50 results about "Aceglutamide" patented technology

The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and/or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.

Herein is disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated aqueous solution of phenylacetylglutamine and phenylacetylisoglutamine in a 4:1 ratio, at an infusion rate of from 100 mL/hr to 400 mL/hr. In a further embodiment, herein is also disclosed a method of treating neoplastic disease, including cancer, comprising administering a pharmaceutical composition, the pharmaceutical composition comprising a highly concentrated aqueous solution of phenylacetate and (phenylacetylglutamine or phenylacetylisoglutamine) in a 4:1 ratio, at an infusion rate of from 100 mL/hr to 400 mL/hr. Herein are also disclosed the pharmaceutical compositions used in the above methods.

The invention relates to a health food field, particularly a health food containing the following components of: D-ribose, L-carnitine, vitamin C, arginine, taurine, aceglutamide, nicotinamide and corrigent. An effective combination proportion of a reasonable prescription is screened by experiments, to make the prescription efficacy generate synergism, thereby effectively performing anti-hypoxia and anti-fatigue health care effects, and helping sub-healthy patients and persons enter a plateau to regain sufficient energy needed by life activities and to recover body vitality.

An acetylglutamide injection is prepared from the acetylglutamide (0.01-5.00 wt.%) and medicinal carrier (95.00-99.99 wt.%). Its advantages are no need of diluting, and high safety.

The invention relates to an aceglutamide powder injection medicine composition for injection and a preparation method of the medicine composition, in particular belongs to the technical field of medicines, relates to a medicine for treating brain traumatic coma, coma caused by neurosurgery, hepatic coma, hemiplegia, high paraplegia, infantile paralysis, nerve headache and lumbago, in particular relates to a medicine composition such as a freeze-dried powder injection prepared by taking aceglutamide as an active component and also relates to a preparation method of the medicine composition. In one embodiment of the invention, the aceglutamide powder injection medicine composition for injection comprises aceglutamide, a freeze-drying excipient and an acid-base regulation agent, wherein the freeze-drying excipient is selected from mannitol, glycine, lactose, saccharose, glucose and the like or the combination thereof. The aceglutamide powder injection for injection has excellent medicinal properties.

The invention discloses a detection method for hydroxysafflor yellow A metabolic products. The method includes the steps of: 1) performing intravenous injection to an SD rat with a safflower extract and aceglutamide injection, performing orbid blood sampling, and centrifugally separating the blood sample to obtain plasma; 2) sucking the plasma with a micro sample injector, adding acetonitrile with volume ratio of plasma to acetonitrile being 1:3-3.5, uniformly mixing the substances with vortex and centrifuging the mixture to obtain a supernatant, blow-drying the supernatant with nitrogen gas, dissolving the dried substance in acetonitrile, and centrifuging the solution to obtain a supernatant as a detection sample; and 3) detecting and analyzing the sample through high performance liquid chromatography-triple quadrupoles linear ion trap tandem mass spectrometry, and analyzing the metabolic products in a p-MRM-IDA-EPI mode. In the invention, a p-MRM method is employed in the mass spectrum with combination of Light Sight software to quickly identify and analyze the sample for tracing metabolic change of component change and structure change in the plasma; 11 hydroxysafflor yellow A metabolic products are found in the result. The method can be used for obtaining a time change curve of the hydroxysafflor yellow A and the metabolic product thereof in plasma, and successfully deduces and identifies the molecular structures of seven metabolic products and isomers of the hydroxysafflor yellow A. The method, compared with a chemical structure analytic method, is more quick and sensitive.

The invention relates to the technical field of analysis and detection, in particular to a method for simultaneously detecting trimethylamine oxide and phenylacetylglutamine as well as a detection kit and application thereof. According to the detection method provided by the invention, a to-be-detected sample is subjected to sample pretreatment, then detection is performed by adopting a liquid chromatography-tandem mass spectrometry method, the sample pretreatment comprises the following steps: the to-be-detected sample is subjected to precipitation treatment by adopting a precipitant to obtain separated supernate, and the precipitant is an acetonitrile and methanol mixed solution containing 10-100mM ammonium acetate. The method has the advantages of simple sample reservation, simple sample treatment, small sample use amount and fast detection speed, can reduce the problems of two-time sample reservation, time consumption, cost increase and the like due to respective determination, and is easy to popularize and apply; the detection method has high precision and low matrix effect, and can significantly improve the accuracy of trimethylamine oxide and phenylacetyl glutamine detection.

