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49results about How to "Good molecular recognition" patented technology
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Preparation method of bionic artemisinin molecular imprinting composite membrane
InactiveCN104231166AHigh selectivityEasy to separateOther chemical processesMethacrylateFunctional monomer
The invention relates to a preparation method of a bionic artemisinin molecular imprinting composite membrane, belonging to the technical field of environmental material preparation. The preparation method comprises the following specific steps: by taking a regenerated cellulose membrane as a substrate, artemisinin as a template molecule, acrylamide (AM) as a functional monomer and ethylene glycol dimethacrylate (EGDMA) as a cross-linking agent, inlaying silicon dioxide nanoparticles with functional monomer modified surfaces to the surface of a membrane material by combination with a dopamine bionic principle, and performing two-step temperature polymerization to prepare the bionic artemisinin molecular imprinting composite membrane. The static adsorption experiment is used for making a research on the adsorption balance, dynamics and selective recognition performance of the prepared imprinting membrane. A result shows that the artemisinin imprinting membrane prepared by adopting the method is relatively high in adsorption capacity and superior in artemisinin molecular recognition penetration performance.
Owner:JIANGSU UNIV
Preparation method for molecular recognition sensor by electrodeposition
InactiveUS20120285833A1Simple and controllable preparationLow costMaterial nanotechnologyMaterial analysis by electric/magnetic meansUltraviolet lightsIrradiation
A preparation method for molecular recognition sensor by electrodeposition is provided. The preparation method is as following: forming molecularly imprinted polymeric micelles by self-assembly of ionic type photosensitive copolymers; forming a film on the surface of an electrode by electrodepositing the molecularly imprinted polymeric micelles at a constant potential; crosslinking the electrodeposited micellar film via ultraviolet light irradiation; extracting the template molecules from the crosslinked film to obtain electrode modified by the molecularly imprinted polymeric micellar film; and connecting the modified electrode with a sensor device and a computer to construct a molecular recognition sensing system capable of specifically detecting the template molecules.
Owner:JIANGNAN UNIV
Preparation method and application of electrochemical immunosensor based on HS-beta-CD-Ag-GOD conjugate
ActiveCN104459124ACatalytic reductionDoubly magnifiedBiological material analysisMaterial analysis by electric/magnetic meansImmune profilingBovine serum albumin
The invention belongs to the technical fields of immunoassay and biosensing and discloses a preparation method and application of an electrochemical immunosensor based on an HS-beta-CD-Ag-GOD conjugate. The electrochemical immunosensor is used for rapidly detecting a hog cholera virus antigen CSFV. The manufacturing scheme comprises the following steps: modifying a working electrode a bare platinum carbon electrode by using MWCNTs-CD-Fc-Ab1, and sequentially adding bovine serum albumin, hog cholera virus antigen CSFV and an Ab2-HS-beta-CD-Ag-GOD conjugate. The HS-beta-CD-Ag-GOD conjugate can convert glucose into gluconic acid, two protons and two electrons are transferred to oxygen molecules, hydrogen peroxide is generated, and an HS-beta-CD-Ag nanometer material serves as a mimic enzyme, the reduction of the hydrogen peroxide is catalyzed, the dual amplification of an electrochemical signal is realized, the high sensitivity is realized, and the detection limit can be low to 0.33pg / mL.
Owner:UNIV OF JINAN
Preparation method and application of arteannuin molecularly imprinted membrane
InactiveCN103709434AHigh selectivityEasy to separateSemi-permeable membranesOther chemical processesMethacrylatePolymer science
The invention relates to a preparation method of an arteannuin molecularly imprinted composite membrane, belonging to the technical field of environmental material preparation. The method comprises the following steps: by using a regenerated cellulose membrane as a substrate, the arteannuin as a template molecule, acrylamide (AM) as a functional monomer and ethylene glycol dimethyl acrylate (EGDMA) as a crosslinking agent, cuprous bromide and N,N',N'',N''-pentamethyldiethylenetriamine constitute a catalytic system, and an atom transfer free-radical polymerization process is utilized to prepare the arteannuin molecularly imprinted composite membrane. A static adsorption experiment is used for researching the adsorption equilibrium, dynamics and selective recognition performance of the imprinted membrane; and the result proves that the arteannuin imprinted membrane has fast adsorption dynamical properties and excellent arteannuin molecule recognition performance.
