149 results about "Fluorobenzenes" patented technology

Disclosed herein are novel methods for preparing 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile, including various solvate forms and intermediates thereof. Also disclosed herein are novel solvate forms and intermediates of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile.

The invention discloses a method for continuously producing fluorobenzene, which comprises the following steps: S10) mixing anhydrous hydrogen fluoride and aniline in a tubular reactor to obtain an aniline hydrofluoride mixture; s20) introducing the aniline hydrofluoride mixture into a venturi tube reactor in an inert gas atmosphere, sucking powdered and dried sodium nitrite into the venturi tube reactor in a negative pressure environment formed by the venturi tube reactor, and carrying out a synthetic reaction to obtain a diazonium solution; s30) transferring the diazonium solution into a tubular reactor for pyrolytic reaction to obtain a crude fluorobenzene solution; s40) refining the crude fluorobenzene raw material to obtain fluorobenzene; according to the method disclosed by the invention, the crossing from an intermittent artificial kettle reaction to a continuous reaction is realized, the reaction is sufficient and complete, no 70% hydrofluoric acid mother liquor, no 70% sulfuric acid waste liquor, no high-concentration wastewater and no yellow mud solid waste are produced, a high-quality fluorobenzene product can be continuously prepared in a large batch, and the method has good economic and environmental benefits and a wide market application prospect.

Methods for treating children, adolescents and adults with persistent or chronic immune thrombocytopenia comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

Methods for treating itch in human patients with atopic dermatitis (AD) and / or prurigo nodularis (PN) comprising administering a therapeutically effective amount of at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3- yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The invention discloses injectable hydrogel for alveolar bone repair, the injectable hydrogel comprises a first component and a second component, the first component comprises 4-carboxyl-3-fluorophenylboronic acid modified carboxymethyl chitosan CMCS-FPBA and beta-tricalcium phosphate, and the second component comprises oxidized dextran, PPS-HA nano-micelle and curcumin. The invention also discloses a preparation method and application of the injectable hydrogel. The injectable hydrogel disclosed by the invention has the effects of resisting oxidation, resisting inflammation and promoting bone tissue regeneration, is high in biocompatibility, can be customized in a personalized manner, and can be used for repairing alveolar bones.

This invention relates to N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide drug substance substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide and novel processes of preparation thereof. The invention further relates to pharmaceutical composition comprising N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide, wherein the composition is substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide. Pharmaceutical products containing said drug substance and compositions are also disclosed, as well as methods for preparing said drug substance, pharmaceutical compositions and products.

The invention relates to the technical field of glass fiber reinforced plastics, and discloses a corrosion-resistant composite glass fiber reinforced plastic and a preparation method thereof. The preparation method comprises the following steps: carrying out Mannich reaction, reduction reaction and addition reaction on 2, 4 ', 4'-methylene triphenol, 5-aminoisophthalonitrile, formaldehyde, RaneyNi, 3-isocyanatopropyltriethoxysilane and the like which serve as raw materials to obtain benzoxazine polysilane, carrying out surface modification on basalt fibers and carbon fibers by using the benzoxazine polysilane to obtain modified hybrid fibers, and carrying out surface modification on the basalt fibers and the carbon fibers by using the modified hybrid fibers. P-fluorobenzaldehyde and aminopropyltriethoxysilane are used as raw materials, fluorine-containing silane is obtained through a Schiff base reaction, the fluorine-containing silane and hydroxyl on the surface of graphene oxide are subjected to a hydrolytic condensation reaction, fluorine-containing modified graphene oxide is obtained, finally, a curing agent, the modified hybrid fibers and the fluorine-containing modified graphene oxide are added into epoxy resin to be stirred and mixed to be uniform, curing is conducted, and the modified hybrid fibers are obtained. The corrosion-resistant composite glass fiber reinforced plastic is obtained. The composite glass fiber reinforced plastic prepared by the invention has excellent corrosion resistance, heat resistance and mechanical properties.

