43 results about "Cerebral metabolism" patented technology

Prior approaches have delivered O₂ to a subject by inhalation, but the relationship between local signal changes and metabolism has been complicated by H₂¹⁷O created in non-cerebral tissues. During a brief pulse of ¹⁷O₂ inhalation, this arterial input function for H₂¹⁷O is negligible due to convective transport delays. Additional delays in the arterial input function due to restricted diffusion of water makes pulsed inhalation of ¹⁷O₂ even more effective. Accordingly, ventilator system are provided to deliver ¹⁷O₂ as a brief pulse to a subject. Subsequent MR imaging demonstrates delayed appearance of H₂¹⁷O in the cerebral ventricles, suggesting that the arterial input function of H₂¹⁷O is delayed by restricted water diffusion in addition to convective transit delays. Delivery as a brief pulse therefore offers significant advantages in relating MR signal changes directly to metabolism.

A pharmaceutical composition comprising at least one of components (a) and at least one of components (b) shown in below: (a) a compound represented by the general formula (I) (wherein R1 represents a hydrogen atom or a hydroxyl group) or an acid addition salt or hydrate thereof; and (b) an ameliorant of cerebral circulation, a vasodilator, a cerebral protecting drug, an brain metabolic stimulants, an anticoagulant, an antiplatelet drug, a thrombolytic drug, an amelirant of psychiatric symptom, a antihypertensive drug, an antianginal drug, a diuretic, a cardiotonic, an antiarrhythmic drug, an antihyperlipidemic drug, an immunosuppressant, or a pharmaceutically acceptable salt (except the components shown in (a)). It is useful as a preventive or remedy for cerebrovascular disorders and cardiac diseases.

The invention relates to the technical field of health-care food, and discloses a combination with a memory-improving function and a preparation method and application thereof. The combination disclosed by the invention is prepared from longan pulp, poria cocos, lotus seeds, enzymatically hydrolyzed walnut extract, phosphatidylserine and taurine. The longan pulp as a monarch drug and the poria cocos and the lotus seeds as ministerial drugs are matched to synergically exert the efficacy of tranquilizing mind by nourishing the heart and tonifying the kidney and the spleen, moreover, the enzymatically hydrolyzed walnut extract for improving cerebral metabolism to increase memory, the phosphatidylserine as a functional factor for increasing the fluidity of cell membranes to enhance plasticity and the taurine for improving memory can jointly achieve the purpose of improving memory, and the various materials are in medicine and food homology and new resource food, so the combination is safe, does not have toxic and side effects, and can be eaten as health-care food for a long time.

The invention provides a preparation method of 4-hydroxyl ketopyrrolidine-2-acetamide as a medicine with a cerebral metabolism improving function, comprising the following steps of: 1, reducing 4-halogenated acetylacetic ester as a raw material into 4-chloro-3hydroxybutyrate by using a reducing agent; and 2, condensing the obtained 4-chloro-3-hydroxybutyrate of the step 1 and glycine amide or glycine amide hydrochloride to obtain 4-hydroxyl ketopyrrolidine-2-acetamide and purifying the obtained 4-hydroxyl ketopyrrolidine-2-acetamide. The invention ensures that the total yield of a product is increased above 36 percent, shortens a process route and reaction time, reduces an intermediate process and is more suitable for the large-scale production of medical industry.

The present invention provides one kind of brain extract extracted from brain tissue of mammal, including pig, dog, ox, sheep, deer, horse and rabbit. The brain extract contains polypeptide, free lysine, free glutamic acid and total sugar in the weight ratio of 1-200 to 0.1-100 to 0.1-80 to 0.1-12, and has molecular weight of 5,000-10,000. The brain extract contains active matters capable of regulating and improving cerebral metabolism and may be used in treating cerebral vascular diseases and corresponding cerebral metabolic disturbance sequela.