Owner:JIANGSU UNIV
Method for preparing apiolin molecularly imprinted polymer
InactiveCN101665551AHigh affinityImprove adsorption capacityOther chemical processesFunctional monomerPolymer science
The invention relates to a method for preparing an apiolin molecularly imprinted polymer, comprising the following steps: dissolving apiolin and a functional monomer of 1 mol fraction of template molecule according to the mole ratio of 1:4-1:10 in 40 parts by volume of butylene oxide of a pore-foaming agent; vibrating away from light at constant temperature for 6h; then adding ethylene dimethacrylate as a crosslinking agent, the amount of which is 4-7 times of that of the monomer, and azodiisobutyronitrile as an initiating agent, the quality of which is 1 percent of that of the monomer and thecrosslinking agent, and completely mixing; sealing after N2 is introduced to remove oxygen; carrying out thermal-initiated polymerization at the temperature of 40-60 DEG C for 24-48h, and then obtaining a rod-shaped solid polymer; rubbing and then sieving the polymer; utilizing a methanol / acetic acid (v / v=6:4) eluent to elute so as to remove the template molecule; putting in a vacuum drying cabinet and then drying until constant weight, and then obtaining the apiolin molecularly imprinted polymer. The apiolin molecularly imprinted polymer prepared by the method has specific identification ability and selective adsorption performance on apiolin. Compared with common sorbents, the polymer has the advantages of accuracy, rapidness and sensitivity. Moreover, the polymer has high percent recovery, good repeatability and long service life, thereby having wide application prospects.
Owner:JIANGSU UNIV
Process for preparing microspheres of molecular blot polymer in water medium
A process for preparing microspheres of molecular blot polymer in water medium includes such steps as dissolving ethoxyl cellulose in water while stirring, putting functional monomer in water, mixing trimethoxyl propane, trimethyl acrylate, trigger and diluent together, mixing said three solutions together, introducing nitrogen gas, sealing, stirring at 65-80 deg.C and 300-400 rpm for 6-10 hr, washing with organic solvent, eluting with diluted acid until temp moleculae are removed, washing with water until it shows neutral, and drying in air.
Owner:TIANJIN UNIV
Preparation method and application of diamide insecticide molecular imprinted polymer
ActiveCN101724112AEasy to makeEasy to operateIon-exchange process apparatusComponent separationOrganic acidOrganic solvent
The invention discloses a preparation method and application of a diamide insecticide molecular imprinted polymer with special recognition performance on the diamide insecticide. The method comprises the following steps: mixing one or more of diamide insecticide template molecules and one or more of polymerization reaction monomer, crosslinking agent, pore former and initiator, then performing a thermal initiation polymerization reaction or photopolymerization reaction to prepare the polymer of diamide insecticide, grinding the obtained polymer, screening, firstly cleaning with organic solvent, then washing with a mixed solution of organic solvent and organic acid to obtain the template molecules without diamide insecticide; and finally cleaning the molecular imprinted polymer of the template molecules without diamide insecticide with organic solvent to neutral, and drying in vacuum to obtain the diamide insecticide molecular imprinted polymer. The invention can be used to screen, enrich, separate and purify the diamide insecticide in environmental and biological samples and can also be used for the pretreatment and fast detection of the residual diamide insecticide in various environmental samples.
