59 results about "Arterial dissection" patented technology

The invention discloses a method for preparing a personalized bionic drug eluting coronary stent by using a 3D printing technology and a product. The method for preparing the personalized bionic drug eluting coronary stent comprises the step that according to image data of coronary angiogram, adopting a QCA technique for measuring the diameter of a diseased coronary artery and reconstructing in a three-dimensional manner. According to indexes such as lesion vascular diameter, lesion length and lesion vascular pattern, a personalized coronary stent can be made for each patient in a customized manner and a stent most suitable for the lesion state of a patient can be prepared. The personalized bionic drug eluting coronary stent can be made of degradable poly L-lactic acid (PLLA) or other materials, after 3D printing molding, the surface of the stent can be coated with a polymer with anti-proliferation medicines by using a conventional process, and in-stent restenosis can be reduced (the polymer is prepared by mixing a medicine with PDLLA in a ratio of the medicine to PDLLA being 1:1). The most suitable personalized bionic drug eluting coronary stent can be customized for the patient according to diseased coronary arteries of different states, requirements of different lesions can be met, customization of coronary stents can be achieved, and complications such as vascular injury, thrombus and coronary arterial dissection caused by mismatching of the diameter of the stent and that of the blood vessel can be reduced.

The invention discloses a human body thoracic and abdominal cavity CT image aorta segmentation method based on a GVF Snake model. The method overcomes the shortcomings of the heavy workload and long time consuming of the traditional manual and semi-automatic segmentation, the repeatability of the method is good, and the uncertainty caused by artificial segmentation is prevented. The method includes (1) reading a CT image and performing image preprocessing; (2) performing the initial profile setting of the GVF Snake model on the image obtained after the preprocessing; (3) obtaining the edge image of the image after the preprocessing; (4) obtaining gradient vector flow GVF as the external energy field by the diffusion equation based on the obtained edge image; (5) establishing an internal energy model to maintain the smoothness of the profile; and (6) constructing an energy function E by means of internal energy and external energy, obtaining the minimum value of energy E by means of iteration operation, and the target boundary of the profile can be obtained at the end. The method has important application values in the field of human body thoracic and abdominal cavity aorta interlayer segmentation diagnosis treatment.

The methods and devices disclosed herein pertain to the percutaneous treatment of various forms of aortic dissection by at least partially filling the false lumen of the aortic dissection with a stabilization agent percutaneously and steps to decrease the size of the false lumen using the devices. Fluid maybe aspirated from the false lumen to decrease the volume of the false lumen. And the entrance opening between the true lumen and the false lumen may be sealed with a sealing agent such as a biocompatible adhesive. The medical devices disclosed herein generally comprise an extendable sealing element that is used in conjunction with a catheter to expand the true lumen while reducing the size of the false lumen. The device has the ability to aspirate and/or deliver fluid containing the stabilization agent into the false lumen.

An occlusion device for vascular surgery, suitable for clogging treatments of vascular entry sites and for endovascular interventions such as embolizations of blood vessels, treatment of arteriovenous malformations or small aneurysms, arterial dissections and the like, by releasing in an operation region a quick setting surgical glue or haemostatic fluid, through an outlet mouth of a duct. The device prevents the surgical glue from contacting within the duct a patient's biological fluids, in particular blood, which would close the duct. In the case of clogging treatments of vascular entry sites, a backflow preventing device may be provided, preferably provided by a coupling device between the duct and an introducer sheath by which an outlet mouth is kept in contact to keep in a one-way fluid tight contact against the outer surface of the introducer sheath until an injection pressure P2 is applied to cause release of the surgical glue.

