138 results about "O-hydroxyacetophenone" patented technology

The invention discloses a preparation method and application of a photo-thermal dual-response membrane material, and relates to the field of membrane materials. When the photo-thermal double-response membrane material is prepared, a photo-thermal material firstly reacts with 4-(triethoxysilyl) aniline and then reacts with 2, 4, 6-trihydroxy-1, 3, 5-benzenetricarboxaldehyde and p-phenylenediamine, and a modified photo-thermal material is prepared; the preparation method comprises the following steps: sequentially reacting benzaldehyde with 2-hydroxyacetophenone and 3-N, N-dimethylamino methacryloyl chloride to prepare a photo-initiation monomer; the preparation method comprises the following steps: mixing N-isopropylacrylamide, a photo-initiation monomer, N, N '-methylene bisacrylamide and a modified photo-thermal material, combining with a hydrophobic substrate membrane, preparing a membrane, and finishing the surface by using 2-bromo-1-[3, 5-di (tert-butyl)-4-hydroxyphenyl] ethanone, thereby obtaining the photo-thermal dual-response membrane material. The photo-thermal dual-response membrane material prepared by the invention has the characteristics of pollution resistance, easiness in cleaning, durability, antibacterial property, metal ion recovery and low energy consumption.

The invention belongs to the field of personal care, and particularly relates to a glycoside derivative flexible liposome and a preparation method and application thereof, the glycoside derivative flexible liposome comprises a main shell material, a humectant, a wrapped raw material, an auxiliary shell material, a preservative and a solvent; the main shell material is phosphatidylcholine, and the auxiliary shell material is polyquaternium-51; the preservative is any one or more of 1, 2-hexanediol, p-hydroxyacetophenone, methylparaben, phenoxyethanol and caprylyl glycol; the moisturizing agent is butanediol; the wrapped raw material is hydroxypropyl tetrahydrofurantriol; the solvent is deionized water. According to the invention, the permeability and penetration depth of the glassine and the concentration of the glassine at a target position are improved by utilizing a flexible liposome wrapping technology, the bioavailability of the glassine is improved, and the addition amount is reduced under the condition of realizing the same tightening and anti-wrinkle effects, so that the cost is reduced.

The present invention relates to detergents and cleaning compositions that comprise a surfactant, an anti-redeposition agent, and an effective amount of 1,2-heptanediol and / or 2,3-heptanediol or a specific type of anti-redeposition boosting agent, such as alkanediols, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin or tropolone, and the use of said detergents and cleaning compositions for the preparation of a detergent and cleaning product for household, institutional and industrial application. Furthermore, the present invention relates to a method of treating a stained and / or soiled substrate, using the detergents and cleaning compositions according to the present invention. Additionally, the present invention relates to the use of 1,2-heptanediol and / or 2,3-heptanediol or of specific substances as defined herein for boosting the activity of an anti-redeposition agent in a detergent and cleaning composition and / or for improving cleaning performance of a detergent and cleaning composition. Moreover, the present invention relates to a method of boosting the activity of an anti-redeposition agent in a detergent and cleaning composition and / or of improving cleaning performance of a detergent and cleaning composition by adding an effective amount of 1,2-heptanediol and / or 2,3-heptanediol or of specific anti-redeposition agents, such as alkanediols, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin or tropolone to said detergent and cleaning composition. Finally, the present invention relates to the use of 1,2-heptanediol, 2,3-heptanediol or a mixture comprising 1,2-heptanediol and 2,3-heptanediol or at least one anti-redeposition boosting agent, such as alkanediols, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin or tropolone as anti-redeposition agent.

