66 results about "Fluorobenzenes" patented technology

The invention discloses injectable hydrogel for alveolar bone repair, the injectable hydrogel comprises a first component and a second component, the first component comprises 4-carboxyl-3-fluorophenylboronic acid modified carboxymethyl chitosan CMCS-FPBA and beta-tricalcium phosphate, and the second component comprises oxidized dextran, PPS-HA nano-micelle and curcumin. The invention also discloses a preparation method and application of the injectable hydrogel. The injectable hydrogel disclosed by the invention has the effects of resisting oxidation, resisting inflammation and promoting bone tissue regeneration, is high in biocompatibility, can be customized in a personalized manner, and can be used for repairing alveolar bones.

The invention discloses a low-dielectric polyimide film based on a fluorine-containing triphenylmethane unit as well as a preparation method and application of the low-dielectric polyimide film, and the low-dielectric polyimide film is a novel polyimide material FPOPF-6FDA obtained by polymerizing a fluorine-containing triaryl methane diamine monomer and 4, 4 '-(hexafluoroisopropenyl) diphthalic anhydride. The fluorine-containing triarylmethane diamine monomer is preferably 4, 5-diphenyl-1, 3, 5-triazine. According to the invention, 4, 4 '-((4-fluoro-3-phenoxy phenyl) methylene)) bis (2-fluoroaniline) is used, specifically, 4, 4'-diaminotriphenylmethane is used as a functional core, a fluorine-containing group and a large-volume side chain group are introduced, and non-coplanar twisted conformation destroys close packing of molecular chains and increases the chain spacing, so that the effect of a charge transfer complex (CTC) is weakened, and the photoelectric conversion efficiency is improved. And the heat resistance and optical transparency of polyimide are maintained while the dielectric constant of the material is reduced.

The invention provides an electrolyte, a lithium iron manganese phosphate battery and an electric device. The electrolyte comprises a lithium salt and a solvent, the solvent comprises ethylene carbonate, propylene carbonate, ethyl methyl carbonate, fluorobenzene and a low-viscosity solvent in a volume ratio of (2-5): (2-5): (3-5): (3-5): (2-5). The high dielectric constants of ethylene carbonate and propylene carbonate improve the dissolving capacity of the electrolyte to lithium salt, and meanwhile, the molecular structure can form a stable interface layer on the surface of a positive electrode to inhibit migration and dissolution of manganese ions; due to the low viscosity characteristic of the low-viscosity solvent, the overall viscosity of the electrolyte is reduced, and the permeability of the porous positive electrode material is enhanced, so that the wettability is improved, and uniform de-intercalation of lithium ions is promoted; a physical adsorption protection layer can be formed on the surface of the positive electrode through the coordination effect of high-electronegativity fluorine atoms in fluorobenzene and manganese, and direct contact between manganese and electrolyte is further blocked.

The invention discloses a high-flux interface modification method of an oxide-based all-solid-state battery and a lithium ion battery, and belongs to the technical field of solid-state lithium ion batteries. The method comprises the following steps: mixing LTFSI, PVDF-HFP, m-fluorobenzamide and LLZO powder, and adding dimethylformamide to obtain a mixed raw material; adding an organic wet grinding solvent into the mixed raw material, and carrying out ball milling to obtain interface modification slurry; and coating one side of an LLZO electrolyte sheet with the interface modification slurry, and drying to complete interface modification. According to the interface modification method disclosed by the invention, the solid electrolyte has a lithium-loving property, can be in good contact with a metal lithium negative electrode, and can generate LiFamp through an in-situ reaction; and Li3N fills up interface defects and pores, and meanwhile, lithium dendrite growth and electron permeation can be inhibited, so that the interface structure of the obtained modified layer is stable. In addition, the lithium ion conductivity at the interface is further improved, the lithium ion flux at the interface is enhanced, the cycle life of the lithium battery is prolonged, and the preparation method is simple and suitable for industrial large-scale production.

