The invention discloses a multilayer circuit board manufacturing method with high density interconnection and high reliability combination. The method comprises the following steps of: rough shape cutting, sticking of dry film, transferring of inner layer patterns, etching of patterns, removing of a dry film, inspecting of patterns, brownification, stitching of a laminate, stitching, boring and burying, copper deposition, electrifying of the board, sticking of the dry film, transferring of patterns, electroplating of patterns, etching of patterns, brownification, stitching of laminated, stitching, copper deposition, electrifying of the board, sticking of the dry film, transferring of patterns, electroplating of patterns, etching of patterns, inspecting of patterns and molding. The invention aims to provide a multilayer circuit board method, after the cold and heat impulsion and the hot-oil high reliability testing, the resistance change rate is small, and the failure of the circuit board product is not easy to occur.