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Preparation method and application of arteannuin molecularly imprinted membrane

A molecularly imprinted membrane, molecularly imprinted technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., to achieve high selectivity, significant separation effect, and repeated use.

Inactive Publication Date: 2014-04-09
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extraction and separation methods of artemisinin are mainly steam distillation, organic solvent extraction, Soxhlet extraction, ultrasonic extraction, microwave-assisted extraction, supercritical fluid extraction, and the method of separating and purifying artemisinin by molecular imprinted composite membrane has not been reported yet.

Method used

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  • Preparation method and application of arteannuin molecularly imprinted membrane
  • Preparation method and application of arteannuin molecularly imprinted membrane
  • Preparation method and application of arteannuin molecularly imprinted membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Purification of regenerated cellulose membrane surface

[0039] Take a piece of regenerated cellulose membrane and place it in 100ml of methanol, let it stand at room temperature for 30 minutes, wash it thoroughly with deionized water, and dry it in a vacuum oven at 60°C to constant weight.

[0040] (2) Atom transfer-based polymerization initiator fixed on the surface of regenerated cellulose membrane

[0041]Add 1 mL of bromoisobutyryl bromide (2-BIB) to 15 mL of refined tetrahydrofuran, mix well and add to the dropping funnel for later use. Place the regenerated cellulose membrane in a 100 mL three-neck round bottom flask, add 25 mL Refined tetrahydrofuran and 1 mL of dry triethylamine, shaken at 0°C and blown nitrogen gas for 30 min, added the above 2-BIB solution dropwise, and kept at 0°C for 2 h, took out the flask, and sealed it with paraffin after 25 Continue to shake the reaction for 24 h at ℃, take out the membrane after the reaction, wash thoroughly with ...

Embodiment 2

[0052] (1) Purification of regenerated cellulose membrane surface

[0053] A piece of regenerated cellulose membrane was placed in methanol, and after standing at room temperature for 30 min, it was fully washed with deionized water, and dried in a vacuum oven at 60 °C to constant weight.

[0054] (2) Atom transfer-based polymerization initiator fixed on the surface of regenerated cellulose membrane

[0055] Add 1 mL of bromoisobutyryl bromide (2-BIB) to 15 mL of refined tetrahydrofuran, mix well and add to the dropping funnel for later use. Place the regenerated cellulose membrane in a 100 mL three-neck round bottom flask, add 25 mL Refined tetrahydrofuran and 1 mL of dry triethylamine, shaken at 0°C and blown nitrogen gas for 30 min, added the above 2-BIB solution dropwise, and kept at 0°C for 2 h, took out the flask, and sealed it with paraffin after 25 Continue to shake the reaction for 24 h at ℃, take out the membrane after the reaction, wash thoroughly with tetrahydrofu...

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Abstract

The invention relates to a preparation method of an arteannuin molecularly imprinted composite membrane, belonging to the technical field of environmental material preparation. The method comprises the following steps: by using a regenerated cellulose membrane as a substrate, the arteannuin as a template molecule, acrylamide (AM) as a functional monomer and ethylene glycol dimethyl acrylate (EGDMA) as a crosslinking agent, cuprous bromide and N,N',N'',N''-pentamethyldiethylenetriamine constitute a catalytic system, and an atom transfer free-radical polymerization process is utilized to prepare the arteannuin molecularly imprinted composite membrane. A static adsorption experiment is used for researching the adsorption equilibrium, dynamics and selective recognition performance of the imprinted membrane; and the result proves that the arteannuin imprinted membrane has fast adsorption dynamical properties and excellent arteannuin molecule recognition performance.

Description

technical field [0001] The invention belongs to the technical field of material preparation, and relates to an artemisinin molecularly imprinted composite film and a preparation method and application thereof. Background technique [0002] Molecular imprinting technology (MIT) is to simulate the molecular recognition in nature, such as: enzymes and substrates, antibodies and antigens, etc., using target molecules as template molecules to prepare polymers (Molecularly imprinted polymers) that have specific and selective recognition functions for the molecules. A technique of Imprinted Polymers (MIPs): select functional monomers capable of specific interactions with template molecules, polymerize with cross-linking agents around the template molecules to form a three-dimensional cross-linked polymer network, and finally through physical chemistry After removing the template molecule by other methods, a functional polymer with a special affinity for the template molecule and a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/26C08J7/16C08J7/12B01J20/26B01J20/28B01D71/10B01D69/12B01D67/00
Inventor 吴易霖闫永胜李春香孟敏佳潘建明刘馨琳戴江栋
Owner JIANGSU UNIV
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