The invention discloses a lithium iron phosphate battery as well as a preparation method and application thereof. In the lithium iron phosphate battery, a positive pole piece comprises a lithium iron phosphate positive active material layer and a polyimide ceramic coating arranged at the edge of a positive current collector, and the edge of the tab side of a negative pole piece is completely covered by a negative active material without exposing a blank current collector; the edge of the polyimide ceramic coating on the tab side of the positive pole piece and the edge of the tab side of the negative pole piece are coated in a staggered manner; the diaphragm comprises a base membrane, a meta-aramid ceramic coating and a water-based polyvinylidene fluoride coating, additives in the electrolyte comprise fluorobenzene, biphenyl and a third additive, and the third additive is lithium difluorophosphate and / or lithium difluoroborate. By means of the design, it is guaranteed that the battery cell passes through an overcharge thermal runaway test in the national standard GB38032, the battery cell does not catch fire or explode in the overcharge process, and the overcharge thermal runaway time meets 12 min.

A method for treating pruritus in patients with atopic dermatitis (AD) and / or nodular prurigo (PN) is disclosed, comprising administering a therapeutically effective amount of at least one compound selected from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-carbonyl]-4-methyl-4-[4-(oxecyclobutane-3-yl)piperazin-1-yl]pent-2-enonitrile (rezabrutinib) and pharmaceutically acceptable salts thereof.

The invention relates to the technical field of lithium ion batteries, and particularly discloses an electrolyte, a battery, a battery pack and electric equipment. The electrolyte comprises a first additive and a second additive, wherein the first additive comprises a fullerene-containing fluorobenzene solution; the second additive is a boric acid ester film-forming agent, the structural general formula of the boric acid ester film-forming agent is B (OR) 3, and R is an organic group. Therefore, according to the electrolyte, the gas production phenomenon in the battery circulation process is greatly reduced, the battery circulation performance is effectively improved, the circulation life is prolonged, meanwhile, the electrolyte has good adaptability with the ternary-doped lithium iron manganese phosphate battery, the circulation capacity retention rate is high, capacity fading or structural damage cannot be caused, and the service life of the battery is prolonged. On the premise of not sacrificing the core electrical property of the battery, the circulating gas production is reduced, so that the safety performance of the lithium ion battery is remarkably improved, and the key contradiction that the high energy density and the high safety of the lithium battery are difficult to consider is relieved.

The present application relates to a plurality of anhydrous crystal forms of N-(3-(6-amino-5-(2-(N-methacrylamido) ethyoxyl) pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide, as well as compositions, methods of preparation and methods of use thereof. These crystalline forms are useful in the treatment of diseases and disorders that are typically ameliorated by inhibition of BTK. Such diseases and disorders may include inflammation and autoimmune disorders as well as lung and respiratory tract inflammation.

The invention discloses a preparation method of a medical intermediate halogenated alkyl fluorobenzene, which comprises the following steps: adding a compound 1 and a halogenating reagent into an organic solvent according to a certain proportion, and reacting under a heating condition to obtain the halogenated alkyl fluorobenzene, the chemical structural formula of the compound 1 is shown in the specification, the halogenating reagent is a mixture of one or more of CBr4 and PBr3, the chemical structural formula of the halogenated alkyl fluorobenzene is shown in the specification, halogenated alkyl fluorobenzene can be prepared with high selectivity, and the yield of halogenated alkyl fluorobenzene can be greatly improved.

The invention provides a preparation method of N-(4-(tert-butyl) thiazole-2-yl)-3-fluorobenzamide, which comprises the following steps: mixing a compound as shown in a formula I, N, N-diisopropylethylamine and 2-succinimido-1, 1, 3, 3-tetramethylurea tetrafluoroborate for reaction, then adding a compound as shown in a formula II for amidation reaction, and finally obtaining the N-(4-(tert-butyl) thiazole-2-yl)-3-fluorobenzamide. And reacting the N-(4-(tert-butyl) thiazole-2-yl)-3-fluorobenzamide to obtain the N-(4-(tert-butyl) thiazole-2-yl)-3- According to the preparation method provided by the invention, by innovatively changing the reaction sequence, firstly activating the raw materials and then carrying out amidation reaction, the polarity of by-products is successfully changed, the polarity of main by-products is obviously smaller than that of target products, the products are easy to separate, the column chromatography separation efficiency is greatly improved, the yield is increased, and the post-treatment time is shortened.

