39 results about "Arterial dissection" patented technology

The invention discloses a medical image segmentation method and system for an aortic dissection true cavity, an aortic dissection false cavity and an aortic dissection false cavity thrombus. The method comprises the following steps: firstly, acquiring three-dimensional medical image data of the aortic dissection, performing preprocessing operation on the image data to obtain a two-dimensional slice image, and performing local region division on the two-dimensional slice image; secondly, performing feature extraction on the divided image through a hierarchical feature extraction module; then, a dynamic region self-adaption module is used for carrying out region adjustment on the extracted feature map, a region response map is generated through a guide path, and explicit adjustment weights are given to different space regions in the feature map; and finally, uniformly aggregating the multi-scale feature maps after region adjustment, outputting a segmentation mask through a prediction module, and generating a segmentation result with a clear structural boundary and complete semantics. According to the method, while the recognition precision of the complex anatomical structure is improved, the detection capability and boundary sensing performance of a small-size focus are enhanced, and the method has good universality and stability.

The invention relates to the technical field of medical data processing, in particular to an aortic dissection rupture risk early warning method based on a CTA image, and the method comprises the steps: determining the blood pressure abnormity trend representation degree corresponding to a target patient according to the systolic pressure distribution condition of the target patient in a preset historical time period, and predicting a possible high pressure time interval; obtaining a CTA image of a target patient, and determining a precursor rupture early warning index, a new rupture spread degree and a blood pressure image correlation degree; and on the basis of the systolic pressure, the overall correlation coefficient and the current CTA image of the target patient in the current period, aortic dissection rupture risk early warning is realized through a pre-trained aortic dissection rupture risk early warning network. When the network is used, the systolic pressure, the overall correlation coefficient and the current CTA image in the current period are combined, so that the richness of network input data is enriched, and the accuracy of aortic dissection rupture risk early warning is improved.

The application discloses a kind of false cavity plugging device, assembly and system, belong to medical instrument technical field, wherein false cavity plugging device includes elastic membrane and elastic support, elastic support includes warp beam and weft beam, warp beam is continuously bent wave shape, warp beam is equipped with weft beam, and weft beam can be bent into annular ring.Assembly includes release device and false cavity plugging device.System includes conveying device and false cavity plugging assembly, and conveying device includes sheath and guide wire, and sheath is equipped with guide wire passage and conveying passage.Weft beam bends into annular ring can make elastic membrane roll up, reduce the size in width direction, to be contained in sheath, after being separated from sheath, weft beam will be re-opened and contacted with the inner wall of artery dissection, and can be implanted, in the whole process of being received and being separated from sheath, elastic membrane does not have length direction change, and preset release position and actual release position can be kept consistent, reduce the operation requirement to operator, and it is beneficial to popularization and use.

The present invention discloses a set of diagnostic markers for aortic dissection and their applications. The markers include the genes MMP8, ALOX15, HP, FXYD2, SIGLEC8, and CCL2. The genes MMP8, ALOX15, HP, FXYD2, SIGLEC8, and CCL2 protected by the present invention can be used as biomarkers for AD and as indicators for assessing disease severity in AD patients, enabling efficient diagnosis of patients with aortic dissection.

The application provides an auxiliary identification method and system for aortic dissection, and the method comprises the following steps: acquiring chest cavity plain scan images of a user's aorta through a CT device, and identifying cross-sectional contour images of the aorta in each chest cavity plain scan image through an image edge recognition algorithm; identifying edge structure information of each cross-sectional contour image, and extracting image features of each cross-sectional contour image; identifying each abnormal image area and abnormal information thereof in each cross-sectional contour image, identifying the abnormal type and abnormal degree of each cross-sectional contour image based on the abnormal information of each abnormal image area, and obtaining auxiliary identification information of aortic dissection of the user through an aortic dissection analysis strategy, aortic dissection probability prediction and prediction reasons. The scheme can improve the auxiliary identification efficiency of aortic dissection in emergency.

The invention relates to the technical field of medical image processing, and relates to an aortic dissection noninvasive blood flow velocity measurement method, system and device and a storage medium. The aortic dissection noninvasive blood flow velocity measurement method comprises the following steps: acquiring four-dimensional computed tomography angiography image data to be detected; analyzing the four-dimensional computed tomography angiography image data by using an optical flow method to obtain an aorta blood flow velocity field; analyzing the four-dimensional computed tomography angiography image data, segmenting an aorta image and extracting a center line of the aorta; determining the open area of each position of the aorta according to the aorta image and the center line of the aorta; and determining the instantaneous flow velocity of each position of the aorta according to the aorta blood flow velocity field and the overflowing area of each position of the aorta to obtain a blood flow velocity measurement result. According to the invention, the blood flow velocity of the aorta can be accurately identified.

