108 results about "Fluorobenzenes" patented technology

Methods for treating itch in human patients with atopic dermatitis (AD) and / or prurigo nodularis (PN) comprising administering a therapeutically effective amount of at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3- yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The invention discloses injectable hydrogel for alveolar bone repair, the injectable hydrogel comprises a first component and a second component, the first component comprises 4-carboxyl-3-fluorophenylboronic acid modified carboxymethyl chitosan CMCS-FPBA and beta-tricalcium phosphate, and the second component comprises oxidized dextran, PPS-HA nano-micelle and curcumin. The invention also discloses a preparation method and application of the injectable hydrogel. The injectable hydrogel disclosed by the invention has the effects of resisting oxidation, resisting inflammation and promoting bone tissue regeneration, is high in biocompatibility, can be customized in a personalized manner, and can be used for repairing alveolar bones.

This invention relates to N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide drug substance substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide and novel processes of preparation thereof. The invention further relates to pharmaceutical composition comprising N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide, wherein the composition is substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide. Pharmaceutical products containing said drug substance and compositions are also disclosed, as well as methods for preparing said drug substance, pharmaceutical compositions and products.

The invention discloses a continuous synthesis coordinated temperature control integrated method of fluorobenzene. The method comprises the following steps: carrying out salt-forming exothermic reaction on hydrogen fluoride liquid and aniline liquid in a salt-forming tubular reactor to obtain aniline hydrofluoride; carrying out diazotization exothermic reaction on aniline hydrofluoride and sodium nitrite solid in a diazotization tubular reactor to obtain diazonium salt; performing multi-stage pyrolysis exothermic reaction on the diazonium salt in a multi-stage temperature control tubular reactor to obtain pyrolysis liquid; performing liquid-liquid centrifugal separation on the pyrolysis liquid to continuously obtain a fluorobenzene product; thermal coupling heat exchange channels are respectively arranged among a sodium nitrite solid feeding pipeline, a diazonium salt feeding pipeline, an aniline hydrofluoride feeding pipeline, a diazotization tubular reactor, a hydrogen fluoride liquid feeding pipeline, liquid-liquid centrifugal separation equipment, an aniline liquid feeding pipeline, a salifying tubular reactor and a multi-stage temperature control tubular reactor, so that heat transfer temperature control is realized; according to the invention, continuous synthesis of fluorobenzene and temperature control integrated control are realized, and batch continuous stable production of fluorobenzene is further promoted.

Disclosed herein are novel methods for preparing 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile, including various solvate forms and intermediates thereof. Also disclosed herein are novel solvate forms and intermediates of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile.

The invention relates to the technical field of batteries, in particular to a lithium ion secondary battery. Comprising a positive electrode plate, a negative electrode plate and an electrolyte, the positive electrode plate comprises lithium cobalt oxide, the negative electrode plate comprises a silicon-based material, the electrolyte comprises a fluorosulfonamide compound, a nitrile compound and a first solvent, the first solvent comprises at least one of fluoroether, fluorobenzene and acetic acid 2, 2-difluoroethyl ester, and by taking the total mass of the electrolyte as a standard, the total mass of the lithium cobalt oxide and the total mass of the nitrile compound are equal to or smaller than 1. The content c1 of the fluorosulfonamide compound and the content c2 of the nitrile compound meet the following condition: 0.1 < = c1 / c2 < = 30; and the charging cut-off voltage of the lithium ion battery is greater than or equal to 4.48 V. The lithium ion secondary battery disclosed by the invention has relatively high energy density, relatively good cycle performance, excellent high-temperature storage performance and relatively good low-temperature performance.

The invention discloses a low-dielectric polyimide film based on a fluorine-containing triphenylmethane unit as well as a preparation method and application of the low-dielectric polyimide film, and the low-dielectric polyimide film is a novel polyimide material FPOPF-6FDA obtained by polymerizing a fluorine-containing triaryl methane diamine monomer and 4, 4 '-(hexafluoroisopropenyl) diphthalic anhydride. The fluorine-containing triarylmethane diamine monomer is preferably 4, 5-diphenyl-1, 3, 5-triazine. According to the invention, 4, 4 '-((4-fluoro-3-phenoxy phenyl) methylene)) bis (2-fluoroaniline) is used, specifically, 4, 4'-diaminotriphenylmethane is used as a functional core, a fluorine-containing group and a large-volume side chain group are introduced, and non-coplanar twisted conformation destroys close packing of molecular chains and increases the chain spacing, so that the effect of a charge transfer complex (CTC) is weakened, and the photoelectric conversion efficiency is improved. And the heat resistance and optical transparency of polyimide are maintained while the dielectric constant of the material is reduced.

