34 results about "Aortic sinus" patented technology

The present invention provides an aortic valvuloplasty catheter which, in one preferred embodiment, has a tapered distal balloon segment that anchors within the left ventricle outflow track of the patient's heart and a rounded proximal segment which conforms to the aortic sinuses forcing the valve leaflets open. In addition, this embodiment of the valvuloplasty catheter includes a fiber-based balloon membrane, a distal pigtail end hole catheter tip, and a catheter sheath.

The present invention is an apparatus designed to effectuate restoration of normal aortic valvular function where there is aortic valvular regurgitation either primary or secondary to diseases of the aorta such as aortic aneurysm, aortic dissection, rheumatic aortic disease annuloaortic ectasia and etc. is present. The present invention provides an apparatus for repairing aortic annulus composed of (1) a band type inner stabilizer (sometimes ring type inner stabilizer) which is implanted in the true aortic lumen to fix the aortic annular diameter and (2) an outer felt stabilizer which is implanted on the outside surface of aorta to support the inner stabilizer. Furthermore, the present invention provides an apparatus for restoring the sinotubular junction in the ascending aorta which is composed of (1) a ring type inner stabilizer which is implanted in the sinotubular junction in the ascending aorta and (2) an outer felt stabilizer which is implanted on the outside surface of the sinotubular junction to support the inner stabilizer.

The invention relates to a woven aortic sinus prosthesis (1) having a first substantially cylindrical section (2) not close to the heart, which possibly transitions into an aortic arch, a second section (6) forming a bulb, which is expanded in comparison to the first section with regard to the diameter and which connects to the first section (2), and possibly a third substantially cylindrical section (8) close to the heart, which connects to the bulb section (6).

The invention provides a coronary artery center line generation method and device based on bidirectional coronary artery blood vessel tracking. The method comprises the steps that according to an input coronary artery mask, blood vessel starting points, located at the aortic sinus, of coronary artery blood vessels and all tail end points in a connected domain in the mask where all the starting points are located are extracted; coronary artery center lines are extracted by tracking coronary artery blood vessels from top to bottom from a starting point, and a coronary artery center line tree isconstructed; coronary vessels are tracked from bottom to top from the tail end point, and a coronary center line tree is complemented; removing blood vessel adhesion and vein center lines, and combining all extracted coronary artery center line trees to obtain a complete coronary artery center line.

The invention belongs to the medical image processing technical field and provides a method for extracting cardiovascular vessels from CTA (computed tomography angiography) images, a device for extracting cardiovascular vessels from CTA images, an apparatus for extracting cardiovascular vessels from CTA images and a storage medium. The method includes the following steps that: etching operation and expansion operation are sequentially performed on image data by using preset structural elements, so that a structural template is obtained; layer-by-layer transformation is performed on the sectional images of the structural template, so that a first ascending aorta structure in the structural template can be obtained, aorta center coordinates and an aorta radius are obtained from the last sectional image layer of the structural template; and a binary sphere structure is built according to the aorta center coordinates and the aorta radius, and the first ascending aorta structure is combined with the structural template and the binary sphere structure, so that a second ascending aorta structure can be obtained through combination. With the method, device, apparatus and storage medium of the invention adopted, ascending aortas and the shapes of aortic sinuses at the roots of the ascending aortas can be extracted, and therefore, the structures and shapes of the aortas can be accurately visualized, and the solving level and capability of medical image research on clinical problems can be improved.

The invention provides an aortic root stent system. The aortic root stent system comprises an aortic stent and a sinus anchoring stent, wherein the aortic stent is correspondingly arranged on the inner wall of the ascending aorta; the sinus anchoring stent is attached to the inner wall of the aortic sinus and extends downwards from the junction of sinus canals; the bottom of the sinus anchoring stent extends inwards to form a plurality of crown valve stents attached to the aortic sinus; the peripheral surfaces of the crown valve stents form a garlic-clove-shaped structure; the top ends of theinner sides of the crown valve stents correspondingly extend to the outer side of the valve ring; and an opening allowing valve leaflets to move freely is formed in the tail end of each crown valve stent. For the aortic root stent system, the crown valve stents can increase the anchoring area of the whole sinus anchoring stent in the aortic valve, the positioning is firm, displacement seldom occurs under the impact of blood flow, and thus the stability of the aortic root anchoring system in the aortic valve is improved.