The invention discloses an environment-friendly p-hydroxyacetophenone production process, and particularly relates to the technical field of p-hydroxyacetophenone production, which comprises the following steps: step 1, respectively putting dissolved phenol and acetic anhydride into a synthesis reaction kettle, stirring and heating to 128 DEG C, refluxing for 5 hours at normal pressure, then carrying out heat preservation treatment, and reacting to generate phenyl acetate; 2, cooling phenyl acetate generated by the reaction to 60 DEG C, washing with water, standing for layering, and discharging phenyl acetate to generate a small amount of by-products containing 90% of glacial acetic acid; and 3, pumping the dehydrated phenyl acetate into a reaction kettle by a vacuum pump, gradually adding aluminum trichloride, then adding acidic water for hydrolysis, cooling to 60 DEG C, and discharging to obtain a liquid crude product of p-hydroxyacetophenone and o-hydroxyacetophenone. The environment-friendly performance of implementation is good, conditions needed by the technology are mild, the unstable condition is not prone to occurring in the operation process, and the practical application effect of the method is ideal.

Suggested is a synergistic antimicrobial mixture comprising a hydroxyacetophenone and one additional antimicrobial agent. The mixture is particular useful for fighting Aspergillus brasiliensis.

The invention discloses a self-crystallization type amino acid cleansing cream composition and a preparation method thereof. Comprising the following components in percentage by weight: 20%-40% of glycerol, 15%-25% of cocoyl glycinate, 1%-10% of cocoyl hydrolyzed collagen potassium, 0.1%-5% of sodium lauroamphoacetate, 0.1%-3% of citric acid, 0.1%-3% of sodium methyl cocoyl taurate, 0.1%-3% of sodium chloride, 0.1%-3% of sodium lauroyl glutamate, 0.1%-3% of ethyoxyl diethylene glycol, 0.1%-3% of propylene glycol laurate, 0.1%-3% of PEG-150 stearate, 0.1%-3% of ethylene glycol distearate, 0.0%-2% of 1, 3-propylene glycol distearate, 0.0%-2% of 1, 3-propylene glycol distearate and the balance of water. The cleaning agent is prepared from the following components in percentage by weight: 0.0 to 2 percent of 1, 2-hexanediol, 0.0 to 2 percent of p-hydroxyacetophenone and The self-crystallization type cleansing cream composition disclosed by the invention is high in crystallization point, good in thermal stability, mild and low in irritation, and has the effects of moisturizing and promoting cell proliferation, and the overall performance is improved.

The invention relates to the technical field of whitening and freckle removing, in particular to light-sensitive whitening and freckle removing essence and a preparation method and application thereof.The light-sensitive whitening and freckle removing essence is prepared from, by mass, 72.07% of water, 6% of butanediol, 3%-5% of X-resveratrol, 3% of tranexamic acid, 2.5% of nicotinamide, 2% of a red removing factor, 1% of panthenol, 1% of an anti-inflammatory agent, 0.5% of an anti-allergy agent, 0.5% of carnosine, 0.5% of p-hydroxyacetophenone, 1% of 1, 2-propylene glycol and the balance 1, 2-propylene glycol. The mask comprises the following components in percentage by weight: 0.5% of 1, 2-hexanediol, 0.2% of carbomer, 0.18% of arginine, 0.05% of sodium hyaluronate, 0.1%-1% of a light stabilizer and 5% of bis-ethylhexyloxyphenol sulfonate. According to the invention, the resveratrol is esterified by methyl propiolate, so that the molecular structure of the resveratrol is optimized, the performance of the resveratrol in the aspect of light stability is enhanced, and the degradation under the illumination condition is reduced; the esterified resveratrol can effectively inhibit tyrosinase activity, regulate melanocyte signal transduction and realize whitening and spot fading effects.

A process for producing 4-hydroxyacetophenone (4-HAP) comprises the steps of providing phenyl acetate and methanesulfonic acid (MSA) source; feeding the phenyl acetate and the MSA source into a reactor; and allowing the phenyl acetate and the MSA to react under conditions suitable for forming 4-HAP by Fries rearrangement to yield a 4-HAP containing phase.