Owner:湖南化研院检测技术有限公司
Preparation method of nanometer silicon gel surface gastrodin molecular engram polymers
InactiveCN101864021AHigh affinityImprove adsorption capacityOther chemical processesAlkali metal oxides/hydroxidesCross-linkFunctional monomer
The invention relates to a preparation method of nanometer silicon gel surface gastrodin molecular engram polymers, which belongs to the technical field of biochemical engineering. The preparation method of the invention comprises the following steps: dissolving template molecules of gastrodin and functional monomers of alpha-methacrylic acid into hole forming agents of methanol; sufficiently mixing the materials under the conditions of constant temperature and light shielding to obtain mixed liquid; adding silanization nanometer silicon gel particles, cross linking agents and catalytic amount triggering agents into the mixed liquid; carrying out repeated ultrasonic treatment after sufficient and uniform mixing; introducing nitrogen gas for deoxygenation; sealing the materials; carrying out reaction for 6h in water bath of 50 DEG C; then, carrying out reaction for 24h at 60 DEG C to obtain solid polymers; adopting a Sohxlet extraction method for extracting the solid polymers for more than 48h; carrying out elution for removing template molecules; drying the polymers till the constant weight after the extraction is completed; and obtaining the silicon gel surface gastrodin molecular engram polymers. The molecular engram polymers prepared by the invention have specific identification capability and selective absorption performance on the gastrodin. Compared with ordinary absorping agents, the molecular engram polymers prepared by the invention have the advantages of accuracy, high speed and sensitivity.
Owner:JIANGSU UNIV +1
Full biodegradable amphipathic polysaccharides grafts as well as preparation method and use thereof
InactiveCN101250235AMild reaction conditionsSimple and efficient operationOrganic active ingredientsPharmaceutical non-active ingredientsIonSolvent
The invention discloses an amphiphilic polysaccharide ppma which can be degraded biologically, a relative preparation method, a micellization route of the polysaccharide ppma in selective solvent, a nanometer micelle drug carrier and a drug release route in vitro. The preparation method comprises synthesizing 1-methyl-3-butyl imidazole bromonium ionic liquid, using stannous octoate as catalyst to catalyze the ring-opening polymerization reaction of dextran and caprolactone in the ionic liqud, to obtain the amphiphilic polysaccharide ppma which can be degraded biologically, as dextran amphiphilic ppma containing polycaprolactone chain. The ppma can form stable micelle in selective solvent and can prepare the micelle for carrying indenemethyl drug. The amphiphilic polysaccharide ppma which can be degraded biologically has the ability for self-assembling micelle in selective solvent and loading ability for hydrophobic drug. And the product has the advantages of chemical modification, biodegradability and biocompatibility, with wide application in biological medicine technical field.
Owner:SUN YAT SEN UNIV
Method for preparing molecularly-imprinted monolithic column by using molecular crowding reagent and ionic liquid as pore-foaming agent
InactiveCN104316628AUniform structureEasy to identifyComponent separationCross-linkFunctional monomer
The invention relates to a method for preparing a molecularly-imprinted monolithic column by using a molecular crowding reagent and ionic liquid as a pore-foaming agent. The method comprises the following steps: through special formulation of the pore-foaming agent, adding a template molecule ursolic acid or oleanolic acid into a pore-foaming agent consisting of a macromolecular crowding reagent, the ionic liquid and dimethyl sulfoxide, adding a functional monomer, a cross-linking agent and an initiator, performing ultrasonic degassing, and introducing nitrogen for removing oxygen to obtain an ursolic acid or oleanolic acidmolecularly-imprinted monolithic column. By the method, the macromolecular reagent and the green solvent ionic liquid can form the molecularly-imprinted monolithic column with good permeability and a significant imprinting effect; the imprinting effect of the obtained ursolic acid or oleanolic acidmolecularly-imprinted monolithic column is better than that when the macromolecular reagent and the ionic liquid are independently used as the pore-foaming agent; the method has the characteristics of simple preparation, avoidance of a complicated preparation process, good molecular recognition performance and the like; the obtained molecularly-imprinted monolithic column has good permeability and a significant imprinting effect; a new method is provided for preparing the molecularly-imprinted monolithic column with better imprinting effect.
