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Vinpocetine medicine composition and preparation method thereof

A technology of vinpocetine and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations of non-active ingredients, etc., and can solve the problems of thermal instability and low bioavailability

Active Publication Date: 2010-08-04
九瑞健康股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, vinpocetine-related dosage forms include tablets, injections, freeze-dried powder injections, etc. Among them, oral preparations generally have low bioavailability. Although the bioavailability of injection dosage forms is relatively high compared with oral preparations, vinpocetine is Such compounds are easily oxidized by external influences, and are unstable to heat. Currently, the injections and freeze-dried powder injections prepared generally choose to add antioxidant components. The prior art has also studied suitable co-solvents to help Solvents include citric acid, tartaric acid, acetic acid, lactic acid, sorbic acid, hydrochloric acid, ascorbic acid, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 Vinpocetine freeze-dried powder injection

[0031] composition

[0032] Vinpocetine 10g,

[0033] Mannitol 70g,

[0034] Sorbitol 20g,

[0035] 20% phosphoric acid 50ml,

[0036] Add water for injection to 2000ml.

[0037] A total of 1000 bottles were made

[0038] Preparation:

[0039] 1) Add mannitol and sorbitol to sterile water for injection with a total volume of 40%, stir to dissolve; dissolve vinpocetine with 20% phosphoric acid solution. Mix the two, add sterile water for injection to the full amount, and stir evenly.

[0040] 2) Add 0.1% activated carbon for needles into the solution, heat and stir for 15 minutes, and filter to decarbonize.

[0041] 3) Measure the pH value of the solution and adjust the pH value to 2.7-4.3.

[0042] 4) After the semi-finished product passes the inspection, fine filter it with a 0.22 μm sterile microporous membrane.

[0043] 5) After passing the clarity inspection, it is divided into antibiotic glass bottl...

Embodiment 2

[0047] Embodiment 2 Vinpocetine freeze-dried powder injection

[0048] composition

[0049] Vinpocetine 20g,

[0050] Mannitol 70g,

[0051] Sorbitol 20g,

[0052] 10% phosphoric acid 100ml,

[0053] Add water for injection to 2000ml.

[0054] A total of 1000 bottles were made

[0055] The preparation method refers to the method of Example 1.

Embodiment 3

[0056] Embodiment 3 Vinpocetine freeze-dried powder injection

[0057] composition

[0058] Vinpocetine 30g,

[0059] Mannitol 70g,

[0060] Sorbitol 20g,

[0061] 15% phosphoric acid 70ml,

[0062] Add water for injection to 2000ml.

[0063] The preparation method refers to the method in Example 1.

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PUM

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Abstract

The invention relates to a stable vinpocetine medicine composition belonging to the technical field of medicine preparations. The composition is a freeze-dried powder injection and is characterized in that the freeze-dried powder injection is prepared from the following components: 10-30g of vinpocetine, 70g of mannite, 20g of sorbitol, 10-20g of 50-100 ml of phosphoric acid and the balance of water for injection up to 2000ml. The freeze-dried powder injection prepared by the invention has better stability.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a stable vinpocetine composition, which is freeze-dried powder injection. Background technique [0002] Vinpocetine (vinpocetine, Kangweinao, Kalan tablets, Runtan) is a cerebral vasodilator, which can inhibit the activity of phosphodiesterase, increase the effect of vascular smooth muscle relaxation messenger C-GMP, and selectively increase cerebral blood flow. In addition, it can inhibit platelet aggregation, reduce human blood viscosity, increase red blood cell deformability, improve blood flow and microcirculation, promote brain tissue uptake of glucose, increase brain oxygen consumption, and improve brain metabolism. Vinpocetine has a variety of pharmacological effects beneficial to the brain, cardiovascular, blood circulation and other systems: (1) increase cerebral blood flow; (2) promote the uptake and utilization of glucose and oxygen in the brain, increase...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K47/04A61K9/19A61P9/00A61P9/10
Inventor 王保明
Owner 九瑞健康股份有限公司
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