The invention provides a model building method for dissection of aorta, a model and a surgery simulation detection method. The model building method includes acquiring CTA video data of the aorta of apatient; building a three-dimensional model for the dissection of aorta according to the acquired CTA video data; performing 3D printing according to the three-dimensional model to prepare a model for dissection of aorta by utilizing a transparent material having elasticity same as that of blood vessels of the patient; arranging a pressure sensor on the inner side of the wall of the aorta in themodel for dissection of aorta, and arranging a flow sensor at an aorta branch outlet of the model for dissection of aorta. Accordingly, a physician can perform surgery simulation before actual surgeries.

The invention discloses a covered stent for aortic dissection surgery, a conveying device and a use method. The stent comprises a body which is a covered stent body. The stent is a conical stent with the diameter gradually reduced from the cardiac proximal portion to the thoracic aorta distal portion. An exposed portion is arranged on the lower portion of the body of the stent and is not covered. Three balloon dilatation stents are connected to the upper edge of the middle of the body. A protective gasket made from polytetrafluoroethylene is arranged at the near end of the body. The three balloon dilatation stents are provided with three catheters respectively. Each catheter is about 2 m long. The conveying device comprises a conveying sheath, the body of the stent is compressed in the conveying sheath, and the three balloon dilatation stents on the middle section of the body are compressed in the conveying sheath. A conveying sheath system is provided with an apex, and notches are formed in the tip end of the conveying sheath system for the body of the stent and guide wires and the catheters of the three balloon dilatation stents. The invention provides the covered stent for aortic dissection surgery. The stent is used for minimally invasive surgery treatment of Stanford A type aortic dissection with a wound among three branch vessels on the arcus aortae, avoids injuries caused by thoracotomy, and can be directly used for intra-cardiac wound occlusion.

An implantable medical device (30) for treating aortic dissections includes a stent graft part (34) having a bulbous section (48) of greater radial diameter than the radial diameter of first and second sections (60,62) of the stent graft part (34). The bulbous section (48) is able to close off the false lumen (10) of an aortic dissection, thereby to prevent any fluid backflow into the false lumen (10). Radiopaque markers (70) may be provided for orientation and deployment purposes. The device (30) is able to treat chronic dissections and reduce false lumen backflow, which remains otherwise an unresolved issue in the endovascular treatment of false lumen aneurysms.

The invention relates to the technical field of biology, in particular to a purpose of an HSP90 inhibitor in preparation of medicine for preventing and treating aortic diseases. The HSP90 inhibitor is used for preparing medicine or a reagent for preventing or treating aortic dissection. The invention also provides a method for screening potential substances for preventing or treating the aortic diseases, and a method for preventing or treating the aortic diseases of mammal. The invention discloses the purpose of the HSP90 inhibitor for specially inhibiting the aortic dissection cracking for the first time, and discloses the close relevancy of the HSP90 expression to the aortic diseases for the first time, so that a novel target point is provided for the large vessel disease prevention and treatment.

The invention provides an establishment method of an animal model for acute Stanford A-type aortic dissection (AD) accompanied with MODS (multiple organ dysfunction syndrome), a use of emodin for preparing a medicine for treating acute Stanford A-type AD accompanied with MODS as well as a viscera protective agent for acute Stanford A-type AD accompanied with MODS. In the invention, an AD surgery method is improved and meanwhile manually controlled hypertension is formed by continuously pumping adrenaline into veins so as to promote expansion of the AD stripping range and accelerate disease progression, thus acute Stanford A-type AD accompanied with MODS can be rapidly formed so as to successfully make the model. The animal model for acute Stanford A-type AD accompanied with MODS creates conditions for further deep research in application foundation and intervention treatment.

