56 results about "Aortic sinus" patented technology

The present invention provides an aortic valvuloplasty catheter which, in one preferred embodiment, has a tapered distal balloon segment that anchors within the left ventricle outflow track of the patient's heart and a rounded proximal segment which conforms to the aortic sinuses forcing the valve leaflets open. In addition, this embodiment of the valvuloplasty catheter includes a fiber-based balloon membrane, a distal pigtail end hole catheter tip, and a catheter sheath.

The present invention is an apparatus designed to effectuate restoration of normal aortic valvular function where there is aortic valvular regurgitation either primary or secondary to diseases of the aorta such as aortic aneurysm, aortic dissection, rheumatic aortic disease annuloaortic ectasia and etc. is present. The present invention provides an apparatus for repairing aortic annulus composed of (1) a band type inner stabilizer (sometimes ring type inner stabilizer) which is implanted in the true aortic lumen to fix the aortic annular diameter and (2) an outer felt stabilizer which is implanted on the outside surface of aorta to support the inner stabilizer. Furthermore, the present invention provides an apparatus for restoring the sinotubular junction in the ascending aorta which is composed of (1) a ring type inner stabilizer which is implanted in the sinotubular junction in the ascending aorta and (2) an outer felt stabilizer which is implanted on the outside surface of the sinotubular junction to support the inner stabilizer.

The invention relates to a woven aortic sinus prosthesis (1) having a first substantially cylindrical section (2) not close to the heart, which possibly transitions into an aortic arch, a second section (6) forming a bulb, which is expanded in comparison to the first section with regard to the diameter and which connects to the first section (2), and possibly a third substantially cylindrical section (8) close to the heart, which connects to the bulb section (6).

The invention provides a coronary artery center line generation method and device based on bidirectional coronary artery blood vessel tracking. The method comprises the steps that according to an input coronary artery mask, blood vessel starting points, located at the aortic sinus, of coronary artery blood vessels and all tail end points in a connected domain in the mask where all the starting points are located are extracted; coronary artery center lines are extracted by tracking coronary artery blood vessels from top to bottom from a starting point, and a coronary artery center line tree isconstructed; coronary vessels are tracked from bottom to top from the tail end point, and a coronary center line tree is complemented; removing blood vessel adhesion and vein center lines, and combining all extracted coronary artery center line trees to obtain a complete coronary artery center line.

The invention belongs to the medical image processing technical field and provides a method for extracting cardiovascular vessels from CTA (computed tomography angiography) images, a device for extracting cardiovascular vessels from CTA images, an apparatus for extracting cardiovascular vessels from CTA images and a storage medium. The method includes the following steps that: etching operation and expansion operation are sequentially performed on image data by using preset structural elements, so that a structural template is obtained; layer-by-layer transformation is performed on the sectional images of the structural template, so that a first ascending aorta structure in the structural template can be obtained, aorta center coordinates and an aorta radius are obtained from the last sectional image layer of the structural template; and a binary sphere structure is built according to the aorta center coordinates and the aorta radius, and the first ascending aorta structure is combined with the structural template and the binary sphere structure, so that a second ascending aorta structure can be obtained through combination. With the method, device, apparatus and storage medium of the invention adopted, ascending aortas and the shapes of aortic sinuses at the roots of the ascending aortas can be extracted, and therefore, the structures and shapes of the aortas can be accurately visualized, and the solving level and capability of medical image research on clinical problems can be improved.

The invention provides an aortic root stent system. The aortic root stent system comprises an aortic stent and a sinus anchoring stent, wherein the aortic stent is correspondingly arranged on the inner wall of the ascending aorta; the sinus anchoring stent is attached to the inner wall of the aortic sinus and extends downwards from the junction of sinus canals; the bottom of the sinus anchoring stent extends inwards to form a plurality of crown valve stents attached to the aortic sinus; the peripheral surfaces of the crown valve stents form a garlic-clove-shaped structure; the top ends of theinner sides of the crown valve stents correspondingly extend to the outer side of the valve ring; and an opening allowing valve leaflets to move freely is formed in the tail end of each crown valve stent. For the aortic root stent system, the crown valve stents can increase the anchoring area of the whole sinus anchoring stent in the aortic valve, the positioning is firm, displacement seldom occurs under the impact of blood flow, and thus the stability of the aortic root anchoring system in the aortic valve is improved.