The present application relates to a kind of chalcone amide alpha-glucosidase inhibitors and its preparation and application, the inhibitor structural formula is: preparation method specifically is (1) after 2-hydroxyacetophenone, sodium hydroxide and methyl p-formylbenzoate are reacted, intermediate in formula (a) is obtained after post-processing;(2) intermediate in formula (a) is dissolved in organic solvent and potassium hydroxide is reacted, after reaction, intermediate in formula (b) is obtained after post-processing;(3) intermediate in formula (b) and substituted aniline are dissolved in organic solvent, after reaction, the inhibitor shown in formula (c) is obtained after post-processing.Compared with prior art, the compound of the present application is novel, and experiments show that it has good alpha-glucosidase inhibitory activity, and can be used for preparing alpha-glucosidase activity inhibiting drug.

The invention discloses snowflake cream with pearly luster and a preparation process of the snowflake cream. The snowflake cream comprises the following raw material components: a phase A: water; butanediol; glycerol; methyl glucitol polyether-20; a polyacrylate cross-linked polymer-6; sodium hyaluronate; potassium hydroxide (90%); 4-hydroxyacetophenone; xanthan gum; phase B: caprylic / capric triglyceride; cetostearyl alcohol; stearic acid; a polydimethylsiloxane; squalane; simmondsia chinensis seed oil; mineral oil; and polyethylene glycol (PEG)-100 stearate. Glyceryl stearate; tocopheryl acetate; isononyl isononanoate; a phase C: 1, 2-hexanediol; carnosine; a centella asiatica extract; collagen; the snowflake cream has the advantages of uniform pearly luster texture and the advantages of traditional snowflake cream.

The application discloses a controllable visual carbon monoxide releasing agent and a preparation method and application thereof, the releasing agent is Fla and Cys P molecules, Fla molecules are prepared by taking N,N-dimethyl-p-phenylenediamine as raw material, and the Fla molecules are prepared by cyclization, selenium dioxide oxidation, then hydroxy aldehyde condensation with 2-hydroxyacetophenone ketone under alkaline conditions, and esterification after acryloyl chloride; the structure of the Fla molecules is broken after light irradiation, and CO molecules are released; Cys P can react with cysteine (Cys) to generate flavone molecules Fla, and the releasing agent realizes visual detection of cysteine (Cys) and controllable release of CO.

Title: Cosmetic composition comprising a glycolipid and a hydroxyacetophenone, according to specific contents, with a particular weight ratio between the glycolipid and the hydroxyacetophenone. The present invention relates to a cosmetic composition comprising: a) from 0.3 to 5% by weight of at least one glycolipid relative to the total weight of the composition; b) from 0.3 to 5% by weight of at least one hydroxyacetophenone relative to the total weight of the composition, and in which the weight ratio between the total content of the glycolipid(s) a) and the total content of the hydroxyacetophenone(s) b) is greater than or equal to 1.

The invention provides a preparation method of 2, 6-dihydroxyacetophenone, and belongs to the technical field of organic matter synthesis. According to the method, 2, 6-difluoroacetophenone is used as a raw material to be hydrolyzed in a strong alkaline environment, fluorine atoms are replaced with hydroxyl through nucleophilic substitution, the process is simple, and the yield is high; rearrangement is not needed, generation of a by-product 2, 4-dihydroxyacetophenone is avoided, and the product is easy to separate and high in purity; high-temperature, high-pressure and expensive catalysts are not needed, the operation is convenient, and the cost is low. The result of the embodiment shows that according to the preparation method provided by the invention, the yield is 82-87.7%, and the product purity is higher than 98%.