The invention discloses a processing method of blackberry phyllanthus emblica fruit vinegar and belongs to the technical field of food processing. The processing method is characterized in that the blackberry phyllanthus emblica fruit vinegar mainly contains the following materials in 100 parts by weight: 40-55 parts of blackberry juice, 25-35 parts of phyllanthus emblica juice, 5-10 parts of lily juice, 5-7 parts of honey and 4-8 parts of white granulated sugar. The blackberry phyllanthus emblica fruit vinegar is processed by the steps of respectively beating, taking the juice and mixing, pre-cooking, adding sugar, performing alcoholic fermentation, performing acetic fermentation, filtering, blending, canning, sterilizing and the like. The blackberry phyllanthus emblica fruit vinegar disclosed by the invention is strong in fruit flavor and unique in faint scent, contains rich amino acids, organic acids, vitamin C and the like, has the function of promoting blood circulation, and can be used for delaying senescence, enhancing immunity, promoting cerebral metabolism, reducing blood pressure and blood fat, resisting arrhythmia and the like. Meanwhile, the blackberry phyllanthus emblica fruit vinegar is also a green and healthy condiment and health food.

Neuro-metabolic and endocrine-function regulating/modulating compositions, are disclosed. The compositions of the present invention comprise Selegiline Hydrochloride, Procaine Hydrochloride, Vinpocetine, trimethylglycine, and an ingredient selected from a group consisting of N-nicotinoyl-gamma-aminobutyric acid (N-GABA), niacin, niacinamide, gamma-aminobutyric acid (GABA), and combinations thereof. Methods of using the compositions, compositions, and compositions of the present invention are also disclosed.

The novel safflower medicine composition is medicine preparation prepared with acetyl glutamine and Chinese medicinal material safflower in the amount of 1-50 times weight of acetyl glutamine. The present invention also discloses the preparation process and use of the medicine composition. By means of the complementary and synergistic effect of both acetyl glutamine and Chinese medicinal material safflower, the medicine composition has the e of promoting blood circulation to disperse blood clots and improving brain metabolism and brain function and may be used in treating coma, paralysis, hypophrenia, memory impairment and other diseases caused by obliterative cerebral vascular diseases, hepatic coma, hemiplegia, etc. It may be also used in treating coronary heart disease, angeitis and other diseases.

The invention discloses a medicinal composition containing total safflower flavones for treating cardiac and cerebral vascular diseases, which comprises total safflower flavones and aceglutamide by a predetermined proportion.

The invention provides a preparation method for cerebroprotein hydrolysate in piracetam cerebroprotein hydrolysate tablets. The cerebroprotein hydrolysate is extracted from brain tissues of mammals except for human being and contains specific polypeptide and various amino acids including free lysine and free glutamic acid, and molecular weight of all compositions is below 5,000-10,000 daltons. The weight proportion of polypeptide to free lysine to free glutamic acid in the cerebroprotein hydrolysate is (1-200):(0.1-100):(0.1-80). According to the invention, the pharmaceutical composition contains active substances capable of treating cranial vascular disease and cerebral metabolism disorder sequela caused thereby, the active substances can regulate and improve cerebral metabolism. After determination, the content of amino nitrogen in the cerebroprotein hydrolysate achieves 40-50 percent of total nitrogen content, so that the cerebroprotein hydrolysate can be used for preparing compound piracetam cerebroprotein hydrolysate tablets.

A medicinal composition for preparing the medicine to improve the cerebral function contains proportionally the active polypeptide, amino acid and nucleic acid, which are extracted from the muscle tissue of mammal and ganglioside extracted from the cerebral tissue of mammal. Its preparing process is also disclosed.

The invention discloses a functional food with mental stress relieving and sleep aiding effects and a preparation method thereof. The functional food with mental stress relieving and sleep aiding effects is prepared from the following components in parts by weight: 5 to 25 percent of gamma-aminobutyric acid, 5 to 30 percent of a plant extract, 1 to 10 percent of tea leaf theanine, 0 to 1 percent of a nutrition enhancer, 1 to 5 percent of a calcium supplement and the balance of dextrin. The functional food is prepared from gamma-aminobutyric acid, the plant extract, the calcium supplement and other raw materials, and is good in taste, convenient to eat, free of side effects and simple in preparation process; gamma-aminobutyric acid, the calcium supplement and the plant extract are matched to achieve a synergistic effect, nerve cell overexcitation can be effectively inhibited, cerebral blood circulation can be improved, the functions of cerebral nerve cells can be adjusted, brain metabolism can be promoted, and sleep can be obviously enhanced and improved.

