanoate, pentan-1,2-diol, heptan-1,2-diol and hydroxyacetophenone for reducing the growth of microorganisms.

This invention provides a cadmium ion detection reagent, its preparation method, and its application, to solve the problems of cadmium ion detection in the prior art. 2+ Ion detection suffers from high costs, technical complexity, and time consumption, and does not allow for high-throughput analysis. This invention addresses the Cd... 2+ The structure of the ion detection reagent is as follows: ; its preparation method includes the following steps: (1) Add phenanthroline aldehyde and 2-hydroxyacetophenone to a solvent and stir evenly, then add alkali and catalyst, react at room temperature, and then purify to obtain the target product. The cadmium ion detection reagent of the present invention can qualitatively and quantitatively detect cadmium ions, with a detection limit of 2.12 × 10⁻⁶. ‑7 M.

This invention discloses the preparation and application of a recombinant cholesterol esterase immobilized enzyme preparation. This invention will... Ophiostoma piceae Cholesterol esterase mutant gene ope-D136P Linked to pPICZαA plasmid, via signal peptide replacement and rDNA Gene insertion yielded the pEESB-3 plasmid; the protein disulfide isomerase gene was inserted. pdi The pPIC9K plasmid was ligated to obtain the pEESB-4 plasmid. This plasmid was electroporated into Pichia pastoris GS115, and after resistance selection and methanol-induced expression selection, recombinant Pichia pastoris engineered strains were obtained. Recombinant cholesterol esterase was obtained from this strain after methanol-induced expression. An aminated immobilization vector was prepared using APTES and TEOS as silane precursors. After grafting with 2,4-dihydroxyacetophenone and nickel ion chelation, the recombinant cholesterol esterase was immobilized to obtain an immobilized enzyme preparation. This immobilized enzyme preparation can catalyze the synthesis of stigmasterol ferulic acid ester from stigmasterol in a non-aqueous phase system, with a conversion rate of 33% (based on stigmasterol) or 32% (based on ferulic acid).

The present application belongs to the technical field of chemical component analysis and detection of traditional Chinese medicinal materials, and particularly relates to a method for simultaneously and quantitatively detecting six components in radix impatiens and application thereof. The method comprises the following steps: standard samples of six components, i.e. hydroxybenzoic acid, vanillic acid, syringic acid, 4-hydroxyacetophenone, 2,4-dihydroxyacetophenone and A-O-DCDT, are weighed respectively and prepared into a mixed control solution containing all the standard samples by using an organic solvent; an extracting agent is added to a test sample, and then the test sample is placed, ultrasonically extracted, cooled, fixed in volume, centrifuged, filtered, and dried to obtain a residue; the residue is redissolved and filtered to obtain a supernatant, which is the test sample solution; the mixed control solution and the test sample solution are detected by UPLC-DAD to obtain corresponding chromatograms; and the six components are qualitatively identified and quantitatively determined by comparing and analyzing the chromatograms of the mixed control solution and the test sample solution.

The application discloses application of 2,3-dihydroxyacetophenone in treating ischemic diseases, the compound has pharmacological effects of resisting brain damage of mice caused by cerebral ischemia, and has pharmacological activities of resisting neuron damage caused by oxygen-glucose deprivation, and is expected to be developed into a drug for treating ischemic diseases.

This invention discloses a toner rich in water-soluble β-glucan and its preparation method, belonging to the field of cosmetic technology. The toner, by mass fraction, comprises: 0.2-1% β-glucan, 0.1-0.5% *Epipremnum aureum* extract, 10-20% *Dendrobium nobile* extract, 0.1-0.5% dipotassium glycyrrhizate, 0.1-0.2% bisabolol, 0.1-0.5% hyaluronic acid, 3-10% glycerin, 0.5-1.5% trehalose, 0.1-0.7% p-hydroxyacetophenone, 0.1-0.3% pH adjuster, and the balance being deionized water. This invention achieves deep hydration and barrier repair of the skin's stratum corneum through a ternary compound system of β-glucan, *Epipremnum aureum* extract, and *Dendrobium nobile* extract. It retains the antioxidant activity of *Epipremnum aureum*, while also forming an anti-inflammatory and soothing system with dipotassium glycyrrhizate and bisabolol.

This invention relates to the field of organic synthesis technology and discloses a high-yield synthesis method for benzofuran-2,3-dione 3-(O-methyloxime)2-oxime. The method uses o-hydroxyacetophenone as the starting material and includes the following steps: Step 1, the starting material is refluxed with N,N-dimethylformamide dimethyl acetal in an aromatic hydrocarbon solvent to obtain an enamine ketone intermediate; Step 2, the enamine ketone intermediate is nitrosated and oxidatively cyclized using sodium nitrite and tert-butyl nitrite in a ketone solvent; Step 3, the cyclized product is reacted with methoxyamine hydrochloride in an alcohol solvent to obtain the target product. This invention avoids the use of hazardous reagents such as sodium hydride and concentrated nitric acid by constructing an enamine ketone intermediate and employing a mild two-component nitrosation system. The reaction conditions are mild, and post-processing only requires solid-liquid separation. This method has the advantages of high yield, good purity, high safety, and simple operation, making it suitable for industrial production.