The invention discloses a function and application of an MAPK (mitogen-activated protein kinase) signal-integrating kinase 1 (Mnk1) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<- / -> mouse and an Mnk1<- / ->ApoE<- / -> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<- / -> mouse, the gene defect of the Mnk1 obviously reduces the plaque area of an aorta tree, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the Mnk1 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion of the atherosclerosis. Aiming at the function of the Mnk1, the Mnk1 can be used as a drug target for screening a medicament for preventing, relieving and / or treating the atherosclerosis and an inhibitor of the Mnk1 can be used for preparing the medicament for preventing, relieving and / or treating the atherosclerosis.

The invention discloses a function and application of an MAPK (mitogen-activated protein kinase) signal-integrating kinase 2 (Mnk2) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<- / -> mouse and an Mnk2<- / ->ApoE<- / -> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<- / -> mouse, the gene defect of the Mnk2 obviously reduces the plaque area of an aorta, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the Mnk2 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion for the atherosclerosis. Aiming at the function of the Mnk2, the Mnk2 can be used as a drug target for screening a medicament for preventing, relieving and / or treating the atherosclerosis and an inhibitor of the Mnk2 can be used for preparing the medicament for preventing, relieving and / or treating the atherosclerosis.

The invention discloses an occluder for rupture of aortic sinusal aneurysm. A fabric body comprises a circular-arc area, a cylindrical area and a circular disk area, wherein the edge of the circular-arc area is formed by extending out of the outer edge of the cylindrical area by 3-4 millimeters; the cylindrical area is a hollow cylinder of which the diameter is 4-20 millimeters, and the thickness is 2.5-4 millimeters; the circular disk area is a circular flat plate which extends outwards by 0.5-2 millimeters; the closed portion of the fabric body is positioned in the center of the circular disk area and is depressed inwards, and a threaded column is fixed to a recess; expanded films are arranged in the internal cavities of the circular-arc area, the cylindrical area and circular-disk area respectively. The radian of the circular-arc area can be perfectly jointed with one side of an aortic valve, thereby realizing protection in the swinging process of the aortic valve; since the convex edge of the circular disk area is small, a clamping function can be realized; meanwhile, resistance to blood during the flow of blood is reduced as much as possible, and the blood flow smoothness is ensured.

The invention discloses function and application of signal regulatory protein 1 (SHPS1) treating atherosclerosis, and belongs to the field of functions and application of genes. According to the technical scheme, an ApoE<- / -> mouse and a SHPS1<- / ->ApoE<- / -> mouse are taken as experiment objects, atherosclerotic models are obtained through high-fat diet induction, and results show that compared with the ApoE<- / -> mouse, SHPS1 gene defect leads to substantial reduction of the aorta plaque area, stability enhancement of aortic sinus plaque and mitigation of inflammation reaction. The results show that SHPS1 mainly has the effects of promoting formation of aorta plaque area and especially promoting atherosclerosis in the functions of atherosclerosis. Aiming at the above functions of SHPS1, SHPS1 can be used as a medicine target and is applied to screen medicines for preventing, alleviating and / or treating atherosclerosis, and an inhibitor of SHPS1 is applicable to prepare medicines for preventing, alleviating and / or treating atherosclerosis.

The invention discloses applications of an interferon regulatory factor 1 gene in treatment of atherosclerosis, belonging to the field of the functions and applications of a gene. An atherosclerosis model is obtained by taking ApoE- / -mice and IRF1- / -ApoE- / -mice as experimental objects through induction of high-fat diet, results show that the IRF1 gene defects markedly reduce the plaque area of the aorta, enhance the stability of aortic sinus plaque, and markedly lighten the inflammatory response compared with the ApoE- / -mice. The function of the IRF1 in the atherosclerosis is mainly reflected by the fact that the IRF1 achieves the effect of promoting the formation of the aortic plaque, especially the effect of promoting the atherosclerosis. Aiming to the functions of the IRF1, the IRF1 can be used as a drug target for screening drugs preventing, alleviating and / or treating atherosclerosis, and an inhibitor of the IRF1 can be used for preparing a drug for preventing, alleviating and / or treating atherosclerosis.

The invention discloses an ascending aortic stent graft, and relates to the field of medical instruments. The ascending aortic stent graft includes a stent, a cover at least partially covering the stent and a valve leaflet for reconstructing an aortic valve, and the valve leaflet is disposed at a proximal end of the stent and connected with the stent and the cover. The ascending aortic stent graftis provided with the valve leaf for reconstructing the aortic valve adapted to allowing blood from a left ventricle to flow into aortas and preventing the blood from flowing back from the aortas to the left ventricle; the stent graft is provided with two windows adapted to being aligned with two coronary artery openings. Therefore, for aortic root lesions involving both an aortic sinus and the aortic valve, minimally invasive endovascular treatment can be used for implanting the ascending aortic stent graft into an ascending aortic root, which repairs the ascending aortas, and reconstructs the aorta valve, the aortic sinus and the coronary artery openings, and the goal of integrated healing is achieved.