Owner:XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
Glycosyl functional bacterial toxin molecularly imprinted membrane substrate as well as preparation method and application thereof
InactiveCN101666773AGood molecular recognition performanceHigh sensitivity and selectivityMaterial analysis by electric/magnetic meansFunctional monomerMolecularly imprinted polymer
The invention relates to a glycosyl functional bacterial toxin molecularly imprinted membrane substrate as well as a preparation method and an application thereof. The molecularly imprinted membrane substrate forms a reaction layer on the surface of a gold quartz crystal substrate by taking a glycosyl functional bacterial toxin molecularly imprinted polymer as a recognition element. The preparation method comprises the following steps: selecting a carbohydrate molecule functional monomer which can carry out specificity recognition with bacterial toxin and compound the corresponding molecularly imprinted polymer; preparing a glycosyl functional molecularly imprinted polymer solution; and modifying the glycosyl functional molecularly imprinted polymer on the surface of the gold quartz crystal substrate by a substrate surface modifying technology to form a reaction layer. The glycosyl functional molecularly imprinted membrane substrate prepared by the method is connected to a piezoelectric quartz crystal microbalance to detect bacterial toxin in an environmental sample extracting solution. The molecularly imprinted membrane substrate has favorable molecular recognition performance and greatly improves the sensitivity and the selectivity for detecting the bacterial toxin.
Owner:UNIV OF JINAN
Organic arsenide molecularly imprinted membrane substrate in aptamer-based marine products, and production method and application thereof
InactiveCN102519820AHigh sensitivityHigh selectivityWeighing by absorbing componentAptamerFunctional monomer
The invention discloses an organic arsenide molecularly imprinted membrane substrate in aptamer-based marine products, and a production method and application thereof, wherein an organic arsenide molecularly imprinted polymer in the aptamer-based marine product is taken as a recognition element to form a reaction layer on the surface of a gold quartz body substrate; and the organic arsenide molecularly imprinted polymer in the aptamer-based marine product is formed by polymerizing organic arsenide template molecule, aptamer functional monomer, cross-linking agent, porogen, initiating agent and organic solvent in the marine product according to the molar ratio of (0.1-2.5):3:(0.1-3):(30-60):(0.01-0.15):(1.0-10). The surface finish technology is applied to the preparation of the organic arsenide molecularly imprinted membrane substrate in the aptamer-based marine product, so the preparation of the organic arsenide molecularly imprinted membrane substrate in the aptamer-based marine product has controllability, and the sensitivity and the accuracy of the substrate are improved.
Owner:UNIV OF JINAN
Preparation method of estradiol magnetic molecularly imprinted nanoparticle electrochemical sensing membrane
InactiveCN104833716AEasy reprocessingImprove self-cleaning effectMaterial electrochemical variablesNanoparticleElution
The invention discloses a preparation method of an estradiol magnetic molecularly imprinted nanoparticle electrochemical sensing membrane. According to the preparation method, an estradiol magnetic molecularly imprinted polymer is obtained via preparation of a molecularly imprinted self-assembled solution, polymerization, and template molecule elution. The estradiol magnetic molecularly imprinted nanoparticle electrochemical sensing membrane is high in selectivity, response speed, sensitivity, stability, tolerability, and universality, and is capable of realizing high efficiency, sensitive, real-time detection of estradiol in composite matrix.
