45 results about "Brain arteries" patented technology

The utility model discloses a microcatheter assembly with an OCT probe, and relates to the technical field of medical instruments. A microcatheter assembly with an OCT probe, comprising: a microcatheter; the micro-catheter is provided with a first side hole; the first side hole is close to the front end of the micro catheter; a micro guide wire; the micro guide wire is matched with the first side hole; a balloon and an OCT probe; the balloon and the OCT probe are both arranged on the micro catheter. The balloon and the OCT probe are both arranged in the micro catheter, so that the balloon or the OCT probe does not need to be frequently pulled out of or inserted into the cerebral artery during use, and only the balloon or the OCT probe needs to move in the cerebral artery by a small distance (dozens of millimeters or dozens of millimeters). Compared with the prior art, the operation difficulty in use is small, the operation time is short, the risk that the inner wall of the cerebral artery of a patient is damaged can be reduced, and other risks borne by the patient in an operation can also be reduced.

The invention provides a quantitative risk assessment method and system for head and neck artery stenosis, and the method comprises the steps: collecting the medical image of the head and neck artery of a patient, the blood pressure of the upper arm artery, and the heart rate; a narrow local form, a cerebral artery network anatomical structure / geometric size and a microcirculation blood flow automatic regulation mechanism are comprehensively incorporated into hemodynamic analysis through a geometric multi-scale modeling technology, and information such as an arterial stenosis far-end and near-end pressure ratio, cerebral artery blood flow and hemodynamic parameters of a narrow part is output; quantitative information support is provided for risk assessment of head and neck artery stenosis; the method has the advantages that patient data are obtained only through noninvasive measurement, and the risk that complications are increased due to invasive measurement is avoided; according to the method, a geometric multi-scale modeling method is adopted to achieve integrated analysis of the three-dimensional flow field and the whole-brain circulation hemodynamic parameters of the stenosis part, the blood flow regulation effect of brain microcirculation is considered, and the physiological significance and clinical application value of the evaluation result can be remarkably improved.

The invention provides a theaflavin composition for treating hypertension as well as a preparation method and application thereof, and relates to the technical field of medicines. The theaflavin composition comprises theaflavin, a celery seed extract, a gastrodia elata extract, a parasitic loranthus extract, a centella asiatica extract, a lotus leaf extract and a licorice extract. Wherein the theaflavin can regulate blood fat, inhibit atherosclerosis and improve the vascular endothelial function; the celery seed extract inhibits the activity of angiotensin converting enzyme, and cooperates with theaflavin to regulate blood pressure; the gastrodia elata extract can calm liver wind and improve cerebral circulation; the loranthus parasiticus extract has the effects of tonifying liver and kidney and regulating water sodium metabolism; the centella asiatica extract can resist inflammation and repair vascular endothelium; the lotus leaf extract can clear heat, promote diuresis, calm the liver and suppress yang; and the licorice extract harmonizes the medicines and resists oxidation. According to the invention, theaflavin is taken as a core, multi-dimensional effects of reducing blood pressure, protecting blood vessels and resisting inflammation and oxidation are realized, and a natural and comprehensive health management scheme is provided for hypertensive patients.

The invention discloses a potential stroke risk assessment method and system after coronary artery recanalization, and the method comprises the steps: obtaining the heart and cerebral vessel image data of a patient, and constructing a complete heart and cerebral artery blood vessel geometric model; based on the cardio-cerebral artery blood vessel geometric model, numerical simulation is conducted on the flowing conditions of blood flow in coronary arteries and cerebral vessels by means of a computational fluid mechanics method, and the pressure ratio before and after coronary artery stenosis and the partial pressure ratio of the cerebral vessels are calculated; according to the pressure ratio and the partial pressure ratio, the potential risk of the cerebral arterial thrombosis is quantitatively evaluated, and a cerebral blood flow partial pressure ratio numerical value and a cerebral arterial thrombosis risk evaluation report are generated. According to the cerebral apoplexy risk quantitative evaluation method, by integrating coronary artery CTA and cranial CTA or MRA data, reconstructing a complete heart and cerebral vessel geometric model and simulating heart and cerebral blood flow changes before and after a coronary artery recanalization operation, and particularly by calculating coronary artery FFR and cerebral blood flow partial pressure ratio FPR, an evaluation report is generated, and a basis for quantitative evaluation of the cerebral apoplexy risk in the operation is provided for clinical doctors.