The invention provides weight-losing massage cream and a preparation method thereof, and relates to the technical field of massage products. The weight-losing massage cream is prepared from the following components in percentage by mass: 15 percent to 25 percent of glycerol, 0.1 percent to 1 percent of p-hydroxyacetophenone, 0.1 percent to 1 percent of carbomer, 1 percent to 5 percent of cetyl stearic acid, 1 percent to 5 percent of polydimethylsiloxane, 15 percent to 25 percent of ethylhexyl palmitate, 0.5 percent to 2 percent of stearyl alcohol polyether-2, 1 percent to 6 percent of stearyl alcohol polyether-21, 0.1 percent to 0.5 percent of arginine, 0.1 percent to 1 percent of 1, 2-hexanediol, 0.1 percent to 1 percent of carnitine, 0.01 percent to 0.3 percent of acetylchitosamine, 0.5 percent to 3 percent of vanillyl butyl ether, 0.1 percent to 0.5 percent of essence and the balance of water. The weight-losing massage cream disclosed by the invention has the effects of losing weight and tightening, has no side effect and is safe and convenient to use. The preparation method is simple in process, convenient to operate and convenient for production.

The invention discloses a method for preparing phenylephrine hydrochloride genotoxic impurities, which comprises the following steps: by taking 3-hydroxyacetophenone as a starting material and copper bromide as a bromine source in isopropanol, reacting, and then preparing and separating to obtain dibromide impurities. The reaction condition for preparing the phenylephrine hydrochloride genotoxic impurity is mild, the operation is simple, the product purity is high, and the quality requirement for controlling phenylephrine hydrochloride can be met.

The invention belongs to the technical field of medicine preparation, and particularly relates to a fenoprofen calcium preparation method which comprises the following steps: 1) m-hydroxyacetophenone and bromobenzene generate an intermediate 1, namely m-phenoxyacetophenone under the action of alkali and cuprous iodide; 2) reacting the intermediate 1 with ethyl chloroacetate under the action of strong base, and then performing hydrolysis and decarboxylation reaction to generate an intermediate 2, namely 2-(3-phenoxy phenyl) propionaldehyde; the invention discloses a preparation method of fenoprofen calcium, which comprises the following steps: (1) preparing fenoprofen, (2) preparing fenoprofen, (3) carrying out oxidation reaction on an intermediate 2 to obtain fenoprofen, (4) reacting fenoprofen with a sodium hydroxide solution to obtain fenoprofen sodium, and (5) salifying fenoprofen sodium with a calcium chloride solution to obtain fenoprofen calcium.

The invention discloses a moisturizing and soothing cosmetic containing an artemisia apiacea extract and a preparation method of the moisturizing and soothing cosmetic. The cosmetic is prepared from the following raw materials in percentage by weight: 0.5%-2% of 1, 2-hexanediol, 0.3%-1% of p-hydroxyacetophenone, 5%-15% of butanediol, 0.1%-1% of dimethyl sulfone, 0.3%-2% of zanthoxylum armatum extract, 0.2%-1.5% of aesculus chinensis extract, 0.1%-0.5% of dipotassium glycyrrhizinate, 0.5%-3% of panthenol, 0.1%-0.8% of allantoin, 0.1%-1% of oat beta-glucan, 0.05%-0.5% of hydrolyzed sodium hyaluronate, 0.001%-0.01% of caramel color, 0.1%-1% of cyclodextrin, 0.05%-0.3% of acetyl dipeptide-1 cetyl ester, 0.5%-2.5% of scutellaria baicalensis extract, 0.3%-2% of purslane extract and 0.2%-1.5% of a chamomile extract and the balance of deionized water. The traditional Chinese medicine composition has the advantages that various extracts are in synergistic interaction; the safety is high; the composition is suitable for sensitive skin, dry skin and other skin types, and can be prepared into emulsion, face cream, essence and other dosage forms.