The invention discloses a method for preparing concentrated mulberry and radish compound juice, and belongs to the field of beverage processing. The method is characterized by comprising the following processing technological flow: raw material selection, cleaning and juice extraction, filtration, mixing, degassing, homogenization, sterilization and filling, thereby obtaining the finished product. The method has the beneficial effects that the product is amaranth transparent uniform liquid, has the faint scent and sweet flavors of mulberry and radish juice, has the mellow fruit flavor and the unique faint scent flavor, contains rich nutritional substances necessary to a human body, has the effects of preventing brain nerve aging, enhancing the immunity, promoting cerebral metabolism, maintaining the beauty and the like and is a green and healthy food.

A medicine for improving cerebral function and treating the disfunction caused by cardiac and cerebral diseases contains the active polypeptide and hypoxanthine, which are extracted from the muscle tissue of mammal other than people and the ganglioside extracted from the brain tissue of mammal other than people. Its preparing process is also disclosed.

The invention discloses a method for preparing nano-liposome marked by colloidal gold and loaded with a PD (pharmacodynamics) medicine. The method comprises the following steps: dispersing lecithin and a cholesterol and ethanol solution in a PBS (Phosphate Buffer Solution) containing colloidal gold and levodopa or amantadine PD therapeutic medicine under specific conditions, then adding the PBS solution into a water bath to stir, completely volatilizing the ethanol and then performing appropriate ultrasonic treatment to prepare the nano-liposome. The prepared nano-liposome marked by colloidal gold and loaded with the PD medicine is small in particle diameter and excellent in stability; meanwhile, the nano-liposome is located and marked by the gold, thereby improving the stability of the PD medicine, improving the bioavailability, reducing the usage amount of the medicine and reducing the toxicity. The preparation method is simple to operate; the reaction is easy to control; the product, namely the nano-liposome can be used for researching the medicine administration effect of the nano-levodopa or amantadine liposome, improving the toxic and side effects of the levodopa or the amantadine and enhancing the brain targetability. The product also can be used as a probe which is used for researching a cerebral metabolism pathway of the nano-liposome.

The invention discloses an emergency ambulance for acute stroke. The emergency ambulance for the acute stroke includes an ambulance stretcher and a fixed bandage, and further includes an ambulance cover, a headrest, two clamping plates, three fixing plates, a fixing bolt, a slide rail, a storage battery and an oxygen bag. The slide rail includes a slide rail body A and a slide rail body B. The ambulance cover is provided with a control panel, an exhaust fan, an air inlet, a cavity, a Peltier element and a temperature-sensitive element. The control panel, the exhaust fan, the Peltier element, the temperature-sensitive element and the storage battery are all connected by wires. The fixing plate includes a fixing plate body A and fixing plate bodies B. The three fixing bolts correspondingly penetrate through the fixing plate body A and the two fixing plate bodies B and are connected with the ambulance cover and the two clamping plates in an abutting mode. The emergency ambulance for the acute stroke utilizes the protective effect of mild hypothermia on brain tissue, and adopts the ambulance cover to provide emergency rescue to a brain of a patient, more rescue time is wined for the patient by various methods such as reducing inflammatory response of the brain tissue, reducing brain metabolic rate and oxygen consumption, reducing brain cell structural protein destruction, reducinglactic acid accumulation in the brain tissue and improving brain microcirculation, and the emergency ambulance for the acute stroke is simple in structure and convenient to operate.

