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A preparation method of biomimetic artemisinin molecularly imprinted composite film

A technology of molecular imprinting and composite membrane, which is applied in chemical instruments and methods, and other chemical processes, can solve the problems of poor kinetic performance and slow kinetic rate, and achieve remarkable separation effect, multiple times of reuse, and selectivity high effect

Inactive Publication Date: 2016-04-06
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surface molecular imprinting technology builds molecular recognition sites on the surface of the matrix material, which facilitates the removal and recombination of template molecules, and better solves some serious defects that still exist in traditional molecular imprinting technology, such as active sites. Embedding is too deep, the kinetic rate of mass transfer and charge transfer is slow, the kinetic performance of adsorption-desorption is not good, etc.

Method used

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  • A preparation method of biomimetic artemisinin molecularly imprinted composite film
  • A preparation method of biomimetic artemisinin molecularly imprinted composite film
  • A preparation method of biomimetic artemisinin molecularly imprinted composite film

Examples

Experimental program
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Effect test

Embodiment 1

[0048] (1) SiO 2 Preparation of nanoparticles

[0049] First, prepare solution A: put 8mL of ammonia water, 16mL of ethanol and 24mL of water in a flask, and stir magnetically (1100rpm). Then configure solution B: mix 5mL tetraethyl orthosilicate (TEOS) and 45mL ethanol evenly. Add solution B to A quickly, and try not to let solution B touch the bottle wall. After one minute the stirring speed was reduced to 500 rpm. Seal the mouth of the reaction flask with parafilm, and react at room temperature for 3 hours. Centrifuge three times with ethanol and dry in vacuum.

[0050] (2) Acrylamide surface modified SiO 2 Preparation of nanoparticles

[0051] First, 0.1 g of SiO obtained in (1) 2 Nanoparticles and 2mL 3-aminopropyltriethoxysilane (APTES) were mixed and dispersed in 50mL anhydrous toluene, under nitrogen protection for 50 o C was reacted for 12 hours. After the reaction, the resulting SiO 2 - APTES was centrifuged three times with toluene and dispersed in 50 mL o...

Embodiment 2

[0067] (1) SiO 2 Preparation of nanoparticles

[0068] First, prepare solution A: put 7mL of ammonia water, 14mL of ethanol and 21mL of water in a flask, and stir magnetically (1100rpm). Then configure solution B: mix 6mL tetraethyl orthosilicate (TEOS) with 54mL ethanol and mix well. Add solution B to A quickly, and try not to let solution B touch the bottle wall. After one minute the stirring speed was reduced to 500 rpm. Seal the mouth of the reaction flask with parafilm, and react at room temperature for 5 hours. Centrifuge three times with ethanol and dry in vacuum.

[0069] (2) Acrylamide surface modified SiO 2 Preparation of nanoparticles

[0070] First, 0.15 g of SiO obtained in (1) 2 Nanoparticles and 3mL 3-aminopropyltriethoxysilane (APTES) were mixed and dispersed in 50mL anhydrous toluene, under nitrogen protection for 50 o C was reacted for 12 hours. After the reaction, the resulting SiO 2 - APTES was centrifuged three times with toluene and dispersed in...

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Abstract

The invention relates to a method for preparing a bionic molecular imprinted composite membrane, which belongs to the technical field of environmental material preparation. Specifically refers to the use of regenerated cellulose film as the substrate, artemisinin as the template molecule, acrylamide (AM) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent, combined with dopamine biomimetic The principle is to embed silica nanoparticles modified by surface functional monomers on the surface of the membrane material, and adopt a two-step temperature polymerization method to prepare a biomimetic artemisinin molecularly imprinted composite membrane. Static adsorption experiments were used to study the adsorption equilibrium, kinetics and selective recognition performance of the prepared imprinted membranes. The results show that the artemisinin imprinted membrane obtained by the invention has high adsorption capacity and superior artemisinin molecular recognition and penetration performance.

Description

technical field [0001] The invention relates to a biomimetic artemisinin molecularly imprinted composite membrane and a preparation method and application thereof, belonging to the technical field of material preparation. Background technique [0002] Artemisinin is a powerful antimalarial drug with independent intellectual property rights that is extracted from Artemisia annua by Chinese scientists and has been internationally recognized. It has become a drug recommended by the World Health Organization. With the in-depth research on the pharmacological effects of artemisinin drugs, it has been confirmed that artemisinin drugs have anti-malarial, anti-pregnancy, anti-fibrosis, anti-schistosomiasis, anti-toxoplasma gondii, anti-arrhythmia and anti-tumor cytotoxic effects. . Therefore, artemisinin has broad development prospects and great scientific research value. The extraction and separation methods of artemisinin are mainly steam distillation, organic solvent extraction...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/56C08F222/14C08K9/04C08K3/36C08J9/26B01J20/26B01J20/30
Inventor 吴易霖李春香闫永胜吕鹏刘馨琳
Owner JIANGSU UNIV
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