Preparation and application of silanized cadmium telluride quantum dot molecularly imprinted polymer

A technology of cadmium tellurium silanization and molecular imprinting, which is applied in the application field of identifying acetaminophen, and can solve problems such as poor selectivity and limited application range

Inactive Publication Date: 2019-09-10
NORTHWEST NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the fluorescence analysis method and chemiluminescence analysis method based on quantum dots have exposed the shortcomings of poor selectivity in the detection of similar substances with similar structures and properties, which greatly limits the traditional optical recognition and detection methods of quantum dots in the analysis of complex samples. The scope of application in

Method used

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  • Preparation and application of silanized cadmium telluride quantum dot molecularly imprinted polymer
  • Preparation and application of silanized cadmium telluride quantum dot molecularly imprinted polymer
  • Preparation and application of silanized cadmium telluride quantum dot molecularly imprinted polymer

Examples

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Effect test

Embodiment 1

[0042] Example 1. Preparation of silanized CdTe quantum dot surface molecularly imprinted polymers (CdTe@MIPs QDs)

[0043] (1) Synthesis of the precursor NaHTe: Add 0.0128 g tellurium powder and 0.06 g sodium borohydride into a 10 mL distillation bottle, blow nitrogen gas for 30 minutes, then add 5 mL high-purity water treated with nitrogen gas, and react in a water bath at 60 ° C. The black tellurium powder disappeared completely, and the solution became colorless to obtain the precursor solution NaHTe for subsequent use. The whole experimental process is protected with nitrogen, and hydrogen will be generated at the same time;

[0044] (2) Synthesis of CdTe QDs: 0.1828 g cadmium chloride, 50 mL high-purity water and 134 µL mercaptoacetic acid were sequentially added into a 100 mL three-necked flask. Stirred at low temperature for 30 min, then quickly added to the above precursor solution NaHTe, reacted at 100 °C for 10 min, added 1.5 mL tetraethoxysilane, reacted for 3 h, ...

Embodiment 2

[0046] Example 2, CdTe@MIPs QDs Molecularly Imprinted Polymer Recognition of Acetaminophen

[0047] In molecularly imprinted polymer CdTe@MIPs QDs, add acetaminophen (AP), phenol (Phenol), p-nitrophenol (P-Nitrophenol), 2,4-dinitrophenol (2,4-DNP ), phenacetin (Phenacetin), and the molecularly imprinted polymer CdTe@MIPs QDs have the largest degree of fluorescence quenching for acetaminophen (AP).

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Abstract

The invention discloses a preparation of a silanized cadmium telluride quantum dot molecularly imprinted polymer. An aqueous phase CdTe QDs modified by thioglycolic acid (TGA) is used as a fluorescentcarrier, the surface of the fluorescent carrier is subjected to alkylation modification, then paracetamol is used as a template molecule, 3-aminopropyltriethoxysilane is uses as a functional monomer,ethyl orthosilicate is used as a cross-linking agent, ammonia water is used as a catalyst, and a polymer in which the outer layer of quantum dots is coated with molecular imprinting is successfully synthesized. Results of selective adsorption experiments show that the prepared CdTe@MIPs QDs has hole sites of a target molecule AP, and can selectively recognize AP from a complex matrix, the recognition is not easily interfered by other structural analogs, and results show that the method has good molecular recognition performance for AP molecules.

Description

technical field [0001] The invention relates to a preparation method of a cadmium tellurium silanized quantum dot molecularly imprinted polymer. The invention also relates to the application of the quantum dot molecularly imprinted polymer in identifying acetaminophen, which belongs to the technical field of composite materials and the technical field of chemiluminescence analysis . Background technique [0002] Acetaminophen (Acetaminophen, AP), also known as paracetamol, has antipyretic and analgesic effects, and is mainly used clinically to relieve fever, headache, joint pain, neuralgia, cancer pain, etc. Establishing a rapid, accurate and sensitive analytical method for the determination of acetaminophen content is of great significance in clinical medicine and pharmaceutical research. [0003] Quantum dots (QDs) are a type of quasi-zero-dimensional nanocrystals with a particle size smaller than or close to the exciton Bohr radius, and their size is generally between 1....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G77/26C08K9/06C08K9/04C08K3/30C08J9/26B01J20/30B01J20/26G01N21/64
CPCC08G77/26C08K9/06C08K9/04C08K3/30C08J9/26B01J20/268G01N21/6428G01N2021/6432
Inventor 周敏陈琪琪
Owner NORTHWEST NORMAL UNIVERSITY
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