The invention discloses a function and an application of a blood shear stress responding protein 1 (RECS1) in treatment of atherosclerosis and belongs to the field of functions and applications of genes. In the invention, an ApoE - / - mouse and an RECS1 - / - ApoE - / - mouse are employed as experimental subjects and an atherosclerosis model is obtained through high-fat diet induction. A result proves that compared with the ApoE - / - mouse, a RECS1 gene defect can significantly reduce a plague area in aorta, enhance stability of aortic sinus plagues and significantly alleviate inflammatory response, which indicate that the RECS1 in the atherosclerosis mainly has effects of promoting formation of a plague in the aorta, especially promoting the atherosclerosis. On the basis of the functions of the RECS1, the RECS1, as a drug target, can be used for screening a drug for preventing, alleviating and / or treating the atherosclerosis. An inhibitor of the RECS1 can be used for preparing a drug for preventing, alleviating and / or treating the atherosclerosis.

The invention discloses functions and applications of nucleotide synthetase CAD in treatment of atherosclerosis, belonging to the fields of functions and applications of genes. ApoE- / - mice and CAD- / -ApoE- / - mice are taken as experimental subjects, an atherosclerosis model is obtained through high fat diet induction, the result proves that compared with the ApoE- / - mice, the plaque area of the aorta is obviously reduced due to the CAD gene defects, the stability of sinus plaques of the aorta is enhanced, and the inflammatory response is obviously alleviated. The functions of the CAD in atherosclerosis mainly refer to the effects of promoting aorta plaque formation, particularly the effect of promoting the atherosclerosis. Aiming at the functions of the CAD, the CAD can serve as a drug target to be used for screening medicines for preventing, relieving and / or treating the atherosclerosis, and inhibitors of the CAD can be used for preparing medicines for preventing, relieving and / or treating the atherosclerosis.

A first cylindrical section (2) away from a heart verges into an aortic curve, if required. A second cylindrical section (6) has a wider diameter compared to the first section, forms a bulbus and links to the first section. If required, a third cylindrical section (8) near to a heart links to the section forming the bulbus.

The present invention is applicable to the technical field of medical image processing, and provides a method, an apparatus, a device, and a storage medium for extracting a cardiovascular vessel from a CTA image. The method comprises: performing erosion operation and dilation operation on image data successively via a preset structural element to obtain a structure mask; performing a slice-by-slice transformation on the plane of section images of the structural mask to acquire the first ascending aortic structure in the structural mask, and acquiring an aortic center position and an aortic radius in the last slice of the plane of section image of the said structural mask; establishing a binarized sphere structure according to the aortic center position and the aortic radius, and synthesizing a second ascending aorta structure by combining the first ascending aorta structure with the structure mask and the binarized sphere structure. The present invention realizes extracting shapes of ascending aorta and root aortic sinus, so that the aortic structure and morphology can be accurately visualized, thereby greatly improving the level and ability of medical imaging researches to solve clinical issues.

The invention relates to a valved conduit device for an aortic root. A transplanting conduit comprises an ascending aorta replacement tube and an aortic sinus replacement portion. A bioprosthetic valve comprises a bovine pericardium and a nickel-titanium support, wherein the nickel-titanium support is located outside the bovine pericardium, and the bovine pericardium is wrapped with the nickel-titanium support and fixed through the nickel-titanium support; the bioprosthetic valve is arranged in the aortic sinus replacement portion through an opening device, and is opened through the opening device to be closely attached to the inner wall of the aortic sinus replacement portion, the height of the nickel-titanium support is higher than the height of the aortic sinus replacement portion, and the nickel-titanium support is divided into an ascending aorta section and an aortic sinus section. According to the valved conduit device for the aortic root, the operation time of the aortic root is shortened, the biocompatibility is improved through the bioprosthetic valve, and the side effects brought by mechanical valve anticoagulation is reduced.

The invention discloses a function and application of microRNA150 (miR150) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<- / -> mouse and an miR150<- / ->ApoE<- / -> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<- / -> mouse, the gene defect of the miR150 obviously reduces the plaque area of an aorta, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the miR150 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion for the atherosclerosis. Aiming at the function of the miR150, the miR150 can be used as a drug target for screening a medicament for preventing, relieving and / or treating the atherosclerosis and an inhibitor of the miR150 can be used for preparing the medicament for preventing, relieving and / or treating the atherosclerosis.