The invention provides an electrolyte, a lithium iron manganese phosphate battery and an electric device. The electrolyte comprises a lithium salt and a solvent, the solvent comprises ethylene carbonate, propylene carbonate, ethyl methyl carbonate, fluorobenzene and a low-viscosity solvent in a volume ratio of (2-5): (2-5): (3-5): (3-5): (2-5). The high dielectric constants of ethylene carbonate and propylene carbonate improve the dissolving capacity of the electrolyte to lithium salt, and meanwhile, the molecular structure can form a stable interface layer on the surface of a positive electrode to inhibit migration and dissolution of manganese ions; due to the low viscosity characteristic of the low-viscosity solvent, the overall viscosity of the electrolyte is reduced, and the permeability of the porous positive electrode material is enhanced, so that the wettability is improved, and uniform de-intercalation of lithium ions is promoted; a physical adsorption protection layer can be formed on the surface of the positive electrode through the coordination effect of high-electronegativity fluorine atoms in fluorobenzene and manganese, and direct contact between manganese and electrolyte is further blocked.

The invention discloses a high-flux interface modification method of an oxide-based all-solid-state battery and a lithium ion battery, and belongs to the technical field of solid-state lithium ion batteries. The method comprises the following steps: mixing LTFSI, PVDF-HFP, m-fluorobenzamide and LLZO powder, and adding dimethylformamide to obtain a mixed raw material; adding an organic wet grinding solvent into the mixed raw material, and carrying out ball milling to obtain interface modification slurry; and coating one side of an LLZO electrolyte sheet with the interface modification slurry, and drying to complete interface modification. According to the interface modification method disclosed by the invention, the solid electrolyte has a lithium-loving property, can be in good contact with a metal lithium negative electrode, and can generate LiFamp through an in-situ reaction; and Li3N fills up interface defects and pores, and meanwhile, lithium dendrite growth and electron permeation can be inhibited, so that the interface structure of the obtained modified layer is stable. In addition, the lithium ion conductivity at the interface is further improved, the lithium ion flux at the interface is enhanced, the cycle life of the lithium battery is prolonged, and the preparation method is simple and suitable for industrial large-scale production.

The invention discloses a lithium iron phosphate battery as well as a preparation method and application thereof. In the lithium iron phosphate battery, a positive pole piece comprises a lithium iron phosphate positive active material layer and a polyimide ceramic coating arranged at the edge of a positive current collector, and the edge of the tab side of a negative pole piece is completely covered by a negative active material without exposing a blank current collector; the edge of the polyimide ceramic coating on the tab side of the positive pole piece and the edge of the tab side of the negative pole piece are coated in a staggered manner; the diaphragm comprises a base membrane, a meta-aramid ceramic coating and a water-based polyvinylidene fluoride coating, additives in the electrolyte comprise fluorobenzene, biphenyl and a third additive, and the third additive is lithium difluorophosphate and / or lithium difluoroborate. By means of the design, it is guaranteed that the battery cell passes through an overcharge thermal runaway test in the national standard GB38032, the battery cell does not catch fire or explode in the overcharge process, and the overcharge thermal runaway time meets 12 min.

The invention relates to the field of compound preparation, and discloses a method for preparing carboxylic acid aryl ester through in-situ oxyarylation of aryl halide and carboxylic acid under the catalysis of light-induced iron, which comprises the following steps: by taking aryl halide and carboxylate as raw materials, iron metal salt as a catalyst and nonmetal Lewis acid as an additive, carrying out light illumination in an inert gas atmosphere, and carrying out in-situ oxyarylation on aryl halide and carboxylic acid to obtain the carboxylic acid aryl ester. And reacting in an organic solvent according to a reaction formula to obtain the carboxylic acid aryl ester compound as shown in the formula III. According to the method, the problem of high bond energy of a C-F bond in aryl fluoride is overcome by innovatively utilizing a system formed by photo-activated iron catalysis-nonmetal Lewis acid, efficient coupling of fluorobenzene and aryl halide containing electron donating / withdrawing substituents and inorganic carboxylate is realized, the range of aryl halide substrates is widened, reaction conditions are mild, strong acid and strong base are not needed, and the method is suitable for industrial production. And precious metal is replaced by a cheap iron catalyst. The invention provides an efficient and environment-friendly new way for green synthesis of the ester-based aromatic compounds, and has a remarkable industrial application prospect.