The invention discloses a continuous synthesis coordinated temperature control integrated method of fluorobenzene. The method comprises the following steps: carrying out salt-forming exothermic reaction on hydrogen fluoride liquid and aniline liquid in a salt-forming tubular reactor to obtain aniline hydrofluoride; carrying out diazotization exothermic reaction on aniline hydrofluoride and sodium nitrite solid in a diazotization tubular reactor to obtain diazonium salt; performing multi-stage pyrolysis exothermic reaction on the diazonium salt in a multi-stage temperature control tubular reactor to obtain pyrolysis liquid; performing liquid-liquid centrifugal separation on the pyrolysis liquid to continuously obtain a fluorobenzene product; thermal coupling heat exchange channels are respectively arranged among a sodium nitrite solid feeding pipeline, a diazonium salt feeding pipeline, an aniline hydrofluoride feeding pipeline, a diazotization tubular reactor, a hydrogen fluoride liquid feeding pipeline, liquid-liquid centrifugal separation equipment, an aniline liquid feeding pipeline, a salifying tubular reactor and a multi-stage temperature control tubular reactor, so that heat transfer temperature control is realized; according to the invention, continuous synthesis of fluorobenzene and temperature control integrated control are realized, and batch continuous stable production of fluorobenzene is further promoted.

Disclosed herein are novel methods for preparing 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile, including various solvate forms and intermediates thereof. Also disclosed herein are novel solvate forms and intermediates of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile.

The invention relates to the technical field of batteries, in particular to a lithium ion secondary battery. Comprising a positive electrode plate, a negative electrode plate and an electrolyte, the positive electrode plate comprises lithium cobalt oxide, the negative electrode plate comprises a silicon-based material, the electrolyte comprises a fluorosulfonamide compound, a nitrile compound and a first solvent, the first solvent comprises at least one of fluoroether, fluorobenzene and acetic acid 2, 2-difluoroethyl ester, and by taking the total mass of the electrolyte as a standard, the total mass of the lithium cobalt oxide and the total mass of the nitrile compound are equal to or smaller than 1. The content c1 of the fluorosulfonamide compound and the content c2 of the nitrile compound meet the following condition: 0.1 < = c1 / c2 < = 30; and the charging cut-off voltage of the lithium ion battery is greater than or equal to 4.48 V. The lithium ion secondary battery disclosed by the invention has relatively high energy density, relatively good cycle performance, excellent high-temperature storage performance and relatively good low-temperature performance.

The invention discloses a preparation method of 3-amino-2-fluorobenzoyl halide (formula V). The method comprises two routes: a route I and # imgabs 0 # or a route II and # imgabs 1 #, wherein R, R1 and R2 are defined in the specification.

The invention belongs to the technical field of wastewater treatment, and discloses a fluorobenzene production wastewater treatment device which comprises a device body, supporting legs are symmetrically mounted at the lower end of the device body, a water outlet pipe is connected to the lower end of the left side of the device body, a water inlet pipe is arranged at the upper end of the device body, and a first flow guide pipe is connected to the lower end of the water inlet pipe; the upper end of the right side of the device body is connected with a waste gas filtering pipe, the upper end of the left side of the device body is connected with a discharging hopper, the interior of the discharging hopper is connected with a transmission rod, the exterior of the transmission rod is connected with a grinding roller, and the transmission rod is arranged in the device body. According to the wastewater treatment device for fluorobenzene production, by arranging a stirring linkage medicament grinding structure, a medicament can be ground and crushed, the particle size of the medicament is reduced, the powdery medicament can be dissolved in wastewater more quickly, and the mixing efficiency and the wastewater purification efficiency are improved.

The invention discloses a low-dielectric polyimide film based on a fluorine-containing triphenylmethane unit as well as a preparation method and application of the low-dielectric polyimide film, and the low-dielectric polyimide film is a novel polyimide material FPOPF-6FDA obtained by polymerizing a fluorine-containing triaryl methane diamine monomer and 4, 4 '-(hexafluoroisopropenyl) diphthalic anhydride. The fluorine-containing triarylmethane diamine monomer is preferably 4, 5-diphenyl-1, 3, 5-triazine. According to the invention, 4, 4 '-((4-fluoro-3-phenoxy phenyl) methylene)) bis (2-fluoroaniline) is used, specifically, 4, 4'-diaminotriphenylmethane is used as a functional core, a fluorine-containing group and a large-volume side chain group are introduced, and non-coplanar twisted conformation destroys close packing of molecular chains and increases the chain spacing, so that the effect of a charge transfer complex (CTC) is weakened, and the photoelectric conversion efficiency is improved. And the heat resistance and optical transparency of polyimide are maintained while the dielectric constant of the material is reduced.

