Establishment method of animal model for acute Stanford A-type aortic dissection (AD) accompanied with MODS (multiple organ dysfunction syndrome)

Abstract

The invention provides an establishment method of an animal model for acute Stanford A-type aortic dissection (AD) accompanied with MODS (multiple organ dysfunction syndrome), a use of emodin for preparing a medicine for treating acute Stanford A-type AD accompanied with MODS as well as a viscera protective agent for acute Stanford A-type AD accompanied with MODS. In the invention, an AD surgery method is improved and meanwhile manually controlled hypertension is formed by continuously pumping adrenaline into veins so as to promote expansion of the AD stripping range and accelerate disease progression, thus acute Stanford A-type AD accompanied with MODS can be rapidly formed so as to successfully make the model. The animal model for acute Stanford A-type AD accompanied with MODS creates conditions for further deep research in application foundation and intervention treatment.

Description

Technical field [0001] The invention relates to a method for establishing an animal model of acute Stanford A type aortic dissection with MODS. Background technique [0002] Acute aortic dissection (AD) refers to the occurrence of a tear in the middle layer of the aorta, and blood enters the false cavity through the tear in the intima-media. It is a critical emergency in cardiovascular surgery, with rapid progress and high mortality. The early mortality rate is about 1% per hour, and the mortality rate can be as high as 50% within 48 hours. There are many types of aortic dissection. In terms of guiding clinical treatment, the Stanford type is the most commonly used and most valuable. Stanford type A aortic dissection refers to the lesion involving the ascending aorta with or without involving the descending aorta, and the Stanford type B aortic dissection refers to the lesion involving only the descending aorta. After the occurrence of aortic dissection, arterial blood flow con...

AI Technical Summary

Problems solved by technology

[0004] Although the predecessors have made beneficial attempts to make aortic dissection models, these models all have the disadvantages of limited dissection tear length and low success rate of dissection, and these models are all Stanford type B dissections.

There is no relevant report on the production of A-type interlayer, and there is no relevant record on the accompanying MODS after the interlayer is produced.

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