Safflower medicine composition and its prepn process and use

A composition, safflower technology, applied in the direction of drug combination, pharmaceutical formulation, drug delivery, etc., to achieve the effects of improving nerve cell metabolism, reducing blood ammonia, and enhancing dissolution

Active Publication Date: 2005-07-13
通化谷红制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on combining safflower and acetylglutamine according to a specific ratio, and further extractin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 2000g safflower, add water and decoct 3 times, add 10 times the amount of safflower for 1 hour for the first time, add 8 times the amount of water for 50 minutes for the second time, and decoct for 30 minutes with 6 times the amount for the third time Minutes, combine the decoctions, filter, concentrate the filtrate to a relative density of 1.18±0.02, add ethanol to make the alcohol content reach 70%, refrigerate, let stand for 48 hours, filter, recover the ethanol from the filtrate and concentrate to a relative density of 1.12±0.02, Add ethanol to make the alcohol content reach 80%, refrigerate, stand for 48 hours, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.18±0.02, add 10 times the amount of water, refrigerate, stand for 20 hours, filter, and concentrate the filtrate When the relative density is 1.02, which is about 1300ml, the safflower extract is ready for use. After appropriate dilution, press WS 3 -B-3825-98 stipulate...

Embodiment 2

[0034] Take 3000g of safflower, add water to decoct twice, first add 10 times the amount of water to decoct for 1.5 hours, second time add 6 times the amount of water to decoct for 80 minutes, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.22 ±0.02, add ethanol to make the alcohol content reach 80%, refrigerate, stand still for 44 hours, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.16±0.02, add ethanol to make the alcohol content reach 70%, refrigerate, stand still Set aside for 38 hours, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.16, add 9 times the amount of water, refrigerate, let stand for 20 hours, filter, concentrate the filtrate to a relative density of 1.05, about 1000ml, and obtain safflower The extract is ready for use, after appropriate dilution, press WS 3 -B-3825-98 stipulates that the absorbance is greater than 1.0.

[0035] Weigh acetylgluta...

Embodiment 3

[0038] Take 2250g of safflower, add water to decoct 3 times, first add 9 times the amount of water to decoct for 1.5 hours, second time add 8 times the amount of water to decoct for 60 minutes, third time add 7 times the amount of water to decoct for 40 minutes, Combine the decoctions, filter, concentrate the filtrate to a relative density of 1.20±0.02, add ethanol to make the alcohol content reach 65%, refrigerate, let stand for 40 hours, filter, recover the ethanol from the filtrate and concentrate to a relative density of 1.14±0.02, Add ethanol to make the alcohol content reach 75%, refrigerate, stand for 48 hours, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.20, add 8 times the amount of water, refrigerate, stand for 24 hours, filter, and concentrate the filtrate When the relative density is 1.04, which is about 900ml, the safflower extract is ready for use. After appropriate dilution, press WS 3 -B-3825-98 stipulates that the absorb...

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PUM

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Abstract

The novel safflower medicine composition is medicine preparation prepared with acetyl glutamine and Chinese medicinal material safflower in the amount of 1-50 times weight of acetyl glutamine. The present invention also discloses the preparation process and use of the medicine composition. By means of the complementary and synergistic effect of both acetyl glutamine and Chinese medicinal material safflower, the medicine composition has the e of promoting blood circulation to disperse blood clots and improving brain metabolism and brain function and may be used in treating coma, paralysis, hypophrenia, memory impairment and other diseases caused by obliterative cerebral vascular diseases, hepatic coma, hemiplegia, etc. It may be also used in treating coronary heart disease, angeitis and other diseases.

Description

technical field [0001] The invention relates to a pharmaceutical composition, its preparation method and its application, in particular to a combination of acetylglutamine and safflower, a traditional Chinese medicinal material, which can be obtained by extracting active ingredients and acetylglutamine. A novel pharmaceutical composition in dosage form, its preparation method and its use in the treatment of obliterative cerebrovascular disease, hepatic coma, hemiplegia, coma, paralysis, mental retardation, memory impairment and other diseases caused by neurosurgery. Background technique [0002] Acetylglutamine is N 2 -Acetyl-L-glutamine (C 7 h 12 N 2 o 4 ), which is a white crystalline powder, is often used clinically as a drug for improving brain function. The drug can pass through the blood-cerebrospinal fluid barrier, and after passing through the blood-cerebrospinal fluid barrier, it can be decomposed into glutamic acid and gamma-aminobutyric acid (GABA) to play a ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/16A61K9/19A61K9/20A61K9/48A61P9/10A61P9/14A61P43/00
Inventor 王建辉
Owner 通化谷红制药有限公司
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