The utility model discloses a micro catheter assembly and a movable balloon thereof, and relates to the technical field of medical instruments. The movable balloon includes: a balloon; the balloon is of a tubular structure, and the balloon can be movably arranged outside the micro catheter in a sleeving mode; a closed cavity is formed in the balloon; the pushing catheter is connected with the rear end of the balloon; and the pushing guide pipe is communicated with the closed cavity. Through the arrangement of the movable balloon, the position of the balloon in the micro-catheter can be adjusted based on the position of the narrow part in the cerebral artery, so that the micro-catheter assembly formed by combining the balloon and the micro-catheter can be suitable for the application scene that the narrow part is located at the tail end of the cerebral artery.

Methods and devices are disclosed that enable safe, rapid and relatively short and straight access to the cerebral arteries for the introduction of interventional devices to treat acute ischemic stroke. In addition, the disclosed methods and devices provide means to securely close the access site to the cerebral arteries to avoid the potentially devastating consequences of a transcervical hematoma.

The invention provides a pharmaceutical composition for treating Alzheimer's disease. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 10-15 parts of ginseng, 10-15 parts of rhizoma acori graminei, 10-15 parts of polygala tenuifolia, 15-20 parts of rhizoma polygonati, 15-20 parts of ginkgo leaves and 5-10 parts of schisandra chinensis. Therefore, the ginseng and the ginkgo leaves jointly regulate a cholinergic system and cerebral blood flow, and the cognitive function is enhanced; the rhizoma acori graminei and the ginkgo leaves cooperate to inhibit aggregation of beta-amyloid protein, improve cerebral circulation and relieve neurotoxicity. Polygonatum sibiricum and Chinese magnoliavine fruit protect nerve cells through anti-oxidation and anti-inflammatory effects and reduce nerve injury. Schizandrin further stabilizes a neurotransmitter system and enhances the synergistic effect of other medicinal materials, a multi-layer treatment network of Abeta deposition inhibition, cholinergic system regulation, anti-inflammation and anti-oxidation and nerve protection is integrally formed, and the core pathological link of the Alzheimer's disease is comprehensively intervened, so that the cognitive function is improved, and the disease progress is delayed.

The invention discloses a cerebral artery blood flow velocity prediction method, device and equipment and a medium, and relates to the field of blood flow velocity prediction.The method comprises the steps that cerebral artery nuclear magnetic imaging data are obtained and preprocessed; performing image segmentation to obtain a cerebral artery three-dimensional model; extracting geometric topology information of the cerebral artery; constructing a 0-1-dimensional geometric multi-scale model of the crowd averaged cerebral artery; determining entrance boundary conditions of the 0-1-dimensional model to obtain a 0-1-dimensional patient personalized hemodynamic model; according to a clinical preset contrast agent concentration-time curve and based on the law of conservation of mass, a 0-1-dimensional patient personalized hemodynamic model is used for simulating a contrast agent injection process, and a contrast agent concentration-time curve of each position in the cerebral artery topology network is obtained; based on the concentration data of the contrast agent at the near end and the far end of the target blood vessel, the flow velocity of the contrast agent at different blood vessel segments of the cerebral artery is determined, and the method can be suitable for blood flow velocity estimation of an artery system with a complex topological structure.

The invention discloses a perfusion imaging method and device for low-rotating-speed imaging equipment, a medium and a product, and relates to the field of medical image processing. The method comprises the following steps: acquiring plain-scan projection data and time sequence projection data of a brain interested body layer; determining a target time decay curve associated with the interested cerebral artery according to the time sequence projection data; determining a difference value between projection data corresponding to each scanning moment in the time sequence projection data and the plain scanning projection data, and taking the difference value as target projection data of the corresponding scanning moment; determining a target independent variable capable of enabling the target projection data and the forward model projection data to meet a difference minimization condition, and determining a perfusion parameter diagram combination based on the target independent variable; the forward model projection data is determined based on a target time decay curve and an independent variable, and the independent variable comprises a cerebral blood flow chart to be optimized and an average passing time chart. According to the invention, the accuracy of the perfusion parameter diagram combination determined based on the projection data acquired by the low-rotating-speed imaging equipment can be improved.