The invention discloses a function and application of an MAPK (mitogen-activated protein kinase) signal-integrating kinase 1 (Mnk1) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<- / -> mouse and an Mnk1<- / ->ApoE<- / -> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<- / -> mouse, the gene defect of the Mnk1 obviously reduces the plaque area of an aorta tree, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the Mnk1 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion of the atherosclerosis. Aiming at the function of the Mnk1, the Mnk1 can be used as a drug target for screening a medicament for preventing, relieving and / or treating the atherosclerosis and an inhibitor of the Mnk1 can be used for preparing the medicament for preventing, relieving and / or treating the atherosclerosis.

The invention discloses a function and application of an MAPK (mitogen-activated protein kinase) signal-integrating kinase 2 (Mnk2) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<- / -> mouse and an Mnk2<- / ->ApoE<- / -> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<- / -> mouse, the gene defect of the Mnk2 obviously reduces the plaque area of an aorta, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the Mnk2 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion for the atherosclerosis. Aiming at the function of the Mnk2, the Mnk2 can be used as a drug target for screening a medicament for preventing, relieving and / or treating the atherosclerosis and an inhibitor of the Mnk2 can be used for preparing the medicament for preventing, relieving and / or treating the atherosclerosis.

The invention discloses an occluder for rupture of aortic sinusal aneurysm. A fabric body comprises a circular-arc area, a cylindrical area and a circular disk area, wherein the edge of the circular-arc area is formed by extending out of the outer edge of the cylindrical area by 3-4 millimeters; the cylindrical area is a hollow cylinder of which the diameter is 4-20 millimeters, and the thickness is 2.5-4 millimeters; the circular disk area is a circular flat plate which extends outwards by 0.5-2 millimeters; the closed portion of the fabric body is positioned in the center of the circular disk area and is depressed inwards, and a threaded column is fixed to a recess; expanded films are arranged in the internal cavities of the circular-arc area, the cylindrical area and circular-disk area respectively. The radian of the circular-arc area can be perfectly jointed with one side of an aortic valve, thereby realizing protection in the swinging process of the aortic valve; since the convex edge of the circular disk area is small, a clamping function can be realized; meanwhile, resistance to blood during the flow of blood is reduced as much as possible, and the blood flow smoothness is ensured.

The invention discloses function and application of signal regulatory protein 1 (SHPS1) treating atherosclerosis, and belongs to the field of functions and application of genes. According to the technical scheme, an ApoE<- / -> mouse and a SHPS1<- / ->ApoE<- / -> mouse are taken as experiment objects, atherosclerotic models are obtained through high-fat diet induction, and results show that compared with the ApoE<- / -> mouse, SHPS1 gene defect leads to substantial reduction of the aorta plaque area, stability enhancement of aortic sinus plaque and mitigation of inflammation reaction. The results show that SHPS1 mainly has the effects of promoting formation of aorta plaque area and especially promoting atherosclerosis in the functions of atherosclerosis. Aiming at the above functions of SHPS1, SHPS1 can be used as a medicine target and is applied to screen medicines for preventing, alleviating and / or treating atherosclerosis, and an inhibitor of SHPS1 is applicable to prepare medicines for preventing, alleviating and / or treating atherosclerosis.

The invention relates to the technical field of medical image processing, in particular to an aortic valve automatic segmentation method based on a multi-temporal CTA image. The method comprises the following steps: identifying a laminar flow dark area and a vortex bright area on a cross section of an aortic sinus area; according to the first feature size of the laminar flow dark area and the second feature size of the vortex bright area, the valve leaflet-sinus wall spacing is determined; determining a first deviation index according to the change trend of the valve leaflet-sinus wall spacing in the cardiac cycle; determining a second deviation index according to a difference characteristic between the CT value of the laminar flow dark area and the CT value of the eddy current bright area; if the first deviation index and the second deviation index both exceed the corresponding threshold values, judging that the data is in a to-be-corrected time phase; correcting the spacing by using the correction weight calculated by the second deviation index; and extracting key parameters of each time phase on the longitudinal section, and associating the corrected valve leaflet-sinus wall spacing to construct a valve three-dimensional dynamic model, thereby facilitating the three-dimensional dynamic model to output more accurate valve motion data.

The invention discloses applications of an interferon regulatory factor 1 gene in treatment of atherosclerosis, belonging to the field of the functions and applications of a gene. An atherosclerosis model is obtained by taking ApoE- / -mice and IRF1- / -ApoE- / -mice as experimental objects through induction of high-fat diet, results show that the IRF1 gene defects markedly reduce the plaque area of the aorta, enhance the stability of aortic sinus plaque, and markedly lighten the inflammatory response compared with the ApoE- / -mice. The function of the IRF1 in the atherosclerosis is mainly reflected by the fact that the IRF1 achieves the effect of promoting the formation of the aortic plaque, especially the effect of promoting the atherosclerosis. Aiming to the functions of the IRF1, the IRF1 can be used as a drug target for screening drugs preventing, alleviating and / or treating atherosclerosis, and an inhibitor of the IRF1 can be used for preparing a drug for preventing, alleviating and / or treating atherosclerosis.

