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Traditional Chinese medicine active ingredient composition and purpose thereof

A technology of active ingredients and compositions, applied in the field of active ingredients and compositions of traditional Chinese medicine, can solve problems such as increased bacterial resistance, achieve the effects of protecting organ damage, reducing inflammatory cascade reactions, and inhibiting the release of inflammatory factors

Inactive Publication Date: 2020-06-19
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, although the extensive use of antibiotics has reduced the mortality of patients with sepsis to a certain extent, the increase in bacterial resistance has brought enormous pressure to follow-up treatment

Method used

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  • Traditional Chinese medicine active ingredient composition and purpose thereof
  • Traditional Chinese medicine active ingredient composition and purpose thereof
  • Traditional Chinese medicine active ingredient composition and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 A preparation method for treating endotoxemia or sepsis, systemic inflammatory response syndrome and multiple organ dysfunction syndrome.

[0024] A traditional Chinese medicine active component composition is composed of the following traditional Chinese medicine active components in parts by weight: 42 parts of geniposide, 34 parts of baicalin, 20 parts of berberine and 10 parts of palmatine.

[0025] The preparation method of the active ingredient composition of traditional Chinese medicine comprises the following steps:

[0026] Coptidis Jiedu Decoction weighed 1 kg of medicinal materials with a total weight of 1 kg according to the ratio of Coptidis: Scutellaria: Phellodendron: Gardenia = 3:2:2:3, crushed, decocted and refluxed to extract twice (10 times the amount of water for the first time, 8 times the amount of water for the second time), 1 hour each time, filter while hot, combine the two filtrates, let stand, settle for 3 days, centrifuge (4200 r / mi...

Embodiment 2

[0031] Example 2 Pharmacodynamic study data.

[0032] 1. In vitro activity research.

[0033]Take out the Raw264.7 cells from the -80°C refrigerator, and recover the cells in a 37°C water bath. Cells were collected by centrifugation, centrifuged at room temperature for 5 min, and the supernatant was discarded. The cells were suspended in complete medium containing 10% fetal bovine serum, inoculated into culture dishes, and cultured at 37°C and 5% CO2. When the cell density reaches 80%, discard the medium, wash with PBS, add 1-2ml of 0.25% trypsin to digest the cells for 1-2min, and observe under the microscope. Discard the trypsin, add complete medium, passage at a ratio of 1:4, and expand the culture at 37°C and 5% CO2 saturated humidity. Raw264.7 cells in logarithmic growth phase and in good growth state were seeded in a 24-well plate at a cell density of 1.0×105 cells / well, and cultured overnight at 37°C. The experiment was divided into blank group, control group and ac...

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Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine active ingredient composition and a purpose thereof. The traditional Chinese medicine active ingredient composition is prepared from the following traditional Chinese medicine active ingredients in parts by weight: 30 to 50 parts of geniposide, 25 to 40 parts of scutelloside, 15 to 40 parts of berberine and 6 to 30 parts of palmatine. The traditional Chinese medicine active ingredient composition is applied to preparation of medicine for treating endotoxemia or sepsis, systemic inflammatory response syndrome and multiple organ dysfunction syndrome. After the traditional Chinese medicine active ingredient composition provided by the invention is used for treatment, a patient cannot easily generate recurrence after recovery; and no other toxic and side effects are clinically shown during medication. The traditional Chinese medicine active ingredient composition provided bythe invention has the advantages that the active ingredients are simple; the anti-sepsis effect is strong; the release of inflammatory factors can be well inhibited; the visceral organs are protectedfrom being damaged; the sepsis inflammation cascade reaction is reduced; and the anti-sepsis effect is achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a composition of active ingredients of traditional Chinese medicine and its application. Background technique [0002] Systemic inflammatory response syndrome (systemic inflammatory response syndrome, SIRS) is an out-of-control self-sustained amplification and self-destructive systemic inflammatory response caused by infection or non-infection etiology. In severe cases, it can cause complications such as multiple organ dysfunction syndrome (MODS). Among them, SIRS caused by infectious factors is called sepsis. Sepsis is a dangerous condition with a high fatality rate. About 14,000 people worldwide die from its complications every day, and about 215,000 people die in the United States every year. According to foreign epidemiological surveys, the fatality rate of sepsis has surpassed that of myocardial infarction, and it has become the main cause of death of non-cardia...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/4375A61P31/04A61P7/00A61P29/00A61P9/00A61P1/16A61P11/00A61P13/12A61P1/00
CPCA61K31/7048A61K31/4375A61P31/04A61P7/00A61P29/00A61P9/00A61P1/16A61P11/00A61P13/12A61P1/00A61K2300/00Y02A50/30
Inventor 陈桂荣
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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