Vinpocetine injection and preparation method thereof

Abstract

The invention relates to a vinpocetine injection. Each 1000ml of the vinpocetine injection provided by the invention contains 3-15g of vinpocetine, 5-25g of cosolvent, 0.2-2g of antioxidant, 20-100g of physical stabilizer and 10-25g of vessel stimulation regulator. The invention also relates to a preparation method of the vinpocetine injection.

Description

Vinpocetine injection and preparation method thereof technical field The invention relates to a vinpocetine injection and a preparation method thereof. Background technique Vinpocetine is a medicine obtained by chemical synthesis from the extract of the evergreen shrub Vinca vinca from central and southern Europe. Its chemical name is: ethyl (13as, 13bs)-13a-ethyl-2,3 , 5,6-13a,13b Hexahydro-1H-indole[3,2,1-de]pyridine[3,2,1-ij][1,5]-naphthyridine-12-carboxylic acid, Molecular formula: C22H26N2O2. Vinpocetine is a cerebral vasodilator, which can inhibit the activity of phosphodiesterase, increase the relaxation of vascular smooth muscle, and make the action of C-GMP selectively increase cerebral blood flow. In addition, it can also inhibit platelet aggregation, reduce the viscosity of human blood, and increase the concentration of red blood cells. Deformability, improve blood flow and microcirculation, promote brain tissue uptake of glucose, increase brain oxygen consum...

AI Technical Summary

Problems solved by technology

Among the existing dosage forms of vinpocetine, the bioavailability of oral preparations is poor, the clinical use convenience of freeze-dried powder is poor, and there is a possibility of secondary pollution

And in the existing vinpocetine injection, such as Zhengzhou Lingrui listed preparations use ascorbic acid as a cosolvent, tartaric acid as a pH regulator, because the solubility of vinpocetine is low and unstable, in the preparation process, only ascorbic acid is used as a cosolvent. It takes a long time for the solvent to dissolve, resulting in a longer production cycle and an increase in related substances

Ascorbic acid is unstable. After accelerated and long-term storage, ascorbic acid is easily oxidized and the injection will change color, affecting the related substances and content of the product, thereby affecting the clinical value of the drug.

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