The invention discloses a protamine derivative and application thereof, the protamine derivative is obtained by modifying phenylboronic acid on a protamine side chain amino group, and the phenylboronic acid is selected from 4-carboxyphenylboronic acid, 2-aminophenylboronic acid, 3-carboxyl-4-fluorophenylboronic acid or 4-formyl chlorophenylboronic acid; the protamine derivative can be combined with a nucleic acid drug through a boric acid group and is used as a delivery carrier for preparing a nucleic acid drug delivery system. The invention provides a preparation scheme of phenylboronic acid modified protamine, the phenylboronic acid modified protamine is applied to nucleic acid drug delivery, after phenylboronic acid is modified, a boric acid ester bond is formed between a carrier and nucleic acid, and the nucleic acid drug can be responsively released in a high-concentration ATP environment. The functional modified protamine obviously improves the stability of a nucleic acid delivery system, enables the release of a nucleic acid drug to be controllable, and enhances the curative effect of gene therapy.

A method for treating pruritus in patients with atopic dermatitis (AD) and / or nodular prurigo (PN) is disclosed, comprising administering a therapeutically effective amount of at least one compound selected from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-carbonyl]-4-methyl-4-[4-(oxecyclobutane-3-yl)piperazin-1-yl]pent-2-enonitrile (rezabrutinib) and pharmaceutically acceptable salts thereof.

The invention discloses a low-temperature potassium ion battery electrolyte with a weak solvation structure and application of the low-temperature potassium ion battery electrolyte in a potassium ion battery. The electrolyte comprises carbonic ester serving as a solvent and fluorobenzene serving as a diluent. According to the invention, carbonic ester and a fluorobenzene diluent are combined for use, on one hand, interaction between FB and PC can weaken the coordination strength of K + and PC, and the desolvation behavior of an electrode interface is improved, so that the electrochemical compatibility of PC and an electrode is improved; and on the other hand, the concentration of the electrolyte is reduced and the low-temperature viscosity is improved by introducing the FB, so that the low-temperature interface impedance is improved and the low-temperature performance of the battery is favorably exerted.

The invention belongs to the technical field of biological medicine, and discloses a mitochondrial targeting fluorescent probe and a preparation method and application thereof.The mitochondrial targeting fluorescent probe has the structural general formula shown in the formula (I), and the preparation method comprises the step that in the presence of a basic catalyst, the mitochondrial targeting fluorescent probe is prepared. And carrying out Knoevenagel condensation reaction on the nitrogen-containing heterocyclic ring onium iodide and 4-(di (2-chloroethyl) amino)-2-fluorobenzaldehyde, thereby obtaining the compound. The mitochondrial targeting fluorescent probe has mitochondrial targeting, fluorescence imaging capability and antitumor activity, can be used for preparation of tumor cell mitochondrial imaging reagents and antitumor drugs, provides a new strategy for tumor diagnosis and treatment, and has a good application prospect.

The invention relates to the technical field of lithium ion batteries, and particularly discloses an electrolyte, a battery, a battery pack and electric equipment. The electrolyte comprises a first additive and a second additive, wherein the first additive comprises a fullerene-containing fluorobenzene solution; the second additive is a boric acid ester film-forming agent, the structural general formula of the boric acid ester film-forming agent is B (OR) 3, and R is an organic group. Therefore, according to the electrolyte, the gas production phenomenon in the battery circulation process is greatly reduced, the battery circulation performance is effectively improved, the circulation life is prolonged, meanwhile, the electrolyte has good adaptability with the ternary-doped lithium iron manganese phosphate battery, the circulation capacity retention rate is high, capacity fading or structural damage cannot be caused, and the service life of the battery is prolonged. On the premise of not sacrificing the core electrical property of the battery, the circulating gas production is reduced, so that the safety performance of the lithium ion battery is remarkably improved, and the key contradiction that the high energy density and the high safety of the lithium battery are difficult to consider is relieved.

This invention relates to a new process for preparing N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2- fluorobenzamide (LOU064) drug substance substantially free of nitrosamine impurities as well as new crystalline forms of salt and solvate of LOU064 used in the process. The invention further relates to pharmaceutical composition comprising N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2- fluorobenzamide, wherein the composition is substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2- methylphenyl)-4-cyclopropyl-2-fluorobenzamide. Pharmaceutical products containing said drug substance and compositions are also disclosed, as well as methods for preparing said drug substance, pharmaceutical compositions and products.