The present invention relates to detergents and cleaning compositions comprising an enzyme, an effective amount of a particular type of enzyme enhancer, such as an alkanediol having a carbon chain of 5 to 14 carbon atoms, glyceryl caprylate, 4-hydroxyacetophenone, ethylhexylglycerin, tropolone, or a mixture of the aforementioned enzyme enhancers, and a surfactant, as well as the use of the aforementioned detergents and cleaning compositions for preparing detergents and cleaning products for household, institutional and industrial applications. Furthermore, the present invention relates to a method for treating stained and / or soiled substrates using the enzyme detergents and cleaning compositions according to the present invention. In addition, the present invention relates to the use of certain substances, as defined herein, for enhancing the performance of enzymes in detergents and cleaning compositions and / or for improving the cleaning performance of detergents and cleaning compositions. Finally, the present invention relates to a method for enhancing the enzyme performance in detergents and cleaning compositions and / or improving the cleaning performance in detergents and cleaning compositions by adding an effective amount of a specific enzyme enhancer, for example, an alkanediol having a carbon chain of 5 to 14 carbon atoms, glyceryl caprylate, 4-hydroxyacetophenone, ethylhexylglycerin, tropolone, or a mixture of the aforementioned enzyme enhancers, to the aforementioned detergents and cleaning compositions.

The present invention relates to a method for alleviating asthenopia and a liquid composition for ophthalmic use. Specifically, on one hand, the invention relates to a liquid composition for eyes. The invention relates to a skin-care lotion, which is prepared from the following components: glycerol, p-hydroxyacetophenone, sodium hyaluronate, propylene glycol, menthol, borneol, methyl diisopropyl propionamide, menthol, SOLUBILISANT LRI, edetate disodium, water-locking magnetite, radix gentianae extract, totarol, sodium citrate, ectodoine, ergothioneine, hydrolyzed red algae extract and water. Furthermore, the invention also relates to an application of the liquid composition in preparation of a product for relieving eye asthenopia for eye use. The liquid composition of the present invention exhibits excellent properties, for example as described in the specification.

Proposed are preparations comprising (i) a mixture of substances comprising (a) one, two or more compounds selected from the group consisting of (a1) alcohol monoterpenes of the formula (I) where R1 is H or methyl, R2 is H or C2-alkenyl, and R3 is a linear or branched, saturated or unsaturated hydrocarbon radical having 4 to 10 carbon atoms, and their enantiomers, diastereomers, racemates, solvates and physiologically acceptable salts, and / or (a2) bicyclic epoxy monoterpenes, (b) at least two lactones of the formula (II) where R4 is H or methyl, R5 is a linear or branched, saturated or unsaturated hydrocarbon radical having 2 to 10 carbon atoms and n is the number 1 or 2, and their enantiomers, diastereomers and racemates, and (c) one, two or more Solvent selected from the group consisting of ethanol, water, dipropylene glycol (DPG), diethyl phthalate (DEP), propylene glycol (PG),Isopropyl myristate (IPM), isopropyl palmitate (IPP), triethyl citrate (TEC), triacetin (TRI), 1,2-propanediol, 1,3-propanediol, propanetriol, pentanediol, hexanediol, octanediol, decanediol, dodecanol, 4-hydroxyacetophenone, butylene glycol, pentylene glycol, hexylene glycol, decylene glycol, propylene carbonate, butylene carbonate, glycerol carbonate, 2-benzylheptanol, trimethyl hydroxypentyl isobutyrate, glyceryl caprylate, ethylhexylglycerin, benzyl benzoate (BB), and optionally (d) further flavorings or fragrances selected from the group consisting of 3-phenylbutanal, acetylmethylcarbinol, anethole, anisyl acetate, dihydroeugenol, linalyl formate, 2-methyldecanal, 2-Benzyl-2-methylbut-3-ene nitrile, 3-hexenyl acetate, styralyl acetate, citronellal, cinnamyl acetate, rhubafuran, betalonone, anther, prenyl acetate, 2-phenylpropanal, 4-(4-hydroxyphenyl)butan-2-one, ethylphenoxyacetate, isoraldein, gamma-terpinene, Limonene, Neocyclocitral, Methyl Lavender Ketone, Styralyl Propionate, Phenyl Ethyl Propionate, Limonenal,4-Isopentylcyclohexanol, 4-methyl-2-phenyl-3,6-dihydro-2H-pyran / 4-methylene-2-phenyl-tetrahydropyran, hydrocitronitrile, phenoxanol, isoamylphenyl acetate, damascone, silvial, nectaryl, ambroxide, acetylpyrazine, trimethylpyrazine, isoamyl acetate, cresyl methyl ether para, filbertone, cyclohexyl acetate, heliotropin, acetophenone, anisaldehyde, methylacetophenone para, veratraldehyde, methyl anisate and vertoprenal, and (ii) aldehydes of the formula (III) where R6 is a saturated or unsaturated, linear hydrocarbon radical, and / or (iii) free fatty acids of the formula (IV) where R7 is a linear or branched, saturated hydrocarbon radical.

