74 results about "O-hydroxyacetophenone" patented technology

The present invention relates to detergents and cleaning compositions that comprise a surfactant, an anti-redeposition agent, and an effective amount of 1,2-heptanediol and / or 2,3-heptanediol or a specific type of anti-redeposition boosting agent, such as alkanediols, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin or tropolone, and the use of said detergents and cleaning compositions for the preparation of a detergent and cleaning product for household, institutional and industrial application. Furthermore, the present invention relates to a method of treating a stained and / or soiled substrate, using the detergents and cleaning compositions according to the present invention. Additionally, the present invention relates to the use of 1,2-heptanediol and / or 2,3-heptanediol or of specific substances as defined herein for boosting the activity of an anti-redeposition agent in a detergent and cleaning composition and / or for improving cleaning performance of a detergent and cleaning composition. Moreover, the present invention relates to a method of boosting the activity of an anti-redeposition agent in a detergent and cleaning composition and / or of improving cleaning performance of a detergent and cleaning composition by adding an effective amount of 1,2-heptanediol and / or 2,3-heptanediol or of specific anti-redeposition agents, such as alkanediols, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin or tropolone to said detergent and cleaning composition. Finally, the present invention relates to the use of 1,2-heptanediol, 2,3-heptanediol or a mixture comprising 1,2-heptanediol and 2,3-heptanediol or at least one anti-redeposition boosting agent, such as alkanediols, glyceryl caprylate, 4-hydroxyacetophenone, ethyl hexyl glycerin or tropolone as anti-redeposition agent.

A process for producing 4-hydroxyacetophenone (4-HAP) comprises the steps of providing phenyl acetate and methanesulfonic acid (MSA) source; feeding the phenyl acetate and the MSA source into a reactor; and allowing the phenyl acetate and the MSA to react under conditions suitable for forming 4-HAP by Fries rearrangement to yield a 4-HAP containing phase.

The present application relates to a kind of chalcone amide alpha-glucosidase inhibitors and its preparation and application, the inhibitor structural formula is: preparation method specifically is (1) after 2-hydroxyacetophenone, sodium hydroxide and methyl p-formylbenzoate are reacted, intermediate in formula (a) is obtained after post-processing;(2) intermediate in formula (a) is dissolved in organic solvent and potassium hydroxide is reacted, after reaction, intermediate in formula (b) is obtained after post-processing;(3) intermediate in formula (b) and substituted aniline are dissolved in organic solvent, after reaction, the inhibitor shown in formula (c) is obtained after post-processing.Compared with prior art, the compound of the present application is novel, and experiments show that it has good alpha-glucosidase inhibitory activity, and can be used for preparing alpha-glucosidase activity inhibiting drug.

The invention discloses snowflake cream with pearly luster and a preparation process of the snowflake cream. The snowflake cream comprises the following raw material components: a phase A: water; butanediol; glycerol; methyl glucitol polyether-20; a polyacrylate cross-linked polymer-6; sodium hyaluronate; potassium hydroxide (90%); 4-hydroxyacetophenone; xanthan gum; phase B: caprylic / capric triglyceride; cetostearyl alcohol; stearic acid; a polydimethylsiloxane; squalane; simmondsia chinensis seed oil; mineral oil; and polyethylene glycol (PEG)-100 stearate. Glyceryl stearate; tocopheryl acetate; isononyl isononanoate; a phase C: 1, 2-hexanediol; carnosine; a centella asiatica extract; collagen; the snowflake cream has the advantages of uniform pearly luster texture and the advantages of traditional snowflake cream.

The application discloses a controllable visual carbon monoxide releasing agent and a preparation method and application thereof, the releasing agent is Fla and Cys P molecules, Fla molecules are prepared by taking N,N-dimethyl-p-phenylenediamine as raw material, and the Fla molecules are prepared by cyclization, selenium dioxide oxidation, then hydroxy aldehyde condensation with 2-hydroxyacetophenone ketone under alkaline conditions, and esterification after acryloyl chloride; the structure of the Fla molecules is broken after light irradiation, and CO molecules are released; Cys P can react with cysteine (Cys) to generate flavone molecules Fla, and the releasing agent realizes visual detection of cysteine (Cys) and controllable release of CO.