The invention discloses an ascending aortic stent graft, and relates to the field of medical instruments. The ascending aortic stent graft includes a stent, a cover at least partially covering the stent and a valve leaflet for reconstructing an aortic valve, and the valve leaflet is disposed at a proximal end of the stent and connected with the stent and the cover. The ascending aortic stent graftis provided with the valve leaf for reconstructing the aortic valve adapted to allowing blood from a left ventricle to flow into aortas and preventing the blood from flowing back from the aortas to the left ventricle; the stent graft is provided with two windows adapted to being aligned with two coronary artery openings. Therefore, for aortic root lesions involving both an aortic sinus and the aortic valve, minimally invasive endovascular treatment can be used for implanting the ascending aortic stent graft into an ascending aortic root, which repairs the ascending aortas, and reconstructs the aorta valve, the aortic sinus and the coronary artery openings, and the goal of integrated healing is achieved.

The invention discloses a function and an application of a blood shear stress responding protein 1 (RECS1) in treatment of atherosclerosis and belongs to the field of functions and applications of genes. In the invention, an ApoE - / - mouse and an RECS1 - / - ApoE - / - mouse are employed as experimental subjects and an atherosclerosis model is obtained through high-fat diet induction. A result proves that compared with the ApoE - / - mouse, a RECS1 gene defect can significantly reduce a plague area in aorta, enhance stability of aortic sinus plagues and significantly alleviate inflammatory response, which indicate that the RECS1 in the atherosclerosis mainly has effects of promoting formation of a plague in the aorta, especially promoting the atherosclerosis. On the basis of the functions of the RECS1, the RECS1, as a drug target, can be used for screening a drug for preventing, alleviating and / or treating the atherosclerosis. An inhibitor of the RECS1 can be used for preparing a drug for preventing, alleviating and / or treating the atherosclerosis.

The invention relates to the field of medical instruments, in particular to a prosthesis capable of treating valve regurgitation, which comprises a stent main body capable of expanding in the radial direction, the stent main body comprises a plurality of rhombic grids and at least three clamping pieces arranged at the outflow end of the stent main body, and the clamping pieces are used for positioning aortic sinus and clamping autologous valve leaflets; a sealing bag bulging outwards is arranged on the stent body between the adjacent clamping pieces, the position of the sealing bag corresponds to the junction area of the aortic valve leaflet, the sealing bag is attached to the tissue of the junction area of the aortic valve leaflet, and the structure of the sealing bag is configured in a way that when blood regurgitates, the sealing bag can seal the tissue of the junction area of the aortic valve leaflet. The regurgitated blood is guided to be shunted to the two sides into the adjacent aortic sinus; the sealing bag enables backflow blood to flow into the adjacent aortic sinus in a guiding and shunting mode, backflow of the blood is avoided, meanwhile, when blood is pumped next time on the aorta, the blood in the aortic sinus is ejected out, and thrombus caused by blood deposition is avoided.

The present application relates to the technical field of medical image processing, and in particular to an aortic valve automatic segmentation method based on multi-phase CTA images. The method identifies the laminar flow dark area and the vortex light area on the cross section of the aortic sinus region; determines the leaflet-sinus wall distance according to the first characteristic size of the laminar flow dark area and the second characteristic size of the vortex light area; determines the first deviation index according to the change trend of the leaflet-sinus wall distance in the cardiac cycle; determines the second deviation index according to the difference characteristics between the CT value of the laminar flow dark area and the CT value of the vortex light area; if the first deviation index and the second deviation index both exceed the corresponding threshold, it is determined that the data is in the phase to be corrected; corrects the distance by using the correction weight calculated by the second deviation index; extracts the key parameters of each phase on the longitudinal section, associates the corrected leaflet-sinus wall distance to construct a three-dimensional dynamic model of the valve, and thus the three-dimensional dynamic model outputs more accurate valve motion data.

The application relates to the field of medical devices, in particular to a prosthesis capable of treating valve regurgitation, comprising a radially expandable stent body, the stent body comprising a plurality of diamond-shaped meshes, and at least three clamping members arranged at the outflow end of the stent body, used for positioning the aortic sinus and clamping the native valve leaflets; a sealing bag bulging outward is arranged on the stent body between adjacent clamping members, wherein the position of the sealing bag corresponds to the junction area of the aortic valve leaflets, and the sealing bag is attached to the tissue of the junction area of the aortic valve leaflets, and the configuration of the sealing bag is configured to guide the regurgitant blood to flow to the adjacent aortic sinuses on both sides when the blood regurgitates; in the application, the sealing bag guides the regurgitant blood to flow to the adjacent aortic sinuses in a diversion manner, so that blood regurgitation is avoided, and meanwhile, when the aorta pumps blood again, the blood in the aortic sinus is ejected, so that blood stasis is avoided.