The invention relates to a synthesis method of an N-aryl amide compound. The invention relates to a photo-induced metal catalytic synthesis method of N-aryl amide, which is characterized in that aryl amide and aryl halide are taken as raw materials, and N-aryl amide is synthesized through single electron transfer under the illumination condition: the aryl amide, the aryl halide, an iridium metal complex catalyst and alkali are taken and added into a reaction container; adding a solvent into a reaction container, fully dissolving, and then carrying out a synthetic reaction under the conditions of illumination and nitrogen protection; and after the reaction is finished, taking out a final product, and carrying out column chromatography separation to obtain the N-aryl amide. According to the N-aryl amide photoinduced metal catalytic synthesis method, the difficulty of coupling of chlorobenzene, fluorobenzene and aryl amide is reduced, the problem that chlorobenzene and fluorobenzene are difficult to react due to high bond energy is solved, the reaction of electron transfer from weak electron donor amide to fluorobenzene and chlorobenzene is realized, and the reaction yield is improved.

The invention provides an electrolyte, a lithium iron manganese phosphate battery and an electric device. The electrolyte comprises a lithium salt and a solvent, the solvent comprises ethylene carbonate, propylene carbonate, ethyl methyl carbonate, fluorobenzene and a low-viscosity solvent in a volume ratio of (2-5): (2-5): (3-5): (3-5): (2-5). The high dielectric constants of ethylene carbonate and propylene carbonate improve the dissolving capacity of the electrolyte to lithium salt, and meanwhile, the molecular structure can form a stable interface layer on the surface of a positive electrode to inhibit migration and dissolution of manganese ions; due to the low viscosity characteristic of the low-viscosity solvent, the overall viscosity of the electrolyte is reduced, and the permeability of the porous positive electrode material is enhanced, so that the wettability is improved, and uniform de-intercalation of lithium ions is promoted; a physical adsorption protection layer can be formed on the surface of the positive electrode through the coordination effect of high-electronegativity fluorine atoms in fluorobenzene and manganese, and direct contact between manganese and electrolyte is further blocked.

The invention discloses a high-flux interface modification method of an oxide-based all-solid-state battery and a lithium ion battery, and belongs to the technical field of solid-state lithium ion batteries. The method comprises the following steps: mixing LTFSI, PVDF-HFP, m-fluorobenzamide and LLZO powder, and adding dimethylformamide to obtain a mixed raw material; adding an organic wet grinding solvent into the mixed raw material, and carrying out ball milling to obtain interface modification slurry; and coating one side of an LLZO electrolyte sheet with the interface modification slurry, and drying to complete interface modification. According to the interface modification method disclosed by the invention, the solid electrolyte has a lithium-loving property, can be in good contact with a metal lithium negative electrode, and can generate LiFamp through an in-situ reaction; and Li3N fills up interface defects and pores, and meanwhile, lithium dendrite growth and electron permeation can be inhibited, so that the interface structure of the obtained modified layer is stable. In addition, the lithium ion conductivity at the interface is further improved, the lithium ion flux at the interface is enhanced, the cycle life of the lithium battery is prolonged, and the preparation method is simple and suitable for industrial large-scale production.

The invention discloses a lithium iron phosphate battery as well as a preparation method and application thereof. In the lithium iron phosphate battery, a positive pole piece comprises a lithium iron phosphate positive active material layer and a polyimide ceramic coating arranged at the edge of a positive current collector, and the edge of the tab side of a negative pole piece is completely covered by a negative active material without exposing a blank current collector; the edge of the polyimide ceramic coating on the tab side of the positive pole piece and the edge of the tab side of the negative pole piece are coated in a staggered manner; the diaphragm comprises a base membrane, a meta-aramid ceramic coating and a water-based polyvinylidene fluoride coating, additives in the electrolyte comprise fluorobenzene, biphenyl and a third additive, and the third additive is lithium difluorophosphate and / or lithium difluoroborate. By means of the design, it is guaranteed that the battery cell passes through an overcharge thermal runaway test in the national standard GB38032, the battery cell does not catch fire or explode in the overcharge process, and the overcharge thermal runaway time meets 12 min.

