8 results about "Flavone derivatives" patented technology

The application belongs to the field of pharmaceutical chemistry, and particularly relates to a solid dispersion of 3,5,7-trihydroxy flavone derivatives, a preparation method and application thereof. The 3,5,7-trihydroxy flavone derivatives and PEG are firstly ground to form a solid dispersion, and then hot melt extrusion is carried out, the hot melt temperature of the 3,5,7-trihydroxy flavone derivatives and PEG is reduced by controlling specific hot melt extrusion conditions, the stability of the drug is ensured, and the obtained solid dispersion can achieve a rapid dissolution effect in a dissolution medium, and the bioavailability is correspondingly improved.

The utility model relates to essence sampling technical field discloses a kind of white orchid flavone derivative whitening essence sampling equipment, including sampling cylinder main part and protective shell, the output shaft of electric push rod is fixed with rubber plug block, the lower portion of hose is equipped with sleeve, the lower end outer wall of hose is sleeved with collar, the outer wall of sleeve is sleeved with locating ring, the inner wall of locating ring is embedded with magnetic sheet two, the outer wall of collar is embedded with magnetic sheet one, the utility model is provided with locating ring, convex strip, collar, guide strip, sleeve and push column, first push locating ring along the convex strip of sleeve outer wall inlaying sliding when operating, accurately remove it to target sampling scale position of scale table, collar is driven along sleeve inner wall stable sliding by push column, when collar slides to the corresponding position of locating ring, magnetic sheet two and magnetic sheet one produce adsorption force, simultaneously, dismounting link does not need to be assisted by tool, guarantee the accuracy of subsequent whitening active ingredient detection result.

Use of a flavonoid derivative of formula I or a salt thereof in preparing a medicament for preventing and / or treating sarcopenia. The chemical structural formula of formula I is as follows, wherein R1 and R2 are monosaccharides or oligosaccharides composed of glucose (glc) and / or rhamnose (rha) combined in different amounts and manners.

The invention discloses a novel CYP1B1 enzyme degradation agent as well as a preparation method and application thereof, and particularly discloses a CYP1B1 enzyme targeted hydrophobic tag HyT degradation agent which comprises an affinity ligand, a hydrophobic tag and a connecting chain for connecting the affinity ligand and the hydrophobic tag, each of the affinity ligand and the hydrophobic tag comprises an alpha-naphthylflavone derivative; the connecting chain comprises a plurality of repetitive units, and the repetitive units are composed of ethylene glycol fragments or alkyl groups. The invention also discloses a preparation method of the hydrophobic tag HyT degradation agent and application of the hydrophobic tag HyT degradation agent or a pharmaceutical composition thereof. The novel CYP1B1 enzyme degradation agent provided by the invention has stronger CYP1B1 enzyme targeting capability, and can specifically target tumors, realize sensitization anti-PD-L1 monoclonal antibody immunotherapy and enhance the tumor immunotherapy effect.

This invention relates to the fields of chemistry and pharmaceutical compounds, specifically to a coumarin-flavonoid derivative, its preparation method, and its applications. The coumarin-flavonoid derivative is a compound with the structure shown in Formula I, or a pharmaceutically acceptable salt, solvent compound, enantiomer, diastereomer, tautomer, or mixture thereof in any proportion; wherein n is an integer from 5 to 11; and X is any one of Cl, Br, and I. This compound exhibits good antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus, with high yield and low cytotoxicity. Formula I

The invention relates to the technical field of medicine, in particular to a compound containing a nitric oxide (NO) donor or pharmaceutically acceptable salt, a preparation method of the compound or the pharmaceutically acceptable salt, a pharmaceutical composition of the compound or the pharmaceutically acceptable salt, and application of the compound or the pharmaceutically acceptable salt to treatment or prevention of ophthalmic intraocular hypertension related diseases and optic nerve injury related diseases.

The invention discloses an iodinated flavone derivative electrochemical synthesis method, which comprises: adding a flavone derivative, potassium iodide and a solvent into an unseparated electrolytic bath, using a graphite rod as an anode and a platinum sheet as a cathode, stirring under the current condition of 10 milliamperes, and separating and purifying a reaction crude product to obtain the iodinated flavone derivative. The invention develops an electrochemical C-H iodination reaction of potassium iodide and flavone derivatives, a series of functionalized iodinated flavone derivatives can be constructed through simple operation, and compared with the traditional synthesis method, the method has the main advantages that: 1) the reaction condition is mild, and the reaction can be smoothly carried out at room temperature; the method has the advantages of simple operation, no need of nitrogen protection, no use of a chemical oxidant due to the fact that an electric oxidation method is used in the reaction, good tolerance of functional groups, high yield and short reaction time.

The invention discloses an application of poplatin in preparation of a medicine for preventing and / or treating pulmonary fibrosis, the poplatin is at least one of poplatin, a poplatin derivative or a plant extract containing the poplatin, and the poplatin derivative can be converted into the poplatin in vivo to play a role. The invention provides an application of poplatin as an active component in preparation of a medicine for preventing and / or treating pulmonary fibrosis. The poplatin is a medicine capable of intervening in a pulmonary fibrosis core pathway. According to the invention, the poplatin is used as an active component for preparing the medicine for preventing and / or treating pulmonary fibrosis for the first time.