The invention discloses a batching device for producing p-hydroxyacetophenone, and particularly relates to the technical field of p-hydroxyacetophenone production, the batching device comprises a batching tank body, the top of the batching tank body is provided with eight feeding channel openings, and feeding mechanisms are arranged on the eight feeding channel openings; the feeding mechanism comprises a fixed rack, the fixed rack is welded to the inner wall of one side of a feeding channel opening in the corresponding position, a carrying base plate is hinged to one side of the fixed rack, the carrying base plate is arranged in the feeding channel opening, and a pressure sensor is arranged on the carrying base plate. Through the arrangement of the feeding mechanism, the automatic batching device has the functions of precise weighing of fed materials and automatic discharging, during batching, a worker only needs to carry out feeding according to reminding of an indicator lamp, operation is simple, additional weighing and operation of pouring raw materials into batching equipment are not needed, the time needed for batching is greatly shortened, the batching speed is high, and the work efficiency is improved. And the actual use effect of the device is relatively good.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method and application of a 2-phenyl-2H-chromene compound. According to the method, benzaldehyde and o-hydroxyacetophenone are taken as initial raw materials, Claisen-Schmidt condensation is carried out under an alkaline condition to prepare 2-hydroxychalcone, NaBH4 is utilized to reduce carbonyl to prepare an intermediate 2-(1-hydroxy-3-phenyl allyl) phenol, and then in an alkaline environment created by organic alkali Et3N, a 2-phenyl-2H-chromene skeleton is constructed by utilizing the complexing effect of BTC for the first time. According to the synthesis route, the synthesis efficiency of the chromene is remarkably improved, a practical method is provided for rapidly constructing a 2-phenyl-2H-chromene skeleton, and an important foundation is laid for efficient synthesis and structure-function relationship research of the chromene and structural analogues thereof.

This invention discloses a method for preparing 2,4-dihydroxyacetophenone using acetaldehyde as the acetyl source. Under the presence of an oxidant and a catalyst, acetaldehyde, as the acetyl source, undergoes a direct free radical acylation reaction with resorcinol to obtain 2,4-dihydroxyacetophenone. No transition metal salts are required during the reaction. This method, using acetaldehyde as the acetyl source, facilitates a highly efficient free radical acylation reaction with resorcinol under the combined action of N-hydroxyphthalimide (NHPI) and benzoyl peroxide (BPO), producing 2,4-dihydroxyacetophenone in one step without the need for any transition metal salts. This method completely solves the environmental pollution and metal residue problems associated with traditional methods. The reaction conditions are mild, no special equipment is required, and the method exhibits high selectivity, non-corrosiveness, high product purity, and low production cost, showing broad prospects for industrial application.

The invention provides a preservative composition, a preservative, a cosmetic and a preparation method and application thereof, and belongs to the technical field of cosmetics. The anti-corrosion composition is prepared from p-hydroxyacetophenone, hexanediol and a saccharide isomeride. According to the preservative composition, the p-hydroxyacetophenone, the hexanediol and the saccharide isomer are matched, and the anti-allergy effect of the p-hydroxyacetophenone and the moisturizing effect of the saccharide isomer are utilized, so that the preservative composition is mild and non-irritating, and meanwhile, the inhibition effect on fungi and bacteria is good.