The invention relates to the field of compound preparation, and discloses a method for preparing carboxylic acid aryl ester through in-situ oxyarylation of aryl halide and carboxylic acid under the catalysis of light-induced iron, which comprises the following steps: by taking aryl halide and carboxylate as raw materials, iron metal salt as a catalyst and nonmetal Lewis acid as an additive, carrying out light illumination in an inert gas atmosphere, and carrying out in-situ oxyarylation on aryl halide and carboxylic acid to obtain the carboxylic acid aryl ester. And reacting in an organic solvent according to a reaction formula to obtain the carboxylic acid aryl ester compound as shown in the formula III. According to the method, the problem of high bond energy of a C-F bond in aryl fluoride is overcome by innovatively utilizing a system formed by photo-activated iron catalysis-nonmetal Lewis acid, efficient coupling of fluorobenzene and aryl halide containing electron donating / withdrawing substituents and inorganic carboxylate is realized, the range of aryl halide substrates is widened, reaction conditions are mild, strong acid and strong base are not needed, and the method is suitable for industrial production. And precious metal is replaced by a cheap iron catalyst. The invention provides an efficient and environment-friendly new way for green synthesis of the ester-based aromatic compounds, and has a remarkable industrial application prospect.

The invention discloses a light-emitting diode based on boron-nitrogen-fluorine co-doped carbon dots and a preparation method thereof, and belongs to the technical field of luminescent materials, specifically, 4-fluorophenylboronic acid is used as a first precursor, m-phenylenediamine is used as a second precursor, and a series of blue carbon dot fluorescent powder BNF-CDs can be prepared through reaction under different molar ratios. And preparing a light-emitting layer mixed solution by taking the BNF-CDs with the highest fluorescence quantum yield as a guest material, poly (9-vinylcarbazole) (PVK) as a host material and o-dichlorobenzene as a solvent, and preparing the light-emitting diode with excellent structural stability and high efficiency by taking the light-emitting layer mixed solution as a light-emitting layer raw material.

The invention discloses a protamine derivative and application thereof, the protamine derivative is obtained by modifying phenylboronic acid on a protamine side chain amino group, and the phenylboronic acid is selected from 4-carboxyphenylboronic acid, 2-aminophenylboronic acid, 3-carboxyl-4-fluorophenylboronic acid or 4-formyl chlorophenylboronic acid; the protamine derivative can be combined with a nucleic acid drug through a boric acid group and is used as a delivery carrier for preparing a nucleic acid drug delivery system. The invention provides a preparation scheme of phenylboronic acid modified protamine, the phenylboronic acid modified protamine is applied to nucleic acid drug delivery, after phenylboronic acid is modified, a boric acid ester bond is formed between a carrier and nucleic acid, and the nucleic acid drug can be responsively released in a high-concentration ATP environment. The functional modified protamine obviously improves the stability of a nucleic acid delivery system, enables the release of a nucleic acid drug to be controllable, and enhances the curative effect of gene therapy.

A method for treating pruritus in patients with atopic dermatitis (AD) and / or nodular prurigo (PN) is disclosed, comprising administering a therapeutically effective amount of at least one compound selected from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-carbonyl]-4-methyl-4-[4-(oxecyclobutane-3-yl)piperazin-1-yl]pent-2-enonitrile (rezabrutinib) and pharmaceutically acceptable salts thereof.

The invention discloses a low-temperature potassium ion battery electrolyte with a weak solvation structure and application of the low-temperature potassium ion battery electrolyte in a potassium ion battery. The electrolyte comprises carbonic ester serving as a solvent and fluorobenzene serving as a diluent. According to the invention, carbonic ester and a fluorobenzene diluent are combined for use, on one hand, interaction between FB and PC can weaken the coordination strength of K + and PC, and the desolvation behavior of an electrode interface is improved, so that the electrochemical compatibility of PC and an electrode is improved; and on the other hand, the concentration of the electrolyte is reduced and the low-temperature viscosity is improved by introducing the FB, so that the low-temperature interface impedance is improved and the low-temperature performance of the battery is favorably exerted.

The invention belongs to the technical field of biological medicine, and discloses a mitochondrial targeting fluorescent probe and a preparation method and application thereof.The mitochondrial targeting fluorescent probe has the structural general formula shown in the formula (I), and the preparation method comprises the step that in the presence of a basic catalyst, the mitochondrial targeting fluorescent probe is prepared. And carrying out Knoevenagel condensation reaction on the nitrogen-containing heterocyclic ring onium iodide and 4-(di (2-chloroethyl) amino)-2-fluorobenzaldehyde, thereby obtaining the compound. The mitochondrial targeting fluorescent probe has mitochondrial targeting, fluorescence imaging capability and antitumor activity, can be used for preparation of tumor cell mitochondrial imaging reagents and antitumor drugs, provides a new strategy for tumor diagnosis and treatment, and has a good application prospect.