The invention discloses a method for preparing phenylephrine hydrochloride genotoxic impurities, which comprises the following steps: by taking 3-hydroxyacetophenone as a starting material and copper bromide as a bromine source in isopropanol, reacting, and then preparing and separating to obtain dibromide impurities. The reaction condition for preparing the phenylephrine hydrochloride genotoxic impurity is mild, the operation is simple, the product purity is high, and the quality requirement for controlling phenylephrine hydrochloride can be met.

The invention belongs to the technical field of medicine preparation, and particularly relates to a fenoprofen calcium preparation method which comprises the following steps: 1) m-hydroxyacetophenone and bromobenzene generate an intermediate 1, namely m-phenoxyacetophenone under the action of alkali and cuprous iodide; 2) reacting the intermediate 1 with ethyl chloroacetate under the action of strong base, and then performing hydrolysis and decarboxylation reaction to generate an intermediate 2, namely 2-(3-phenoxy phenyl) propionaldehyde; the invention discloses a preparation method of fenoprofen calcium, which comprises the following steps: (1) preparing fenoprofen, (2) preparing fenoprofen, (3) carrying out oxidation reaction on an intermediate 2 to obtain fenoprofen, (4) reacting fenoprofen with a sodium hydroxide solution to obtain fenoprofen sodium, and (5) salifying fenoprofen sodium with a calcium chloride solution to obtain fenoprofen calcium.

The invention discloses a moisturizing and soothing cosmetic containing an artemisia apiacea extract and a preparation method of the moisturizing and soothing cosmetic. The cosmetic is prepared from the following raw materials in percentage by weight: 0.5%-2% of 1, 2-hexanediol, 0.3%-1% of p-hydroxyacetophenone, 5%-15% of butanediol, 0.1%-1% of dimethyl sulfone, 0.3%-2% of zanthoxylum armatum extract, 0.2%-1.5% of aesculus chinensis extract, 0.1%-0.5% of dipotassium glycyrrhizinate, 0.5%-3% of panthenol, 0.1%-0.8% of allantoin, 0.1%-1% of oat beta-glucan, 0.05%-0.5% of hydrolyzed sodium hyaluronate, 0.001%-0.01% of caramel color, 0.1%-1% of cyclodextrin, 0.05%-0.3% of acetyl dipeptide-1 cetyl ester, 0.5%-2.5% of scutellaria baicalensis extract, 0.3%-2% of purslane extract and 0.2%-1.5% of a chamomile extract and the balance of deionized water. The traditional Chinese medicine composition has the advantages that various extracts are in synergistic interaction; the safety is high; the composition is suitable for sensitive skin, dry skin and other skin types, and can be prepared into emulsion, face cream, essence and other dosage forms.

The present invention relates to detergents and cleaning compositions comprising an enzyme, an effective amount of a particular type of enzyme enhancer, such as an alkanediol having a carbon chain of 5 to 14 carbon atoms, glyceryl caprylate, 4-hydroxyacetophenone, ethylhexylglycerin, tropolone, or a mixture of the aforementioned enzyme enhancers, and a surfactant, as well as the use of the aforementioned detergents and cleaning compositions for preparing detergents and cleaning products for household, institutional and industrial applications. Furthermore, the present invention relates to a method for treating stained and / or soiled substrates using the enzyme detergents and cleaning compositions according to the present invention. In addition, the present invention relates to the use of certain substances, as defined herein, for enhancing the performance of enzymes in detergents and cleaning compositions and / or for improving the cleaning performance of detergents and cleaning compositions. Finally, the present invention relates to a method for enhancing the enzyme performance in detergents and cleaning compositions and / or improving the cleaning performance in detergents and cleaning compositions by adding an effective amount of a specific enzyme enhancer, for example, an alkanediol having a carbon chain of 5 to 14 carbon atoms, glyceryl caprylate, 4-hydroxyacetophenone, ethylhexylglycerin, tropolone, or a mixture of the aforementioned enzyme enhancers, to the aforementioned detergents and cleaning compositions.

