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Isoflavone derivative and preparation method and application thereof

A technology for isoflavones and derivatives, applied in the field of isoflavone derivatives and their preparation, can solve the problems of unsatisfactory anti-coxsackie virus effect and the like, and achieve the effects of remarkable effect, simple preparation process and low cost

Inactive Publication Date: 2010-06-09
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent applications with application numbers of 200510020635.9 and 200410044484.6 also disclose that the total flavonoid extract of iris and partial derivatives of irisin compounds have anti-Coxsackie virus effects at the cellular level, but the drugs disclosed in the above-mentioned documents are only carried out on cells. It is not yet known whether it is effective in the in vivo test, and from the results of the cell test, its anti-Coxsackie virus effect is not very satisfactory

Method used

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  • Isoflavone derivative and preparation method and application thereof
  • Isoflavone derivative and preparation method and application thereof
  • Isoflavone derivative and preparation method and application thereof

Examples

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Embodiment 1

[0036] The preparation of embodiment 1 isoflavone derivatives of the present invention

[0037] 1.1 Extraction and separation of irisin

[0038] The crude drug of Iris (Chuan Shegan) was dried at 60°C, crushed into a coarse powder and passed through a 20-mesh sieve, placed in an extraction container, heated and refluxed with 95% ethanol for 3 extractions, each time for 1 hour, and the amount of solvent used each time was the amount of the medicinal material. 4 times (w / w). Filtrate while hot, combine filtrate, 60 DEG C depressurize recovery solvent, obtain the syrup-like substance (brown yellow extract) of specific gravity 1.2g / ml (60 DEG C measure), its yield is 49~51% (w / w). Treat the extract with chloroform, recover the solvent, add 95% ethanol (1 / 5 of the medicinal material, w / w) to the residue, stir evenly, and filter with suction to obtain crude irisin. Take the crude irisin, add 95% ethanol and heat to reflux for 1 hour (the amount of solvent is 2 times that of the ...

Embodiment 2

[0052] Embodiment 2 Preparation of anti-Coxsackievirus drug of the present invention

[0053] 2.1 Preparation of oral preparations

[0054] Including: tablets, powders, granules, capsules, pills, dropping pills, micropills and oral solutions, etc.

[0055] Preparation of powder: Add appropriate amount of auxiliary material talcum powder to the isoflavone derivative of the present invention prepared in Example 1 to increase its fluidity, and pack it separately to obtain the product.

[0056] Preparation of granules: thoroughly mix the isoflavone derivatives of the present invention prepared in Example 1 with auxiliary materials, then add appropriate binders, wetting agents, etc. to granulate, dry, granulate, and pack. Instantly.

[0057] Preparation of capsules: Capsules are divided into soft capsules and hard capsules. Hard capsules are made by encapsulating drug powder or granules, and soft capsules are made by sealing medicinal liquid in spherical or soft capsule materials...

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Abstract

The invention relates to an isoflavone derivative and a preparation method and application thereof, which belong to the field of chemical medicaments. The technical problem solved by the invention is to provide the isoflavone derivative and the preparation and the application thereof. The isoflavone derivative has a structural formula as shown by (I), wherein R1 and R2 in the structural formula are C1-C5 alkyls. The isoflavone derivative has a significant effect of resisting Coxsackie viruses, can be used for preparing medicaments for resisting the Coxsackie viruses, and has an intensive application prospect.

Description

technical field [0001] The invention relates to an isoflavone derivative and its preparation method and application, belonging to the field of chemical medicine. Background technique [0002] Iris tectorum Maxim, a plant of the Iridaceae family, has the functions of clearing heat and detoxifying, reducing phlegm and relieving throat, and is often used for sore throat, phlegm, cough and asthma. Its main medicinal ingredients are isoflavones. In recent years, it has been reported that the isoflavones in iris have antiviral effects, such as: the patent application whose application number is 200510020635.9 discloses that the total flavonoids extract of iris has antiviral effects at the cellular level; the patent application whose application number is 200410044484.6 It is disclosed that partial derivatives of irisin compounds have antiviral effects at the cellular level. [0003] Coxsackie virus is an enterovirus, divided into two types, type A and type B. After the virus ent...

Claims

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Application Information

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IPC IPC(8): C07D311/36A61K31/352A61P31/12
Inventor 徐学民袁崇均王笳陈帅罗森吴燕
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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