Method for detecting small-molecule metabolic markers in peripheral blood of aortic dissection, and its application

A technology for aortic dissection and metabolic markers, applied in the field of screening small molecule metabolite markers in peripheral blood for aortic dissection, can solve the problems of unfavorable promotion of early diagnosis technology and high cost of protein detection

Active Publication Date: 2018-02-09
广东行海生物科技有限公司
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Problems solved by technology

Moreover, the detection cost of protein as an early diagnostic marker is relatively high, which is not conducive to the promotion of early diagnostic technology

Method used

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  • Method for detecting small-molecule metabolic markers in peripheral blood of aortic dissection, and its application
  • Method for detecting small-molecule metabolic markers in peripheral blood of aortic dissection, and its application
  • Method for detecting small-molecule metabolic markers in peripheral blood of aortic dissection, and its application

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Embodiment 1

[0033] Example 1: Screening of Small Molecule Markers of Aortic Dissection Peripheral Blood Metabolism

[0034] Step 1: Sample collection and storage

[0035] Inclusion criteria for aortic dissection samples: 1. Diagnosed with aortic dissection by imaging data (CTA, DSA or MRA); 2. The time interval from the first onset to sampling is less than or equal to 14 days;

[0036] Sample exclusion criteria: 1. Patients with various types of aortic injury caused by trauma, such as aortic transection, aortic pseudotumor, etc.; 2. Aortic dissection samples whose time interval from the first onset to sampling exceeds 14 days; 3. Acute Or patients with chronic infectious diseases, patients with connective tissue diseases or malignant tumors, patients with a history of long-term use of immunosuppressants, patients with a history of venous thrombosis in the lower extremities, patients with a history of myocardial infarction, patients with severe liver and kidney insufficiency or severe elec...

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Abstract

The invention relates to a method for detecting small-molecule metabolic markers in the peripheral blood of aortic dissection, and its application. Combined chromatography and mass spectrometry are employed for high-flux large-scale metabonomic analysis of patients with aortic dissection to determine small-molecule metabolic profiling of the peripheral blood of the aortic dissection, and three small-molecule metabolic markers with greatest difference is obtained, wherein the three small-molecule metabolic markers are N1-acetyl-N2-formyl-5-methoxy kynurenine, glycerophosphorylcholine and 2-mercaptohistidine betaine. The invention provides a simple, low-harm and cheap method for screening and diagnosis of aortic dissection, and effective reference bases can be provided for diagnosis of clinical patients and assessment of the treatment efficacy of drugs.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a method for screening small molecule metabolite markers in peripheral blood of aortic dissection and an application thereof. Background technique [0002] Acute myocardial infarction, pulmonary embolism, and aortic dissection (AD) are the common causes of clinical chest pain patients, and they are also the main diseases leading to death in patients with acute chest pain. AD disease refers to the partial tearing of the intima and the strong blood impact, the intima gradually peels off and expands, forming two true and false lumens in the artery, resulting in a series of manifestations including tearing pain. The aorta is the main blood vessel of the body. It bears the pressure directly from the beating of the heart. The blood flow is huge, and the intimal layer is torn. If proper and timely treatment is not carried out, the chance of rupture is very high, and the mortalit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8822
Inventor 刘锡君操龙斌
Owner 广东行海生物科技有限公司
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