The present invention relates to a method for alleviating asthenopia and a liquid composition for ophthalmic use. Specifically, on one hand, the invention relates to a liquid composition for eyes. The invention relates to a skin-care lotion, which is prepared from the following components: glycerol, p-hydroxyacetophenone, sodium hyaluronate, propylene glycol, menthol, borneol, methyl diisopropyl propionamide, menthol, SOLUBILISANT LRI, edetate disodium, water-locking magnetite, radix gentianae extract, totarol, sodium citrate, ectodoine, ergothioneine, hydrolyzed red algae extract and water. Furthermore, the invention also relates to an application of the liquid composition in preparation of a product for relieving eye asthenopia for eye use. The liquid composition of the present invention exhibits excellent properties, for example as described in the specification.

The invention discloses a batching device for producing p-hydroxyacetophenone, and particularly relates to the technical field of p-hydroxyacetophenone production, the batching device comprises a batching tank body, the top of the batching tank body is provided with eight feeding channel openings, and feeding mechanisms are arranged on the eight feeding channel openings; the feeding mechanism comprises a fixed rack, the fixed rack is welded to the inner wall of one side of a feeding channel opening in the corresponding position, a carrying base plate is hinged to one side of the fixed rack, the carrying base plate is arranged in the feeding channel opening, and a pressure sensor is arranged on the carrying base plate. Through the arrangement of the feeding mechanism, the automatic batching device has the functions of precise weighing of fed materials and automatic discharging, during batching, a worker only needs to carry out feeding according to reminding of an indicator lamp, operation is simple, additional weighing and operation of pouring raw materials into batching equipment are not needed, the time needed for batching is greatly shortened, the batching speed is high, and the work efficiency is improved. And the actual use effect of the device is relatively good.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method and application of a 2-phenyl-2H-chromene compound. According to the method, benzaldehyde and o-hydroxyacetophenone are taken as initial raw materials, Claisen-Schmidt condensation is carried out under an alkaline condition to prepare 2-hydroxychalcone, NaBH4 is utilized to reduce carbonyl to prepare an intermediate 2-(1-hydroxy-3-phenyl allyl) phenol, and then in an alkaline environment created by organic alkali Et3N, a 2-phenyl-2H-chromene skeleton is constructed by utilizing the complexing effect of BTC for the first time. According to the synthesis route, the synthesis efficiency of the chromene is remarkably improved, a practical method is provided for rapidly constructing a 2-phenyl-2H-chromene skeleton, and an important foundation is laid for efficient synthesis and structure-function relationship research of the chromene and structural analogues thereof.

This invention discloses a method for preparing 2,4-dihydroxyacetophenone using acetaldehyde as the acetyl source. Under the presence of an oxidant and a catalyst, acetaldehyde, as the acetyl source, undergoes a direct free radical acylation reaction with resorcinol to obtain 2,4-dihydroxyacetophenone. No transition metal salts are required during the reaction. This method, using acetaldehyde as the acetyl source, facilitates a highly efficient free radical acylation reaction with resorcinol under the combined action of N-hydroxyphthalimide (NHPI) and benzoyl peroxide (BPO), producing 2,4-dihydroxyacetophenone in one step without the need for any transition metal salts. This method completely solves the environmental pollution and metal residue problems associated with traditional methods. The reaction conditions are mild, no special equipment is required, and the method exhibits high selectivity, non-corrosiveness, high product purity, and low production cost, showing broad prospects for industrial application.

The invention provides a preservative composition, a preservative, a cosmetic and a preparation method and application thereof, and belongs to the technical field of cosmetics. The anti-corrosion composition is prepared from p-hydroxyacetophenone, hexanediol and a saccharide isomeride. According to the preservative composition, the p-hydroxyacetophenone, the hexanediol and the saccharide isomer are matched, and the anti-allergy effect of the p-hydroxyacetophenone and the moisturizing effect of the saccharide isomer are utilized, so that the preservative composition is mild and non-irritating, and meanwhile, the inhibition effect on fungi and bacteria is good.