The invention discloses a combination-type intra-operative on-demand blocking branched stent-type blood vessel. The stent-type blood vessel is used in open-type operations of replacing aorta arches and branch blood vessels thereof during the aortic dissection treatment. The combination-type intra-operative on-demand blocking branched stent-type blood vessel comprises two or three stent-type blood vessel bodies from the distal end of the aorta arch to the proximal end of the aorta arch, can be suitable for individual structures of three branch blood vessels of the aorta arch of a patient, and improves the matching degrees between the stent-type blood vessel and the three branch blood vessels of the human-body aorta arch. When the stent-type blood vessel is used, dissociative brachiocephalic blood vessels can be avoided or reduced, it is unnecessary to replace the aorta arch and branch blood vessels, anastomotic stomas are reduced, and the extracorporeal circulation time and the unilateral cerebral perfusion time are shortened, so that operative manipulation difficulties and operative wounds are reduced, the operation time is shortened, postoperative complications are reduced, and the mortality rate is reduced.

The invention relates to the technical field of medical instruments, in particular to an endovascular repair graft for treating the aortic dissection false lumen. The endovascular repair graft is composed of an occluding part and a conveying device, wherein the body of the occluding part is of a cylinder structure formed by knitting wire mesh, and the body is covered with membranes, so that the occluding part forms a closed cavity. The endovascular repair graft can be stably fixed to the dissection false lumen and effectively occlude slits to cut off false lumen blood flow. Different from an existing occluder repair device which is placed in the aorta to precisely cover a slit, the occluding part is a closed stent graft and completely covers multiple or even all slits; meanwhile, as both ends, in the axial direction, of the occluding part are covered with the membranes, the occluding part is a closed cylinder, the shape and mechanical properties are strictly suitable for the false lumen, the occluding part can basically or even completely fill the false lumen, it is more difficult for blood to flow in or flow out, the false lumen blood flow is cut off, and thrombosis in the false lumen is accelerated.

The invention discloses application of histone methyltransferase EZH2 to preparation of a medicinal preparation for preventing or treating aortic diseases. The invention confirms that the EZH2 can effectively inhibit autophagy of vascular smooth muscle cells and promote the survival of smooth muscle cells; a novel target spot and strategy are provided for effective treatment of aortic dissection and other aortic diseases with reduction of the vascular smooth muscle cells as the basis of cytology, and a basic is provided for the development of a novel medicament for treating diseases of the type.

The invention discloses a device and method for detecting biomechanical properties of aortic dissection lesion blood vessels. The biomechanical property of the diseased blood vessel is detected by using the detection device with two tension handles; when the biomechanical properties of the aortic dissection lesion blood vessels are detected, the bilateral tensile strain, the corresponding stress and the cutting stress of the penetrating suture on the lesion blood vessel wall material due to traction are tested. Through the testing of the bilateral tensile strain, the corresponding stress and the cutting stress generated by the penetrating suture on the vascular wall material of the lesion due to traction for the lesion blood vessel wall, the device achieved the detecting and recording of the biomechanical properties of walls of the aortic dissection lesion blood vessels and provides accurate and effective guidance data for doctors; therefore, the accurate implementation parameters areprovided for the operation process of the aortic canal wall with the dissection lesion, and the operation risk is greatly reduced.

The invention provides an aorta covered stent. The aorta covered stent comprises a main stent, the main stent comprises a main stent body, the main stent body is provided with at least one concave part, a main stent membrane covers the main stent body, and the main stent membrane of the concave part is provided with at least one through hole for a branch arterial stent to stretch into the main stent. The aorta covered stent can be used for treating aortic aneurysm or aortic dissection, internal hemorrhage can be effectively reduced, branch blood flow clogging can be effectively prevented, andthe operation is also convenient.

The invention discloses a group of biomarkers for assessing the aortic dissection risks and application of the biomarkers. The biomarkers can be one or a combination of several of gene mutation sitesin Table 1. The invention further provides application of the gene mutation sites to preparation of detection products for detecting or assessing the aortic dissection disease. The invention finds 44aortic dissection susceptible mutation sites and studies application prospects thereof in early prediction of aortic dissection; aortic dissection-related gene sites provided by the invention can be used as early biomarkers for the aortic dissection; a new direction is provided for further studying the genetic molecular mechanism of the aortic dissection and exploring medicine targets for early prevention and treatment of the aortic dissection.