Owner:NANJING MEDICAL UNIV
Open-ring cucurbituril column aromatic hydrocarbon double-main-body compound and preparation method and application thereof
ActiveCN112409388AGood molecular recognitionThe synthesis method is simpleGroup 5/15 element organic compoundsFluorescence/phosphorescenceAlkaneCarboxyl radical
The invention discloses an open-ring cucurbituril column aromatic hydrocarbon double-main-body compound and a preparation method thereof. According to the ring-opening cucurbituril column aromatic hydrocarbon double-main-body compound, haloalkane modified ring-opening cucurbituril reacts with carboxyl on carboxylic acid modified column aromatic hydrocarbon to form an ester bond, and the ester bondis linked into the double-main-body compound; compared with single open-ring cucurbituril and pillar arene, the open-ring cucurbituril column aromatic hydrocarbon double-main-body compound has two cavities with different properties, one cavity is a pillar arene cavity, the other cavity is an open-loop cucurbituril cavity, the two cavities are arranged in a linear structure, and the cavities of the carrier have different properties. The compound has the properties of both pillar arene and open-ring cucurbituril, has very good molecular recognition capability, can be used as a molecular ion transmembrane transport molecule, and is applied to the industries of biomedical research, pharmacy, food, essence and flavor, tobacco and the like.
Owner:KUNMING UNIV OF SCI & TECH
Common and convenient epitope imprinting method and application of molecular imprinting polymer
ActiveCN108722369AEasy to getImprove universalityIon-exchange process apparatusOther chemical processesProtein targetSilylation
The invention discloses a common and convenient epitope imprinting method. The method comprises the following steps: firstly, selecting terminal polypeptide of target protein as a characteristic epitope; carrying out saccharification treatment to obtain saccharified polypeptide and taking the saccharified polypeptide as an imprinting template; anchoring the imprinting template on a boric acid functionalized substrate material through boron affinity interaction; then selecting monomer silylation reagents with different types and ratios and carrying out non-covalent imprinting; accurately imprinting the thickness of an imprinting layer through adjusting the imprinting time, so as to obtain a molecular imprinting polymer. The imprinting technology has the advantages of good commonality, convenience for preparation, good identification performance and the like. A molecular imprinting material prepared by the method can be used for identifying an epitope segment and also can be used for specifically identifying complete target protein, so that the molecular imprinting material has an important application prospect in the fields of separation, enrichment, purification, sensing, proteomics, target identification and the like.
Owner:NANJING UNIV
Preparation and application of silanized cadmium telluride quantum dot molecularly imprinted polymer
InactiveCN110218325ALess susceptible to interferenceGood molecular recognitionOther chemical processesFluorescence/phosphorescenceCross-linkFunctional monomer
The invention discloses a preparation of a silanized cadmium telluride quantum dot molecularly imprinted polymer. An aqueous phase CdTe QDs modified by thioglycolic acid (TGA) is used as a fluorescentcarrier, the surface of the fluorescent carrier is subjected to alkylation modification, then paracetamol is used as a template molecule, 3-aminopropyltriethoxysilane is uses as a functional monomer,ethyl orthosilicate is used as a cross-linking agent, ammonia water is used as a catalyst, and a polymer in which the outer layer of quantum dots is coated with molecular imprinting is successfully synthesized. Results of selective adsorption experiments show that the prepared CdTe@MIPs QDs has hole sites of a target molecule AP, and can selectively recognize AP from a complex matrix, the recognition is not easily interfered by other structural analogs, and results show that the method has good molecular recognition performance for AP molecules.
Owner:NORTHWEST NORMAL UNIVERSITY
Method for preparing organophosphorus insecticide nano silica gel surface molecular imprinted polymer
InactiveCN101811033AGood molecular recognitionOther chemical processesAlkali metal oxides/hydroxidesChlorpyrifosPolymer science
The invention relates to a method for preparing an organophosphorus insecticide nano silica gel surface molecular imprinted polymer. The method comprises the following steps of: preparing nano SiO2 microspheres; performing three different kinds of surface graft modification on the produced SiO2 microspheres; preparing pre-assembled solution; ultrasonically dispersing one of the modified SiO2 microspheres in a polymer solvent; adding a crosslinking agent, an initiator and the pre-assembled solution; performing centrifugation to remove supernatant after a reaction is finished; removing template molecules from the precipitate by using the mixed solution of methanol / acetic acid; putting the polymer microspheres with the template molecules removed in a vacuum drying box; and drying the polymer microspheres at the temperature of 60 DEG C to constant weight to obtain the molecular imprinted polymer microspheres. The three different molecular imprinted polymers prepared by the method have specificity identification to an organophosphorus insecticide (dursban) and can perform selective separation and enrichment on the residues of the organophosphorus insecticide.