The application discloses an aortic dissection risk reverse evaluation method and system, relates to the technical field of cardiovascular disease risk evaluation, and discloses an aortic dissection risk reverse evaluation method and system, which calculates a contradiction coefficient of blood vessel stability and behavior load by integrating medical image data and daily behavior dynamic data, generates early warning information based on the difference, effectively solves the technical problems that a traditional evaluation method cannot dynamically capture mechanical changes of a blood vessel wall and identify potential risk conflicts, can dynamically monitor the contradictory relationship between the geometric stability of a blood vessel and daily behavior load in real time, generates high-risk early warning information in time, avoids the early warning loss caused by too long an examination interval in the traditional evaluation method, and improves the accuracy and timeliness of risk evaluation.

This invention provides an information processing device, an information processing method, and an information processing program that can support the diagnosis of arterial dissection. [Solution] The information processing device 10 includes a processor, which acquires an input image including blood vessels, generates path information indicating the blood flow path based on the input image, identifies at least the starting position of the arterial dissection based on the path information, and determines the true lumen and false lumen of the arterial dissection based on the path information within a range set according to the starting position.

The utility model discloses a semi-covered stent applied to treatment of aortic dissection in Glardson's surgery, which comprises a metal framework, the metal framework is provided with a main support section and an auxiliary support section connected to the lower end of the main support section, and the main support section and the auxiliary support section are both constructed into an annular net-shaped structure capable of expanding along the radial direction, a covering film is arranged on the circumferential surface of the main supporting section, and meshes are distributed in the circumferential direction of the auxiliary supporting section after the auxiliary supporting section expands in the radial direction. The intravascular stent has the advantages that the descending aorta can be supported in an omnibearing mode only by being placed in the intravascular stent for one time, and blood supply of spinal cord branch blood vessels cannot be blocked.

The plugging device and plugging system provided by the present invention are used for targeted plugging of distal ruptures, and include an anchoring and supporting component and an elastic component. The elastic component is sleeved on the anchoring and supporting component. Wherein, the elastic component includes an elastic bag and a graft. The elastic bag wraps the anchoring and supporting component, and the elastic bag has an opening. The graft is used to be loaded into the elastic bag from the opening. By wrapping the anchoring and supporting component with the elastic bag, and the elastic bag having an opening, and the graft being used to be loaded into the elastic bag from the opening, the present invention can adapt to the characteristics of high blood pressure and fast blood flow in the false lumen of aortic dissection. The plugging device can effectively plug the blood flow in the false lumen, and there is no risk of displacement after implantation, reducing the occurrence of endoleak, with a high treatment success rate, and also reducing the physical damage to the inner wall of the false lumen in the tail section located in the false lumen.

The invention discloses an aortic dissection risk reverse assessment method and system, relates to the technical field of cardiovascular disease risk assessment, and discloses the aortic dissection risk reverse assessment method and system, which calculates a contradictory coefficient between vascular stability and behavior load by integrating medical image data and daily behavior dynamic data. The technical problem that a traditional evaluation method cannot dynamically capture mechanical changes of the blood vessel wall and cannot recognize potential risk conflicts is effectively solved, the contradictory relation between the geometric stability of the blood vessel and daily behavior loads can be dynamically monitored in real time, high-risk early warning information is generated in time, and the safety of the blood vessel is improved. The early warning deficiency caused by too long check interval in a traditional assessment method is avoided, and the accuracy and timeliness of risk assessment are improved.

This invention discloses a method and apparatus for diagnosing aortic dissection. The method involves registering CTA images and plain CT images to obtain a patient's aortic CT image dataset and a corresponding aortic CTA image dataset. The aortic centerline is extracted from both the CTA and CT image datasets. A model for extracting the aortic centerline based on the CT image centerline extraction results is then trained. This model is used to extract the aortic centerline from the patient's CT images. Simultaneously, based on the extracted results and corresponding patient labels, the method provides auxiliary diagnosis of aortic dissection. This invention addresses the problem of diagnosing aortic dissection based on extracting the vascular centerline from plain CT images.