The application belongs to the technical field of medical image processing, and discloses a coronary artery origin anomaly automatic identification method, device, equipment and storage medium. The method comprises the following steps: determining an aorta segmentation binary image, a coronary artery multi-class segmentation image, an aortic sinus multi-class segmentation image and an aorta center line according to a coronary CTA image; intercepting the aortic sinus multi-class segmentation image to obtain a maximum aorta cross section; respectively performing inflation processing on a left coronary artery segmentation image and a right coronary artery segmentation image, and determining distances from a left centroid of a left connected domain and a right centroid of a right connected domain to the maximum aorta cross section as a first plane distance and a second plane distance based on the inflated left coronary artery segmentation image, the inflated right coronary artery segmentation image and the aorta segmentation binary image; and determining that the origin anomaly is a coronary artery high position when determining that the first plane distance or the second plane distance is greater than a preset distance. Through the above method, the coronary artery origin anomaly can be automatically identified.

The invention discloses functions and applications of nucleotide synthetase CAD in treatment of atherosclerosis, belonging to the fields of functions and applications of genes. ApoE- / - mice and CAD- / -ApoE- / - mice are taken as experimental subjects, an atherosclerosis model is obtained through high fat diet induction, the result proves that compared with the ApoE- / - mice, the plaque area of the aorta is obviously reduced due to the CAD gene defects, the stability of sinus plaques of the aorta is enhanced, and the inflammatory response is obviously alleviated. The functions of the CAD in atherosclerosis mainly refer to the effects of promoting aorta plaque formation, particularly the effect of promoting the atherosclerosis. Aiming at the functions of the CAD, the CAD can serve as a drug target to be used for screening medicines for preventing, relieving and / or treating the atherosclerosis, and inhibitors of the CAD can be used for preparing medicines for preventing, relieving and / or treating the atherosclerosis.

A first cylindrical section (2) away from a heart verges into an aortic curve, if required. A second cylindrical section (6) has a wider diameter compared to the first section, forms a bulbus and links to the first section. If required, a third cylindrical section (8) near to a heart links to the section forming the bulbus.

The application provides a valve stent and artificial valve, which comprises a stent body, a plurality of first support arms arranged along the circumference of the stent body, one end of the first support arm being connected with the outflow end of the stent body, the other end being arranged outside the stent body and extending towards the inflow end of the stent body, and a second support arm, one end of the second support arm being connected with the outflow end of the stent body, the other end being arranged outside the stent body; the stent body can be placed at the aortic valve, the stent body and the first support arm accommodate the native valve leaflet, the other end of the first support arm extends into the corresponding aortic sinus to provide anchoring, at least one first support arm can be arranged in each aortic sinus, and the second support arm can support the aortic wall. The application can replace the aortic valve regurgitation, realize stable and reliable anchoring through the unique anchoring structure, and is not easy to block the coronary artery opening.

The present invention is applicable to the technical field of medical image processing, and provides a method, an apparatus, a device, and a storage medium for extracting a cardiovascular vessel from a CTA image. The method comprises: performing erosion operation and dilation operation on image data successively via a preset structural element to obtain a structure mask; performing a slice-by-slice transformation on the plane of section images of the structural mask to acquire the first ascending aortic structure in the structural mask, and acquiring an aortic center position and an aortic radius in the last slice of the plane of section image of the said structural mask; establishing a binarized sphere structure according to the aortic center position and the aortic radius, and synthesizing a second ascending aorta structure by combining the first ascending aorta structure with the structure mask and the binarized sphere structure. The present invention realizes extracting shapes of ascending aorta and root aortic sinus, so that the aortic structure and morphology can be accurately visualized, thereby greatly improving the level and ability of medical imaging researches to solve clinical issues.

