124results about How to "Fast elution" patented technology

The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.

Embodiments of the present invention provide a method for treatment of nonvascular body lumen strictures such as benign prostatic hyperplasia (BPH), urethral strictures, ureteral strictures, prostate cancer, esophageal strictures, sinus strictures, biliary tract strictures, asthma and chronic obstructive pulmonary disease (COPD). The method involves delivering, preferably via drug coated balloon catheters, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues) and one or more additives.

Medical device are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.

Embodiments of the present invention provide a method of treating a stricture in a nonvascular body lumen such as urethral strictures, benign prostatic hyperplasia (BPH) strictures, ureteral strictures, esophageal strictures, sinus strictures, and biliary tract strictures. Embodiments of the present invention provide a method for treating at least one of benign prostatic hyperplasia (BPH), prostate cancer, asthma, and chronic obstructive pulmonary disease (COPD). The method can include delivering, for example, via drug coated balloon catheters, anti-inflammatory and anti-proliferative drugs (e.g., rapamycin, paclitaxel, and their analogues) and one or more additives.

The invention belongs to the technical field of detection and relates to a pretreatment method for biogen amine neurotransmitter and/or metabolites thereof. The method comprises the following steps of: performing derivatization on a sample containing the biogen amine neurotransmitter and/or the metabolites thereof, and carrying out online solid-phase extraction on derivatization products. On the basis, the invention also relates to a detection method for the biogen amine neurotransmitter and/or the metabolites thereof, a detection kit and application thereof. The pretreatment method has the advantages that impurities in the derivatization products can be eliminated, and after being enriched, the derivatization products with proper concentration are transferred into the following detection steps. The detection method has the advantages that the content of the biogen amine neurotransmitter and/or the metabolites thereof in a biological sample can be fast and accurately measured, and the detection sensitivity is high.

A nanofiber adsorption based array solid-phase extraction device relates to an extraction device applied to quick enrichment and purification pretreatment of micro and trace samples of biomedical complicated samples, environmental samples, toxicants and pollutants. The nanofiber adsorption based array solid-phase extraction device comprises five layers from bottom to top; the lowermost is a base on which a waste liquid cell (9) capable of being conveniently taken out is arranged; a receiving tube support (8) is arranged above the waste liquid cell (9); a fixed solid-phase extraction small-column support (7) is arranged above the receiving tube support (8); a layer of fixed tube inserting rack (6) is arranged above the fixed solid-phase extraction small-column support (7); one end of the tube inserting rack (6) is provided with a connecting shaft (4) which is sleeved with a pressplate (5) capable of sliding vertically and rotating laterally; an injector (3) is fixed on the tube inserting rack (6); a push rod end of the injector (3) is connected with the pressplate (5); the front end of the injector (3) is provided with an extraction small column (10); a small test tube (11) is positioned on the receiving tube support (8); and the front end of the extraction small column (10) passes through the solid-phase extraction small-column support (7) and is positioned at an opening end of the small test tube (11).

The invention relates to a restoration method of polycyclic aromatic hydrocarbon-heavy metal polluted soil. According to the soil dry weight, an eluting agent is added to the polycyclic aromatic hydrocarbon-heavy metal polluted soil for eluting the polycyclic aromatic hydrocarbon-heavy metal polluted soil for 12-24h according to a weight ratio of the eluting agent to the polycyclic aromatic hydrocarbon-heavy metal polluted soil being 10:1 to 30:1; the eluting agent consists of 5000-8000mg/L N-dodecanoyl ED3A solution and 200-300mg/L chitosan solution. By adopting and compounding the chitosan solution and the N-dodecanoyl ED3A solution for forming the eluting agent, the elution rates of heavy metal and organic matters in the polycyclic aromatic hydrocarbon-heavy metal polluted soil are raised significantly, and the antagonism on the elution of the organic matters due to the heavy metal when N-dodecanoyl ED3A is used to elute the polycyclic aromatic hydrocarbon-heavy metal polluted soil is overcome. In addition, a chelating type surfactant, namely, the N-dodecanoyl ED3A, and the chitosan solution have no toxicity to the environment and are prone to biological degradation.