The invention discloses a function and application of an MAPK (mitogen-activated protein kinase) signal-integrating kinase 2 (Mnk2) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<- / -> mouse and an Mnk2<- / ->ApoE<- / -> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<- / -> mouse, the gene defect of the Mnk2 obviously reduces the plaque area of an aorta, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the Mnk2 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion for the atherosclerosis. Aiming at the function of the Mnk2, the Mnk2 can be used as a drug target for screening a medicament for preventing, relieving and / or treating the atherosclerosis and an inhibitor of the Mnk2 can be used for preparing the medicament for preventing, relieving and / or treating the atherosclerosis.

The invention discloses an anti-regurgitation artificial heart valve, which comprises a tubular support, skirt cloth covering the inner surface of the tubular support, a plurality of artificial valve leaflets fixed in the tubular support, and an anti-regurgitation ring arranged outside the tubular support in a sleeving mode, wherein the anti-regurgitation ring comprises a plurality of anchoring parts; the anchoring parts are designed into a unique shape with double supporting feet at the bottom and a deformable grid in the middle; one pair of side ribs is inserted along two sides of the interior of the semilunar valve; a first bottom rib and a second bottom rib are abutted against two sides of the bottom of the aortic sinus so as to form two acting points; and a contact area is increased through a grid consisting of inner ribs. Compared with most existing technical schemes adopting a U-shaped or V-shaped simple outer frame to exert force at a single point, when the anchoring parts and the native valve leaflet are inserted and positioned, an alignment deviation is small, positioning is accurate and convenient, the anchoring parts have a good shaping effect on the native valve leaflet, a clamping area is large, and the native valve leaflet can be more stably and firmly clamped when the native valve leaflet is clamped inside and outside the anti-regurgitation ring and the tubular support.

The invention belongs to the field of medical technology and discloses an intraoperative image localization system and a method in cardiovascular medicine based on big data analysis. The localizationsystem comprises an image acquisition module, a central processing module, an image processing module, an image extraction module, an image projection module, a cloud service module and a display module. Also disclosed is an intraoperative image localization method of cardiovascular medicine based on big data analysis. On the basis of keeping the hue value of each pixel unchanged, the image processing module enhances and corrects the color saturation value of the pixel, thereby avoiding the generation of color deviation phenomenon. The system solves the technical problem that the existing image enhancement methods are easy to produce color deviation phenomenon. The shape of ascending aorta and its root aortic sinus can be extracted by image extraction module so that the structure and shapeof aorta can be accurately visualized and the level and ability of medical imaging research to solve clinical problems can be greatly improved.

The invention discloses an automatic positioning device for a TAVI preoperative key target and a method thereof, and relates to the technical field of medical image processing. The device comprises a data acquisition module for acquiring heart CTA data; a data extraction module used for extracting data required for key target positioning from the heart CTA data; and a key target positioning module used for positioning a key target required before the TAVI operation and outputting a positioning result. The method comprises the following steps: acquiring the heart CTA data; segmenting the aorta and the coronary artery; positioning left and right coronary artery opening positions and determining an aorta center line; sampling points on the center line to obtain cross sections with segmentation results on the center line by taking each sampling point as the center, wherein the normal of each cross section corresponds to the tangent line of the sampling point; determining a segmentation plane of the aorta from each aorta cross section with the segmentation result to obtain a series of aorta planes; and positioning an aortic sinus tube junction plane, an aortic annulus plane, an ascending aortic plane, and an aortic sinus annulus plane from the aortic plane.

Disclosed herein is a stent graft for ascending aorta, comprising a stent; a cover attachment at least partially covering the stent; a valve leaflet for reconstructing aortic valves, which are positioned at the proximal end of the stent and attached to the cover attachment and the stent. The valve leaflet for reconstructing aortic valves is configured to allow blood to flow from the left ventricle to the aorta and prevent blood from flowing from the aorta back to the left ventricle. In addition, the stent graft has two windows aligning with two openings of the coronary artery. Therefore, for the aortic root diseases involving aortic sinus and aortic valves, the stent graft for ascending aorta can be implanted into ascending aortic root by minimally invasive endovascular surgery to repair the ascending aorta lesions and reconstruct the aortic valves, aortic sinus, openings of the coronary artery, thereby achieving overall cure.