The invention provides a method for preparing p-isopropenylphenol, which is characterized by comprising the following steps: S1, carrying out nucleophilic addition reaction on 4-hydroxyacetophenone and a tetrahydrofuran solution of alkyl magnesium halide in a solvent 1 to obtain 4-(2-hydroxypropyl-2-yl) phenol; and S2, carrying out an elimination reaction on the 4-(2-hydroxypropyl-2-yl) phenol and beta zeolite in a solvent 2 to obtain the p-isopropenyl phenol. The preparation method provided by the invention only comprises two steps of reaction, is simple and efficient, is strong in atom economy, and is relatively high in yield and purity of the obtained target product; in addition, beta zeolite is used as a catalyst, is green and efficient, and can be recycled, so that the production cost is reduced, and the generation of solid wastes and acid-base wastewater is reduced; the two-step reaction and post-treatment conditions are mild, the operation is simple, and the method is suitable for industrial large-scale production.

Compositions providing a stabilized antimicrobial formulation concentrate are described. The composition can include at least one glycol. The at least one glycol can include a first glycol with a carbon chain with less than six carbons. In some variations, the composition can include a non-ionic surfactant. The composition can also include hydroxyacetophenone. The hydroxyacetophenone can provide at least 10% of the composition by weight.

The invention discloses efficient crystallization equipment for p-hydroxyacetophenone, and belongs to the technical field of p-hydroxyacetophenone production, and the efficient crystallization equipment is technically characterized by comprising a supporting table, the equipment can flexibly switch medicament forms according to process parameters such as feed liquid concentration, temperature and stirring rate, when feed liquid is in a high-viscosity state, liquid medicaments are easier to uniformly mix, and the crystallization efficiency is improved. When a crystallization system needs to be stabilized for a long time, the solid medicament can prolong the action period, reduce the supplementing frequency, adapt to intermittent and continuous production processes, is small in dosage and high in stability, does not need to be additionally provided with a dissolving device, and reduces energy consumption; according to the present invention, the automatic control is achieved, the manual operation error is reduced, the continuous production process is formed through the arranged crystallization treatment mechanism, the previous process creates the high-quality condition for the subsequent process, and the advantages of easy agent selective addition and good crystallization effect are provided.

The invention provides a preparation method of a key intermediate of Hibomib. The key intermediate (compound V) of Hibomib is prepared by taking methyl 4-chlorobutyrate and 4 '-fluoro-2-hydroxyacetophenone as raw materials through a three-step reaction. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple and safe operation, good stereoselectivity, high yield and low cost, and is suitable for industrial mass production.

The utility model relates to the technical field of p-hydroxyacetophenone production, in particular to a filtering device for p-hydroxyacetophenone production, which comprises a box body, a feeding hole is formed in the top of the box body, a vibrating plate is mounted in the middle of the interior of the box body, and a screening box is mounted in the middle of the vibrating plate in a penetrating manner; a first filter screen and a second filter screen are installed in the screening box, vibration filtering devices are fixedly installed on the inner walls of the two sides of the box body at the bottom of the vibration plate in a front-back mode, and a collecting box is placed under a discharging port in the bottom of the screening box. A feeding port is formed in the top of a box body, a vibration plate connected with a material screening box in a penetrating mode is installed in the middle of the interior of the box body, a first filter screen and a second filter screen are installed in the material screening box, a vibration filtering device is fixedly installed at the bottom of the vibration plate, and a material collecting box is placed under the bottom of the material screening box. The two filter screens are mounted in the screening box, and are matched with the vibrating plate and the vibrating filter device to secondarily filter and screen hydroxyacetophenone, so that the problem that few impurities are left after filtration is solved.