The application relates to the technical field of medical image processing, and relates to an aortic dissection noninvasive blood flow velocity measurement method, system, device and storage medium; the aortic dissection noninvasive blood flow velocity measurement method comprises the following steps: acquiring four-dimensional computed tomography angiography image data to be detected; analyzing the four-dimensional computed tomography angiography image data by using an optical flow method to obtain an aortic blood flow velocity field; analyzing the four-dimensional computed tomography angiography image data, segmenting an aortic image and extracting a center line of the aorta; determining the flow area of each position of the aorta according to the aortic image and the center line of the aorta; determining the instantaneous flow velocity of each position of the aorta according to the aortic blood flow velocity field and the flow area of each position of the aorta, and obtaining a blood flow velocity measurement result. The application can accurately identify the blood flow velocity of the aorta.

The invention provides a pharmaceutical composition comprising ticagrelor for use in the reduction or prevention of thromboembolic events before and / or during and / or following a neurovascular arterial procedure of a patient in need thereof, comprising administering to the patient an effective amount of the pharmaceutical composition comprising ticagrelor, characterized in, that the pharmaceutical composition is an aqueous solution comprising a solubilizer for ticagrelor and the pharmaceutical composition is administered intravenously; wherein the patient is suffering from a cerebral aneurysm, a brain artery sclerosis, a neck artery sclerosis, a neurovascular carotid arterial dissection or a carotid artery dissection.

The invention relates to an aortic dissection embolism system based on a shape memory polymer, and the system comprises an embolism part which is made of shape memory polymer foam and has a compressed loading state and a preset state after expansion, and the embolism part is provided with a through central cavity and an edge cavity surrounding the periphery of the central cavity; an interventional catheter for accommodating the embolic member in a loaded state to perform interventional delivery; the delivery shaft is arranged in the intervention catheter in a sliding mode and used for carrying the embolism part to be released from the far end side of the intervention catheter to the aortic dissection, the embolism part in the loading state is integrally wound around the periphery of the delivery shaft, or the delivery shaft is arranged in the central cavity in a penetrating mode. Through the structural improvement of the embolism parts and the control of the expansion starting time, the released and expanded embolism parts are arranged in order, the space filling rate is high, and the surgical treatment effect can be further improved.

The invention relates to the technical field of medical instruments, and discloses a form-adaptive aortic dissection false cavity or aneurysm cavity thrombosis promoting embolism device which comprises a double-layer metal grid spindle-shaped skeleton of a hollow structure. Comprising a connecting point at the upper end and the lower end and an arc-shaped side face connected between the two points. The isolating membrane is located between the double-layer metal grid fusiform skeletons, and the double-layer metal grid fusiform skeletons are small in size after being compressed, can be quickly released and automatically adapt to the shape of an aortic dissection false cavity or an aneurysm cavity, so that the aneurysm cavity or the false cavity is fully blocked, and thrombosis of the aneurysm cavity or the false cavity is promoted. The device is simple in structure, convenient to operate, capable of adapting to the shape of an interlayer false cavity to be fully filled, good in blood flow isolation effect, capable of rapidly promoting thrombosis and remodeling of the false cavity, free of reverse compression of a true cavity and capable of being applied to occasions where embolism needs to be conducted on abdominal aortic aneurysm cavities and other branch arteries.

The invention discloses an application of valerian triester in preparation of products for preventing and treating aortic dissection, which can reduce the occurrence rate of aortic events, relieve the reduction of survival rate caused by aortic dissection, inhibit aortic dilatation caused by aortic dissection, reduce the number of elastic fiber fractures caused by aortic dissection and improve the survival rate of aortic dissection. The hematoma and the false cavity between aortic walls caused by the aortic dissection are improved, and the structural damage of the aortic walls caused by the aortic dissection is improved. According to the technical scheme provided by the invention, a brand new compound option is provided for the drug treatment of the aortic dissection.

A system for treating aortic dissection including an aortic dissection implant comprising an expandable anchoring structure and an elongate tubular structure. The expandable anchoring structure can be configured to apply radial force to the sinuses of the aortic root and / or the sinotubular junction when expanded. The elongate tubular structure can comprise an expandable support frame and one or more layers. The expandable support frame can be configured to extend from the descending aorta to the ascending aorta and curve along with a curvature of the aortic arch when expanded within the aorta. The one or more layers can comprise a first porous layer comprising an atraumatic outer surface positioned over the expandable support frame and a second non-porous layer positioned over a portion of the first porous layer. The second non-porous layer may be configured to be positioned on opposite sides of the aortic dissection and to be inflatable via blood flow to seal against the dissection.

