7 results about "Aceglutamide" patented technology

The invention relates to the field of traditional Chinese medicine, in particular to application of phenylacetyl glutamine as a marker in preparation of a product for diagnosing and / or treating damp-heat syndrome of diabetes. The invention finds that the PAGln in the plasma and urine of a patient with the damp-heat syndrome of diabetes is increased, and the PAGln can be used as a biomarker for dialectical treatment of the damp-heat syndrome of diabetes.

This invention discloses a method for constructing an animal model of sensorineural hearing loss induced by phenylacetylglutamine and its application. The method includes: selecting 6-8 week old male C57BL / 6J mice, intraperitoneally injecting phenylacetylglutamine solution at a dose of 50 mg / kg body weight / day, once daily, for at least 4 months to obtain the sensorineural hearing loss animal model. This model is characterized by a significantly elevated auditory brainstem response threshold, loss of cochlear outer hair cells, and increased oxidative stress levels. This invention establishes for the first time an animal model of sensorineural hearing loss induced by the circulating metabolite phenylacetylglutamine, filling the technical gap in existing models that cannot simulate hearing loss mediated by metabolic abnormalities. The model construction method is simple to operate, has a high success rate, and good reproducibility, and can be used for research on the pathogenesis of sensorineural hearing loss and screening for preventive and therapeutic drugs.

Methods and consumer products for detecting a metabolite, the method comprising: testing a urine sample from a subject for a metabolite selected from the group consisting of ascorbate, dehydroascorbate, CEHC-sulfate, CEHC-taurine, CEHC-glucronide, pantoate, 5-amino valerate, galactonate, phenylacetylalanine, methylcatecholsulfate, phenylacetylglutamine, carboxysuccinate, carboxyethylvaline, arabinose, threonate, methylcrotonylglycine, glucuronate, carboxyethylisoleucine, glycoursodeoxycholate, leucylalanine, lithocholatesulfate, alio-threonine, cholic, glucuronide and combinations thereof; and producing a metabolic profile for the metabolite.

A method of estimating glomerular filtration rate of a feline can include measuring a blood sample of a feline for blood serum concentrations of pseudouridine and acetylthreonine, and optionally phenylacetylglutamine, and / or tryptophan, and also calculating a blood serum level product. The method can also include applying a feline factor as a multiple to the blood serum level product resulting in an estimated glomerular filtration rate. Calculating the blood serum level product can be based on a first weighted value based upon the blood serum concentration of pseudouridine, a second weighted value based upon the blood serum concentration of acetylthreonine,, an optional third weighted value based upon the blood serum concentration of phenylacetylglutamine, and an optional fourth weighted value based upon the blood serum concentration of tryptophan.

Methods of diagnosing Crohn's disease and ulcerative colitis in subjects is provided based on the determination of metabolites in urine samples, such as serine, hypoxanthine, kynurenine, threonine, dimethylglycine, tryptophan, indoxylsulfate, phenylacetylglutamine, sialic acid, 5-hydroxy-6-indolyl-o-sulfate, 5-(Δ-carboxybutyl) homocysteine, and / or an anion having m / z:RMT:polarity of 345.1553:0.770:n, or determination of metabolites in stool samples, such as ketodeoxycholic acid, cholic acid, choline, tryptophan, trimethyllysine, serine, butyric acid, lactic acid, hypoxanthine and / or guanine.

The present invention relates to a personal care composition. Particularly, the present invention relates to a personal care composition that provides protection from sun-induced damages. The composition comprises a skin care benefit agent selected from acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, or a salt, or mixtures thereof, in combination with an oil-soluble sunscreen, a water-soluble sunscreen, and a non-ionic surfactant with select HLB value and select polymers. The composition provides protection from ROS generation induced by exposure to UV and / or blue light.

Methods of diagnosing Crohn's disease and ulcerative colitis in subjects is provided based on the determination of metabolites in urine samples, such as serine, hypoxanthine, kynurenine, threonine, indoxylsulfate, phenylacetylglutamine, 5-hydroxy-6-indolyl-O-sulfate, 5-(δ-carboxybutyl) homocysteine, sialic acid, guanidinosuccinic acid (GSA), glutamyl(iso) leucine, trigonelline, cresol sulfate, an anion having m / z: RMT: polarity of 345.1553:0.770: n, aminohippurate: GSA ratiometric biomarker, unknown anion (160.0615:0.830: n): tyrosine ratiometric biomarker and [GSA×Tyr]: [AHA×(an anion having m / z: RMT: polarity of 160.0615:0.830: n)] ratiometric biomarker.