Owner:NANJING MEDICAL UNIV
Nanometer synergistic glycosyl group functionalized bacterial toxin molecular engram film substrate as well as preparation method and application thereof
InactiveCN101672755AGood molecular recognitionHigh sensitivityWeighing by absorbing componentFunctional monomerPiezoelectric quartz
The invention relates to a nanometer synergistic glycosyl group functionalized bacterial toxin molecular engram film substrate as well as a preparation method and an application thereof. The nanometersynergistic bacterial toxin molecular engram film substrate is to form a plurality of layers of mutually-alternating nanometer materials and glycosyl group functionalized bacterial toxin molecular engram polymers on a gold quartz crystal substrate by taking the glycosyl group functionalized bacterial toxin molecular engram polymers as coupling agents. The preparation method is realized as follows: selecting sugar molecule functional monomers which can recognize the specificity of bacterial toxin and synthesize corresponding molecular engram polymers; preparing molecular engram polymer solution; and modifying the nanometer materials and the molecular engram polymers on the surface of the gold quartz crystal substrate. The molecular engram substrate is connected to a piezoelectric quartz crystal microbalance to detect the bacterial toxin in an environment sample extraction solution. The invention has simple operation and high specificity and sensitivity for detecting the bacterial toxin.
Owner:UNIV OF JINAN
A preparation method of biomimetic artemisinin molecularly imprinted composite film
InactiveCN104231166BHigh mechanical strengthAvoid breakingOther chemical processesFunctional monomerAdsorption equilibrium
The invention relates to a method for preparing a bionic molecular imprinted composite membrane, which belongs to the technical field of environmental material preparation. Specifically refers to the use of regenerated cellulose film as the substrate, artemisinin as the template molecule, acrylamide (AM) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent, combined with dopamine biomimetic The principle is to embed silica nanoparticles modified by surface functional monomers on the surface of the membrane material, and adopt a two-step temperature polymerization method to prepare a biomimetic artemisinin molecularly imprinted composite membrane. Static adsorption experiments were used to study the adsorption equilibrium, kinetics and selective recognition performance of the prepared imprinted membranes. The results show that the artemisinin imprinted membrane obtained by the invention has high adsorption capacity and superior artemisinin molecular recognition and penetration performance.
Owner:JIANGSU UNIV
Preparation method and application of loofah-sponge-based imprinted membrane material with reinforced-concrete-like structure
ActiveCN110746538AImprove mechanical strength propertiesHigh blotting efficiencyOther chemical processesAlkali metal oxides/hydroxidesPolymer scienceMolecular imprinting
The invention belongs to the technical field of material preparation and separation, and discloses a preparation method and application of a loofah-sponge-based imprinted membrane material of a reinforced-concrete-like structure. The preparation method comprises the following steps: step 1, preparing loofah sponge; step 2, modifying the loofah sponge with dopamine; step 3, preparing an artemisininmolecularly imprinted polymer; and step 4, preparing the loofah-sponge-based artemisinin molecularly imprinted membrane. The molecularly imprinted membrane prepared by using a loofah-sponge impregnation and permeation method can effectively overcome the defects that the molecularly imprinted polymer cannot be in full contact with target molecules, the mechanical strength and performance of the membrane are poor, and template molecules take much time to elute and even cannot be completely eluted, and has the advantages of simple synthesis, high selectivity efficiency and the like.