A device (100) for removing emboli from a cerebral artery, comprising (i) a catheter (150), (ii) a funnel (130) biased to assume an expanded state in which a mouth (133) of the funnel is wider than a proximal end (1311) of the funnel, (iii) a stem (132) attached to the proximal end of the funnel and extending proximally through the catheter, and (iv) a handle (120) at a proximal portion of the catheter, the handle comprising: (a) a deployment knob (122) configured to deploy an embolus from the catheter; the device includes (a) a catheter (126) operably coupled to the rod so as to be manually operable to transition the funnel toward a deployed expanded state in which the funnel is in sealing engagement with the catheter such that suction applied by the catheter draws the emboli into the mouth, and (b) a stabilizer (126) configured to stabilize the device in the deployed state by applying tension to the rod.

To provide a suction catheter system with a suction extension part.SOLUTION: A suction extension part is interfaced with a guide catheter to form a continuous suction lumen extending through a portion of the guide catheter and through the suction extension part. The suction extension part can be positioned by tracking the suction nozzle through a vessel while moving a proximal portion of the suction extension part within a lumen of the guide catheter. The suction extension part can include a connecting section 400 with a non-circular cross section for interfacing with the inner lumen of an engagement section of the guide catheter. A tubular body of the guide catheter can have a reduced diameter distal section that can be useful to restrain the movement of the suction extension part. Proximal fittings attached to the guide catheter can facilitate safe removal of the catheter system from the patient by allowing for the removal of some or all of an annular extension part of the suction extension part from the guide catheter behind a hemostatic seal.SELECTED DRAWING: Figure 21

The invention discloses a generative artificial intelligence cerebral artery lesion detection method based on plain-scan brain CT. The method comprises the steps that 1, a plain-scan brain CT image to be processed is acquired; 2, converting the plain scanning brain CT image into a CTA image through an adaptive noise elimination network; and 3, carrying out multi-modal lesion detection on the basis of the CTA image generated in the step 2. According to the method, a CTA image is generated through an adaptive noise elimination network (ANE-NET), and a real-time lesion feature analysis engine (RTAL-FE) is embedded in the generation process, so that real-time classification prediction of lesion types is realized. And furthermore, a detection result is output through a dynamic weight decision model (DWD-M), so that the generation quality and the detection efficiency are remarkably improved. The problems that a traditional method is low in generation quality and lags behind detection are solved, and the method is particularly suitable for low-dose and non-invasive cerebrovascular disease screening scenes and has important clinical application value.

1. The name of the design product: Doppler apparatus. 2. The use of the design product: The design is used for checking the brain artery and other arteries of patients. 3. The design points of the design product: The combination of shape and pattern. 4. The picture or photo that best shows the design points: Fig. 1.

The present invention relates to the field of neuroscience, and proposes a method and system for realizing the cause identification of ischemic stroke based on neuroimaging, wherein the method comprises: obtaining a patient's brain nerve image, including CT and MRI scan images, diagnosing and analyzing the stroke patient, extracting the vascular load value by identifying the vascular tissue and the high-density sign of the cerebral artery in the CT scan image, identifying the thrombus pore through the MRI scan image, extracting the thrombus morphological characteristics, calculating the thrombus shape coefficient, combining the vascular load value and the thrombus shape coefficient, determining the abnormal area in the brain nerve image, identifying the ischemic area, and detecting the damaged nerve tissue, and finally, using the cause identification network to classify the lesions of the damaged nerve tissue, correlating the cause of stroke with the clinical index, and generating a cause report. The present invention can improve the accuracy of the cause identification of ischemic stroke.

The invention, which relates to the medical health management field, discloses an intelligent hypertension health management system comprising a data acquisition module, a data processing module, an early warning module and an interaction module. By constructing the cerebral circulation-blood pressure association model, the potential association relationship between the cerebral hemodynamic parameters and the blood pressure data can be accurately mined, so that the possibility of blood pressure abnormality caused by cerebral vasculopathy is effectively judged, and when abnormality is detected, the system can send out an early warning signal in time, so that the early warning effect is improved. And according to the abnormal degree and the historical health data of the user, customized health suggestions are provided for the user through a personalized health suggestion generation algorithm, and the combination of the precise early warning and the personalized health suggestions helps the user to timely discover and process potential health problems and improve the health management effect.