The invention provides a method for preparing p-isopropenylphenol, which is characterized by comprising the following steps: S1, carrying out nucleophilic addition reaction on 4-hydroxyacetophenone and a tetrahydrofuran solution of alkyl magnesium halide in a solvent 1 to obtain 4-(2-hydroxypropyl-2-yl) phenol; and S2, carrying out an elimination reaction on the 4-(2-hydroxypropyl-2-yl) phenol and beta zeolite in a solvent 2 to obtain the p-isopropenyl phenol. The preparation method provided by the invention only comprises two steps of reaction, is simple and efficient, is strong in atom economy, and is relatively high in yield and purity of the obtained target product; in addition, beta zeolite is used as a catalyst, is green and efficient, and can be recycled, so that the production cost is reduced, and the generation of solid wastes and acid-base wastewater is reduced; the two-step reaction and post-treatment conditions are mild, the operation is simple, and the method is suitable for industrial large-scale production.

The present invention belongs to the field of personal care, and particularly relates to a glycoside derivative flexible liposome, a preparation method and an application thereof. The glycoside derivative flexible liposome comprises a main shell material, a humectant, a raw material to be encapsulated, an auxiliary shell material, a preservative and a solvent. The main shell material is phosphatidylcholine, and the auxiliary shell material is polyquaternium-51. The preservative is any one or more of 1,2-hexanediol, p-hydroxyacetophenone, methylparaben, phenoxyethanol, and caprylyl glycol. The humectant is butanediol. The raw material to be encapsulated is hydroxypropyltetrahydrofurantriol. The solvent is deionized water. The present invention uses a flexible liposome encapsulation technology to improve the permeability and penetration depth of boswellia serrata extract and its concentration at the target site, improve the bioavailability of boswellia serrata extract, reduce the addition amount under the condition of achieving the same firming and anti-wrinkle effect, and thus reduce the cost.

Compositions providing a stabilized antimicrobial formulation concentrate are described. The composition can include at least one glycol. The at least one glycol can include a first glycol with a carbon chain with less than six carbons. In some variations, the composition can include a non-ionic surfactant. The composition can also include hydroxyacetophenone. The hydroxyacetophenone can provide at least 10% of the composition by weight.

The invention discloses efficient crystallization equipment for p-hydroxyacetophenone, and belongs to the technical field of p-hydroxyacetophenone production, and the efficient crystallization equipment is technically characterized by comprising a supporting table, the equipment can flexibly switch medicament forms according to process parameters such as feed liquid concentration, temperature and stirring rate, when feed liquid is in a high-viscosity state, liquid medicaments are easier to uniformly mix, and the crystallization efficiency is improved. When a crystallization system needs to be stabilized for a long time, the solid medicament can prolong the action period, reduce the supplementing frequency, adapt to intermittent and continuous production processes, is small in dosage and high in stability, does not need to be additionally provided with a dissolving device, and reduces energy consumption; according to the present invention, the automatic control is achieved, the manual operation error is reduced, the continuous production process is formed through the arranged crystallization treatment mechanism, the previous process creates the high-quality condition for the subsequent process, and the advantages of easy agent selective addition and good crystallization effect are provided.

The present invention relates to the use of multifunctional protectants comprising (i) hydroxyacetophenone with (ii) at least one of natural 1,3-propanediol and a mastic extract to protect a formulation from biodegradation. The present invention also relates to the use of a protectant comprising (i) hydroxyacetophenone with (ii) at least one of vitamin B5, vitamin C, and vitamin E to protect a formulation from biodegradation.

The invention provides a preparation method of a key intermediate of Hibomib. The key intermediate (compound V) of Hibomib is prepared by taking methyl 4-chlorobutyrate and 4 '-fluoro-2-hydroxyacetophenone as raw materials through a three-step reaction. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple and safe operation, good stereoselectivity, high yield and low cost, and is suitable for industrial mass production.