The invention provides a medicinal composition containing carthamus tinctorius yellow color, which comprises aceglutamide and carthamus tinctorius yellow color by a predetermined proportion, and can be used for preparing medicament for the treatment of cerebrovascular diseases, hepatic coma, hemiplegia, paralysis, memory obstacle, coronary disease and angiitis.

A novel dentifrice composition is provided for prevention or treatment of carcinoma of the oral cavity, caries and periodontal diseases of the oral cavity. The dentifrice composition contains a silica abrasive and medicinal agents useful in the treatment of human neoplastic disease. The medicinal agent is selected from the group consisting of 3-N-phenylacetylamino-2,6-piperidinedione, phenylacetylglutamine, phenylacetylisoglutamine, phenylbutyrate, phenylacetate, combinations thereof and pharmaceutically acceptable salts thereof. The components of the dentifrice composition act advantageously to allow the composition to remove plaque, tartar, and oral disease-causing bacteria.

The invention relates to the technical field of textile auxiliary agents, and discloses a water-soluble thermal-reactive polyurethane hydrophilic, flame-retardant and antibacterial finishing agent. The water-soluble thermal-reactive polyurethane hydrophilic, flame-retardant and antibacterial finishing agent comprises components by following weight part: 15-20 parts of water-soluble thermal-reactive polyurethane, 0.1-10 parts of aceglutamide and 2-12 parts of glycerol. The aceglutamide is added as an additive in the finishing agent, and the water-soluble thermal-reactive polyurethane hydrophilic, flame-retardant and antibacterial finishing agent can catalyze proceeding of reaction and significantly improve crosslinking rate of the polyurethane and synthetic fibers, the lower concentration polyurethane can endow the synthetic fibers and wool fibers with lasting hydrophilicity, and simultaneously significantly enhances reactivity and softness, and is high in durability, and a fabric after being tidied not only has good hydrophilicity, but also has fire resistance and antibacterial performance.

The invention provides an aceglutamide composition freeze-dried powder injection for injection, and relates to the technical field of medicines and medicine preparation. The aceglutamide composition freeze-dried powder injection for injection comprises the following raw material components in parts by weight: 2.35-6.35 parts of aceglutamide, 6.70-10.70 parts of chitosan nanoparticles and 84.96-88.96 parts of water for injection. The aceglutamide composition freeze-dried powder injection for injection has the advantages that 1) the composition can remarkably enhance the repairing effect of aceglutamide, the use level of aceglutamide can be clinically reduced, and the adverse reaction of aceglutamide can be alleviated; 2) the chitosan nanoparticles have the effect of targeted therapy and are taken as a medicine carrier to improve the bioavailability of aceglutamide, thereby facilitating clinical application; 3) the chitosan nanoparticles can replace mannitol as a freeze-dried skeleton agent of the freeze-dried powder injection, so that the activity of mannitol on human body is eliminated.

The invention discloses a pharmaceutical composition and preparation comprising active constituents of aceglutamide and safflower, which can be used for preparing medicaments for treating cardiovascular and cerebrovascular diseases, and can be prepared into tablets, capsules, drop pills, injections, pills, syrups, granules, oral liquids, orally administered turbid liquors or oral emulsions.

The invention discloses a pharmaceutical composition which is a compound preparation prepared from aceglutamide and Safflomin A. The pharmaceutical composition can be used for treating cerebrovascular diseases, liver stupor, memory obstacle, coronary disease and vascular diseases.

The invention provides aceglutamide freeze-dried powder for injection.The powder is prepared from 1-10 parts by weight of aceglutamide, 0.5-20 parts by weight of freeze-drying protective additive and a proper amount of pH modifier.Preferably, the freeze-drying protective additive is the composition of mannitol, dextran and saccharose in the proportion of 1:1:1.