The invention relates to a hydroxydecyl quinone derivative for treating or preventing nerve diseases. Specifically, the invention relates to the hydroxydecyl quinone derivative as shown in formula I, a pharmaceutical composition containing the compound as shown in the formula I, and a preparation method and uses of the hydroxydecyl quinone derivative in preparation of medicaments for cerebrovascular diseases. The compound disclosed by the invention can effectively treat or prevent the diseases or disease symptoms: the cerebrovascular diseases, improve cerebral metabolism and improve mental symptoms, activate brain mitochondrial respiratory activity, improve cerebral energy metabolism of cerebral ischemia, improve the utilization rate of cerebral glucose, increase the production of cerebral triphosadenine, inhibit the generation of lipid hydroperoxide from brain mitochondria and inhibit the membrane disorder caused by overoxidation action of the brain mitochondrial membrane lipid, reduce impaired brain functions caused by chronic cerebrovascular diseases, cerebral trauma and the like, improve subjective symptoms, language, anxiety, depression, hypomnesia, intelligence decrease and other mental and behavioral disorders, promote the intelligence, and activate brain mitochondrial functions, improve the cerebral energy metabolism and improve brain functions.

The invention discloses a preparation method of cheddar cheese rich in gamma-aminobutyric acid. The cheddar cheese comprises the following raw materials of raw milk, chymosin, calcium chloride, a fermenting agent and the like. The cheddar cheese rich in gamma-aminobutyric acid is made through the working procedures of standardization of the raw milk, sterilization, cooling, innoculating streptococcus thermophilus and a commercial direct-vat type fermenting agent, generating acid, adding the calcium chloride, adding the chymosin for obtaining milk curds, cutting the milk curds, cheddaring, crushing the milk curds, salting, and maturing. The gamma-aminobutyric acid has the effects of regulating the blood pressure, stimulating the insulin secretion, restraining arteriosclerosis, improving the functions of the liver and the kidney, activating cerebral metabolism, calming and the like. According to the preparation method disclosed by the invention, the streptococcus thermophilus and the commercial direct-vat type fermenting agent are compounded, so that the content of the gamma-aminobutyric acid is continuously accumulated in the making and maturing stage of the cheese, and the content of the gamma-aminobutyric acid in the cheddar cheese is 10-100mg/100g. The cheese not only reserves the nutrient value, but also increases the physiology efficacies of the gamma-aminobutyric acid, so that the added value of products is increased.

The invention discloses Chinese medicinal jingnaoning capsules for treating mental retardation of cerebral infarction. Aiming at the pathogenesis of the formation of cerebral infarction, and starting with the improvement on cerebral blood flow and promotion of cerebral metabolism, and by taking the treatment principle of saving neurons and reducing neurologic impairment and sequelae farthest, the Chinese medicinal jingnaoning capsules are prepared scientifically from Chinese medicinal herbs such as leonurus heterophyllus, peach seed, Chinese flowering quince, suberect spatholobus stem, himalayan teasel root, cortex acanthopanax radicis and angelica dahurlica which have the effects of relaxing muscles and stimulating blood circulation and dissolving stasis and removing obstruction in channels. Clinical experiments prove that the jingnaoning capsules have the effects of improving cerebral microcirculation selectively, reducing vascular resistance and increasing cerebral blood flow on the basis of enhancing cerebral tissue metabolism, can improve the cognitive function, improve memory, promote the recovery of mental retardation, recover cerebral function completely and improve life quality, and are worthy of clinical popularization and application.

A concentrated clear solution used for intravenous injection after diluted contains cervitalin for improving cerebral metabolism, the mixture of alcohol and glycerine or propanediol, and additive.

The invention relates to a composition of an oral solid medicine having good vivo behaviors. The composition of the solid medicine has unit dosage forms and is measured with a releasing rate measuring method, and the release amounts of each unit dosage form are 15%-45%, 40%-80% and more than 80% of the labelled amount when the time period reaches one hour, four hours or eight hours respectively. The composition of the oral solid medicine can be applied to cerebrovascular diseases, improves brain metabolism and psychiatric symptoms, activates the respiratory activity of brain mitochondria, and improves brain energy metabolism of cerebral ischemia and the utilization rate of glucose inside the brain, so that the production of triphosadenine inside the brain is increased, the brain mitochondria are prevented from producing lipid peroxidase, and the membrane barrier caused by lipid peroxidation of a brain mitochondrial membrane and brain function damages caused by chronic cerebrovascular diseases, cerebral traumas and the like are prevented; and mental and behavioral disorders such as subjective symptoms, language barriers, dysphoria, depression, hypomnesia, mental decline and the like are improved.