This invention discloses a dehydration reactor for fluorobenzene production, relating to the field of chemical production technology. The dehydration reactor for fluorobenzene production includes a dehydration reactor with a support fixedly connected to its outer wall. A sealing plate is hinged to the lower side of the dehydration reactor. An observation window, an air inlet pipe, an exhaust pipe, and a feed pipe are fixedly connected to the side walls of the dehydration reactor, respectively. The observation window is located at the front of the dehydration reactor, the air inlet pipe is located on the middle side wall of the dehydration reactor, and the exhaust pipe and feed pipe are located above the air inlet pipe. The observation window, air inlet pipe, exhaust pipe, and feed pipe all connect the inside and outside of the dehydration reactor. A motor is fixedly connected to the upper side of the dehydration reactor, and a rotating rod is fixedly connected to the lower output end of the motor. This dehydration reactor for fluorobenzene production, by incorporating a feed pipe and a vertically movable scraper, achieves the purpose of scraping downwards the solid dehydrating agent adhering to the inner wall of the dehydration reactor, reducing its residue on the inner wall.

This invention discloses a high-purity fluorobenzene recovery process in the production of 1,4-bis(4-fluorobenzoyl)benzene, belonging to the field of organic waste liquid recovery technology. Step 1 involves reacting the fluorobenzene waste liquid through a tubular reactor containing anhydrous aluminum chloride particles to obtain dehydrated fluorobenzene waste liquid. The reaction temperature is 5-40℃, the residence time is 60-200 min, and the flow rate of the fluorobenzene waste liquid is 0.1-0.4 m / min. Step 2 involves filtering the dehydrated fluorobenzene waste liquid through a micron filter, then distilling it in a fluorobenzene distillation column. The organic vapor at the top of the column is compressed by a compressor, heat-exchanged by an MVR heat exchanger, condensed, and then refluxed in a reflux tank. High-purity fluorobenzene is obtained from the fluorobenzene distillation column, wherein the fluorobenzene purity is greater than 99.99 wt% and the water content is less than 10 ppm. This invention uses fluorobenzene waste liquid from the production process of 1,4-bis(4-fluorobenzoyl)benzene as raw material. Through reaction dehydration, crystalline aluminum chloride filtration and distillation, it achieves continuous batch production of high-purity fluorobenzene. The process is simple and has low energy consumption.

The present application relates to the field of fluorobenzene synthesis production, and discloses a fluorobenzene continuous preparation method with solvent closed loop circulation, comprising: S1. mixing aniline with an organic solvent to obtain an aniline solution, feeding anhydrous hydrogen fluoride and the aniline solution into a fluorination reactor respectively to carry out fluorination reaction to obtain a fluorination intermediate product; S2. mixing sodium nitrite with an organic solvent to obtain a sodium nitrite suspension, feeding the fluorination intermediate product and the sodium nitrite suspension into a diazotization reactor respectively to carry out continuous diazotization reaction to obtain a diazonium salt product; S3. carrying out fractional continuous pyrolysis on the diazonium salt product to obtain a pyrolysis product; S4. carrying out liquid-liquid phase separation on the pyrolysis product, feeding the organic phase into a solvent recovery device to establish a solvent circulation pipeline; and carrying out rectification and purification on the kettle bottom material to obtain a fluorobenzene product; the present application introduces a special organic solvent to participate in auxiliary reaction, obviously optimizes material compatibility and heat exchange performance, fundamentally reduces byproduct generation, and significantly improves the yield and quality of the fluorobenzene product.

