Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Artemisinin molecular imprinting film, preparation method and applications thereof

A molecular imprinting, artemisinin technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., to achieve the effects of good thermal stability, fast adsorption kinetic properties, and not easy to damage

Inactive Publication Date: 2014-08-27
JIANGSU UNIV
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extraction and separation methods of artemisinin are mainly steam distillation, organic solvent extraction, Soxhlet extraction, ultrasonic extraction, microwave-assisted extraction, supercritical fluid extraction, and the method of separating and purifying artemisinin by molecular imprinted composite membrane has not been reported yet.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Artemisinin molecular imprinting film, preparation method and applications thereof
  • Artemisinin molecular imprinting film, preparation method and applications thereof
  • Artemisinin molecular imprinting film, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Activation of the surface of polyvinylidene fluoride membrane

[0043] A piece of polyvinylidene fluoride membrane was placed in 100 mL of methanol, and after standing at room temperature for 60 min, it was fully washed with deionized water, and dried in a vacuum oven at 45 °C to constant weight.

[0044] (2) Preparation of catalytic system

[0045] 0.1 mmol cuprous bromide (CuBr 2 ), 0.2 mmol 2,2-bipyridine (2,2'-Bipyridine) and 0.2 g n-hexadecane were dissolved in a round bottom flask containing 5 mL ethanol, 60 o C oil bath heating for 3 h. After heating, cool quickly in an ice-water bath and set aside.

[0046] (3) Preparation of artemisinin molecularly imprinted composite membrane

[0047] Dissolve 1 mmol of artemisinin and 4 mmol of acrylamide in 100 mL of ethanol, sonicate it to fully dissolve it, then leave the system at room temperature for 24 h to form a stable template-monomer complex , and then adding 20 mmol ethylene glycol dimethacrylate (EGDMA) t...

Embodiment 2

[0061] (1) Activation of the surface of polyvinylidene fluoride membrane

[0062] A piece of polyvinylidene fluoride membrane was placed in 100 mL of methanol, and after standing at room temperature for 60 min, it was fully washed with deionized water, and dried in a vacuum oven at 45 °C to constant weight.

[0063] (2) Preparation of catalytic system

[0064] 0.1 mmol cuprous bromide (CuBr 2 ), 0.15 mmol 2,2-bipyridine (2,2'-Bipyridine) and 0.2 g n-hexadecane were dissolved in a round bottom flask containing 5 mL ethanol, 60 o C oil bath heating for 3 h. After heating, cool quickly in an ice-water bath and set aside.

[0065] (3) Preparation of artemisinin molecularly imprinted composite membrane

[0066] Dissolve 1 mmol of artemisinin and 6 mmol of acrylamide in 100 mL of ethanol, sonicate it to fully dissolve, and then leave the system at room temperature for 24 h to form a stable template-monomer complex , and then adding 20 mmol ethylene glycol dimethacrylate (EGDMA)...

Embodiment 3

[0080] (1) Activation of the surface of polyvinylidene fluoride membrane

[0081] A piece of polyvinylidene fluoride membrane was placed in 100 mL of methanol, and after standing at room temperature for 60 min, it was fully washed with deionized water, and dried in a vacuum oven at 45 °C to constant weight.

[0082] (2) Preparation of catalytic system

[0083] 0.1 mmol cuprous bromide (CuBr 2), 0.1 mmol 2,2-bipyridine (2,2'-Bipyridine) and 0.2 g n-hexadecane were dissolved in a round bottom flask containing 4 mL of ethanol, 60 o C oil bath heating for 3 h. After heating, cool quickly in an ice-water bath and set aside.

[0084] (3) Preparation of artemisinin molecularly imprinted composite membrane

[0085] Dissolve 1 mmol of artemisinin and 8 mmol of acrylamide in 100 mL of ethanol, sonicate it to fully dissolve, and then leave the system at room temperature for 24 h to form a stable template-monomer complex , and then adding 20 mmol ethylene glycol dimethacrylate (EGDMA...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Saturated adsorption capacityaaaaaaaaaa
Saturated adsorption capacityaaaaaaaaaa
Saturated adsorption capacityaaaaaaaaaa
Login to View More

Abstract

The present invention relates to an artemisinin molecular imprinting composite film, a preparation method and applications thereof, and belongs to the technical field of environmental material preparation. The present invention especially relates to a method comprising the following steps: adopting a polyvinylidene fluoride membrane as a substrate, firstly activating the surface of the polyvinylidene fluoride membrane, then making up a combination of cupric bromide and 2, 2-bipyridine as a catalyst system, selecting artemisinin as a template molecule, acrylamide as a functional monomer and ethylene glycol dimethacrylate as a crosslinking agent, conducting activator generated by electron transfer for atom transfer radical polymerization, and synthesizing the artemisinin molecular imprinting composite film by one-step method. The adsorption balance, dynamics and selective recognition performance of the imprinting film prepared in the present invention is studied by static adsorption experiments, the results show that the imprinting film prepared in the present invention has very rapid absorption dynamic properties and superior artemisinin molecular recognition performance, and can be used for selective recognition and separation of artemisinin.

Description

technical field [0001] The invention belongs to the technical field of environmental material preparation, and relates to a preparation method and application of an artemisinin molecularly imprinted composite film. Background technique [0002] Molecular imprinting technology (MIT) is to simulate the molecular recognition in nature, such as: enzymes and substrates, antibodies and antigens, etc., using target molecules as template molecules to prepare polymers (Molecularly imprinted polymers) that have specific and selective recognition functions for the molecules. Imprinted Polymers (MIPs) is a technology that selects functional monomers that can interact specifically with template molecules, polymerizes with cross-linking agents around the template molecules, and forms a three-dimensional cross-linked polymer network. After removing the template molecule by other methods, a functional polymer with a special affinity for the template molecule and a recognition hole is obtain...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08J9/26C08J7/16C08J7/12B01J20/26B01J20/28B01D71/34B01D69/12B01D67/00
Inventor 吴易霖李春香闫永胜孟敏佳
Owner JIANGSU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com