The invention discloses a method for extracting uranium by utilizing a photocatalysis technology under visible light. The method comprises the following steps: performing ultrasonic treatment on C3N4to make the C3N4 fully and uniformly dispersed, adding glucose and Cd(NO3)2.4H2O, performing magnetic stirring, adding L-cysteine, continuing stirring, moving the stirred material to a high-pressure reaction kettle, placing the obtained material in a drying oven, performing constant-temperature treatment, performing cooling, performing suction filtration, performing washing by using ultrapure water and absolute ethanol for a plurality of times, performing freeze drying, performing grinding, adding the ground material into a quartz tube, adding a UO2(NO3)2 solution and ultrapure water or seawater, introducing N2 for a period of time under the dark condition, placing the obtained material under natural light or a xenon lamp, performing irradiation for 10 min, filtering the suspension, adding1 mL of water into the obtained solid, placing the obtained material in air for 24 h, adding 1 mL of 0.1 mol/L Na2CO3 solution, performing desorption for 30 min, and performing filtration, wherein the extracted uranium is obtained in the supernatant. The method disclosed by the invention has the beneficial effects that 0.1 mmol/L uranium in 15 mL of seawater system can be completely extracted within 10 min under irradiation of the visible light.

The invention discloses a preparation method of a PPS (polyphenylene sulfide)-based N-methylimidazole strong base type ion exchange fiber. The method comprises the following steps of: firstly, on the basis of using polyphenylene sulfide fiber as a basic raw material, adding dichloroethane, chloromethyl ether and tin chloride for swelling, heating up for reaction after swelling, cooling after reaction, filtering out the product, and processing the product to get the chloromethylated polyphenylene sulfide fiber; then, adding dichloroethane for swelling, adding alcohol, N-methylimidazole and tetrabutylammonium bromide after swelling, heating up for reaction, filtering out the product after reaction, and sequentially washing, extracting, washing with brine and drying the product, thereby obtaining the product PPS -based N-methylimidazole strong base type ion exchange fiber. The PPS-based N-methylimidazole strong base type ion exchange fiber prepared according to the invention has the characteristics of high oxidation resistance, excellent chemical stability, larger adsorbing capacity, excellent absorption and regeneration performance and the like. The preparation method of the PPS -based N-methylimidazole strong base type ion exchange fiber is simple, low in production cost and easy to generalize in industry.

The invention discloses an industrial gardenia yellow pigment purification device and a method for extracting the gardenia yellow pigment. The device comprises an elution column, a vacuum recycling tank, a condenser, a dehydration column and a solvent heater, wherein the elution column, the vacuum recycling tank, the condenser, the dehydration column and the solvent heater are sequentially communicated with one another by virtue of pipelines; a sampling pipe is communicated with a pipeline between the elution column and the vacuum recycling tank; a sampling valve is arranged on the sampling pipe; a vacuum pump is arranged at the outlet of the dehydration column; a collection pipe is communicated with a pipeline between the dehydration column and the solvent heater; a collection valve is arranged on the collection pipe; the dehydration column is filled with dehydrating agents; and a water bath heating jacket is arranged outside the vacuum recycling tank in a sleeving manner. The method comprises the step of purifying gardenia yellow pigment from fine powder of solid gardenia yellow pigments containing lots of impurities. The device is simple in structure and convenient to use and is suitable for industrial production. The method is simple, low in cost, clean and environmentally friendly. The gardenia yellow pigment obtained by using the method is small in losses, high in purity and high in color value.

The invention discloses a purification and enzyme digestion transformation method of a recombinant human insulin precursor and belongs to the field of preparation of recombinant human insulin and analogues thereof. In the invention, fermentation supernatant of a secretorily expressed recombinant human insulin precursor is purified by using a cation exchange chromatography column, two different washing solutions are used during washing of chromatography, the elution of target proteins is performed more quickly, the elution time is shortened, the precipitation of the target proteins is reduced and the volume of eluted samples is reduced; an eluting solution with pH 7.0 to 9.0 is used during elution, phase change operation does not need to be performed to eluted products, the eluted products are directly added into trypsin for enzyme digestion transformation and the transformation efficiency is high. The method disclosed by the invention is simple to operate, the primary purification and phase change operation of the fermentation supernatant are completed through one step of chromatography purification, the purity of the samples can be improved from 14 percent to 95 percent, the purified samples are directly subjected to enzyme digestion, the enzyme digestion transformation efficiency is above 95 percent, the production process is simplified and the cost is saved.