The invention belongs to the technical field of organic synthesis, and relates to a method and system for preparing p-hydroxyacetophenone through continuous high-temperature alkali fusion demethylation. A three-temperature-zone tubular reactor is matched with a falling film quench cooler, a spiral plate heat exchanger and other devices which are connected in series, p-methoxyacetophenone and a 30% sodium hydroxide solution with the molar ratio being 1: 2-1: 3 serve as raw materials, the raw materials are premixed through a static mixer and then enter the three-temperature-zone tubular reactor, a reaction is conducted for 15-30 min at a certain temperature and pressure, the temperature of a main reaction zone is 245-255 DEG C, and the reaction time is 30-50 min. And carrying out acidification crystallization on the reaction product after millisecond-level quenching. According to the method disclosed by the invention, the problems of incomplete demethylation, acetyl hydrolysis and the like in a traditional intermittent process are solved through processes such as short high-temperature retention time and a spiral turbulence enhanced mass transfer technology, the yield reaches 96.7%, and the purity is greater than 99%; meanwhile, an aluminum trichloride catalyst which is high in price and easy to cause environmental pollution is avoided, so that the method is green and environment-friendly, and the production cost is reduced by about 32%.

The invention belongs to the field of organic synthesis, and discloses a method for efficiently synthesizing 2, 4-dihydroxyacetophenone, which specifically comprises the following steps: by taking a mixed solution of resorcinol, acetic acid and acetic anhydride as a raw material and anhydrous hydrogen fluoride as a catalyst, carrying out acetylation reaction to prepare the 2, 4-dihydroxyacetophenone. The method does not need to adopt Lewis acid, has the advantage of environmental protection, also solves the defects of excessive byproducts, limited protonic acid selection, long reaction time and the like in the traditional protonic acid catalysis process, and is mild and controllable in the whole process, high in conversion rate and good in selectivity.

The present invention concerns an antimicrobial mixture of i) 4-(3-ethoxy-4-hydroxyphenyl) butan-2-one and ii) 4-hydroxyacetophenone and their base salts, their solvates such as hydrates, and a cosmetic, pharmaceutical or food composition containing i) and ii). It is applicable to the care, make-up and cleansing of keratinous materials; to food preservation and to water treatment.

The invention discloses 2-hydroxyacetophenone as well as a preparation method and application thereof. Comprising the following steps: S1, adding deionized water, sodium formate, ammonium chloride and a catalyst into a reaction container, starting mechanical stirring, raising the temperature to 80 DEG C, maintaining the temperature for 15-30 minutes, and closing a heating device; s2, alpha-bromoacetophenone is added in batches, the alpha-bromoacetophenone is added once every 15 minutes, stirring is kept during feeding, stirring is continued for 10-15 minutes after feeding is finished, and after uniform mixing, a heating device is turned on to start heating. The alpha-bromoacetophenone is added in batches, high-rotating-speed stirring is combined, oil-water layering is avoided, brominated substances are hydrophobic organic substances, and phase separation caused by too high local concentration can be prevented through rapid dispersion; the micro-turbulence formed by stirring enables reactants to be in full contact with the catalyst, and the mass transfer coefficient is increased by 2.5 times.

The invention discloses a liquid blusher and a preparation process thereof. The liquid blusher comprises the following raw material components: 80-90% of water; 1%-5% of glycerol; 5%-10% of butanediol; 0.5% to 2% of polysorbate-20; 0.5%-1% of a film forming agent; 0.05%-0.2% of a chelating agent; 0%-0.2% of maltodextrin; 0%-0.1% of an acidity regulator; 0.01%-0.2% of water-based pigment red 33 (1% aqueous solution); 0.01%-0.2% of water-based pigment red 40 (1% aqueous solution); 0%-0.1% of water-based pigment blue No.1 (1% aqueous solution); 0%-0.5% of water-based pigment yellow 6 (1% aqueous solution); 0.5% of p-hydroxyacetophenone; 0.5% of 1, 2-hexanediol; 0.01% to 0.03% of essence; 0%-0.03% of an ultraviolet light absorber; the liquid blusher provided by the invention is lighter and thinner in texture, moisturized, natural in makeup effect, medium in durability and multifunctional.