The invention discloses an auxiliary device for anastomosis in an aortic dissection operation, and relates to the technical field of aortic dissection assistance, the auxiliary device comprises a handle and an extension seat, the extension seat is fixedly mounted on the outer surface of the handle, and an anastomosis mechanism is arranged between a rotating rod and a guide rod; an adjusting mechanism is arranged between the pressing sheet and the positioning block; an extension pipe is fixedly installed on the inner side face of the extension base, and a clamping mechanism facilitating suturing is arranged between the guide pipe and the extension pipe. According to the auxiliary device for anastomosis in the aortic dissection surgery, suture lines can be conveniently positioned through suture grooves formed in the distraction blocks, the distance between the suture lines is more uniform, the anastomosis and suture effect of blood vessels is improved, a positioning block is supported through a guide rod installed on an extension base, and after the three distraction blocks are distraction, the positioning block can be conveniently positioned. The dilating block enables the blood vessel to be dilated to the positioning block, and the dilating block and the positioning block are used for fixing the clamped blood vessel, so that the blood vessel can be conveniently matched with the aortic dissection, and personnel can conveniently suture the blood vessel.

The invention belongs to the technical field of biological medicine, and particularly discloses application of a bioactive composition in prevention, treatment and improvement of aortic dissection. The invention provides application of a bioactive composition in preparation of a medicine for preventing, treating and improving aortic dissection. The bioactive composition comprises docosahexaenoic acid and resveratrol. The invention discloses application of a bioactive composition in prevention, treatment and improvement of aortic dissection, and the aortic dissection is treated by repairing damaged aortic wall, retarding aortic dilatation, protecting elastic structure of aortic smooth muscle layer and recovering elastic phenotype of smooth muscle cells.

The application discloses a training method of an aortic dissection stress field prediction model and related products. First, a plurality of CT images of aortic dissection patients are obtained, and cross sections of the maximum diameter of the dissection are identified to obtain a plurality of target cross sections. Based on the cross sections, initial samples and corresponding geometric mechanics information thereof are constructed, and augmented samples and geometric mechanics information thereof are generated. Then, the initial samples and the augmented samples are determined as training samples, and a three-value label set is constructed for each training sample. Subsequently, the initial stress field of the training sample is physically boundary cleaned according to the three-value label set to obtain a target stress field. Finally, the training sample and a regular coordinate set thereof are taken as input, the target stress field is taken as a label, and a Fourier operator network is trained to generate a prediction model. The application can construct a stress field prediction model with strong generalization ability and high stability under small sample conditions, and realize rapid and accurate mechanical evaluation of individualized anatomical structures of different patients.

The present application relates to the technical field of postoperative risk grading identification, in particular to a system for grading the adverse risk of distal remodeling after aortic dissection surgery. The system first determines a thrombus permeation resistance coefficient according to the gray level difference of CT images of the patient at different times, and extracts the thrombus isolation thickness; based on the thrombus permeation resistance coefficient, solves the anisotropic potential function equation to determine the cumulative leakage cost; performs structure tensor analysis on the gradient in the cumulative loss field formed by the cumulative leakage cost to determine the jet channel consistency factor; combines the cumulative leakage cost, the jet channel consistency factor and the thrombus isolation thickness to calculate the fluid impact load borne by the outer wall of the blood vessel; and based on the fluid impact load and the jet channel consistency factor, determines the risk level of different connected domains in the CT image. The present application improves the accuracy of jet impact risk identification.

The invention discloses application of OSBP2 overexpression lentivirus in preparation of drugs for preventing / treating aortic dissection, the OSBP2 overexpression lentivirus is prepared, vascular smooth muscle cells are infected by the lentivirus, the protein expression level of OSBP2 can be effectively up-regulated, occurrence of aortic dissection is inhibited, and the OSBP2 overexpression lentivirus has potential clinical application value in prevention and treatment of aortic dissection.

The invention relates to an aortic dissection blocking membrane (10) comprising a blocking membrane arranged to be placed in a false lumen of an aortic arch (1) associated with an aortic dissection, wherein the blocking membrane is arranged to provide a blockage to the free flow of blood in the false lumen by being foldable and / or by comprising a plurality of protrusions (11). The invention further relates to an aortic dissection system for treating blood flow within a false lumen of an aortic arch (1) associated with an aortic dissection.

