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Preparation method of nanometer silicon gel surface gastrodin molecular engram polymers

A nano-silica gel and molecular imprinting technology, which is applied in the fields of alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., can solve the problems that have not yet been found in the reports of gastrodin molecularly imprinted polymers, and achieve good affinity Harmony and adsorption properties, broad application prospects

Inactive Publication Date: 2010-10-20
JIANGSU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] After checking the literature of the prior art, no relevant reports on the preparation of gastrodin molecularly imprinted polymers on the surface of silica gel have been found so far

Method used

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  • Preparation method of nanometer silicon gel surface gastrodin molecular engram polymers
  • Preparation method of nanometer silicon gel surface gastrodin molecular engram polymers
  • Preparation method of nanometer silicon gel surface gastrodin molecular engram polymers

Examples

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example 1

[0023] The nano-silica gel was dried in a vacuum oven at 60°C under nitrogen for 12 hours to remove physical water on the surface of the silica gel. Take 6g of activated dry silica gel, 150mL of toluene, 4.5mL of KH-570, and 2mL of triethylamine into a three-neck bottle, and ultrasonically oscillate for 5min. 2 Under the protection of water bath heating and stirring reflux for 24h. The reacted silica gel was filtered, washed repeatedly with toluene, acetone, and methanol, and vacuum-dried for 24 hours to obtain silanized nano-silica gel particles.

[0024] Dissolve 0.25mmol template molecule gastrodin and 1.5mmol functional monomer α-methacrylic acid in 20.0mL porogen methanol to prepare a mixed solution, shake at constant temperature and avoid light for 6h, add cross-linking agent ethylene glycol dimethacrylic acid Ester 7.5mmol, silanized silica gel (consumption is 10% of the mass of monomer and crosslinking agent), initiator azobisisobutyronitrile (consumption is 1% of the...

example 2

[0026] The nano-silica gel was dried in a vacuum oven at 60°C under nitrogen for 12 hours to remove physical water on the surface of the silica gel. Take 6g of activated dry silica gel, 150mL of toluene, 4.5mL of KH-570, and 2mL of triethylamine into a three-neck bottle, and ultrasonically oscillate for 5min. 2 Under the protection of water bath heating and stirring reflux for 24h. The reacted silica gel was filtered, washed repeatedly with toluene, acetone, and methanol, and vacuum-dried for 24 hours to obtain silanized nano-silica gel particles.

[0027] Dissolve 0.25mmol template molecule gastrodin and 1.5mmol functional monomer α-methacrylic acid in 20.0mL porogen methanol to prepare a mixed solution, shake at constant temperature and avoid light for 6h, add cross-linking agent ethylene glycol dimethacrylic acid Ester 9.0mmol, silanized silica gel (consumption is 10% of the mass of monomer and crosslinking agent), initiator azobisisobutyronitrile (consumption is 1% of the...

example 3

[0029] The nano-silica gel was dried in a vacuum oven at 60°C under nitrogen for 12 hours to remove physical water on the surface of the silica gel. Take 6g of activated dry silica gel, 150mL of toluene, 4.5mL of KH-570, and 2mL of triethylamine into a three-neck bottle, and ultrasonically oscillate for 5min. 2 Under the protection of water bath heating and stirring reflux for 24h. The reacted silica gel was filtered, washed repeatedly with toluene, acetone, and methanol, and vacuum-dried for 24 hours to obtain silanized nano-silica gel particles.

[0030]Dissolve 0.25mmol template molecule gastrodin and 1.5mmol functional monomer α-methacrylic acid in 20.0mL porogen methanol to prepare a mixed solution, shake at constant temperature and avoid light for 6h, add cross-linking agent ethylene glycol dimethacrylic acid Ester 7.5mmol, silanized silica gel (consumption is 100% of monomer and crosslinking agent quality), initiator azobisisobutyronitrile (consumption is 1% of silaniz...

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Abstract

The invention relates to a preparation method of nanometer silicon gel surface gastrodin molecular engram polymers, which belongs to the technical field of biochemical engineering. The preparation method of the invention comprises the following steps: dissolving template molecules of gastrodin and functional monomers of alpha-methacrylic acid into hole forming agents of methanol; sufficiently mixing the materials under the conditions of constant temperature and light shielding to obtain mixed liquid; adding silanization nanometer silicon gel particles, cross linking agents and catalytic amount triggering agents into the mixed liquid; carrying out repeated ultrasonic treatment after sufficient and uniform mixing; introducing nitrogen gas for deoxygenation; sealing the materials; carrying out reaction for 6h in water bath of 50 DEG C; then, carrying out reaction for 24h at 60 DEG C to obtain solid polymers; adopting a Sohxlet extraction method for extracting the solid polymers for more than 48h; carrying out elution for removing template molecules; drying the polymers till the constant weight after the extraction is completed; and obtaining the silicon gel surface gastrodin molecular engram polymers. The molecular engram polymers prepared by the invention have specific identification capability and selective absorption performance on the gastrodin. Compared with ordinary absorping agents, the molecular engram polymers prepared by the invention have the advantages of accuracy, high speed and sensitivity.

Description

technical field [0001] The invention belongs to the technical field of biochemical engineering, and in particular relates to a method for preparing a gastrodin molecularly imprinted polymer on the surface of nano silica gel. Background technique [0002] Gastrodin (4-hydroxyphenyl-β-D-glucopyranoside) is an active ingredient of the traditional Chinese medicine Gastrodia elata, which has good sedative and hypnotic effects, and has certain curative effect on neurasthenia, insomnia and headache. It also has a good effect on keeping a clear mind and abundant energy, and delaying aging in the elderly. It has high research and application value in the field of medical care. In recent years, there has been an increasing demand for high-purity gastrodin at home and abroad. At present, gastrodin is mainly isolated and extracted from natural plants. Traditional methods mainly use solvent extraction for enrichment, and then separate and purify through column separation technology. Ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/06C08F2/44C08K9/06C08K3/36C08J9/26B01J20/30B01J20/26B01J20/28
Inventor 贺敏强宋承成陈永强万金城何娟孟敏佳
Owner JIANGSU UNIV
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