This invention discloses a streptomycin module trace solid extraction small column and its process method, which comprises the following: polymer material model module of streptomycin, function single methacrulic acid, and cross linker two methacrylic acid glycol ester combined. It is a cross linked polymers fixed with hole distribution function group, which has the memory function to the streptomycin module space structure and high selection isolation and concentration to the remaining analyzed liquid.

The invention discloses a molecular impriting solid-phase extraction small column capable of high-selectively purifying and enriching diethyl stiboestrol (DES) from sample solution for determining residual amount of artificially-synthetic estrin diethyl stiboestrol (DES) in animal food and its preparation method. Said invention uses diethyl stiboestrol as molecular template to prepare molecular imprinting polymer, it is a cross-linked polymer with fixed hole size and form and definite arranged function group, and has the 'memory' function for steresotructure of diethyl stiboestrol template molecule, so that said material can be fileld into polypropylene small column so as to can obtain the diethyl stiboestrol molecular imprinting solid-phase extraction small column. As compared with general solvent extraction method and C18 solid-phase extraction method said invented imprinting column is more simple, quick and higher in efficiency.

The invention discloses an adsorbent for adsorption separation of m-Xylene, which comprises 90 to 98 percent of Y zeolite by weight and 2 to 10 percent of binder by weight, wherein the exchangeable cathion position of the Y zeolite is occupied commonly by metal ions of IA group and copper or silver ions. The adsorbent has better selectivity of the m-Xylene and better mass transfer rate, and can reduce the usage of strippant.

The invention discloses a preparation method of an inorganic core-shell type quercetin molecularly imprinted polymer microsphere. The method comprises: first subjecting a functional monomer, a crosslinking agent and a template molecule to self-assembly on a silica gel ball surface, then leaving a sol-gel reaction to occur so as to form an inorganic polymer film on the silica gel ball surface, and finally removing residual quercetin molecules from the product, thus obtaining a molecularly imprinted polymer of quercetin. Static adsorption curves, adsorption isotherms and competitive adsorption experiments show that the polymer has a fast selective adsorption ability on quercetin.

The present invention relates to a granulated seasoning salt and a preparation method thereof, characterized by using a gelatinized tapioca starch solution as a binder and an anti-caking agent. The granulated seasoning salt according to the present invention is prepared by using a gelatinized tapioca starch solution as a binder and an anti-caking agent to solve the problem such as caking property due to moisture absorption. Thus, the prepared seasoning salt has high binding capacity and stability, does not turn brown, is rapidly eluted, and can be stored for a long period of time without dissociation of the mixed materials.

An absorption enhancer for the large intestine most suitable for an oral preparation, with a disintegration property in the large intestine, especially the absorption enhancer for the large intestine mixed with a hydrophilic medium and an absorption enhancer is provided.

A homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge are advantageous retention index standards for liquid chromatography, especially for liquid chromatography-mass spectrometry (LC-MS) methods, more especially for LC-MS methods employing electrospray (ESI) or atmospheric pressure chemical ionization (APCI) ionization systems.

The invention discloses a method for extracting scopolamine by virtue of a membrane separation technique. A scopolamine finished product is prepared by the following steps: raw material pretreatment, preparation of a scopolamine extracting solution, ultrafiltration impurity removal, sodium filter desalination, reduced pressure concentration and drying, resin bed purification, scopolamine salt formation and the like. The scopolamine extracting solution is preliminarily purified and concentrated through operations of impurity removal, desalination and the like by virtue of the membrane separation technique and is highly purified through column chromatography, so that the production time is greatly shortened, and the production efficiency is improved; and compared with a conventional method, the product yield and the product purity are relatively high, and the method is applicable to industrial production.