The invention relates to an asymmetric synthesis method of allocolchicine, which is characterized in that 3-hydroxyacetophenone is used as an initial raw material, a key chiral center is constructed by using a ruthenium-catalyzed asymmetric reductive amination reaction, three different allocolchicine drugs are rapidly constructed through the steps of intermolecular Suzuki coupling, intramolecular oxidation cyclization and the like, the route is simple and efficient, and the method is suitable for industrial production. The method has the advantages of no introduction and removal of chemical protecting groups, no dangerous reactions such as long-term high-temperature pressurization, hydrogenation and the like, capability of obtaining the allocolchicine compound only through three to four steps of reactions, safety, greenness, environmental protection and low raw material cost.

The invention relates to a low-viscosity easy-to-absorb human body lubricant and a preparation method thereof, and the low-viscosity easy-to-absorb human body lubricant comprises the following components in percentage by mass: 1.0-1.2 wt% of low-viscosity hydroxyethyl cellulose, 0.05-0.15 wt% of a hyaluronic acid component, 0.5-0.7 wt% of 1, 2-hexanediol, 0.5-0.7 wt% of p-hydroxyacetophenone and the balance of water. The raw materials of the hyaluronic acid component comprise hyaluronic acid and composite zein. The human body lubricant prepared by the invention has the advantages of low viscosity, smoothness, refreshing and non-greasy property, rapid permeation and absorption, and long-acting lubrication, is mild and non-irritant, and has the effects of soothing and maintaining.

A synergistic antimicrobial mixture comprising a hydroxyacetophenone and an additional antimicrobial agent is suggested. The mixture is particularly useful against Aspergillus brasiliensis.

Mass spectrometry is performed on a nucleic acid contained in a sample with a matrix-assisted laser desorption / ionization mass spectrometer using a mixed matrix containing 3-hydroxypicolinic acid and 2,4-dihydroxyacetophenone or a mixed matrix containing 3-hydroxypicolinic acid and 2,4,6-trihydroxyacetophenone monohydrate. This makes it possible to detect [M+H]+ or [M−H]− of the nucleic acid and fragment ions generated by dissociation of the ions with high sensitivity.

The invention discloses a moisturizing, anti-wrinkle and anti-aging multi-effect polypeptide composition and a preparation method thereof, and belongs to the technical field of polypeptide composition preparation. The polypeptide composition is prepared from the following components: 60 percent of process water, 5 percent of glycerol, 3 percent of butanediol, 3 percent of betaine, 0.5 percent of p-hydroxyacetophenone, 5 percent of 1, 2-hexanediol, 2 percent of water-soluble silicone wax, 0.5 to 3 percent of PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerol, 0.5 percent of polyacrylate cross-linked polymer-6, 2 percent of panthenol, 0.5 percent of carnosine, 0.2 percent of xanthan gum, 0.1 to 0.5 percent of dipotassium glycyrrhizinate, 3 percent of lactic acid, 0.1 to 0.5 percent of disodium EDTA (Ethylene Diamine Tetraacetic Acid), 0.5 percent of sodium hyaluronate and 0.2 percent of hydroxyethyl cellulose. According to the polypeptide composition, various moisturizing and hydrating essence components can achieve a synergistic effect, the skin water shortage state can be improved, fine wrinkles can be reduced, the skin can become elastic, tender, tight, moisturized and brightened, and the young muscle state is rejuvenated, the polypeptide composition does not emit moisture after being used by a user, and the moisturizing and hydrating effects are good.

This invention discloses a 2-phenylimidazo[1,2-] α This paper describes pyridine compounds, their preparation methods, and applications, belonging to the field of pharmaceutical technology. These compounds use imidazo[1,2-α]pyridine as the core skeleton and are prepared via a three-step method: first, cyclization of 2-aminopyridine with hydroxyacetophenone yields intermediate LT1-6; then, etherification with a brominated carboxylic acid ester yields LT7-48; finally, hydroxylamine hydrolysis converts them into the target product HDDI1-42, which contains an isohydroxamic acid group. Activity tests show that these compounds possess significant HDAC1 inhibitory activity and anti-tumor cell proliferation activity.