Artemisinin molecular imprinting film, preparation method and applications thereof

A molecular imprinting, artemisinin technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., to achieve the effects of good thermal stability, fast adsorption kinetic properties, and not easy to damage

Inactive Publication Date: 2014-08-27
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extraction and separation methods of artemisinin are mainly steam distillation, organic solvent extraction, Soxhlet extraction, ultrasonic extraction, microwave-as...

Method used

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  • Artemisinin molecular imprinting film, preparation method and applications thereof
  • Artemisinin molecular imprinting film, preparation method and applications thereof
  • Artemisinin molecular imprinting film, preparation method and applications thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] (1) Activation of the surface of polyvinylidene fluoride membrane

[0043] A piece of polyvinylidene fluoride membrane was placed in 100 mL of methanol, and after standing at room temperature for 60 min, it was fully washed with deionized water, and dried in a vacuum oven at 45 °C to constant weight.

[0044] (2) Preparation of catalytic system

[0045] 0.1 mmol cuprous bromide (CuBr 2 ), 0.2 mmol 2,2-bipyridine (2,2'-Bipyridine) and 0.2 g n-hexadecane were dissolved in a round bottom flask containing 5 mL ethanol, 60 o C oil bath heating for 3 h. After heating, cool quickly in an ice-water bath and set aside.

[0046] (3) Preparation of artemisinin molecularly imprinted composite membrane

[0047] Dissolve 1 mmol of artemisinin and 4 mmol of acrylamide in 100 mL of ethanol, sonicate it to fully dissolve it, then leave the system at room temperature for 24 h to form a stable template-monomer complex , and then adding 20 mmol ethylene glycol dimethacrylate (EGDMA) t...

Embodiment 2

[0061] (1) Activation of the surface of polyvinylidene fluoride membrane

[0062] A piece of polyvinylidene fluoride membrane was placed in 100 mL of methanol, and after standing at room temperature for 60 min, it was fully washed with deionized water, and dried in a vacuum oven at 45 °C to constant weight.

[0063] (2) Preparation of catalytic system

[0064] 0.1 mmol cuprous bromide (CuBr 2 ), 0.15 mmol 2,2-bipyridine (2,2'-Bipyridine) and 0.2 g n-hexadecane were dissolved in a round bottom flask containing 5 mL ethanol, 60 o C oil bath heating for 3 h. After heating, cool quickly in an ice-water bath and set aside.

[0065] (3) Preparation of artemisinin molecularly imprinted composite membrane

[0066] Dissolve 1 mmol of artemisinin and 6 mmol of acrylamide in 100 mL of ethanol, sonicate it to fully dissolve, and then leave the system at room temperature for 24 h to form a stable template-monomer complex , and then adding 20 mmol ethylene glycol dimethacrylate (EGDMA)...

Embodiment 3

[0080] (1) Activation of the surface of polyvinylidene fluoride membrane

[0081] A piece of polyvinylidene fluoride membrane was placed in 100 mL of methanol, and after standing at room temperature for 60 min, it was fully washed with deionized water, and dried in a vacuum oven at 45 °C to constant weight.

[0082] (2) Preparation of catalytic system

[0083] 0.1 mmol cuprous bromide (CuBr 2), 0.1 mmol 2,2-bipyridine (2,2'-Bipyridine) and 0.2 g n-hexadecane were dissolved in a round bottom flask containing 4 mL of ethanol, 60 o C oil bath heating for 3 h. After heating, cool quickly in an ice-water bath and set aside.

[0084] (3) Preparation of artemisinin molecularly imprinted composite membrane

[0085] Dissolve 1 mmol of artemisinin and 8 mmol of acrylamide in 100 mL of ethanol, sonicate it to fully dissolve, and then leave the system at room temperature for 24 h to form a stable template-monomer complex , and then adding 20 mmol ethylene glycol dimethacrylate (EGDMA...

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Abstract

The present invention relates to an artemisinin molecular imprinting composite film, a preparation method and applications thereof, and belongs to the technical field of environmental material preparation. The present invention especially relates to a method comprising the following steps: adopting a polyvinylidene fluoride membrane as a substrate, firstly activating the surface of the polyvinylidene fluoride membrane, then making up a combination of cupric bromide and 2, 2-bipyridine as a catalyst system, selecting artemisinin as a template molecule, acrylamide as a functional monomer and ethylene glycol dimethacrylate as a crosslinking agent, conducting activator generated by electron transfer for atom transfer radical polymerization, and synthesizing the artemisinin molecular imprinting composite film by one-step method. The adsorption balance, dynamics and selective recognition performance of the imprinting film prepared in the present invention is studied by static adsorption experiments, the results show that the imprinting film prepared in the present invention has very rapid absorption dynamic properties and superior artemisinin molecular recognition performance, and can be used for selective recognition and separation of artemisinin.

Description

technical field [0001] The invention belongs to the technical field of environmental material preparation, and relates to a preparation method and application of an artemisinin molecularly imprinted composite film. Background technique [0002] Molecular imprinting technology (MIT) is to simulate the molecular recognition in nature, such as: enzymes and substrates, antibodies and antigens, etc., using target molecules as template molecules to prepare polymers (Molecularly imprinted polymers) that have specific and selective recognition functions for the molecules. Imprinted Polymers (MIPs) is a technology that selects functional monomers that can interact specifically with template molecules, polymerizes with cross-linking agents around the template molecules, and forms a three-dimensional cross-linked polymer network. After removing the template molecule by other methods, a functional polymer with a special affinity for the template molecule and a recognition hole is obtain...

Claims

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Application Information

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IPC IPC(8): C08J9/26C08J7/16C08J7/12B01J20/26B01J20/28B01D71/34B01D69/12B01D67/00
Inventor 吴易霖李春香闫永胜孟敏佳
Owner JIANGSU UNIV
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