The invention belongs to the technical field of secondary batteries, and particularly relates to a lithium ion secondary battery and electric equipment. The lithium ion secondary battery provided by the invention comprises a positive plate, a negative plate and an electrolyte, the positive plate comprises a positive active material, the positive active material is doped with a sodium element, the mass percentage content of the sodium element is m2% based on the total mass of the positive active material, and 0.001 < = m2 < = 1; the electrolyte comprises a fluorobenzene compound, the mass percentage content of the fluorobenzene compound is m1% based on the total mass of the electrolyte, and m1 is larger than or equal to 2 and smaller than or equal to 30. According to the lithium ion secondary battery provided by the invention, the sodium element is doped in the positive electrode active material, and the fluorobenzene compound is added in the electrolyte, so that the diffusion rate of lithium ions in the positive electrode active material under high voltage can be improved, and the battery has relatively good charge-discharge performance and cycle performance, especially low-temperature and normal-temperature cycle performance.

The present application relates to a plurality of anhydrous crystal forms of N-(3-(6-amino-5-(2-(N-methacrylamido) ethyoxyl) pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide, as well as compositions, methods of preparation and methods of use thereof. These crystalline forms are useful in the treatment of diseases and disorders that are typically ameliorated by inhibition of BTK. Such diseases and disorders may include inflammation and autoimmune disorders as well as lung and respiratory tract inflammation.

The invention discloses a preparation method of a medical intermediate halogenated alkyl fluorobenzene, which comprises the following steps: adding a compound 1 and a halogenating reagent into an organic solvent according to a certain proportion, and reacting under a heating condition to obtain the halogenated alkyl fluorobenzene, the chemical structural formula of the compound 1 is shown in the specification, the halogenating reagent is a mixture of one or more of CBr4 and PBr3, the chemical structural formula of the halogenated alkyl fluorobenzene is shown in the specification, halogenated alkyl fluorobenzene can be prepared with high selectivity, and the yield of halogenated alkyl fluorobenzene can be greatly improved.

The present invention discloses a flavonol aromatic ether light-up type fluorescent probe for detecting hydrogen sulfide and its preparation method and application. The present invention uses 7-(4-(diphenylamino)phenyl)-2-(furan-2-yl)-3-hydroxychromone as raw material, and carries out etherification reaction with 2,4-dinitrofluorobenzene to prepare a flavonol aromatic ether light-up type fluorescent probe. The flavonol aromatic ether light-up type fluorescent probe can react with hydrogen sulfide quickly and exclusively at room temperature. Under 365nm ultraviolet light, the solution fluorescence color changes from colorless to orange-red, the minimum detection limit is 96nM, and the response time is 3min. Therefore, the flavonol aromatic ether light-up type fluorescent probe has good application prospects in detecting hydrogen sulfide.

This application relates to various anhydrous crystalline forms N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide, as well as compositions, method of making and methods of using the same. These crystalline forms are useful in the treatment of diseases and disorders which are typically ameliorated by the inhibition of BTK. Such diseases and disorders may include inflammatory and autoimmune disorders and pulmonary and respiratory tract inflammation.

The invention provides a preparation method of N-(4-(tert-butyl) thiazole-2-yl)-3-fluorobenzamide, which comprises the following steps: mixing a compound as shown in a formula I, N, N-diisopropylethylamine and 2-succinimido-1, 1, 3, 3-tetramethylurea tetrafluoroborate for reaction, then adding a compound as shown in a formula II for amidation reaction, and finally obtaining the N-(4-(tert-butyl) thiazole-2-yl)-3-fluorobenzamide. And reacting the N-(4-(tert-butyl) thiazole-2-yl)-3-fluorobenzamide to obtain the N-(4-(tert-butyl) thiazole-2-yl)-3- According to the preparation method provided by the invention, by innovatively changing the reaction sequence, firstly activating the raw materials and then carrying out amidation reaction, the polarity of by-products is successfully changed, the polarity of main by-products is obviously smaller than that of target products, the products are easy to separate, the column chromatography separation efficiency is greatly improved, the yield is increased, and the post-treatment time is shortened.

This invention discloses a dehydration reactor for fluorobenzene production, relating to the field of chemical production technology. The dehydration reactor for fluorobenzene production includes a dehydration reactor with a support fixedly connected to its outer wall. A sealing plate is hinged to the lower side of the dehydration reactor. An observation window, an air inlet pipe, an exhaust pipe, and a feed pipe are fixedly connected to the side walls of the dehydration reactor, respectively. The observation window is located at the front of the dehydration reactor, the air inlet pipe is located on the middle side wall of the dehydration reactor, and the exhaust pipe and feed pipe are located above the air inlet pipe. The observation window, air inlet pipe, exhaust pipe, and feed pipe all connect the inside and outside of the dehydration reactor. A motor is fixedly connected to the upper side of the dehydration reactor, and a rotating rod is fixedly connected to the lower output end of the motor. This dehydration reactor for fluorobenzene production, by incorporating a feed pipe and a vertically movable scraper, achieves the purpose of scraping downwards the solid dehydrating agent adhering to the inner wall of the dehydration reactor, reducing its residue on the inner wall.