The invention discloses an SERS (Surface Enhanced Raman Scattering) probe regulated and controlled by an isomeride and application of the SERS probe in detection of various pathogens, and belongs to the technical field of biological detection. According to the invention, p-methoxybenzenethiol, m-methoxybenzenethiol, o-methoxybenzenethiol, p-fluorobenzenethiol, m-fluorobenzenethiol and o-fluorobenzenethiol with different Raman characteristic peaks are used as Raman report molecules, so that the Raman characteristic peaks can be prevented from overlapping; when six groups of probes (a p-methoxybenzenethiol probe, an m-methoxybenzenethiol probe, an o-methoxybenzenethiol probe, a p-fluorobenzenethiol probe, an m-fluorobenzenethiol probe and an o-fluorobenzenethiol probe) are respectively modified and mixed with pathogen antibodies, the obtained SERS probe can be used for synchronously detecting various pathogens; meanwhile, the enhancement effect of the Raman reporter molecule is good, so that multiple pathogens can be conveniently, synchronously, quickly and accurately detected; therefore, the method has a good application prospect.

Disclosed herein are methods for treating pemphigus in a human patient in need thereof comprising administering to the human patient a dose of at least 400 mg of (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (PRN1008) once a day (QD) or twice a day (BID).

The utility model discloses a kind of fluorobenzene hot reaction tail gas innocuous treatment device, comprising: the upper side of the pretreatment box is provided with liquid inlet pipe, and the front side of pretreatment box is provided with liquid outlet pipe.The fluorobenzene hot reaction tail gas innocuous treatment device, hollow column rotation can let periodic contact with the side of serpentine conveying pipe by knocking ball, to facilitate the dust adsorbed in serpentine conveying pipe to fall off, facilitate the heat in the tail gas conveyed in serpentine conveying pipe to be transferred to the liquid in pretreatment box by serpentine conveying pipe, facilitate the tail gas to be cooled and handled, when connecting column is contacted with serpentine conveying pipe by knocking ball, knocking ball will make connecting column slide in hollow column, spring will be elastically deformed at this time, not only can dust removal but also can prevent damage serpentine conveying pipe, separation grating can divide the interior of adsorption box into two parts, can increase the contact area of tail gas and activated carbon particles, to can enhance tail gas absorption treatment effect.

This invention discloses a push-pull type silicon-containing asymmetric Michaelis base derivative heptamethrin chromophore compound, composite material, thin film, and optoelectronic integrated device. The chromophore compound uses a silicon-modified asymmetric Michaelis base derivative as the π-electron donor, six-membered rings modified with different groups as conjugated bridges, and a fluorophenylmethyl-substituted tricyanofuran (TCF) derivative as the π-electron acceptor. The chromophore doping concentration is increased by adjusting the asymmetry of the electron donor. When p-fluorobenzene-substituted tricyanofuran (FP-TCF) is used as the π-electron acceptor and the side chain is modified with diphenyloxazolyl thio, the electro-optic coefficient is the highest. At a working wavelength of 1304 nm, M3FPPhON exhibits the optimal electro-optic coefficient at a number concentration of 1.6 × 10⁻⁶. 20 mL ‑1 At that time, the electro-optic coefficient was 135.6 pm / V.

A lithium ion battery electrolyte with improved wettability and a lithium ion battery is disclosed. The electrolyte includes 10% to 17% of lithium salt, 1.8% to 3.7% of film-forming additive, 0.5% to 10% of wetting additive with the balance being solvent. The wetting additive is fluorobenzene and a silanyl fluorobenzene compound, with a mass fraction of fluorobenzene in the electrolyte being at least 3% and a mass fraction of the silanyl fluorobenzene compound being not less than 1%. Two types of silanyl fluorobenzene compounds provided are mainly composed of silanyl groups which absorb HF and reduce surface tension and fluorophenyl groups which reduce surface tension. By using the silanyl fluorobenzene compounds together with fluorobenzene, a problem of performance deviation caused by generation of HF by fluorobenzene at high temperature can be solved, and wettability of the electrolyte can also be provided.

