Establishing method and application of mouse aortic dissecting aneurysm model

A technology of aneurysm and construction method, which is applied in the direction of antineoplastic drugs, nitrile/isonitrile active ingredients, drug combinations, etc., can solve the problems of high technical requirements for experimenters, difficulty in model establishment, time-consuming and other problems, and achieve a high induction success rate , The establishment method is simple and the operability is strong
CN104706632AInactive Publication Date: 2015-06-17BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES
0 Cites 9 Cited by

Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES
Publication Date
2015-06-17
Estimated Expiration
Not applicable ยท inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses an establishing method and application of a mouse aortic dissecting aneurysm model. The establishing method of the mouse aortic dissecting aneurysm model is simple and convenient, the mouse aortic dissecting aneurysm model can be established within a short time, surgical operation is not needed, trauma to experimental mice can be reduced, and high operability is achieved. The occurrence rate of aortic dissecting aneurysm of a modeling group is 90%, the breaking rate of the aortic dissecting aneurysm of the modeling group is 20%, the occurrence rate of the aortic dissecting aneurysm in chests and aortic dissection above chests is 90%, the occurrence rate of the aortic dissecting aneurysm in abdomen is 20%, and the induction success rate is high. The dissection occurrence position of the aortic dissecting aneurysm is similar to that of human beings, so that the mouse aortic dissecting aneurysm model can be used for easily studying the pathomechanism of the aortic dissecting aneurysm of human beings and can be applied to suspicious virulence gene screening and treatment research.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a method for establishing a mouse aortic dissection aneurysm model and its application in the technical field of making animal models of human diseases. Background technique

[0002] Aortic dissecting aneurysm refers to the rupture of intima vessels in the aortic wall caused by various reasons, and between the intima and the outer and middle layers, due to the pressure of blood hydrodynamics, it is stripped longitudinally along this layer, forming an active blood false lumen. Due to dissection separation, the false lumen expanded and bulged. The resulting dissecting aneurysm is highly susceptible to rupture, making the disease one of the deadliest forms of cardiovascular disease, with a mortality rate of up to 70% within two weeks of onset.

[0003] Aortic aneurysms occur more frequently in the West, mainly in the abdominal aorta, while aortic dissection is more common in China, mostly involving the aortic root, ascending aort...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More