A surface imprinted preparation method for highly selective recognition of ciprofloxacin

A ciprofloxacin, surface imprinting technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problem of poor adsorption-desorption kinetic performance, deep embedding of active sites, mass transfer and charge transfer The problem of slow kinetic rate, etc., achieves the effect of significant separation effect, reduction of non-specific adsorption, and low price.

Inactive Publication Date: 2016-05-25
JIANGSU UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0003] Surface molecular imprinting technology helps the removal and recombination of template molecules by establishing molecular recognition sites on the surface of the matrix material, and overcomes some serious defects in the bulk polymerization method, such as too deep embedding of active sites, The kinetic rate of mass transfer and charge transfer is slow, the kinetic performance of adsorption-desorption is not good, etc.

Method used

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  • A surface imprinted preparation method for highly selective recognition of ciprofloxacin
  • A surface imprinted preparation method for highly selective recognition of ciprofloxacin
  • A surface imprinted preparation method for highly selective recognition of ciprofloxacin

Examples

Experimental program
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Effect test

Embodiment 1

[0031] (1) Preparation of ciprofloxacin surface imprinted polymers (MIPs)

[0032] Put 0.2g of active dry yeast into a 100ml round bottom flask, add 10ml of water, mix until the yeast dissolves, then add 40ml of acetonitrile, sonicate for 10min, then add 0.0625mmol of ciprofloxacin, 0.25mmol of acrylamide, and Alcohol di(methacrylate) ester 1mmol, mix and stir, pass nitrogen for 15min, then carefully add 0.0043g of 2,2'-azobisisobutyronitrile, seal the bottle mouth, put it in a water bath shaker, set the temperature 50°C, rotating speed 180rpm, react for 2h, then increase the temperature to 60°C, continue to react for 22h. Then centrifuge and dry under vacuum at 60°C for 12h. The synthesized product was Soxhlet-extracted for 48 hours with a mixture of 90 mL methanol and 10 mL acetic acid to remove the template molecule ciprofloxacin. Finally, the ciprofloxacin surface imprinted polymer was prepared by vacuum drying at 50°C for 6 hours.

[0033] The corresponding non-imprint...

Embodiment 2

[0042] (1) Preparation of ciprofloxacin surface imprinted polymers (MIPs)

[0043] Put 0.15g of active dry yeast into a 100ml round bottom flask, add 10.5ml of water, mix until the yeast dissolves, then add 42ml of acetonitrile, ultrasonication for 10min, then add ciprofloxacin 0.05mmol, acrylamide 0.3mmol, ethyl 1.5 mmol of diol di(methacrylate) ester, mixed and stirred, passed nitrogen for 15 minutes, then carefully added 0.0096 g of 2,2'-azobisisobutyronitrile, sealed the bottle mouth, and put it in a water bath shaker, Set the temperature at 50°C, rotate at 180rpm, react for 2 hours, and increase the temperature to 60 oC , Continue to react for 22h. Then centrifuge and dry under vacuum at 60°C for 12h. The synthesized product was Soxhlet-extracted for 48 hours with a mixture of 90 mL methanol and 10 mL acetic acid to remove the template molecule ciprofloxacin. Finally, the ciprofloxacin surface imprinted polymer was prepared by vacuum drying at 50°C for 6 hours.

[004...

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Abstract

The invention relates to a preparation method of a surface imprinting adsorbent for identifying ciprofloxacin at high sensitivity and belongs to the technical field of preparing environmental materials, and in particular relates to a method for preparing a surface imprinting adsorbent of ciprofloxacin with active dry yeast as the substrate, ciprofloxacin (CIP) as the template molecule, acrylamide (AM) as the functional monomer, ethylene glycol dimethyl acrylate (EGDMA) as the cross-linking agent and 2,2'-azodiisobutyronitrile (AIBN) as the initiator through a precipitation polymerization process. Static adsorption experiment is carried out to study the adsorption balance, dynamics and high-selectivity identification properties of the prepared imprinting adsorbent, and the result of the static adsorption experiment indicates that the surface imprinting adsorbent has fast adsorption dynamic property and excellent ciprofloxacin molecule identification property.

Description

technical field [0001] The invention relates to a surface imprint preparation method for highly selective recognition of ciprofloxacin, which belongs to the technical field of environmental material preparation. Background technique [0002] Molecular Imprinting Technique (MIT) refers to a technology that uses target molecules as template molecules to prepare molecularly imprinted polymers (Molecularly Imprinted Polymers, MIPs) that have specific and selective recognition functions for the molecule. The reason why molecular imprinting technology has attracted the attention of many scientific workers is mainly because it has three characteristics: namely, predeterminability, specific recognition, and wide applicability. Predeterminability means that people can prepare molecularly imprinted polymers with different template molecules according to different needs to meet various requirements; specific recognition is because molecularly imprinted polymers are customized according...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/56C08F222/14C08J9/26C08J9/28B01J20/26B01J20/30
Inventor 戴江栋王娟曹志晶孟敏佳李春香闫永胜
Owner JIANGSU UNIV
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