Preparation method of bionic artemisinin molecular imprinting composite membrane

A technology of molecular imprinting and composite membrane, which is applied in chemical instruments and methods, and other chemical processes, can solve the problems of slow kinetic rate and poor kinetic performance, and achieve multiple times of repeated use, remarkable separation effect, and selectivity high effect

Inactive Publication Date: 2014-12-24
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surface molecular imprinting technology builds molecular recognition sites on the surface of the matrix material, which facilitates the removal and recombination of template molecules, and better solves some serious defects that sti

Method used

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  • Preparation method of bionic artemisinin molecular imprinting composite membrane
  • Preparation method of bionic artemisinin molecular imprinting composite membrane
  • Preparation method of bionic artemisinin molecular imprinting composite membrane

Examples

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Effect test

Embodiment 1

[0048] (1) SiO 2 Preparation of nanoparticles

[0049] First, prepare solution A: put 8 mL of ammonia water, 16 mL of ethanol and 24 mL of water in a flask, and stir magnetically (1100rpm). Then prepare solution B: mix 5 mL tetraethyl orthosilicate (TEOS) with 45 mL ethanol and mix well. Add solution B to A quickly, and try not to let solution B touch the bottle wall. After one minute the stirring speed was reduced to 500 rpm. Seal the mouth of the reaction flask with parafilm, and react at room temperature for 3 hours. Centrifuge three times with ethanol and dry in vacuum.

[0050] (2) Acrylamide surface modified SiO 2 Preparation of nanoparticles

[0051] First, SiO obtained in 0.1 g (1) 2 Nanoparticles and 2 mL of 3-aminopropyltriethoxysilane (APTES) were mixed and dispersed in 50 mL of anhydrous toluene, under nitrogen protection for 50 o C was reacted for 12 hours. After the reaction, the resulting SiO 2 -APTES was centrifuged three times with toluene and disper...

Embodiment 2

[0067] (1) SiO 2 Preparation of nanoparticles

[0068] First, prepare solution A: put 7 mL of ammonia water, 14 mL of ethanol and 21 mL of water in a flask, and stir magnetically (1100rpm). Then prepare solution B: mix 6 mL tetraethyl orthosilicate (TEOS) with 54 mL ethanol and mix well. Add solution B to A quickly, and try not to let solution B touch the bottle wall. After one minute the stirring speed was reduced to 500 rpm. Seal the mouth of the reaction flask with parafilm, and react at room temperature for 5 hours. Centrifuge three times with ethanol and dry in vacuum.

[0069] (2) Acrylamide surface modified SiO 2 Preparation of nanoparticles

[0070] First, SiO obtained in 0.15 g (1) 2 Nanoparticles and 3 mL of 3-aminopropyltriethoxysilane (APTES) were mixed and dispersed in 50 mL of anhydrous toluene, under nitrogen protection for 50 o C for 12 hours. After the reaction, the resulting SiO 2-APTES was centrifuged three times with toluene and dispersed in 50 mL...

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Abstract

The invention relates to a preparation method of a bionic artemisinin molecular imprinting composite membrane, belonging to the technical field of environmental material preparation. The preparation method comprises the following specific steps: by taking a regenerated cellulose membrane as a substrate, artemisinin as a template molecule, acrylamide (AM) as a functional monomer and ethylene glycol dimethacrylate (EGDMA) as a cross-linking agent, inlaying silicon dioxide nanoparticles with functional monomer modified surfaces to the surface of a membrane material by combination with a dopamine bionic principle, and performing two-step temperature polymerization to prepare the bionic artemisinin molecular imprinting composite membrane. The static adsorption experiment is used for making a research on the adsorption balance, dynamics and selective recognition performance of the prepared imprinting membrane. A result shows that the artemisinin imprinting membrane prepared by adopting the method is relatively high in adsorption capacity and superior in artemisinin molecular recognition penetration performance.

Description

technical field [0001] The invention relates to a biomimetic artemisinin molecularly imprinted composite membrane and a preparation method and application thereof, belonging to the technical field of material preparation. Background technique [0002] Artemisinin is a powerful antimalarial drug with independent intellectual property rights that is extracted from Artemisia annua by Chinese scientists and has been internationally recognized. It has become a drug recommended by the World Health Organization. With the in-depth research on the pharmacological effects of artemisinin drugs, it has been confirmed that artemisinin drugs have anti-malarial, anti-pregnancy, anti-fibrosis, anti-schistosomiasis, anti-toxoplasma gondii, anti-arrhythmia and anti-tumor cytotoxic effects. . Therefore, artemisinin has broad development prospects and great scientific research value. The extraction and separation methods of artemisinin are mainly steam distillation, organic solvent extraction...

Claims

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Application Information

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IPC IPC(8): C08F220/56C08F222/14C08K9/04C08K3/36C08J9/26B01J20/26B01J20/30
Inventor 吴易霖李春香闫永胜吕鹏刘馨琳
Owner JIANGSU UNIV
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