Owner:JIANGSU UNIV
Preparation method of surface imprinting adsorbent for identifying ciprofloxacin at high sensitivity
InactiveCN103788297AKeep aliveCheap and easy to getOther chemical processesMethacrylateFunctional monomer
The invention relates to a preparation method of a surface imprinting adsorbent for identifying ciprofloxacin at high sensitivity and belongs to the technical field of preparing environmental materials, and in particular relates to a method for preparing a surface imprinting adsorbent of ciprofloxacin with active dry yeast as the substrate, ciprofloxacin (CIP) as the template molecule, acrylamide (AM) as the functional monomer, ethylene glycol dimethyl acrylate (EGDMA) as the cross-linking agent and 2,2'-azodiisobutyronitrile (AIBN) as the initiator through a precipitation polymerization process. Static adsorption experiment is carried out to study the adsorption balance, dynamics and high-selectivity identification properties of the prepared imprinting adsorbent, and the result of the static adsorption experiment indicates that the surface imprinting adsorbent has fast adsorption dynamic property and excellent ciprofloxacin molecule identification property.
Owner:JIANGSU UNIV
Preparation method for molecular recognition sensor by electrodeposition
InactiveUS8840768B2Good molecular recognitionHigh sensitivityImmobilised enzymesCell electrodesUltraviolet lightsIrradiation
A preparation method for molecular recognition sensor by electrodeposition is provided. The preparation method is as following: forming molecularly imprinted polymeric micelles by self-assembly of ionic type photosensitive copolymers; forming a film on the surface of an electrode by electrodepositing the molecularly imprinted polymeric micelles at a constant potential; crosslinking the electrodeposited micellar film via ultraviolet light irradiation; extracting the template molecules from the crosslinked film to obtain electrode modified by the molecularly imprinted polymeric micellar film; and connecting the modified electrode with a sensor device and a computer to construct a molecular recognition sensing system capable of specifically detecting the template molecules.
Owner:JIANGNAN UNIV
Preparation methods and applications of menthofuran molecular imprinted polymer and monolithic column
InactiveCN107936175AEasy to identifyEasy to manufactureOrganic chemistryOther chemical processesCross-linkFuran
The invention discloses preparation methods and applications of a menthofuran molecular imprinted polymer and a monolithic column. The preparation method of the monolithic column comprises the following steps: dissolving template molecule menthofuran into a pore forming agent, separately adding a functional monomer, a cross-linking agent and an initiator for mixing, performing ultrasonic treatmentin an ice-water bath, introducing a nitrogen gas, injecting the reactants into a stainless steel chromatographic column and a container, performing sealing, putting the sealed objects into a drying oven with the temperature of 50-60 DEG C, performing a reaction for 12-24h to obtain a molecular imprinted polymer monolithic column through thermal initiation, connecting the monolithic column to a liquid chromatography pump to wash away the template molecule, so as to finally obtain the monolithic column with good separation effects. According to the methods, a frontier chromatography method is utilized to analyze the number of effective binding sites and dissociation constant of the prepared molecular imprinted polymer monolithic column and the menthofuran, the molecular recognition performance of the method is good, the molecular imprinted polymer provided by the invention is used as a liquid chromatography column filler and can realize the separation, enrichment and purification of thementhofuran in essential oil with more complex components.
Owner:XINJIANG UYGUR AUTONOMOUS REGION PROD QUALITY SUPERVISION & INSPECTION RES INST +1
A preparation method of boron-affinity double-recognition molecularly imprinted material
InactiveCN105233801BHigh mechanical strengthGood acid response propertiesOther chemical processesSorbentAtom-transfer radical-polymerization
Owner:JIANGSU UNIV
Nucleic aptamer-based organic arsenic molecular imprinting polymer in marine products, preparation method thereof and application thereof
The invention discloses a nucleic aptamer-based organic arsenic molecular imprinting polymer in marine products, a preparation method thereof and application thereof. The molecular imprinting polymer is prepared by polymerizing organic arsenide template molecules, a functional monomer, a cross-linking agent, a pore-forming agent, an initiator and an organic solvent in a molar ratio of (0.1-2.5):3.0:(0.1-4):(30-60):(0.01-0.10):(1.0-10), wherein the functional monomer is a nucleic aptamer. The method for preparing the organic arsenic molecular imprinting polymer comprises the following steps of: (1) mixing the organic arsenide template molecules, the functional monomer, the cross-linking agent, the pore-forming agent, the initiator and the organic solvent uniformly in a molar ratio, and polymerizing; (2) taking the obtained polymer out of a reactor, grinding and sieving; and eluting by using eluent until the polymer does not contain bacterial toxins, cleaning by using the organic solvent until the solution is neutral, and drying under vacuum to obtain the molecular imprinting polymer. The molecular imprinting polymer has the excellent performance of molecular recognition, so that the sensitivity and selectivity of detecting organic arsenic in the marine products are improved greatly.