The invention relates to edible salt substitute for recuperating 'Five Highs' chronic diseases (High blood pressure, High blood sugar, High blood fat, High uric acid, High body weight). The edible salt substitute is prepared from the components in parts by weight: 0.5 to 1.5 parts of rose salt, 0.5 to 1.5 parts of Himalaya salt, 0.2 to 0.8 part of food grade histidine hydrochloride, 0.05 to 0.15 part of flos caryophyllata, 0.05 to 0.15 part of radix aucklandiae, 0.05 to 0.15 part of fructus foeniculi, 0.05 to 0.15 part of radix curcumae longae, 0.05 to 0.15 part of galanga, 0.05 to 0.15 part of rhizoma zingiberis, 0.05 to 0.15 part of netmeg, 0.05 to 0.15 part of cortex cinnamomi, 0.05 to 0.15 part of fructus crataegi, 0.05 to 0.15 part of sodium tartaric acid, and 0.05 to 0.15 part of aceglutamide. The edible salt substitute for recuperating the 'Five Highs' chronic diseases (High blood pressure, High blood sugar, High blood fat, High uric acid, High body weight) provided by the invention adopts the combination of multiple low sodium salt with different components and multiple condiments, has the efficacies of the edible salt, and substitutes the edible salt so as to reduce the edible salt intake of a human body and recuperate or alleviate the 'Five Highs' chronic diseases (High blood pressure, High blood sugar, High blood fat, High uric acid, High body weight).

The invention provides a acetylglutamine freeze-dried powder injection for injection with double auxiliary materials, relates to the field of pharmaceutical preparations and preparation methods, and mainly solves the problem of freeze-drying of the auxiliary materials in the production formula of the acetylglutamine freeze-dried powder injection for injection in the prior art during production. The disadvantages of long drying time, high drying temperature and high energy consumption. The acetylglutamine freeze-dried powder for injection uses double excipients. The excipients include mannitol and hydroxyethyl starch 130/0.4. The weight ratio of alcohol and hydroxyethyl starch 130/0.4 is 100:80‑100:100. The acetylglutamine freeze-dried powder injection for injection is prepared by using the above-mentioned main drug and auxiliary materials. The acetylglutamine freeze-dried powder for injection provided by the invention is stable in quality, safe and effective, simple in production process, short in freeze-drying time during production, low in drying temperature and low in energy consumption.

The present invention belongs to a medicine preparation containing organic effective component, in particular, it relates to an acetyl-glutamine aluminium oral tablet or capsule preparation. Its composition contains (by weight portion) 200-400 portions of acetyl-glutamine, 0-30 portions of filling agent, 1-10 portions of moistening agent, 0-10 portions of adhesive, 0-10 portions of disintegrating agent and 0-10 portions of lubricating agent. Said invention also provides its preparation method and concrete steps.

The invention discloses a heat-insulating thermal-insulating 3D printing material and a preparation method thereof. The 3D printing material comprises the following raw materials in parts by weight: 55-80 parts of polylactic acid, 18-30 parts of melamine resin micro powder, 13-16 parts of triphenylphosphine, 5-11 parts of aceglutamide, 6-11 parts of multi-amino polyether methylene phosphonic acid,5-10 parts of water-soluble thiosulfate and 2-5 parts of nickel nitrate. The heat-insulating thermal-insulating 3D printing material disclosed by the invention is not only small in heat conduction coefficient and good in heat-preservation effect, but also has the advantages of being good in fire and flame retardancy, good in mechanical property and long in service life, and in addition, the heat-insulating thermal-insulating 3D printing material has a good antibacterial effect, safe to use and high in market popularization value.

The invention discloses the use of pharmaceutical composition containing aceglutamide and safflower extract in preparing medicament for tissue damage assimilation and recovery, wherein animal and human body clinical experiments show that the composition can be used for preparing medicament for promoting assimilation and recovery of bone fracture injury, surgical operation wound and neurotrauma.