The invention discloses a two-dimensional RP type perovskite single crystal based on p-fluorobenzene methylamine bromide and a preparation method and application thereof, and the preparation method comprises the following steps: preparing a precursor solution, adding chlorobenzene into the precursor solution, heating and stirring until the precursor solution is fully dissolved; placing the precursor solution in a constant-temperature furnace for heat preservation, and then placing the precursor solution in an air dry oven for cooling to room temperature in stages; and volatilizing the precursor solution at room temperature until crystals are completely separated out, taking out the crystals, cleaning and drying. Chlorobenzene is added in the crystal preparation process to serve as an anti-solvent for crystallization, the solubility is reduced, the crystallization rate is delayed, diffusion control growth is achieved, large-size single crystal growth, grain boundary reduction and interface contact optimization are achieved by regulating and controlling crystallization kinetics, and the obtained perovskite material is low in defect state density, low in dark current drift and good in performance. When the material is used for preparing an X-ray detector, a device with higher conversion efficiency and more stable photocurrent response can be obtained.

This invention discloses a high-purity fluorobenzene recovery process in the production of 1,4-bis(4-fluorobenzoyl)benzene, belonging to the field of organic waste liquid recovery technology. Step 1 involves reacting the fluorobenzene waste liquid through a tubular reactor containing anhydrous aluminum chloride particles to obtain dehydrated fluorobenzene waste liquid. The reaction temperature is 5-40℃, the residence time is 60-200 min, and the flow rate of the fluorobenzene waste liquid is 0.1-0.4 m / min. Step 2 involves filtering the dehydrated fluorobenzene waste liquid through a micron filter, then distilling it in a fluorobenzene distillation column. The organic vapor at the top of the column is compressed by a compressor, heat-exchanged by an MVR heat exchanger, condensed, and then refluxed in a reflux tank. High-purity fluorobenzene is obtained from the fluorobenzene distillation column, wherein the fluorobenzene purity is greater than 99.99 wt% and the water content is less than 10 ppm. This invention uses fluorobenzene waste liquid from the production process of 1,4-bis(4-fluorobenzoyl)benzene as raw material. Through reaction dehydration, crystalline aluminum chloride filtration and distillation, it achieves continuous batch production of high-purity fluorobenzene. The process is simple and has low energy consumption.

The invention relates to an application of 5-fluorobenzoxazole-2-mercaptan. The 5-fluorobenzoxazole-2-mercaptan is applied to a passivating agent of a perovskite layer in a perovskite solar cell. When the 5-fluorobenzoxazole-2-mercaptan provided by the invention is applied to a battery, the effects of improving the stability of molecules, forming firm chemical bonds with a perovskite layer and optimizing interface energy level matching can be achieved at the same time, and the electron or hole transmission capacity of an interface is improved, so that the surface defects of the perovskite layer can be effectively reduced and filled, and the performance of the battery is improved. And the defect density of the perovskite layer is reduced. According to the single-molecule design, the problem of mixing uniformity possibly existing when multiple small molecules are used in a composite mode is reduced, the problem of inconsistent performance of interface layers is avoided, meanwhile, the preparation technology is simplified, operation complexity and cost are reduced, and repeatability and industrial feasibility are improved.

The utility model discloses a fluorobenzene continuous rectification device which comprises a fluorobenzene raw material tank, a light component removal tower and a refining tower, wherein the fluorobenzene raw material tank is connected with a feed port of the light component removal tower through a fluorobenzene raw material conveying pipeline, a discharge end at the bottom of the light component removal tower is connected with a feed port of the refining tower, a fluorobenzene discharge end is arranged on one side of the upper part of a tower body of the refining tower, and the fluorobenzene discharge end is connected with the fluorobenzene product tank; according to the utility model, the on-line continuous rectification treatment of the fluorobenzene crude product is realized, the rectification time of the fluorobenzene crude product is obviously shortened, the energy consumption of the fluorobenzene production device is reduced, the requirements of increasing the yield of the fluorobenzene finished product and optimizing the energy consumption are met, and the device is very suitable for industrial scale application.