Owner:UNIV OF JINAN
Preparation method and application of a camphor molecularly imprinted polymer and its monolithic column and packed chromatographic column
InactiveCN103265665BAdd processing stepsEasy to manufactureOther chemical processesComponent separationFunctional monomerNitrogen gas
Owner:XINJIANG UYGUR AUTONOMOUS REGION PROD QUALITY SUPERVISION & INSPECTION RES INST +1
A surface imprinted preparation method for highly selective recognition of ciprofloxacin
InactiveCN103788297BCheap and easy to getHigh mechanical strengthOther chemical processesCross-linkFunctional monomer
The invention relates to a preparation method of a surface imprinting adsorbent for identifying ciprofloxacin at high sensitivity and belongs to the technical field of preparing environmental materials, and in particular relates to a method for preparing a surface imprinting adsorbent of ciprofloxacin with active dry yeast as the substrate, ciprofloxacin (CIP) as the template molecule, acrylamide (AM) as the functional monomer, ethylene glycol dimethyl acrylate (EGDMA) as the cross-linking agent and 2,2'-azodiisobutyronitrile (AIBN) as the initiator through a precipitation polymerization process. Static adsorption experiment is carried out to study the adsorption balance, dynamics and high-selectivity identification properties of the prepared imprinting adsorbent, and the result of the static adsorption experiment indicates that the surface imprinting adsorbent has fast adsorption dynamic property and excellent ciprofloxacin molecule identification property.
Owner:JIANGSU UNIV
Preparation method and application of a kind of "reinforced concrete" structure loofah-based imprinted membrane material
ActiveCN110746538BImprove mechanical strength propertiesHigh blotting efficiencyOther chemical processesAlkali metal oxides/hydroxidesPolymer scienceArtemisinins
Owner:JIANGSU UNIV
Preparation method and application of diamide insecticide molecular imprinted polymer
ActiveCN101724112BEasy to makeEasy to operateIon-exchange process apparatusComponent separationOrganic acidOrganic solvent
The invention discloses a preparation method and application of a diamide insecticide molecular imprinted polymer with special recognition performance on the diamide insecticide. The method comprises the following steps: mixing one or more of diamide insecticide template molecules and one or more of polymerization reaction monomer, crosslinking agent, pore former and initiator, then performing a thermal initiation polymerization reaction or photopolymerization reaction to prepare the polymer of diamide insecticide, grinding the obtained polymer, screening, firstly cleaning with organic solvent, then washing with a mixed solution of organic solvent and organic acid to obtain the template molecules without diamide insecticide; and finally cleaning the molecular imprinted polymer of the template molecules without diamide insecticide with organic solvent to neutral, and drying in vacuum to obtain the diamide insecticide molecular imprinted polymer. The invention can be used to screen, enrich, separate and purify the diamide insecticide in environmental and biological samples and can also be used for the pretreatment and fast detection of the residual diamide insecticide in various environmental samples.
Owner:湖南化研院检测技术有限公司
Method for preparing imprinted monolithic column with molecular crowding reagent and ionic liquid as porogen
InactiveCN104316628BUniform structureEasy to identifyComponent separationCross-linkFunctional monomer
Owner:XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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