The invention discloses a preparation method of 3-amino-2-fluorobenzoyl halide (formula V), the method comprises two routes: a route I or a route II, and R, R1 and R2 are defined in the specification.

The invention discloses a pressure-resistant and high-temperature-resistant PE electric power pipe and a preparation method thereof, belongs to the technical field of electric power pipe preparation, and aims to solve the technical problem that the pressure resistance and high-temperature resistance of a PE electric power pipe need to be further improved in the prior art. Functional materials such as modified polyethylene particles, titanium oxide-boron oxide bridging powder and fluorobenzoxazine microgel are adopted, the pipe has excellent mechanical performance, high temperature resistance and electric insulation performance through a precise technological process, the ring stiffness and tensile strength of the pipe are enhanced through a cross-linked structure of modified polyethylene, and the pipe has the good mechanical performance, high temperature resistance and electric insulation performance. A titanium oxide-boron oxide bridging structure improves the creep resistance and the thermal stability of the material, and fluorobenzoxazine microgel effectively improves the electrical insulation performance and the oxidation resistance.

The present application provides a kind of nylon nucleating agent, including 50-65 parts by weight of polycarbonate and 35-50 parts by weight of fulvic acid modified peanut shell powder;Raw materials for preparing the polycarbonate include bisphenol A, 4-fluoro-3-hydroxybenzyl alcohol and 2-hydroxy-4-fluorobenzyl alcohol, and the molar ratio of the bisphenol A, 4-fluoro-3-hydroxybenzyl alcohol and 2-hydroxy-4-fluorobenzyl alcohol is (0.8-1.2):(0.15-0.35):(0.15-0.35). The present application also provides a modified nylon resin comprising the nylon nucleating agent. The modified nylon resin has high flexural modulus, good aging resistance, and low flexural modulus reduction rate after aging.

This invention relates to a new process for preparing N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2- fluorobenzamide (LOU064) drug substance substantially free of nitrosamine impurities as well as new crystalline forms of salt and solvate of LOU064 used in the process. The invention further relates to pharmaceutical composition comprising N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2- fluorobenzamide, wherein the composition is substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2- methylphenyl)-4-cyclopropyl-2-fluorobenzamide. Pharmaceutical products containing said drug substance and compositions are also disclosed, as well as methods for preparing said drug substance, pharmaceutical compositions and products. Formula (I)

Methods for treating children, adolescents and adults with persistent or chronic immune thrombocytopenia comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The invention provides an electrolyte, a preparation method thereof and a battery. The electrolyte comprises a phosphate flame retardant, a cosolvent, a high-donor-number solvent and salt, the cosolvent comprises at least one of a fluorobenzene compound, a fluoroether compound or a nitrile compound, the donor number of the high-donor-number solvent is larger than or equal to 8 kcal / mol, and the salt is sodium salt or lithium salt. The phosphate flame retardant is added, so that the safety of the battery can be improved; a cosolvent which is weakly coordinated with metal cations in salt is introduced into an electrolyte, the cosolvent and a phosphate flame retardant generate dipole-dipole interaction with the phosphate flame retardant due to low polarity and strong dipole moment, a phosphate flame retardant solvent can be pulled outwards, the binding energy between the phosphate flame retardant and the metal cations is weakened, a desolvation energy barrier is reduced, and the desolvation performance of the phosphate flame retardant is improved. The rate capability of the battery is improved; the anions in the high-donor-number solvent and the salt are preferentially coordinated with the metal cations, so that the coordination ratio of the phosphate to the metal cations can be reduced, and the rate capability of the battery can be improved.