The invention relates to a method for recycling heavy metal ion in water body by utilizing ion chelate fiber, belonging to the environmental protection technical field. Ion chelate fiber is prepared into a reaction module; the prepared reaction module is arranged in absorption region of water body to be treated for absorption; the reaction module enters into regeneration region to be regenerated after completing absorption in the absorption region, and the regeneration region includes pickling, washing, alkali regeneration and washing sequentially; after regeneration is completed, the reaction module returns to the absorption region to complete one cycle and then continues absorption, thus forming the continuous process of absorbing and recycling heavy metal ion by the reaction module. The water discharged after the process meets the requirement of 'integrated wastewater discharge standard'. The invention has fast absorption speed, high absorption capacity and high treatment efficiency; elution speed in pickling process is fast, and regeneration speed is fast; the heavy metal ion recycling technology of the invention is simple, equipment is easy to operate, total energy consumption of the process is low, investment is less, and quick returns can be obtained.

The invention relates to a method for simultaneously separating quercetin-3-O-gentian diglucoside and kaempferol-3-O-gentian diglucoside from folium sauropi and belongs to the technical field of separation and purification of a compound monomer. According to the invention, the folium sauropi medicinal material is taken as a raw material, and the quercetin-3-O-gentian diglucoside and kaempferol-3-O-gentian diglucoside monomers are acquired according to the steps of ethanol extraction, concentration, macro-porous resin enrichment and elution, polyamide resin enrichment and elution, efficient preparation, liquid chromatography separation and product recycling. According to the invention, through mature processing steps and parameter conditions, the purities of the quercetin-3-O-gentian diglucoside and the kaempferol-3-O-gentian diglucoside in the product respectively reach above 99%; and meanwhile, the method is simple and convenient in operation and is high in separating efficiency, the raw materials are recyclable, and the quercetin-3-O-gentian diglucoside and kaempferol-3-O-gentian diglucoside monomers can be simultaneously separated and prepared in large batch and high purity.

The invention discloses a method for preparing dietary fiber flour from sweet potato starch production waste. According to the method, a dietary fiber is prepared from sweet potato residues and liquid waste generated in the sweet potato starch production process; the sweet potato residues and nutrient substances contained in the liquid waste are also utilized to cultivate acetobacter xylinum as a carbon source and a partial nitrogen source, and are fermented to prepare bacterial cellulose; the raw materials are fully utilized; meanwhile, methods for carrying out ultra-low temperature frozen pretreatment on the sweet potato residues and carrying out high-pressure gas impact-assisted mixed enzymolysis are adopted in the preparation process; and the yield of the dietary fiber flour is increased and the purity of the dietary fiber flour is improved. According to the method, the sweet potato starch production waste can be fully utilized; the yield of the dietary fiber is increased, and the purity of the dietary fiber is improved; and the pollution to environment caused by sweet potato starch production is reduced.

The invention discloses a method for preparing catechins which comprises the following steps of: (1), preparing a water solution of teat extracts; (2) preparing a chromatography column by mixing 1-3 parts of sorbent and 1 part of flow rate acceleration assistant by weight and then pouring the mixture into a column in a wet mode; (3) loading a sample: uniformly injecting the water solution of tea extracts into the chromatography column; (4) eluting impurities containing caffeine, wherein the effluent liquid is leacheate containing caffeine impurities; (5) eluting catechins: leaching a chromatography column bed again by an ethanol solution of dimethyl sulfoxide(volume concentration is more than or equal to 60%) or dimethyl sulfoxide as eluate, and collecting leacheate containing catechins; and (6) obtaining solid catechins. By adopting the method, the caffeine impurities can be effectively eluted, thereby obtaining the high-purity catechins.

The disclosed method comprises: removing water in glucan microcolumn; adding the liposome on the column for centrifugation; measuring the total content concentration (C0) of capsaicam and the concentration of processed capsicine (C1); finally, obtaining the target value by calculating C0/C1. This invention is fast and low cost.