This invention discloses a method and device for cerebral artery segmentation and classification based on MRI images, belonging to the field of medical image processing. The method uses a U-Net network as its basic architecture, introducing a Swing Transformer module in the encoder to achieve hierarchical feature extraction. First, the 3D MRI image is preprocessed; then, multi-scale features are extracted through a multi-level Swing Transformer encoding stage, and a shift-window attention mechanism is combined to enhance global context awareness; next, a graph structure is constructed to fuse and enhance multi-level features to preserve vascular topology; finally, a convolutional decoder upsamples layer by layer and performs skip connections with the graph fused features to achieve accurate reconstruction and classification of vascular structures. This invention effectively integrates the global modeling capabilities of the Transformer with the local detail extraction advantages of convolutional networks, improving the accuracy and structural integrity of vascular segmentation and classification.

An ex-vivo brain perfusion system for perfusion of a brain includes a reservoir configured to receive perfusate, a housing configured to contain the brain, an arterial circuit configured to fluidly couple the reservoir to the brain, a venous circuit fluidly coupling the housing to the reservoir, and a syringe pump fluidly coupled to the reservoir and configured to introduce a therapeutic agent to the perfusate in the reservoir. The ex-vivo brain perfusion system is configured to perfuse the brain with the therapeutic agent to test at least one property of the therapeutic agent.

The invention discloses a cerebral aneurysm recognition and positioning method based on vascular section defect detection, and aims to search for the maximum inscribed circle of a vascular section by segmenting a vascular section sequence. The normal vascular section is closer to the incircle, and the abnormal aneurysm shows local protrusion, so that the abnormal aneurysm is identified and positioned by taking the abnormal aneurysm as a feature. TOF-MRA images are generally adopted for aneurysm recognition, and relatively pure blood vessel parts need to be obtained through segmentation firstly, so that the method sequentially utilizes binarization threshold segmentation, connected domain filtering and retrograde blood vessel segmentation, then blood vessel surface point cloud is extracted, blood vessel slice sequences are obtained based on point cloud traversal segmentation, and finally maximum inscribed circles of all the sequences are searched. When the area of the vascular section and the maximum inscribed circle exceeds a certain threshold value, the aneurysm appears. Based on the original TOF-MRA image of the brain, the brain aneurysm can be quickly and accurately identified and positioned, and the accuracy rate reaches 86%. A scientific and effective means is provided for early screening of cerebral artery risks of the patient, and timely intervention is facilitated to guarantee the health of the patient.

The invention provides a pharmaceutical composition comprising ticagrelor for use in the reduction or prevention of thromboembolic events before and / or during and / or following a neurovascular arterial procedure of a patient in need thereof, comprising administering to the patient an effective amount of the pharmaceutical composition comprising ticagrelor, characterized in, that the pharmaceutical composition is an aqueous solution comprising a solubilizer for ticagrelor and the pharmaceutical composition is administered intravenously; wherein the patient is suffering from a cerebral aneurysm, a brain artery sclerosis, a neck artery sclerosis, a neurovascular carotid arterial dissection or a carotid artery dissection.

The invention describes catheter systems and methods for accessing the brain during endovascular / neurointervention procedures in the treatment of ischemic stroke. More specifically, catheter systems are described that enable quicker and improved access to cerebral vessels as well as improved processes of accessing and aspirating blood clots from the cerebral vessels of a patient with acute ischemic stroke due to medium or large vessel occlusion.

The utility model discloses a brain circulation function therapeutic instrument convenient to carry, which comprises a box body, one side of the box body is rotatably connected with a box cover, the other side of the box body is provided with an opening and closing buckle, two side walls of an inner cavity of the box body are provided with a limiting plate, a placing box, a fixing assembly and a control instrument, and the top of the box body is provided with a spring groove and a buckle assembly. An electric telescopic rod, a bearing block and a treatment cap are arranged at the bottom of an inner cavity of the box body, a handle is arranged on one side of the box cover, and straps are arranged on the side wall of the box body. According to the brain circulation function therapeutic instrument convenient to carry, the control instrument can be fixed in the inner cavity of the containing box through the fixing assembly, the therapeutic cap is clamped on the bearing block, the therapeutic instrument can be fixed in the inner cavity of the box body, the containing box is fixed through the buckle assembly, the therapeutic instrument is prevented from being damaged when the box body is moved, and the therapeutic instrument is convenient to carry. The box body and the box cover can be fixed conveniently through the opening and closing buckles, the box body can be carried on the back through the straps, and carrying is convenient.