The invention relates to a valved conduit device for an aortic root. A transplanting conduit comprises an ascending aorta replacement tube and an aortic sinus replacement portion. A bioprosthetic valve comprises a bovine pericardium and a nickel-titanium support, wherein the nickel-titanium support is located outside the bovine pericardium, and the bovine pericardium is wrapped with the nickel-titanium support and fixed through the nickel-titanium support; the bioprosthetic valve is arranged in the aortic sinus replacement portion through an opening device, and is opened through the opening device to be closely attached to the inner wall of the aortic sinus replacement portion, the height of the nickel-titanium support is higher than the height of the aortic sinus replacement portion, and the nickel-titanium support is divided into an ascending aorta section and an aortic sinus section. According to the valved conduit device for the aortic root, the operation time of the aortic root is shortened, the biocompatibility is improved through the bioprosthetic valve, and the side effects brought by mechanical valve anticoagulation is reduced.

The invention discloses a function and application of microRNA150 (miR150) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<- / -> mouse and an miR150<- / ->ApoE<- / -> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<- / -> mouse, the gene defect of the miR150 obviously reduces the plaque area of an aorta, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the miR150 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion for the atherosclerosis. Aiming at the function of the miR150, the miR150 can be used as a drug target for screening a medicament for preventing, relieving and / or treating the atherosclerosis and an inhibitor of the miR150 can be used for preparing the medicament for preventing, relieving and / or treating the atherosclerosis.

The invention discloses a function and application of an MAPK (mitogen-activated protein kinase) signal-integrating kinase 2 (Mnk2) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<- / -> mouse and an Mnk2<- / ->ApoE<- / -> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<- / -> mouse, the gene defect of the Mnk2 obviously reduces the plaque area of an aorta, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the Mnk2 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion for the atherosclerosis. Aiming at the function of the Mnk2, the Mnk2 can be used as a drug target for screening a medicament for preventing, relieving and / or treating the atherosclerosis and an inhibitor of the Mnk2 can be used for preparing the medicament for preventing, relieving and / or treating the atherosclerosis.

The invention belongs to the technical field of biological medicines, and particularly relates to application of IAA in preparation of a medicine for preventing and treating atherosclerosis. Atherosclerosis is caused by excessive deposition of cholesterol, and IAA can significantly reduce formation of aorta and aortic sinus lipid plaques of atherosclerosis model mice by adjusting monocyte chemotactic and adhesion functions (specifically, down-regulating expression of chemotactic factors CCL2 and CXCL1, receptors CCR1 and CCR2, adhesion molecules ICAM1 and the like). An injection preparation is preferably selected as a medicine dosage form, the intervention dosage of IAA is 50 mg / kg, and the intervention time is 15 weeks. The new application of IAA in prevention and treatment of atherosclerosis is explored for the first time, the action mechanism of IAA is clear, the intervention effect is remarkable, and a new target spot and thought are provided for developing safe and effective medicines and means for preventing and treating atherosclerosis.

The invention discloses an anti-regurgitation artificial heart valve, which comprises a tubular support, skirt cloth covering the inner surface of the tubular support, a plurality of artificial valve leaflets fixed in the tubular support, and an anti-regurgitation ring arranged outside the tubular support in a sleeving mode, wherein the anti-regurgitation ring comprises a plurality of anchoring parts; the anchoring parts are designed into a unique shape with double supporting feet at the bottom and a deformable grid in the middle; one pair of side ribs is inserted along two sides of the interior of the semilunar valve; a first bottom rib and a second bottom rib are abutted against two sides of the bottom of the aortic sinus so as to form two acting points; and a contact area is increased through a grid consisting of inner ribs. Compared with most existing technical schemes adopting a U-shaped or V-shaped simple outer frame to exert force at a single point, when the anchoring parts and the native valve leaflet are inserted and positioned, an alignment deviation is small, positioning is accurate and convenient, the anchoring parts have a good shaping effect on the native valve leaflet, a clamping area is large, and the native valve leaflet can be more stably and firmly clamped when the native valve leaflet is clamped inside and outside the anti-regurgitation ring and the tubular support.

The invention provides application of Ackermania muciniphila as a biomarker in preparation of a product for diagnosing and / or treating atherosclerosis, and belongs to the technical field of biological medicines. The invention provides an application of Akkermansia muciniphila (Akkermansia muciniphila) as a biomarker in the preparation of a kit for diagnosing and / or detecting atherosclerosis (AS). The Akkermansia muciniphila can be used for detecting atherosclerosis (AS). A high fat diet induced ApoE gene knockout mouse copies an AS mouse model, metagenomics analysis of a control group and a model group shows that the abundance difference of Ackermania muciniphila is significant, and the AUC value under an ROC curve is 1, which indicates that Ackermania muciniphila is a potential biomarker strain of AS. The Ackermania muciniphila can also significantly reduce the AS plaque area of the aortic sinus of the AS model mouse, and the Ackermania muciniphila can play an anti-AS role through a two-component system, ABC transport and other metabolic pathways.