91 results about "Halobenzene" patented technology

The invention discloses a synthesis method of an acaricide cyflumetofen intermediate p-tert-butyl phenylacetonitrile, and belongs to the field of pesticide preparation. The synthesis method is characterized in that a reaction is performed on 4-tert-butyl halobenzene and cyanoacetate to obtain the p-tert-butyl phenylacetonitrile. A reaction process comprises the following steps: 1), under a protective gas condition, uniformly mixing the cyanoacetate, organic alkali and a solvent A, raising the temperature to 80-105 DEG C, controlling the pressure to be 3-5 atmospheric pressures, adding a solution of the tert-butyl halobenzene and a solvent B in three batches within 20-40 min, then controlling the reaction temperature to be 95-120 DEG C, controlling the reaction pressure to be 4-7 atmospheric pressures, carrying out a reaction for 1-3 hours, then adding deionized water, controlling the reaction temperature to be 130-150 DEG C, controlling the reaction pressure to be 6-9 atmospheric pressures, and continuing the reaction for 4-6 hours; 2), removing the solvents from a system by using a rotary evaporator, then transferring a remainder to water, adding a solvent C, stirring, layering, collecting an organic phase, drying by using a drying agent, then filtering, collecting a filtrate, distilling the filtrate under reduced pressure, and collecting a fraction with the temperature of 78-79 DEG C (0.1 torr) to obtain the p-tert-butyl phenylacetonitrile. According to the synthesis method, the steps are few, the yield is relatively high and the pollutant emission is less.

The invention provides a synthesis method of a 4-cyclopentyl biphenyl fluorinated compound. The method comprises the steps of taking p-chloro-halobenzene as a starting material and carrying out Grignard reaction to generate a Grignard reagent II of the p-chloro-halogenated benzene; enabling the generated Grignard reagent II of the p-chloro-halogenated benzene and cyclopentanone to be subjected toa coupling reaction to generate cyclopentanol chlorobenzene; carrying out a dehydration reaction to generate cyclopentene chlorobenzene; carrying out a one-pot reaction to generate 4-cyclopentenyl phenylboronic acid; enabling the generated 4-cyclopentenyl phenylboronic acid and fluorinated halogenated benzene to be subjected to a coupling reaction to generate a 4-cyclopentenyl biphenyl fluorinatedcompound; carrying out a hydrogenation reaction to obtain the 4-cyclopentyl biphenyl fluorinated compound. The synthesis method provided by the invention has the characteristics of being high in conversion rate, low in cost, safe and stable in process, short in reaction steps, environmentally friendly in process route, and less in pollutant emission.