A distal entry point (DEP) to brain aspiration (D2BA) catheter for use in an endovascular procedure for gaining access to cervical and cerebral arteries in a brain of a patient and aspirating one or more intracranial clots from the cerebral arteries, comprising a soft distal tip region having a distal length sufficient to extend from a level 1 or level 2 arterial segment of a cerebral artery or equivalent to an upper neck arterial vessel, a stiffness enabling movement through the level 1 or level 2 arterial segment of the cerebral artery, and an outside diameter (OD) of 6F-10F, a proximal region having a stiffness greater than the stiffness of the soft distal tip region, the proximal region having a length sufficient to extend to outside the patient through the DEP.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a radix euonymi and caulis spatholobi dizziness relieving decoction for relieving Parkinson's disease, and the radix euonymi and caulis spatholobi dizziness relieving decoction comprises euonymus fortunei, caulis spatholobi, radix paeoniae alba, radix polygoni multiflori preparata, glossy privet fruit, radix fici simplicissimae, gastrodia elata and ramulus uncariae cum uncis. Compared with the prior art, the traditional Chinese medicine composition treats both symptoms and root causes through a multi-way synergistic effect, and has the effects of treating liver-kidney deficiency, liver-yang hyperactivity, deficiency wind internal movement and meridian stasis. The modern pharmacological basis mainly relates to the effects of calming, resisting convulsion, reducing blood pressure, improving brain circulation, promoting hematopoiesis, resisting oxidation, resisting platelet aggregation, regulating immunity, relieving spasm and the like, can be used for improving mitochondrial function damage and protein expression of mitochondrial function related protein PGC-1alpha, can be used for improving PD tyrosine hydroxylase expression and reducing abnormal aggregation of alpha-syn, and can be used for treating the mitochondrial function damage and the mitochondrial function related protein PGC-1alpha. Therefore, neurons are protected, and PD pathological conditions are improved.

This invention discloses an artificial intelligence-based method for measuring aneurysms in cranial arterial angiography images, comprising the following steps: S1, acquiring keyframes of DSA images; S2, segmenting the keyframes using a deep neural network to distinguish between the background and blood vessels; S3, determining the aneurysm location region based on the segmentation results, obtaining the contour of the region, and simultaneously obtaining the length of the connection between the gray aneurysm region and the white blood vessel region, i.e., the aneurysm diameter width w; S4, based on the obtained aneurysm contour shape, calculating the aneurysm centroid O by spatial moments, drawing a perpendicular line through the centroid O and intersecting the contour boundary, traversing all angles, and taking the largest intersection line segment as the maximum diameter l of the aneurysm, drawing a perpendicular line from the aneurysm diameter width w and intersecting the contour boundary, the maximum height of which is the aneurysm height h. This invention achieves fully automated measurement of the diameter of cerebral vascular aneurysms through a deep neural network trained on a large amount of data, solving the problems of slow speed, poor accuracy, and large influence of subjective factors in manual measurement.

The invention discloses a brain artery segmentation classification method and equipment based on an MRI image, and belongs to the field of medical image processing. According to the method, a U-Net network is taken as a basic framework, and a Swin Transform module is introduced into an encoder, so that hierarchical feature extraction is realized. Firstly, a three-dimensional MRI image is preprocessed; then multi-scale features are extracted through a multi-stage Swin Transform encoding stage, and global context perception is enhanced in combination with a shift window attention mechanism; constructing a graph structure to fuse and enhance the multi-level features so as to retain a vascular topological relation; and finally, carrying out layer-by-layer up-sampling through a convolution decoder, and carrying out jump connection with image fusion features to realize accurate reconstruction and classification of a blood vessel structure. According to the method, the global modeling capability of Transform and the local detail extraction advantage of the convolutional network are effectively integrated, and the accuracy and structural integrity of blood vessel segmentation classification are improved.

