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Flavone derivative-copper complex as well as preparation method and application thereof

A technology of derivatives and complexes, applied in the field of flavonoid derivatives-copper complexes and their preparation, can solve the problems of inability to completely eradicate malignant tumor cells, toxic and side effects of radiotherapy, recurrent cancer, etc., and achieves shortening drying time, The effect of improving product quality and enhancing antitumor activity

Inactive Publication Date: 2019-08-23
LUDONG UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] 1. When cancer patients are treated with radiotherapy and chemotherapy, a series of side effects will occur, which will cause unbearable pain to the patients;
[0005] 2. Because radiation can also cause radiation reactions and damage to normal human tissues, the progress of radiotherapy will be limited with the accumulation of radiation in the human body. At the same time, radiation therapy will also produce strong toxic side effects;
[0007] 4. Surgical treatment cannot completely eradicate malignant tumor cells, which will lead to recurrence of cancer

Method used

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  • Flavone derivative-copper complex as well as preparation method and application thereof
  • Flavone derivative-copper complex as well as preparation method and application thereof
  • Flavone derivative-copper complex as well as preparation method and application thereof

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Embodiment 1

[0046] A preparation method of a flavone derivative-copper complex, comprising the following steps:

[0047] S1. 2 mg of 6,2'-flavone dicarboxylic acid and 1.8 mg of Cu(NO 3 ) 2 ·5H 2 O is dissolved in a mixed solvent of N-methylpyrrolidone, N,N-dimethylacetamide and water to obtain a mixed solution, wherein the volume of the mixed solvent is 1mL, N-methylpyrrolidone, N,N-dimethyl The volume ratio of acetamide and water is 1:1:1;

[0048] S2. The mixed solution is packed into a glass tube, and the glass tube is vacuum-sealed to obtain a sealed tube;

[0049]S3. Put the sealed tube into the oven, raise the temperature of the oven from room temperature to 80°C during 300 minutes, keep it at 80°C for 3000 minutes, then lower the temperature from 80°C to 30°C within 600 minutes, and then cut the seal tube to get blue cubic crystals;

[0050] S4. The blue cubic crystals were washed with N,N-dimethylacetamide, and vacuum-dried to obtain 3.6 mg of the complex with a yield of 60%...

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Abstract

The invention discloses a flavone derivative-copper complex as well as a preparation method and application thereof. 6,2-flavonoid dicarboxylic acid and N-methyl pyrrolidone are adopted as ligands, copper ions are adopted as central ions, a complex of flavone derivative-copper is prepared through reactions, and the structure of the complex is represented. The invention furthermore studies anti-tumor activity of the flavone derivative-copper complex, control tests show that the complex has cytotoxicity on malignant cells, but has very low toxicity on normal cells. Due to formation of the flavone derivative-copper complex, the anti-tumor activity of a flavone compound is improved, and the complex has the potential of being applied to medicine development.

Description

technical field [0001] The invention relates to the fields of organic synthesis and medicine, in particular to a flavone derivative-copper complex and a preparation method and application thereof. Background technique [0002] Malignant tumors, also known as cancers, are characterized by uncontrollable growth and control of malignant cells, as well as tissue infiltration, and are classified as malignant tumors in accordance with the "Classification of Diseases and Causes of Death" published by the Ministry of Health through pathological examination. Diseases, such as lung cancer, leukemia, osteosarcoma, etc. According to WHO data, in 2005, the number of people suffering from cancer in the world was 600,000, and this number rose to 9 million in 2015. Nowadays, the number of new cancer patients is rising sharply every year, and the pharmaceutical industry is constantly developing cancer drugs in an attempt to achieve the most comprehensive and rapid cell killing. [0003] At...

Claims

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Application Information

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IPC IPC(8): C07F1/08A61P35/00A61P35/02
CPCA61P35/00A61P35/02C07B2200/13C07F1/005
Inventor 孙杰蔡紫薇潘业婷张捷
Owner LUDONG UNIVERSITY
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