The application discloses a fluorobenzene synthesis tail gas nitrogen oxide resource recycling system, which comprises a synthesis reaction kettle, wherein the upper opening of the synthesis reaction kettle is sequentially connected with a kettle cover, a deep cooling heat exchanger, a deep cooling tail gas heat exchanger and an activated carbon adsorption tower, and the activated carbon adsorption tower is connected with an exhaust tail gas pipeline through an air draught fan / return cooling fan. The system is simple, clean, environmentally friendly, stable, efficient and high in nitrogen oxide recycling efficiency.

The invention discloses a preparation method of a light-induced acid generator (4-(cyclohexyl sulfonyl) phenyl) diphenyl sulfonium and bis-trifluoroethoxy bicycloheptane-2-sulfonate) for photoresist. The preparation method is used for synthesizing the light-induced acid generator (4-(cyclohexyl sulfonyl) phenyl) diphenyl sulfonium and bis-trifluoroethoxy bicycloheptane-2-sulfonate). The invention further discloses a preparation method of the light-induced acid generator (4-(cyclohexyl sulfonyl) phenyl) diphenyl sulfonium and bis-trifluoroethoxy bicycloheptane-2-sulfonate). According to the synthesis process, fluorobenzene is used as a reaction raw material, so that the operation procedure is simplified, the product quality is improved, the production cost is reduced, and the market competitiveness is improved; the use of highly toxic raw materials is avoided, the environmental pollution is reduced, and the method is an economical and environment-friendly synthesis process route; the synthesis process is mature in route technology, low in investment and simple in flow, the production process is simplified, potential safety hazards are reduced, and production safety can be ensured.

The present application relates to a kind of slow-release type slump retaining materials and its preparation method, a kind of slow-release type slump retaining materials, it is characterized in that, the preparation raw material of the slow-release type slump retaining material includes: first polyether macromonomer 60~100 parts;Unsaturated carboxylic acid (anhydride) 2~16 parts;Unsaturated phosphonate 0.5~5.0 parts;Unsaturated carboxylic acid ester 15~35 parts;Second polyether macromonomer 100 parts;Initiator 1~5 parts;Molecular weight regulator 0.5~3.2 parts;The present application selects allylamine as initiator to prepare first polyether macromonomer, and using fluorobenzene oxy group epoxy alkane to end cap polyether monomer, the first polyether macromonomer prepared, when participating in copolymerization, first polyether macromonomer molecule adsorbs in cement particle surface layer, can increase the thickness of water film layer between particles, improve the water retention of concrete, the effect of thickening pulp is remarkable, the pulp rate of concrete is slowed down, and the slump performance of concrete is improved simultaneously.

The invention belongs to the technical field of battery preparation, and particularly relates to a battery. The battery comprises a negative pole piece, a diaphragm and an electrolyte, the negative pole piece comprises a negative active material layer, the negative active material layer comprises a negative active material, the negative active material comprises a silicon-based material, and the mass content of the silicon-based material in the negative active material is 5-40%; the battery charging cut-off voltage is greater than or equal to 4.5 V; a temperature-resistance curve of the diaphragm meets a relational expression 1; the electrolyte comprises fluorobenzene, and the mass content of the fluorobenzene in the electrolyte is marked as A%; a plurality of grooves are formed in the surface of the negative electrode active material layer, and the total area proportion of the projections of the grooves on the surface of the negative electrode active material layer is recorded as B% in terms of 100% of the area of the negative electrode active material layer; a and B meet a relational expression 2. The diaphragm meets the relational expression 1, the negative electrode and the electrolyte meet the relational expression 2, the wettability and oxidation resistance of the diaphragm are improved on the basis of improving the heavy object impact passing rate, and the cycle performance of the battery cell is improved.

The present application relates to a plurality of anhydrous crystal forms of N-(3-(6-amino-5-(2-(N-methacrylamido) ethyoxyl) pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide, as well as compositions, methods of preparation and methods of use thereof. These crystalline forms are useful in the treatment of diseases and disorders that are typically ameliorated by inhibition of BTK. Such diseases and disorders may include inflammation and autoimmune disorders as well as lung and respiratory tract inflammation.