A distal entry point of a brain aspiration catheter for obtaining access to carotid and cerebral arteries in the brain of a patient and aspirating one or more intracranial clots from the cerebral arteries during an endovascular procedure comprises: a soft distal tip region having a distal length sufficient to extend from a first or second level arterial segment or equivalent of the cerebral artery to the upper carotid artery vessel, the distal tip region having a distal length sufficient to extend from the first or second level arterial segment or equivalent of the cerebral artery to the upper carotid artery vessel; the rigidity of the first-stage or second-stage arterial section of the cerebral artery enables the first-stage or second-stage arterial section to move, and the outer diameter of the first-stage or second-stage arterial section is 6F- And a proximal region having a stiffness greater than a stiffness of the flexible distal tip region, the proximal region having a length sufficient to extend out of the patient through the distal entry point.

The invention relates to the field of oral traditional Chinese medicine preparations, in particular to an oral traditional Chinese medicine composition for relaxing muscles, promoting blood circulation, removing blood stasis, inducing resuscitation and inducing resuscitation, which comprises the following components in parts by weight: 8-12 parts of ground beetle, 3-7 parts of blood stasis, 10-14 parts of burnt copper, 3-7 parts of pearl sand, 4-8 parts of pseudo-ginseng, 4-6 parts of safflower, 2-10 parts of ginseng, 5-8 parts of ginkgo leaf, 2-6 parts of polygala tenuifolia, 1-5 parts of rhizoma acori graminei and 1-5 parts of fructus alpiniae oxyphyllae. Ginseng is used for enhancing neuroplasticity, ginkgo leaves are used for improving cerebral circulation, polygala tenuifolia and rhizoma acori graminei are used for regulating neurotransmitters, fructus alpiniae oxyphyllae is used for protecting neurons, a three-in-one treatment system of tonifying, dredging and regulating is formed, during raw material preparation, natural copper fragments are placed in a fire-resistant container and calcined to be red thoroughly, then the natural copper fragments are rapidly soaked into rice vinegar to be quenched to be crisp, the operation is repeated for 2-3 times, and the natural copper fragments are prepared. The composition realizes a three-dimensional curative effect network of relaxing the muscles and stimulating the blood circulation, and dispersing blood stasis and inducing resuscitation through a five-dimensional synergistic mechanism of bone fracture repair, brain circulation improvement, blood optimization, neuroprotection and toxicity antagonism, and embodies the advantage of multi-target integrated regulation of a traditional Chinese medicine compound.

Methods and devices are provided for protecting cerebrovascular circulation from embolic fragments released during indexed surgery. The embolic protection filter is delivered in a reduced profile configuration via the access catheter and positioned on the aorta across the three major vascular openings leading to the cerebral circulation. Thereafter, the indexing surgical catheter is advanced through the same access catheter to perform indexing surgery. The indexing procedure may be transcatheter aortic valve replacement.

The invention discloses a neurological serious high-simulation invasive operation simulation training and neuroanatomy demonstration teaching system, and belongs to the technical field of medical education and clinical skill training. The system comprises a neuroanatomy demonstration system, a high-simulation invasive operation simulation training system and an integrated computer host. The dissection demonstration system visually displays key structures such as cerebral artery, vein, cranial nerve and cerebrospinal fluid circulation through a dynamic model and a three-dimensional visualization technology; the operation simulation training system adopts a biomimetic material human body model to truly simulate the hand feeling and feedback of more than ten neurological serious invasive operations such as lateral ventricle puncture, trachea cannula and central venous catheterization; the computer host integrates the functions of case scene simulation, process video recording and redisk and intelligent examination and evaluation. According to the invention, integration, scenario and intelligence of anatomy teaching and operation training are realized, a safe, repeatable and evaluable high-quality training environment is provided for students, and the efficiency and clinical practice ability of neurological intensive medicine teaching are effectively improved.

1. Name of the design product: Main body of cerebral artery intervention model. 2. Use of the design product: The main structure of the teaching model. 3. Design key points of the design product: Lies in the shape. 4. Picture or photograph that best shows the design key points: Perspective view 1.