The invention relates to a sinusal aneurysm plug special for rupture of aortic sinusal aneurysm, and belongs to the technical field of medical instruments. The plug comprises a connecting rivet, a large tray surface, a waist part, a small tray surface and an adduction rivet; the sinusal aneurysm plug is in a cone shape, and a large disc face and a small disc face are arranged at the two ends of the cone respectively. A waist part is arranged between the large disc surface and the small disc surface, the connecting rivet is arranged at the intersection of the central axes of the large disc surface and the cone, and the adduction rivet is arranged at the intersection of the central axes of the small disc surface and the cone. The sinusal aneurysm plug is suitable for traditional interventional therapy and ultrasonic interventional therapy; the sinusal aneurysm plugs with different shapes can be suitable for aortic sinusal aneurysm defects with different sizes and aortic sinusal aneurysm defects with different distances from coronary artery openings and aortic valve rings.

The invention discloses a function and an application of a Mindin gene in treatment of atherosclerosis and belongs to the field of functions and applications of genes. In the invention, an ApoE - / - mouse and a Mindin - / - ApoE - / - mouse are employed as experimental subjects and an atherosclerosis model is obtained through high-fat diet induction. A result proves that compared with the ApoE - / - mouse, a Mindin gene defect can significantly reduce a plague area in aorta, enhance stability of aortic sinus plagues and significantly alleviate an inflammatory response, which indicate that the Mindin, in the atherosclerosis, mainly has an effect of promoting formation of a plague in the aorta and especially promoting the atherosclerosis. On the basis of the functions hereinabove of the Mindin, the Mindin, as a drug target, can be used for screening a drug for preventing, alleviating and / or treating the atherosclerosis. An inhibitor of the Mindin can be used for preparing a drug for preventing, alleviating and / or treating the atherosclerosis.

The invention discloses the function and application of blood shear stress response protein 1 (RECS1) in treating atherosclerosis, belonging to the field of gene function and application. The present invention takes ApoE‑ / ‑ mice and RECS1‑ / ‑ApoE‑ / ‑ mice as experimental objects, and obtains atherosclerosis models through high-fat diet induction. The results show that compared with ApoE‑ / ‑ mice, RECS1 gene defects It significantly reduces the plaque area of ​​the aorta, enhances the stability of the plaque in the aortic sinus, and significantly reduces the inflammatory response. This indicates that the function of RECS1 in atherosclerosis is mainly reflected in the promotion of aortic plaque formation, especially atherosclerosis. According to the function of RECS1, RECS1 can be used as a drug target for screening drugs for preventing, alleviating and / or treating atherosclerosis, and the inhibitor of RECS1 can be used for preparing drugs for preventing, alleviating and / or treating atherosclerosis.

The invention discloses a function and an application of an interferon regulatory factor 4 (IRF4) gene in treatment of atherosclerosis and belongs to the field of functions and applications of genes. In the invention, an ApoE - / - mouse and an IRF4 - / - ApoE - / - mouse are employed as experimental subjects and an atherosclerosis model is obtained through high-fat diet induction. A result proves that compared with the ApoE - / - mouse, an IRF4 gene defect can significantly increase a plague area in aorta, reduce stability of aortic sinus plagues and significantly deteriorate an inflammatory response, which indicate that the IRF4, in the atherosclerosis, mainly has effects of inhibiting formation of a plague in the aorta and especially inhibiting the atherosclerosis. On the basis of the functions hereinabove of the IRF4, the IRF4 can be used for preparing a drug for preventing, alleviating and / or treating the atherosclerosis.

The invention belongs to the field of medical technology, and specifically discloses a method for measuring the anatomical characteristics of the aortic complex, which collects CT angiography data in one cardiac cycle, performs image reconstruction according to 20 time phases, and then analyzes the CT angiography data of each time phase. The angiographic data is subjected to the following operations: segment the coronary tree and obtain the segmented three-dimensional coronary artery data set S; cut the sinus of Valsalvs to obtain the key plane and key parts of the sinus of Valsalvs; detect the ostium of the coronary artery; divide the sinus of Valsalvs transversely to determine the sinotubular junction plane, aortic annulus plane and mid-plane of the aortic sinus; the sinus of Valsalvs was divided vertically to divide the non-coronary sinus, right coronary sinus and left coronary sinus. The present invention can carry out 4D quantitative evaluation on the fine anatomy of the aortic root, and comprehensively evaluate the complex rotation, translation, and scaling motion modes of the aortic root. The statistical model established on this basis provides the parameters of the amplitude and range of motion, and can diagnose abnormalities. The situation provides an early warning and provides a basis for optimizing the surgical plan.