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Preparation method and application of loofah-sponge-based imprinted membrane material with reinforced-concrete-like structure

A reinforced concrete and loofah-based technology, which is applied in chemical instruments and methods, other chemical processes, alkali metal oxides/hydroxides, etc., can solve the problem that molecularly imprinted polymers cannot fully contact target molecules, template molecule elution consumption Incomplete elution, poor membrane mechanical strength and other problems, to achieve obvious artemisinin molecular recognition performance, fast adsorption kinetics, and stable mechanical strength

Active Publication Date: 2020-02-04
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional molecularly imprinted membranes have many defects, such as the molecularly imprinted polymer cannot fully contact with the target molecules during the blending process, the mechanical strength of the membrane is poor, and the elution of template molecules takes time or even cannot be completely washed out. etc., thus limiting the effect of blotting

Method used

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  • Preparation method and application of loofah-sponge-based imprinted membrane material with reinforced-concrete-like structure
  • Preparation method and application of loofah-sponge-based imprinted membrane material with reinforced-concrete-like structure
  • Preparation method and application of loofah-sponge-based imprinted membrane material with reinforced-concrete-like structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Preparation of loofah:

[0043] Take natural loofah, remove sundries and loofah seeds, slice horizontally, and rinse with deionized water for 30 minutes. Then soak it in sodium hydroxide solution for 10 minutes, take it out and dry it, repeat the operation for a total of 3.0 hours, remove the jelly and wax, and rinse it with deionized water for 30 minutes. Finally, it was transferred to a vacuum oven and dried at 60 °C for 24 h.

[0044] (2) Dopamine modified loofah:

[0045] Prepare a Tris(hydroxymethyl)aminomethane buffer solution with a concentration of 0.01mol / L, adjust the pH of the solution to 8.5, and then add 0.1g of dopamine (PDA) and loofah. After stirring evenly, put it into a shaker to react for 8h.

[0046] (3) Preparation of artemisinin molecularly imprinted polymers

[0047] Measure 60 mL of acetonitrile in a flask, add 28.2 mg of artemisinin, 28.4 mg of acrylamide (MAA), 396.4 mg of ethylene glycol dimethacrylate (EGDMA), and 10 mg of azobisisobu...

Embodiment 2

[0052] (1) Preparation of loofah:

[0053] Take natural loofah, remove sundries and loofah seeds, slice horizontally, and rinse with deionized water for 30 minutes. Then soak it in sodium hydroxide solution for 10 minutes, take it out and dry it, repeat the operation for a total of 3.0 hours, remove the jelly and wax, and rinse it with deionized water for 30 minutes. Finally, it was transferred to a vacuum oven and dried at 60 °C for 24 h.

[0054] (2) Dopamine modified loofah:

[0055] Prepare a tris(hydroxymethyl)aminomethane buffer solution with a concentration of 0.01mol / L, adjust the pH of the solution to 8.5, and then add 0.15g of dopamine (PDA) and loofah. After stirring evenly, put it into a shaker to react for 10h.

[0056] (3) Preparation of artemisinin molecularly imprinted polymers

[0057] Measure 60 mL of acetonitrile into a flask, and add 35.25 mg of artemisinin, 35.5 mg of acrylamide (MAA), 495.5 mg of ethylene glycol dimethacrylate (EGDMA), and 12.5 mg of ...

Embodiment 3

[0062] (1) Preparation of loofah:

[0063] Take natural loofah, remove sundries and loofah seeds, slice horizontally, and rinse with deionized water for 30 minutes. Then soak it in sodium hydroxide solution for 10 minutes, take it out and dry it, repeat the operation for a total of 3.0 hours, remove the jelly and wax, and rinse it with deionized water for 30 minutes. Finally, it was transferred to a vacuum oven and dried at 60 °C for 24 h.

[0064] (2) Dopamine modified loofah:

[0065] Prepare a tris(hydroxymethyl)aminomethane buffer solution with a concentration of 0.01mol / L, adjust the pH of the solution to 8.5, and then add 0.2g of dopamine (PDA) and loofah. After stirring evenly, put it into a shaker to react for 12h.

[0066] (3) Preparation of artemisinin molecularly imprinted polymers

[0067] Measure 60 mL of acetonitrile in a flask, add 42.3 mg of artemisinin, 42.6 mg of acrylamide (MAA), 594.6 mg of ethylene glycol dimethacrylate (EGDMA), and 15 mg of azobisisob...

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Abstract

The invention belongs to the technical field of material preparation and separation, and discloses a preparation method and application of a loofah-sponge-based imprinted membrane material of a reinforced-concrete-like structure. The preparation method comprises the following steps: step 1, preparing loofah sponge; step 2, modifying the loofah sponge with dopamine; step 3, preparing an artemisininmolecularly imprinted polymer; and step 4, preparing the loofah-sponge-based artemisinin molecularly imprinted membrane. The molecularly imprinted membrane prepared by using a loofah-sponge impregnation and permeation method can effectively overcome the defects that the molecularly imprinted polymer cannot be in full contact with target molecules, the mechanical strength and performance of the membrane are poor, and template molecules take much time to elute and even cannot be completely eluted, and has the advantages of simple synthesis, high selectivity efficiency and the like.

Description

technical field [0001] The invention belongs to the technical field of material preparation and separation, in particular to a preparation method and application of a loofah-based imprinted membrane material with a "reinforced concrete" structure. Background technique [0002] Artemisinin is a sesquiterpene lactone drug with peroxy groups extracted by Chinese scientists from the stems and leaves of the plant Artemisia annua. It is an internationally recognized anti-malarial drug with independent intellectual property rights and has been obtained worldwide. widely used. Therefore, artemisinin has broad development prospects and great development value. The extraction and separation of artemisinin mainly use methods such as Soxhlet extraction, organic-organic solvent extraction, and water vapor extraction, while the separation and extraction methods using molecularly imprinted membranes are rarely reported. [0003] The development and application of molecular imprinted memb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F220/56C08J9/26C08J5/18C08L35/02C08L27/16C08L97/02B01J20/26B01J20/24B01J20/28B01J20/30
CPCB01J20/24B01J20/261B01J20/268B01J20/28033C08F222/10C08J5/18C08J9/26C08J2201/0422C08J2335/02C08J2427/16C08J2497/02
Inventor 白蒙起兰义营卢健董泽清吴易霖孟敏佳
Owner JIANGSU UNIV
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