The invention provides application of astaxanthin in preparation of drugs for preventing and treating aortic dissection, and discovers that the astaxanthin can obviously reduce the death rate of mice with aortic dissection, improve the survival rate of the mice and reduce the aortic arch dilation degree and the blood vessel inner diameter; the occurrence of the aortic dissection and the cavity and fracture of the aortic middle layer structure are inhibited, and a novel potential prevention and treatment medicine is provided for the aortic dissection.

The invention relates to the technical field of follow-up visit adjustment, in particular to an imaging follow-up visit system after aortic dissection repair. The system comprises an image acquisition module which is used for acquiring and identifying an aorta area of a blood vessel cross section image in follow-up visit; the image registration module is used for registering the adjacent aorta areas in follow-up visit; the false cavity expansion analysis module determines a false cavity region and quantifies the area and the extension direction change of the false cavity to obtain an expansion index; the false cavity recovery evaluation module obtains a remodeling index through false cavity area distribution and stability of an expansion index in combination with true cavity area gray level distribution, and obtains a false cavity recovery index through remodeling time sequence change in combination with an initial false cavity serious condition; the follow-up adjustment module adjusts the follow-up interval based on the false cavity recovery index. According to the method, the aorta area in multiple follow-up visit is registered, the influence of the expansion degree and direction of the false cavity on recovery stability is analyzed, the recovery condition of the false cavity is evaluated, the follow-up visit strategy is adjusted, and a more reasonable and reliable adjustment scheme is provided.

The invention belongs to the technical field of medicinal preparations, particularly relates to a novel medicinal application of coenzyme Q10, and more particularly relates to an application of coenzyme Q10 in preparation of a medicine for preventing and treating acute A-type aortic dissection. The application of the coenzyme Q10 in the aspect of preventing and treating the acute A-type aortic dissection is found and verified by researching the pharmacological action of the coenzyme Q10, the effect of the coenzyme Q10 in the aspect of improving the acute A-type aortic dissection is remarkable, and a solid pharmacodynamic basis is provided for new clinical research and application of the medicine.

The present application discloses an aortic rapid repair stent, a stent kit and a delivery system. The stent of the present invention includes a stent body and a channel surrounded by the stent body, and is characterized in that the stent body has a woven mesh structure, the mesh of the mesh structure is expandable and deformable, and the widest part of the mesh is at least 1 mm when not expanded. The stent of the present invention can quickly alleviate the risk of arterial dissection or aneurysm in the aorta with branched blood vessels by applying a woven, high-elastic mesh with large support force, thereby avoiding the risk of the stent blocking the blood flow of the branched artery on the one hand, and on the other hand, can quickly repair the aorta in advance, reduce the surgical risk and the technical difficulty of the operation, thereby winning precious treatment time for the patient.

The utility model discloses an aortic dissection preoperative patient abdominal cavity pressure monitoring alarm device, which relates to the technical field of monitoring and comprises a bandage body, a positioning buckle is fixedly mounted on the surface of the bandage body, and the inner side and the outer side of the bandage body are respectively connected with a guide buckle and a placing plate in a sliding manner. The opposite sides of the guide buckle and the placement plate abut against the surface of the bandage body, and limiting rods are fixedly installed on the opposite sides of the guide buckle and the placement plate. The device has the advantages that the navel, the left waist and the right waist can be conveniently adjusted and monitored at the same time, meanwhile, the device has a flexible adjusting effect, so that the high efficiency of monitoring and using patients with different body types is realized, and the defect of low operation efficiency when the patients are monitored before the traditional aortic dissection operation is overcome; meanwhile, the monitoring operation steps of the patient are simplified.

This invention belongs to, but is not limited to, the field of medical device technology, and particularly relates to a clamping forceps for clamping different tissues in complex aortic dissections. It comprises a handle assembly, a transmission assembly, and a jaw assembly, with each component connected in a modular, detachable manner. The handle assembly serves as the power input and control terminal, with its internal control module and power output fixedly connected to one end of the transmission assembly to transmit power and clamping force adjustment signals. The other end of the transmission assembly is detachably and fixedly connected to the jaw assembly, accurately transmitting the power and adjustment signals input from the handle assembly to each clamping unit of the jaw assembly. The jaw assembly serves as the clamping execution terminal, with each clamping unit correspondingly connected to a micro-drive mechanism of the transmission assembly, forming an integrated connection architecture of handle control, transmission, and jaw execution.