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Vinpocetine containing high-capacity sodium chloride injection and preparation method thereof

A technology of vinpocetine and sodium chloride, applied in the field of large-capacity sodium chloride injection containing vinpocetine and its preparation, which can solve the problems of poor bioavailability, affecting the convenience of use, secondary pollution, etc., and achieve stable quality , easy to use, high bioavailability

Inactive Publication Date: 2011-03-30
SHENYANG ZHIYING PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral formulations have poor bioavailability
Freeze-dried powder needs to be dissolved twice, which affects the convenience of use and has the possibility of secondary pollution
The quality of clinically used injections is unstable during storage, which affects the curative effect
Vinpocetine is mainly used for middle-aged and elderly patients. Large-capacity glucose injections contain a large amount of glucose, which is not conducive to the treatment of patients with diabetes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4

[0032] Embodiment 1~4 selects raw material kind and quantity for use

[0033]

[0034] Weigh vinpocetine, osmotic pressure regulator, co-solvent according to the formula ratio, and prepare pH value regulator, water for injection; add 1.5% water for injection in the preparation tank, add co-solvent in the preparation tank, stir Make the solution clear, then add vinpocetine into the preparation tank, stir continuously until the solution is clear, then add 1.5% sodium chloride in the formula amount, and after it dissolves, filter it with a microporous membrane; filter the above solution with 0.9% normal saline Dilute to the full amount, adjust the pH to 3.5-4.5 with a pH regulator, filter with a microporous membrane, fill in a 100ml infusion bottle, and fill with CO 2 Gas, stoppered and sealed, the finished product is obtained after sterilization.

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Abstract

The invention provides a vinpocetin containing high-capacity sodium chloride injection and a preparation method thereof, aiming at solving the problems that vinpocetin is mainly applied to middle aged and elderly patients, high-capacity glucose injection contains massive glucose and is not beneficial to treating patients suffering from diabetes at the same time. The invention has the key point that the injection is mainly composed of vinpocetin, osmotic pressure regulator, cosolvent and pH value regulator. The vinpocetin high-capacity sodium chloride injection of the invention has high bioavailability and stable quality, is convenient to use and is applicable to treatment of patients suffering from neurologic disease caused by cerebral circulation restriction, especially the patients suffering from diabetes at the same time.

Description

technical field [0001] The invention relates to an injection containing vinpocetine and a preparation method thereof, in particular to a formula of a large-capacity sodium chloride injection and a preparation method thereof. Background technique [0002] Vinpocetine is a compound obtained from apovincine, an alkaloid extracted from Apocynaceae - Vinca minor, through a series of chemical synthesis and pharmacological screening. This product was first successfully developed by Gedeon Richter Company of Hungary in 1976. It has definite clinical curative effect and has a remarkable effect on neurological diseases caused by cerebral circulation obstruction. [0003] Vinpocetine has a selective effect on cerebral blood vessels. By increasing cerebral blood flow, improving cerebral oxygen supply, reducing cerebral vascular impedance, improving blood flow and microcirculation, improving cerebral metabolism, and protecting cerebral ischemia, it can be used to improve cerebral infarct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4375A61K47/02A61K47/12A61K47/22A61K47/04A61P9/10A61P25/00
Inventor 曾卫东张晶
Owner SHENYANG ZHIYING PHARMA FACTORY
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