The invention relates to the technical field of lithium ion batteries, and particularly discloses an electrolyte, a battery, a battery pack and electric equipment. The electrolyte comprises a first additive and a second additive, wherein the first additive comprises a fullerene-containing fluorobenzene solution; the second additive is a boric acid ester film-forming agent, the structural general formula of the boric acid ester film-forming agent is B (OR) 3, and R is an organic group. Therefore, according to the electrolyte, the gas production phenomenon in the battery circulation process is greatly reduced, the battery circulation performance is effectively improved, the circulation life is prolonged, meanwhile, the electrolyte has good adaptability with the ternary-doped lithium iron manganese phosphate battery, the circulation capacity retention rate is high, capacity fading or structural damage cannot be caused, and the service life of the battery is prolonged. On the premise of not sacrificing the core electrical property of the battery, the circulating gas production is reduced, so that the safety performance of the lithium ion battery is remarkably improved, and the key contradiction that the high energy density and the high safety of the lithium battery are difficult to consider is relieved.

This invention relates to a new process for preparing N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2- fluorobenzamide (LOU064) drug substance substantially free of nitrosamine impurities as well as new crystalline forms of salt and solvate of LOU064 used in the process. The invention further relates to pharmaceutical composition comprising N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2- fluorobenzamide, wherein the composition is substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2- methylphenyl)-4-cyclopropyl-2-fluorobenzamide. Pharmaceutical products containing said drug substance and compositions are also disclosed, as well as methods for preparing said drug substance, pharmaceutical compositions and products.

The invention belongs to the technical field of secondary batteries, and particularly relates to a lithium ion secondary battery and electric equipment. The lithium ion secondary battery provided by the invention comprises a positive plate, a negative plate and an electrolyte, the positive plate comprises a positive active material, the positive active material is doped with a sodium element, the mass percentage content of the sodium element is m2% based on the total mass of the positive active material, and 0.001 < = m2 < = 1; the electrolyte comprises a fluorobenzene compound, the mass percentage content of the fluorobenzene compound is m1% based on the total mass of the electrolyte, and m1 is larger than or equal to 2 and smaller than or equal to 30. According to the lithium ion secondary battery provided by the invention, the sodium element is doped in the positive electrode active material, and the fluorobenzene compound is added in the electrolyte, so that the diffusion rate of lithium ions in the positive electrode active material under high voltage can be improved, and the battery has relatively good charge-discharge performance and cycle performance, especially low-temperature and normal-temperature cycle performance.

The present application relates to a plurality of anhydrous crystal forms of N-(3-(6-amino-5-(2-(N-methacrylamido) ethyoxyl) pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide, as well as compositions, methods of preparation and methods of use thereof. These crystalline forms are useful in the treatment of diseases and disorders that are typically ameliorated by inhibition of BTK. Such diseases and disorders may include inflammation and autoimmune disorders as well as lung and respiratory tract inflammation.

The invention discloses a preparation method of a medical intermediate halogenated alkyl fluorobenzene, which comprises the following steps: adding a compound 1 and a halogenating reagent into an organic solvent according to a certain proportion, and reacting under a heating condition to obtain the halogenated alkyl fluorobenzene, the chemical structural formula of the compound 1 is shown in the specification, the halogenating reagent is a mixture of one or more of CBr4 and PBr3, the chemical structural formula of the halogenated alkyl fluorobenzene is shown in the specification, halogenated alkyl fluorobenzene can be prepared with high selectivity, and the yield of halogenated alkyl fluorobenzene can be greatly improved.

The invention relates to a battery secondary liquid injection formation method and a battery, and the battery secondary liquid injection method comprises the following steps: S1, providing a first electrolyte, carrying out primary liquid injection on the battery, and standing to obtain a primary liquid injection battery; the first electrolyte does not contain electrolyte salt; s2, providing a second electrolyte, carrying out secondary electrolyte injection on the battery after standing, and standing after vacuum sealing to complete a secondary electrolyte injection process; the second electrolyte comprises fluorobenzene and electrolyte salt; s3, formation is carried out; the liquid injection amount of the first liquid injection is m1, the liquid injection amount of the second liquid injection is m2, and m1 / m2 is larger than or equal to 0.1 and smaller than or equal to 1.5. According to the invention, the electrolyte is prepared into the first electrolyte free of electrolyte salt and the second electrolyte containing fluorobenzene and electrolyte salt in advance, secondary electrolyte injection is carried out, and by controlling the injection amount of the two times of electrolyte injection, not only can the overall infiltration time of the electrolyte injection process be obviously reduced, but also the cycle stability of the battery at normal temperature and high temperature can be effectively improved.